Gene ENDOG - ENSG00000167136 | NCBI Gene ID: 2021

Details for: ENDOG

Gene ID: 2021

Symbol: ENDOG

Ensembl ID: ENSG00000167136

Description: endonuclease G

Associated with

Apoptotic dna fragmentation
(GO:0006309)
Dna damage response
(GO:0006974)
Dna endonuclease activity
(GO:0004520)
Dna recombination
(GO:0006310)
In utero embryonic development
(GO:0001701)
Magnesium ion binding
(GO:0000287)
Mitochondrial dna catabolic process
(GO:0032043)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Negative regulation of tor signaling
(GO:0032007)
Nucleic acid binding
(GO:0003676)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of mitochondrial dna replication
(GO:0090297)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Response to antibiotic
(GO:0046677)
Response to tumor necrosis factor
(GO:0034612)
Rna endonuclease activity
(GO:0004521)
Single-stranded dna endodeoxyribonuclease activity
(GO:0000014)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.18
Marker Score: 18917
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.44
Marker Score: 975.5
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.36
Marker Score: 2579.5
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.36
Marker Score: 446
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.32
Marker Score: 45832
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.32
Marker Score: 1943.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.22
Marker Score: 4517
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.21
Marker Score: 3231
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.2
Marker Score: 1987
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.15
Marker Score: 961
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.04
Marker Score: 2379
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71767
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47992
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30402
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.98
Marker Score: 464
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.96
Marker Score: 2409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2405
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.95
Marker Score: 1003
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 486
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 441
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.93
Marker Score: 925
Cell Name: enterocyte (CL0000584)
Fold Change: 0.93
Marker Score: 4447
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2717
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.9
Marker Score: 1890
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5004
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5259
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.83
Marker Score: 2954
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.82
Marker Score: 374
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.81
Marker Score: 8218
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.81
Marker Score: 1990
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.81
Marker Score: 12637
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.8
Marker Score: 1137
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.8
Marker Score: 231
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8
Marker Score: 3143
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.8
Marker Score: 2740
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: peptic cell (CL0000155)
Fold Change: 0.77
Marker Score: 324
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.76
Marker Score: 816
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.75
Marker Score: 369
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 571
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.73
Marker Score: 686
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 377
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.72
Marker Score: 289
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.7
Marker Score: 261
Cell Name: keratocyte (CL0002363)
Fold Change: 0.7
Marker Score: 160
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.69
Marker Score: 440
Cell Name: brush cell (CL0002204)
Fold Change: 0.68
Marker Score: 623
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.68
Marker Score: 234
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.68
Marker Score: 432
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.66
Marker Score: 2770
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 169
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.66
Marker Score: 668
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.65
Marker Score: 5605
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.63
Marker Score: 4047
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.63
Marker Score: 655.5
Cell Name: precursor cell (CL0011115)
Fold Change: 0.62
Marker Score: 151
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.62
Marker Score: 1450
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.61
Marker Score: 646
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6
Marker Score: 150
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.6
Marker Score: 644
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.6
Marker Score: 281
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.6
Marker Score: 1359
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.6
Marker Score: 1874
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.58
Marker Score: 299
Cell Name: stem cell (CL0000034)
Fold Change: 0.58
Marker Score: 1369
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.57
Marker Score: 1085
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.57
Marker Score: 626
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.56
Marker Score: 892
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.55
Marker Score: 1113
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 430
Cell Name: neural cell (CL0002319)
Fold Change: 0.54
Marker Score: 260
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.54
Marker Score: 356
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.52
Marker Score: 216
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.52
Marker Score: 195
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.5
Marker Score: 530
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.49
Marker Score: 5107
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.49
Marker Score: 1891
Cell Name: male germ cell (CL0000015)
Fold Change: 0.48
Marker Score: 137
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.47
Marker Score: 728
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.47
Marker Score: 125
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.47
Marker Score: 4688.5
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.47
Marker Score: 946
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.46
Marker Score: 291
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.46
Marker Score: 149
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.46
Marker Score: 199
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.46
Marker Score: 113
Cell Name: paneth cell (CL0000510)
Fold Change: 0.45
Marker Score: 312
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.44
Marker Score: 3467
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.44
Marker Score: 244
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.44
Marker Score: 293
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.44
Marker Score: 414
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.44
Marker Score: 4929
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.44
Marker Score: 298
Cell Name: leukocyte (CL0000738)
Fold Change: 0.44
Marker Score: 250
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.43
Marker Score: 134
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.43
Marker Score: 516
Cell Name: thymocyte (CL0000893)
Fold Change: 0.42
Marker Score: 445
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.42
Marker Score: 247
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.42
Marker Score: 5594

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**Key characteristics:** * It is a nuclear protein that is found in both eukaryotic and prokaryotic cells. * It is a key regulator of apoptosis, DNA damage response, and mitochondrial DNA catabolic process. * It is involved in the regulation of cell proliferation, differentiation, and survival. * It is a potential therapeutic target for cancer and other diseases. **Pathways and functions:** * **Apoptotic DNA fragmentation:** ENDOG is a key enzyme in apoptotic DNA fragmentation, a process that is essential for the removal of damaged or dysfunctional DNA. * **DNA damage response:** ENDOG is also involved in the DNA damage response pathway, where it helps to repair DNA damage and maintain genome integrity. * **Mitochondrial DNA catabolic process:** ENDOG is involved in the mitochondrial DNA catabolic process, where it degrades mitochondrial DNA to be used as an energy source. **Clinical significance:** * Mutations in the ENDOG gene have been linked to several human diseases, including cancer and cardiovascular disease. * Targeting ENDOG with small molecule inhibitors has shown promise in preclinical models of cancer and other diseases. * However, clinical trials of ENDOG inhibitors have not been successful due to poor drug delivery and low bioavailability. **Additional notes:** * ENDOG is a highly conserved protein that is found in organisms from yeast to humans. * It is a multi-functional protein that can be active as a nuclease or a protein homodimer. * It is a potential target for the development of novel therapeutic strategies for cancer and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Endonuclease G, mitochondrial

Genular Protein ID: 596753999

Symbol: NUCG_HUMAN

Name: Endonuclease G, mitochondrial

UniProtKB Accession Codes:

Q14249 Q5T281 Q9BSP2

Database IDs:

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7789991

Title: Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis.

PubMed ID: 7789991

DOI: 10.1016/0888-7543(95)80058-t

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25355512

Title: Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.

PubMed ID: 25355512

DOI: 10.1093/nar/gku1032

PubMed ID: 29719607

Title: Endonuclease G promotes mitochondrial genome cleavage and replication.

PubMed ID: 29719607

DOI: 10.18632/oncotarget.24822

PubMed ID: 33473107

Title: Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.

PubMed ID: 33473107

DOI: 10.1038/s41467-020-20780-2

Sequence Information:

Length: 297
Mass: 32620
Checksum: 33015E8A619781B7
Sequence:

MRALRAGLTL ASGAGLGAVV EGWRRRREDA RAAPGLLGRL PVLPVAAAAE LPPVPGGPRG 
PGELAKYGLP GLAQLKSRES YVLCYDPRTR GALWVVEQLR PERLRGDGDR RECDFREDDS 
VHAYHRATNA DYRGSGFDRG HLAAAANHRW SQKAMDDTFY LSNVAPQVPH LNQNAWNNLE 
KYSRSLTRSY QNVYVCTGPL FLPRTEADGK SYVKYQVIGK NHVAVPTHFF KVLILEAAGG 
QIELRTYVMP NAPVDEAIPL ERFLVPIESI ERASGLLFVP NILARAGSLK AITAGSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ENDOG

Associated with

Cells (max top 100)

Other Information

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. PubMed ID: 7789991

Initial characterization of the human central proteome. PubMed ID: 21269460

Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination. PubMed ID: 25355512

Endonuclease G promotes mitochondrial genome cleavage and replication. PubMed ID: 29719607

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. PubMed ID: 33473107