Details for: CYP24A1

Gene ID: 1591

Symbol: CYP24A1

Ensembl ID: ENSG00000019186

Description: cytochrome P450 family 24 subfamily A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4201
    Cell Significance Index: 73.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8666
    Cell Significance Index: 111.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7456
    Cell Significance Index: 18.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7337
    Cell Significance Index: 10.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6600
    Cell Significance Index: 18.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4769
    Cell Significance Index: 12.9800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.4521
    Cell Significance Index: 5.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4146
    Cell Significance Index: 6.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2766
    Cell Significance Index: 49.8700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.2448
    Cell Significance Index: 1.5200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.2123
    Cell Significance Index: 1.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1910
    Cell Significance Index: 8.9800
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.1461
    Cell Significance Index: 1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1141
    Cell Significance Index: 16.5900
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.1088
    Cell Significance Index: 1.0000
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.0706
    Cell Significance Index: 0.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0186
    Cell Significance Index: 10.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0179
    Cell Significance Index: 2.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0015
    Cell Significance Index: -0.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -5.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0045
    Cell Significance Index: -3.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -3.9800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0059
    Cell Significance Index: -1.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0083
    Cell Significance Index: -2.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0089
    Cell Significance Index: -0.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0119
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0121
    Cell Significance Index: -3.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0159
    Cell Significance Index: -3.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0192
    Cell Significance Index: -4.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0227
    Cell Significance Index: -3.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0230
    Cell Significance Index: -2.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0230
    Cell Significance Index: -0.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0239
    Cell Significance Index: -1.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0241
    Cell Significance Index: -3.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0241
    Cell Significance Index: -0.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0266
    Cell Significance Index: -1.8800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0275
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0317
    Cell Significance Index: -3.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0336
    Cell Significance Index: -2.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0405
    Cell Significance Index: -3.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0407
    Cell Significance Index: -4.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0548
    Cell Significance Index: -0.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0583
    Cell Significance Index: -2.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0587
    Cell Significance Index: -3.9500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0606
    Cell Significance Index: -0.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0684
    Cell Significance Index: -5.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0709
    Cell Significance Index: -4.3600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0734
    Cell Significance Index: -1.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0742
    Cell Significance Index: -1.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0775
    Cell Significance Index: -1.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0801
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0850
    Cell Significance Index: -1.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0926
    Cell Significance Index: -1.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0936
    Cell Significance Index: -4.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0940
    Cell Significance Index: -2.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0975
    Cell Significance Index: -5.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0995
    Cell Significance Index: -2.9300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0998
    Cell Significance Index: -1.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1005
    Cell Significance Index: -3.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1025
    Cell Significance Index: -5.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1050
    Cell Significance Index: -1.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1121
    Cell Significance Index: -3.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1136
    Cell Significance Index: -3.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1158
    Cell Significance Index: -5.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1213
    Cell Significance Index: -4.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1225
    Cell Significance Index: -3.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1231
    Cell Significance Index: -3.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1232
    Cell Significance Index: -3.2900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1248
    Cell Significance Index: -2.4400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1262
    Cell Significance Index: -1.1200
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1315
    Cell Significance Index: -1.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1362
    Cell Significance Index: -4.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1378
    Cell Significance Index: -5.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1435
    Cell Significance Index: -1.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1440
    Cell Significance Index: -4.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1466
    Cell Significance Index: -2.5900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1469
    Cell Significance Index: -2.3300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1542
    Cell Significance Index: -2.1400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1570
    Cell Significance Index: -1.2100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1573
    Cell Significance Index: -1.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1631
    Cell Significance Index: -4.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1648
    Cell Significance Index: -4.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1650
    Cell Significance Index: -4.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1664
    Cell Significance Index: -4.1500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1726
    Cell Significance Index: -1.5600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1747
    Cell Significance Index: -2.2500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1758
    Cell Significance Index: -2.6300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1773
    Cell Significance Index: -1.8700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1822
    Cell Significance Index: -1.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1849
    Cell Significance Index: -3.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1855
    Cell Significance Index: -1.9200
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.1856
    Cell Significance Index: -1.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CYP24A1 is a non-heme iron-containing monooxygenase that belongs to the cytochrome P450 superfamily. It is primarily expressed in various tissues, including the kidney, liver, and intestine, where it plays a key role in vitamin D metabolism. The enzyme has a high affinity for vitamin D3, allowing it to efficiently degrade calcitriol into its inactive metabolites. CYP24A1 has also been shown to interact with other proteins, including the vitamin D receptor (VDR) and the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ), modulating the transcriptional activity of these receptors. **Pathways and Functions:** CYP24A1 is involved in several key pathways, including: 1. **Vitamin D metabolism:** CYP24A1 is responsible for the degradation of calcitriol, the biologically active form of vitamin D, into its inactive metabolites. This process is crucial for maintaining vitamin D homeostasis and regulating various physiological processes. 2. **Calcium homeostasis:** The degradation products of calcitriol, 1,24,25-trihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3, can regulate calcium homeostasis by influencing calcium absorption and excretion in the kidneys and intestine. 3. **Bone mineralization:** CYP24A1 has been shown to regulate bone mineralization by influencing the expression of genes involved in osteoblast differentiation and bone matrix synthesis. 4. **Immune function:** Vitamin D and its metabolites have been shown to regulate immune function, and CYP24A1 plays a key role in this process by modulating the expression of genes involved in immune cell function. **Clinical Significance:** Dysregulation of CYP24A1 has been implicated in several diseases, including: 1. **Hyperparathyroidism:** Elevated levels of CYP24A1 have been observed in patients with primary hyperparathyroidism, a condition characterized by excessive parathyroid hormone secretion. 2. **Osteomalacia:** Defects in CYP24A1 have been implicated in osteomalacia, a condition characterized by softening of the bones due to impaired mineralization. 3. **Cancer:** CYP24A1 has been shown to be overexpressed in several types of cancer, including breast, prostate, and lung cancer, and has been implicated in tumor progression and metastasis. In conclusion, CYP24A1 plays a critical role in regulating vitamin D metabolism and has significant implications for maintaining calcium homeostasis, bone mineralization, and immune function. Dysregulation of CYP24A1 has been implicated in several diseases, highlighting the importance of this enzyme in human health. Further research is needed to fully understand the role of CYP24A1 in human disease and to develop therapeutic strategies targeting this enzyme.

Genular Protein ID: 701921939

Symbol: CP24A_HUMAN

Name: Cytochrome P450 24A1

UniProtKB Accession Codes:

Q07973 Q15807 Q32ML3 Q5I2W7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 94 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 6 EMBL 7 Ensembl 3 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 6 Rhea 52 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8506296

Title: Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA.

PubMed ID: 8506296

DOI: 10.1073/pnas.90.10.4543

PubMed ID: 15788398

Title: Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis.

PubMed ID: 15788398

DOI: 10.1074/jbc.m414522200

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7632726

Title: Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements.

PubMed ID: 7632726

DOI: 10.1016/0167-4781(95)00060-t

PubMed ID: 8266831

Title: Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets.

PubMed ID: 8266831

DOI: 10.1002/jbmr.5650081114

PubMed ID: 8679605

Title: Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme.

PubMed ID: 8679605

DOI: 10.1021/bi960658i

PubMed ID: 11012668

Title: Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24.

PubMed ID: 11012668

DOI: 10.1046/j.1432-1327.2000.01680.x

PubMed ID: 15574355

Title: Metabolism of vitamin D3 by cytochromes P450.

PubMed ID: 15574355

DOI: 10.2741/1514

PubMed ID: 16617161

Title: Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats.

PubMed ID: 16617161

DOI: 10.1124/mol.106.023275

PubMed ID: 24893882

Title: Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway.

PubMed ID: 24893882

DOI: 10.1111/febs.12862

PubMed ID: 25727742

Title: Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1.

PubMed ID: 25727742

DOI: 10.1016/j.jsbmb.2015.02.010

PubMed ID: 29461981

Title: CYP3A4 mutation causes vitamin D-dependent rickets type 3.

PubMed ID: 29461981

DOI: 10.1172/jci98680

PubMed ID: 21675912

Title: Mutations in CYP24A1 and idiopathic infantile hypercalcemia.

PubMed ID: 21675912

DOI: 10.1056/nejmoa1103864

Sequence Information:

  • Length: 514
  • Mass: 58875
  • Checksum: 8862F63771981195
  • Sequence:
    • MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG ETQNAAALPG 
PTSWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR 
TESAYPQRLE IKPWKAYRDY RKEGYGLLIL EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN 
EVLADFMGRI DELCDERGHV EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM 
AIKTMMSTFG RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD 
FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ KLLKEIQSVL 
PENQVPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK ATVLGEYALP KGTVLMLNTQ 
VLGSSEDNFE DSSQFRPERW LQEKEKINPF AHLPFGVGKR MCIGRRLAEL QLHLALCWIV 
RKYDIQATDN EPVEMLHSGT LVPSRELPIA FCQR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.