Details for: OR7E2P

Gene ID: 8587

Symbol: OR7E2P

Ensembl ID: ENSG00000255203

Description: olfactory receptor family 7 subfamily E member 2 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1650
    Cell Significance Index: 2.4400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1537
    Cell Significance Index: 1.5700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0424
    Cell Significance Index: 0.4100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0393
    Cell Significance Index: 0.5700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0221
    Cell Significance Index: 0.2800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0218
    Cell Significance Index: 0.3000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.0183
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0012
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -1.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0083
    Cell Significance Index: -1.2100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0144
    Cell Significance Index: -0.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0202
    Cell Significance Index: -0.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0204
    Cell Significance Index: -0.5100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0268
    Cell Significance Index: -0.5600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0295
    Cell Significance Index: -0.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0330
    Cell Significance Index: -1.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0330
    Cell Significance Index: -1.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0385
    Cell Significance Index: -1.3500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0403
    Cell Significance Index: -0.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0495
    Cell Significance Index: -1.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0505
    Cell Significance Index: -1.0900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0530
    Cell Significance Index: -0.3100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0532
    Cell Significance Index: -0.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0538
    Cell Significance Index: -1.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0541
    Cell Significance Index: -1.0700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0562
    Cell Significance Index: -0.3700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0641
    Cell Significance Index: -0.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0680
    Cell Significance Index: -1.4900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0681
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0682
    Cell Significance Index: -0.6400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0898
    Cell Significance Index: -1.0200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1017
    Cell Significance Index: -1.2500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1050
    Cell Significance Index: -1.3700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1078
    Cell Significance Index: -1.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1138
    Cell Significance Index: -1.2400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1141
    Cell Significance Index: -1.3700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1268
    Cell Significance Index: -1.3600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1364
    Cell Significance Index: -1.6600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1407
    Cell Significance Index: -1.6100
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1484
    Cell Significance Index: -1.6100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1486
    Cell Significance Index: -1.8500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1562
    Cell Significance Index: -1.8900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1575
    Cell Significance Index: -1.9700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1594
    Cell Significance Index: -1.7800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1607
    Cell Significance Index: -1.7800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1651
    Cell Significance Index: -1.7900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1704
    Cell Significance Index: -1.0700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1830
    Cell Significance Index: -1.7900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1835
    Cell Significance Index: -1.8100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1921
    Cell Significance Index: -1.8000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1971
    Cell Significance Index: -1.8100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2054
    Cell Significance Index: -1.8100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2585
    Cell Significance Index: -2.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR7E2P is a pseudogene, meaning it has undergone significant genetic degradation, resulting in a non-functional gene product. Its designation as a member of the olfactory receptor family 7 subfamily E suggests a shared evolutionary history with functional olfactory receptors. The expression of OR7E2P is widespread, with significantly expressed cells including astrocytes, malignant cells, and endothelial cells. This broad tissue distribution is unusual for a pseudogene, indicating that OR7E2P may have evolved to play a role in maintaining cellular homeostasis or participating in specific biological processes. **Pathways and Functions:** The functional significance of OR7E2P remains unclear. However, its expression in various cell types suggests potential involvement in cellular signaling pathways. Olfactory receptors, including those in the OR7 subfamily, are known to play a crucial role in detecting odorant molecules and modulating downstream signaling cascades. It is possible that OR7E2P, despite being a pseudogene, has evolved to interact with similar signaling pathways, providing a functional "safety net" for cellular homeostasis. Further research is needed to elucidate the specific pathways and mechanisms by which OR7E2P influences cellular behavior. **Clinical Significance:** The clinical significance of OR7E2P is an area of ongoing investigation. While its expression in malignant cells suggests potential involvement in cancer progression, the functional implications of this pseudogene remain unclear. Further studies are necessary to determine whether OR7E2P plays a role in the development or progression of various diseases, including cancer. Additionally, the expression of OR7E2P in endothelial cells raises questions about its potential involvement in vascular biology and disease. Elucidating the clinical significance of OR7E2P will require a multidisciplinary approach, incorporating expertise in genetics, immunology, and disease modeling. In conclusion, the OR7E2P gene, a pseudogene with widespread expression, presents a fascinating case study in the complexities of gene function and regulation. Further research is needed to unravel the mysteries surrounding this enigmatic gene and its potential role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.