Details for: S1PR1

Gene ID: 1901

Symbol: S1PR1

Ensembl ID: ENSG00000170989

Description: sphingosine-1-phosphate receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 100.9353
    Cell Significance Index: -15.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.6220
    Cell Significance Index: -15.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.0917
    Cell Significance Index: -13.8500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 25.4448
    Cell Significance Index: 157.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.6584
    Cell Significance Index: -14.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.7255
    Cell Significance Index: -15.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9787
    Cell Significance Index: -15.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7767
    Cell Significance Index: -11.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 3.5834
    Cell Significance Index: 21.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.3610
    Cell Significance Index: 122.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1867
    Cell Significance Index: 64.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.0332
    Cell Significance Index: 35.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.9203
    Cell Significance Index: 21.8200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.6695
    Cell Significance Index: 11.9900
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.5249
    Cell Significance Index: 5.3100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9430
    Cell Significance Index: 13.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8447
    Cell Significance Index: 22.6400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.8143
    Cell Significance Index: 11.1500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.1948
    Cell Significance Index: 1.2200
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.1664
    Cell Significance Index: 0.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0837
    Cell Significance Index: 10.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0453
    Cell Significance Index: 1.1900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.0443
    Cell Significance Index: 0.1300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0110
    Cell Significance Index: 0.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0017
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0058
    Cell Significance Index: -10.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0119
    Cell Significance Index: -21.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0139
    Cell Significance Index: -18.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0142
    Cell Significance Index: -21.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0199
    Cell Significance Index: -15.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0203
    Cell Significance Index: -14.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0205
    Cell Significance Index: -11.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0209
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0224
    Cell Significance Index: -14.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0253
    Cell Significance Index: -15.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0256
    Cell Significance Index: -18.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0335
    Cell Significance Index: -18.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0343
    Cell Significance Index: -0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0369
    Cell Significance Index: -16.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0403
    Cell Significance Index: -11.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0405
    Cell Significance Index: -14.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0562
    Cell Significance Index: -10.1300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0660
    Cell Significance Index: -0.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0697
    Cell Significance Index: -10.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0753
    Cell Significance Index: -8.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0759
    Cell Significance Index: -15.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0922
    Cell Significance Index: -11.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1041
    Cell Significance Index: -17.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1042
    Cell Significance Index: -13.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1050
    Cell Significance Index: -14.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1052
    Cell Significance Index: -10.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1052
    Cell Significance Index: -22.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1133
    Cell Significance Index: -13.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1161
    Cell Significance Index: -5.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1370
    Cell Significance Index: -10.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1493
    Cell Significance Index: -15.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1581
    Cell Significance Index: -18.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1779
    Cell Significance Index: -13.2600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1956
    Cell Significance Index: -2.7800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1999
    Cell Significance Index: -1.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2005
    Cell Significance Index: -11.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2065
    Cell Significance Index: -13.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2079
    Cell Significance Index: -12.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2098
    Cell Significance Index: -9.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2220
    Cell Significance Index: -13.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2298
    Cell Significance Index: -15.4500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2357
    Cell Significance Index: -4.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2426
    Cell Significance Index: -4.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2427
    Cell Significance Index: -1.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2590
    Cell Significance Index: -12.1800
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.2777
    Cell Significance Index: -2.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2873
    Cell Significance Index: -14.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2939
    Cell Significance Index: -15.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2974
    Cell Significance Index: -8.3100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3073
    Cell Significance Index: -1.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3204
    Cell Significance Index: -8.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3209
    Cell Significance Index: -13.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3248
    Cell Significance Index: -14.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3318
    Cell Significance Index: -8.5300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3340
    Cell Significance Index: -3.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3340
    Cell Significance Index: -17.3500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3653
    Cell Significance Index: -4.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3674
    Cell Significance Index: -16.2500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3676
    Cell Significance Index: -5.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3695
    Cell Significance Index: -9.8700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.3990
    Cell Significance Index: -3.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4006
    Cell Significance Index: -13.9200
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.4043
    Cell Significance Index: -4.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4173
    Cell Significance Index: -15.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4232
    Cell Significance Index: -12.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4289
    Cell Significance Index: -16.2400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4303
    Cell Significance Index: -7.4400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.4409
    Cell Significance Index: -4.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4466
    Cell Significance Index: -15.6500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4505
    Cell Significance Index: -3.9400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.4667
    Cell Significance Index: -5.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4758
    Cell Significance Index: -14.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4820
    Cell Significance Index: -12.0200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.4861
    Cell Significance Index: -2.8700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4952
    Cell Significance Index: -6.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Structure:** S1PR1 is a G-protein coupled receptor that consists of seven transmembrane domains and an intracellular tail. 2. **Sphingosine-1-Phosphate Binding:** S1P binding to S1PR1 triggers a signaling cascade that activates various downstream pathways, including phospholipase C activation and protein kinase C phosphorylation. 3. **Signaling Pathways:** S1PR1 regulates multiple signaling pathways, including actin cytoskeleton organization, cell adhesion, cell migration, and immune response. 4. **Cell Type Expression:** S1PR1 is expressed in various cell types, including endothelial cells, immune cells, and fibroblasts. **Pathways and Functions:** 1. **Angiogenesis:** S1PR1 regulates angiogenesis by promoting endothelial cell migration, proliferation, and tube formation. 2. **Immune Response:** S1PR1 modulates immune responses by regulating T cell migration, proliferation, and cytokine production. 3. **Cell Migration:** S1PR1 promotes cell migration by regulating actin cytoskeleton organization and cell adhesion. 4. **Cardiac Muscle Tissue Growth:** S1PR1 regulates cardiac muscle tissue growth involved in heart morphogenesis. 5. **Infectious Disease:** S1PR1 has been implicated in the regulation of immune responses to infectious diseases, including SARS-CoV. **Clinical Significance:** 1. **Cardiovascular Disease:** Dysregulation of S1PR1 has been implicated in cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 2. **Cancer:** S1PR1 has been shown to promote cancer cell migration, invasion, and metastasis. 3. **Autoimmune Disorders:** S1PR1 has been implicated in the regulation of immune responses in autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. 4. **Infectious Disease:** S1PR1 has been shown to play a critical role in the regulation of immune responses to infectious diseases, including SARS-CoV. 5. **Potential Therapeutics:** Targeting S1PR1 has been proposed as a potential therapeutic strategy for various diseases, including cardiovascular disease, cancer, and autoimmune disorders. In conclusion, the S1PR1 gene encodes for a critical receptor that regulates various cellular processes, including immune response, angiogenesis, and cellular migration. Its dysregulation has been implicated in several diseases, and targeting S1PR1 has been proposed as a potential therapeutic strategy for various diseases. Further research is needed to fully understand the role of S1PR1 in human health and disease.

Genular Protein ID: 470820637

Symbol: S1PR1_HUMAN

Name: Sphingosine 1-phosphate receptor 1

UniProtKB Accession Codes:

P21453 D3DT66 Q9BYY4 Q9NYN8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 10 EMDB 14 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2160972

Title: An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

PubMed ID: 2160972

DOI: 10.1016/s0021-9258(19)38849-0

PubMed ID: 9409733

Title: Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.

PubMed ID: 9409733

DOI: 10.1016/s0014-5793(97)01301-x

PubMed ID: 10982820

Title: Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.

PubMed ID: 10982820

DOI: 10.1074/jbc.m007680200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8626678

Title: The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.

PubMed ID: 8626678

DOI: 10.1074/jbc.271.19.11272

PubMed ID: 9488656

Title: Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.

PubMed ID: 9488656

DOI: 10.1126/science.279.5356.1552

PubMed ID: 10383399

Title: Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.

PubMed ID: 10383399

DOI: 10.1074/jbc.274.27.18997

PubMed ID: 11604399

Title: A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors.

PubMed ID: 11604399

DOI: 10.1074/jbc.m107301200

PubMed ID: 11583630

Title: Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.

PubMed ID: 11583630

DOI: 10.1016/s1097-2765(01)00324-0

PubMed ID: 11230698

Title: Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.

PubMed ID: 11230698

DOI: 10.1126/science.1057559

PubMed ID: 15750791

Title: Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells.

PubMed ID: 15750791

DOI: 10.1007/s10719-004-5540-8

PubMed ID: 19286607

Title: Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids.

PubMed ID: 19286607

DOI: 10.1161/circresaha.108.193367

PubMed ID: 29185452

Title: DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling.

PubMed ID: 29185452

DOI: 10.1038/s41598-017-16457-4

PubMed ID: 22344443

Title: Crystal structure of a lipid G protein-coupled receptor.

PubMed ID: 22344443

DOI: 10.1126/science.1215904

PubMed ID: 37039481

Title: Transmembrane protein CD69 acts as an S1PR1 agonist.

PubMed ID: 37039481

DOI: 10.7554/elife.88204

Sequence Information:

  • Length: 382
  • Mass: 42811
  • Checksum: 0CCE8685A5E1BAD2
  • Sequence:
    • MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKLTSV VFILICCFII 
LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR 
EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNNFRL FLLISACWVI SLILGGLPIM 
GWNCISALSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN 
ISKASRSSEK SLALLKTVII VLSVFIACWA PLFILLLLDV GCKVKTCDIL FRAEYFLVLA 
VLNSGTNPII YTLTNKEMRR AFIRIMSCCK CPSGDSAGKF KRPIIAGMEF SRSKSDNSSH 
PQKDEGDNPE TIMSSGNVNS SS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.