Details for: S1PR1

Gene ID: 1901

Symbol: S1PR1

Ensembl ID: ENSG00000170989

Description: sphingosine-1-phosphate receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 9.25
    Marker Score: 7403
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.92
    Marker Score: 7415
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.64
    Marker Score: 3815
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.56
    Marker Score: 2204
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.04
    Marker Score: 2962
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.95
    Marker Score: 1163
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.85
    Marker Score: 98048
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.72
    Marker Score: 15121
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.59
    Marker Score: 3179
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.58
    Marker Score: 4987
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.5
    Marker Score: 361
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.49
    Marker Score: 9516
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168693
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.47
    Marker Score: 356
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.47
    Marker Score: 1380
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.43
    Marker Score: 2795
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.4
    Marker Score: 6009
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.39
    Marker Score: 295
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.37
    Marker Score: 1324
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.32
    Marker Score: 306
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.3
    Marker Score: 539
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.28
    Marker Score: 1377
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.27
    Marker Score: 2399
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.2
    Marker Score: 1075
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.15
    Marker Score: 360
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.14
    Marker Score: 4407
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.13
    Marker Score: 1140
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.13
    Marker Score: 1904.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.11
    Marker Score: 433
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17083
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.09
    Marker Score: 253
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.08
    Marker Score: 2271
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.07
    Marker Score: 1006
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.05
    Marker Score: 592
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.03
    Marker Score: 12016
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.03
    Marker Score: 753
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.03
    Marker Score: 928.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.02
    Marker Score: 1220
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71792
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48018
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.99
    Marker Score: 228
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.99
    Marker Score: 1365
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.97
    Marker Score: 1048
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.96
    Marker Score: 482
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.96
    Marker Score: 855
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.95
    Marker Score: 1629
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.93
    Marker Score: 820
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5259
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.91
    Marker Score: 1583
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9
    Marker Score: 538
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.88
    Marker Score: 2147
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5273
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.84
    Marker Score: 827
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.81
    Marker Score: 177
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1250
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.75
    Marker Score: 190
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.72
    Marker Score: 387.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.71
    Marker Score: 514
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.71
    Marker Score: 187
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.69
    Marker Score: 650
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.67
    Marker Score: 191
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.67
    Marker Score: 413
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.67
    Marker Score: 14316
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.66
    Marker Score: 712
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.64
    Marker Score: 893.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 552
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.63
    Marker Score: 460
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.61
    Marker Score: 512
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.61
    Marker Score: 1083
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.61
    Marker Score: 378
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.6
    Marker Score: 259
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.57
    Marker Score: 846
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.57
    Marker Score: 1610
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.57
    Marker Score: 332
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.57
    Marker Score: 503
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.55
    Marker Score: 734
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.55
    Marker Score: 132
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.55
    Marker Score: 140
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.53
    Marker Score: 348
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.52
    Marker Score: 742
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.51
    Marker Score: 305
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.5
    Marker Score: 216.5
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.48
    Marker Score: 133
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.48
    Marker Score: 169
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.48
    Marker Score: 391
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.47
    Marker Score: 119
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.46
    Marker Score: 140
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 120
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.45
    Marker Score: 4537.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.45
    Marker Score: 353
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.45
    Marker Score: 123
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.45
    Marker Score: 293

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Other Information

**Key characteristics:** * S1PR1 is a transmembrane protein with a single extracellular domain and seven transmembrane domains. * It is a ligand-gated ion channel that is expressed in high levels in endothelial cells and some immune cells. * When S1PR1 binds to its ligand, sphingosine-1-phosphate (S1P), it undergoes a conformational change that activates the receptor. * This conformational change allows S1PR1 to interact with and activate G proteins, which are signaling molecules that regulate various cellular processes. **Pathways and functions:** * S1PR1 is involved in a variety of signaling pathways, including those involving the cytokines interleukin-4 (IL-4) and interleukin-13 (IL-13). * It is also involved in the regulation of immune responses, with S1P signaling playing a role in the development and maintenance of immune tolerance. * S1PR1 is also involved in the regulation of vascular function, with its expression being upregulated in response to hypoxia and inflammation. * Dysregulation of S1PR1 signaling has been linked to various diseases, including atherosclerosis, asthma, and inflammatory diseases. **Clinical significance:** * S1PR1 is a potential therapeutic target for a variety of diseases that are characterized by inflammation and tissue damage, including atherosclerosis, asthma, and inflammatory bowel disease. * Blockade of S1PR1 signaling has been shown to be effective in reducing inflammation and tissue damage in animal models of these diseases. * S1PR1 is a promising target for the development of new treatments for inflammatory diseases.

Genular Protein ID: 470820637

Symbol: S1PR1_HUMAN

Name: Sphingosine 1-phosphate receptor 1

UniProtKB Accession Codes:

P21453 D3DT66 Q9BYY4 Q9NYN8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 10 EMDB 14 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 16 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2160972

Title: An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

PubMed ID: 2160972

DOI: 10.1016/s0021-9258(19)38849-0

PubMed ID: 9409733

Title: Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.

PubMed ID: 9409733

DOI: 10.1016/s0014-5793(97)01301-x

PubMed ID: 10982820

Title: Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.

PubMed ID: 10982820

DOI: 10.1074/jbc.m007680200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8626678

Title: The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.

PubMed ID: 8626678

DOI: 10.1074/jbc.271.19.11272

PubMed ID: 9488656

Title: Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.

PubMed ID: 9488656

DOI: 10.1126/science.279.5356.1552

PubMed ID: 10383399

Title: Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.

PubMed ID: 10383399

DOI: 10.1074/jbc.274.27.18997

PubMed ID: 11604399

Title: A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors.

PubMed ID: 11604399

DOI: 10.1074/jbc.m107301200

PubMed ID: 11583630

Title: Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.

PubMed ID: 11583630

DOI: 10.1016/s1097-2765(01)00324-0

PubMed ID: 11230698

Title: Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.

PubMed ID: 11230698

DOI: 10.1126/science.1057559

PubMed ID: 15750791

Title: Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells.

PubMed ID: 15750791

DOI: 10.1007/s10719-004-5540-8

PubMed ID: 19286607

Title: Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids.

PubMed ID: 19286607

DOI: 10.1161/circresaha.108.193367

PubMed ID: 29185452

Title: DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling.

PubMed ID: 29185452

DOI: 10.1038/s41598-017-16457-4

PubMed ID: 22344443

Title: Crystal structure of a lipid G protein-coupled receptor.

PubMed ID: 22344443

DOI: 10.1126/science.1215904

Sequence Information:

  • Length: 382
  • Mass: 42811
  • Checksum: 0CCE8685A5E1BAD2
  • Sequence:
    • MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKLTSV VFILICCFII 
LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR 
EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNNFRL FLLISACWVI SLILGGLPIM 
GWNCISALSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN 
ISKASRSSEK SLALLKTVII VLSVFIACWA PLFILLLLDV GCKVKTCDIL FRAEYFLVLA 
VLNSGTNPII YTLTNKEMRR AFIRIMSCCK CPSGDSAGKF KRPIIAGMEF SRSKSDNSSH 
PQKDEGDNPE TIMSSGNVNS SS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.