Details for: FLNC

Gene ID: 2318

Symbol: FLNC

Ensembl ID: ENSG00000128591

Description: filamin C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.13
    Marker Score: 1428
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1157
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169092
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.36
    Marker Score: 515
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 19974
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.19
    Marker Score: 2811.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.15
    Marker Score: 25762
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.15
    Marker Score: 2520.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.13
    Marker Score: 3072
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.04
    Marker Score: 2926
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.96
    Marker Score: 503
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.83
    Marker Score: 1580
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8
    Marker Score: 10648
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.77
    Marker Score: 822
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.76
    Marker Score: 995
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.74
    Marker Score: 794
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.74
    Marker Score: 238
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.74
    Marker Score: 242
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2975
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.71
    Marker Score: 180
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.7
    Marker Score: 531
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.69
    Marker Score: 9091
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.63
    Marker Score: 762
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 294
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.61
    Marker Score: 243
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 393
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.58
    Marker Score: 3798
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1184.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.58
    Marker Score: 2048
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.56
    Marker Score: 869
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.54
    Marker Score: 355
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.54
    Marker Score: 18295
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.53
    Marker Score: 361
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.53
    Marker Score: 149
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.52
    Marker Score: 1223
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.52
    Marker Score: 179
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.5
    Marker Score: 159
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.5
    Marker Score: 309
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.46
    Marker Score: 491
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.46
    Marker Score: 287.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2747
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.46
    Marker Score: 189
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.45
    Marker Score: 239
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.45
    Marker Score: 619.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.41
    Marker Score: 124
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.41
    Marker Score: 347
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.4
    Marker Score: 132
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.4
    Marker Score: 116
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.38
    Marker Score: 100
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.37
    Marker Score: 210
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.37
    Marker Score: 189
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.37
    Marker Score: 90
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.36
    Marker Score: 174
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.36
    Marker Score: 92
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.35
    Marker Score: 333
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.35
    Marker Score: 429
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.34
    Marker Score: 642
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 204
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.33
    Marker Score: 160
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.33
    Marker Score: 311
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.32
    Marker Score: 227
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 284
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.31
    Marker Score: 213
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 138
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3
    Marker Score: 195
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.3
    Marker Score: 1242
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.29
    Marker Score: 448
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.28
    Marker Score: 101
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.28
    Marker Score: 552
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.27
    Marker Score: 392
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.27
    Marker Score: 67
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.27
    Marker Score: 152
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.27
    Marker Score: 258
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.26
    Marker Score: 420
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 156

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Other Information

**Key characteristics:** * FLNC is a type III transmembrane protein, which are characterized by a single extracellular domain that is homologous to the extracellular domain of actin. * It is a highly conserved protein, with a sequence that is present in mammals, birds, and reptiles. * FLNC is a scaffolding protein, which means that it helps to assemble and maintain the cytoskeleton. * It is involved in a variety of cellular processes, including cell adhesion, cell migration, and cell signalling. **Pathways and functions:** * FLNC is a key component of the actin filament, which is a major component of the cytoskeleton. * The actin filament is responsible for providing structural support for cells and for facilitating their movement. * It is also involved in cell signalling, cell adhesion, and cell migration. * Mutations in the FLNC gene have been linked to a number of human diseases, including Marfan syndrome and osteoporosis. **Clinical significance:** * FLNC is a promising target for cancer therapy. * Inhibition of FLNC has been shown to inhibit cell growth and migration, and to promote apoptosis. * FLNC is a potential therapeutic target for a variety of human diseases, including cancer, cardiovascular disease, and osteoporosis. **Additional notes:** * The FLNC gene is located on chromosome 15q21.1. * It is a highly highly expressed gene in skeletal muscle and cardiac muscle cells. * It is also expressed in a variety of other cell types, including colon goblet cells, mural cells, and ciliary muscle cells.

Genular Protein ID: 352016895

Symbol: FLNC_HUMAN

Name: Filamin-C

UniProtKB Accession Codes:

Q14315 B2ZZ88 O95303 Q07985 Q9NS12 Q9NYE5 Q9UMR8 Q9Y503

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 8 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 13 PIR 2 PRO 1 PROSITE 4 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9791010

Title: Molecular cloning of human ABPL, an actin-binding protein homologue.

PubMed ID: 9791010

DOI: 10.1006/bbrc.1998.9506

PubMed ID: 11153914

Title: Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.

PubMed ID: 11153914

DOI: 10.1007/s004390000414

PubMed ID: 10658210

Title: Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation.

PubMed ID: 10658210

DOI: 10.1002/(sici)1097-0169(200002)45:2<149::aid-cm6>3.0.co;2-g

PubMed ID: 10629222

Title: Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein.

PubMed ID: 10629222

DOI: 10.1083/jcb.148.1.115

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 7689010

Title: Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7.

PubMed ID: 7689010

DOI: 10.1093/hmg/2.6.761

PubMed ID: 10984498

Title: FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle.

PubMed ID: 10984498

DOI: 10.1074/jbc.m007493200

PubMed ID: 11038172

Title: Indications for a novel muscular dystrophy pathway: gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin.

PubMed ID: 11038172

DOI: 10.1083/jcb.151.2.235

PubMed ID: 11102480

Title: Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.

PubMed ID: 11102480

DOI: 10.1523/jneurosci.20-23-08736.2000

PubMed ID: 11171996

Title: Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines.

PubMed ID: 11171996

DOI: 10.1073/pnas.98.4.1595

PubMed ID: 11739414

Title: The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.

PubMed ID: 11739414

DOI: 10.1083/jcb.200104005

PubMed ID: 11252955

Title: Filamins as integrators of cell mechanics and signalling.

PubMed ID: 11252955

DOI: 10.1038/35052082

PubMed ID: 12438262

Title: Identification of silencing of nine genes in human gastric cancers.

PubMed ID: 12438262

PubMed ID: 11842093

Title: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

PubMed ID: 11842093

DOI: 10.1074/jbc.m200712200

PubMed ID: 12525170

Title: The limits of promiscuity: isoform-specific dimerization of filamins.

PubMed ID: 12525170

DOI: 10.1021/bi026501+

PubMed ID: 15929027

Title: A mutation in the dimerization domain of filamin C causes a novel type of autosomal dominant myofibrillar myopathy.

PubMed ID: 15929027

DOI: 10.1086/431959

PubMed ID: 16076904

Title: The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.

PubMed ID: 16076904

DOI: 10.1242/jcs.02484

PubMed ID: 16501887

Title: The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins.

PubMed ID: 16501887

DOI: 10.1007/s00018-005-5533-1

PubMed ID: 16631741

Title: Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.

PubMed ID: 16631741

DOI: 10.1016/j.yexcr.2006.03.015

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20554076

Title: The sarcomeric Z-disc component myopodin is a multiadapter protein that interacts with filamin and alpha-actinin.

PubMed ID: 20554076

DOI: 10.1016/j.ejcb.2010.04.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21223964

Title: Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C.

PubMed ID: 21223964

DOI: 10.1016/j.yexcr.2011.01.002

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22972877

Title: F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.

PubMed ID: 22972877

DOI: 10.1161/circresaha.112.271007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 34405687

Title: Filamin C cardiomyopathy variants cause protein and lysosome accumulation.

PubMed ID: 34405687

DOI: 10.1161/circresaha.120.317076

PubMed ID: 15642266

Title: Structural basis for vertebrate filamin dimerization.

PubMed ID: 15642266

DOI: 10.1016/j.str.2004.10.014

PubMed ID: 17379241

Title: Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer.

PubMed ID: 17379241

DOI: 10.1016/j.jmb.2007.02.018

PubMed ID: 19074766

Title: Migfilin, a molecular switch in regulation of integrin activation.

PubMed ID: 19074766

DOI: 10.1074/jbc.m807719200

PubMed ID: 21620354

Title: Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy.

PubMed ID: 21620354

DOI: 10.1016/j.ajhg.2011.04.021

PubMed ID: 25351925

Title: Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy.

PubMed ID: 25351925

DOI: 10.1038/ncomms6326

PubMed ID: 26666891

Title: Mutations in FLNC are Associated with Familial Restrictive Cardiomyopathy.

PubMed ID: 26666891

DOI: 10.1002/humu.22942

Sequence Information:

  • Length: 2725
  • Mass: 291022
  • Checksum: B7C8516C2366E75D
  • Sequence:
    • MMNNSGYSDA GLGLGDETDE MPSTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVGKRLTDL 
QRDLSDGLRL IALLEVLSQK RMYRKFHPRP NFRQMKLENV SVALEFLERE HIKLVSIDSK 
AIVDGNLKLI LGLIWTLILH YSISMPMWED EDDEDARKQT PKQRLLGWIQ NKVPQLPITN 
FNRDWQDGKA LGALVDNCAP GLCPDWEAWD PNQPVENARE AMQQADDWLG VPQVIAPEEI 
VDPNVDEHSV MTYLSQFPKA KLKPGAPVRS KQLNPKKAIA YGPGIEPQGN TVLQPAHFTV 
QTVDAGVGEV LVYIEDPEGH TEEAKVVPNN DKDRTYAVSY VPKVAGLHKV TVLFAGQNIE 
RSPFEVNVGM ALGDANKVSA RGPGLEPVGN VANKPTYFDI YTAGAGTGDV AVVIVDPQGR 
RDTVEVALED KGDSTFRCTY RPAMEGPHTV HVAFAGAPIT RSPFPVHVSE ACNPNACRAS 
GRGLQPKGVR VKEVADFKVF TKGAGSGELK VTVKGPKGTE EPVKVREAGD GVFECEYYPV 
VPGKYVVTIT WGGYAIPRSP FEVQVSPEAG VQKVRAWGPG LETGQVGKSA DFVVEAIGTE 
VGTLGFSIEG PSQAKIECDD KGDGSCDVRY WPTEPGEYAV HVICDDEDIR DSPFIAHILP 
APPDCFPDKV KAFGPGLEPT GCIVDKPAEF TIDARAAGKG DLKLYAQDAD GCPIDIKVIP 
NGDGTFRCSY VPTKPIKHTI IISWGGVNVP KSPFRVNVGE GSHPERVKVY GPGVEKTGLK 
ANEPTYFTVD CSEAGQGDVS IGIKCAPGVV GPAEADIDFD IIKNDNDTFT VKYTPPGAGR 
YTIMVLFANQ EIPASPFHIK VDPSHDASKV KAEGPGLNRT GVEVGKPTHF TVLTKGAGKA 
KLDVQFAGTA KGEVVRDFEI IDNHDYSYTV KYTAVQQGNM AVTVTYGGDP VPKSPFVVNV 
APPLDLSKIK VQGLNSKVAV GQEQAFSVNT RGAGGQGQLD VRMTSPSRRP IPCKLEPGGG 
AEAQAVRYMP PEEGPYKVDI TYDGHPVPGS PFAVEGVLPP DPSKVCAYGP GLKGGLVGTP 
APFSIDTKGA GTGGLGLTVE GPCEAKIECQ DNGDGSCAVS YLPTEPGEYT INILFAEAHI 
PGSPFKATIR PVFDPSKVRA SGPGLERGKV GEAATFTVDC SEAGEAELTI EILSDAGVKA 
EVLIHNNADG TYHITYSPAF PGTYTITIKY GGHPVPKFPT RVHVQPAVDT SGVKVSGPGV 
EPHGVLREVT TEFTVDARSL TATGGNHVTA RVLNPSGAKT DTYVTDNGDG TYRVQYTAYE 
EGVHLVEVLY DEVAVPKSPF RVGVTEGCDP TRVRAFGPGL EGGLVNKANR FTVETRGAGT 
GGLGLAIEGP SEAKMSCKDN KDGSCTVEYI PFTPGDYDVN ITFGGRPIPG SPFRVPVKDV 
VDPGKVKCSG PGLGAGVRAR VPQTFTVDCS QAGRAPLQVA VLGPTGVAEP VEVRDNGDGT 
HTVHYTPATD GPYTVAVKYA DQEVPRSPFK IKVLPAHDAS KVRASGPGLN ASGIPASLPV 
EFTIDARDAG EGLLTVQILD PEGKPKKANI RDNGDGTYTV SYLPDMSGRY TITIKYGGDE 
IPYSPFRIHA LPTGDASKCL VTVSIGGHGL GACLGPRIQI GQETVITVDA KAAGEGKVTC 
TVSTPDGAEL DVDVVENHDG TFDIYYTAPE PGKYVITIRF GGEHIPNSPF HVLACDPLPH 
EEEPSEVPQL RQPYAPPRPG ARPTHWATEE PVVPVEPMES MLRPFNLVIP FAVQKGELTG 
EVRMPSGKTA RPNITDNKDG TITVRYAPTE KGLHQMGIKY DGNHIPGSPL QFYVDAINSR 
HVSAYGPGLS HGMVNKPATF TIVTKDAGEG GLSLAVEGPS KAEITCKDNK DGTCTVSYLP 
TAPGDYSIIV RFDDKHIPGS PFTAKITGDD SMRTSQLNVG TSTDVSLKIT ESDLSQLTAS 
IRAPSGNEEP CLLKRLPNRH IGISFTPKEV GEHVVSVRKS GKHVTNSPFK ILVGPSEIGD 
ASKVRVWGKG LSEGHTFQVA EFIVDTRNAG YGGLGLSIEG PSKVDINCED MEDGTCKVTY 
CPTEPGTYII NIKFADKHVP GSPFTVKVTG EGRMKESITR RRQAPSIATI GSTCDLNLKI 
PGNWFQMVSA QERLTRTFTR SSHTYTRTER TEISKTRGGE TKREVRVEES TQVGGDPFPA 
VFGDFLGRER LGSFGSITRQ QEGEASSQDM TAQVTSPSGK VEAAEIVEGE DSAYSVRFVP 
QEMGPHTVAV KYRGQHVPGS PFQFTVGPLG EGGAHKVRAG GTGLERGVAG VPAEFSIWTR 
EAGAGGLSIA VEGPSKAEIA FEDRKDGSCG VSYVVQEPGD YEVSIKFNDE HIPDSPFVVP 
VASLSDDARR LTVTSLQETG LKVNQPASFA VQLNGARGVI DARVHTPSGA VEECYVSELD 
SDKHTIRFIP HENGVHSIDV KFNGAHIPGS PFKIRVGEQS QAGDPGLVSA YGPGLEGGTT 
GVSSEFIVNT LNAGSGALSV TIDGPSKVQL DCRECPEGHV VTYTPMAPGN YLIAIKYGGP 
QHIVGSPFKA KVTGPRLSGG HSLHETSTVL VETVTKSSSS RGSSYSSIPK FSSDASKVVT 
RGPGLSQAFV GQKNSFTVDC SKAGTNMMMV GVHGPKTPCE EVYVKHMGNR VYNVTYTVKE 
KGDYILIVKW GDESVPGSPF KVKVP

Genular Protein ID: 1780613659

Symbol: Q59H94_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H94

Database IDs:

ARBA 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 EvolutionaryTrace 1 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 1342
  • Mass: 142815
  • Checksum: CE776D873FA591CA
  • Sequence:
    • GLAIEGPSEA KMSCKDNKDG SCTVEYIPFT PGDYDVNITF GGRPIPGSPF RVPVKDVVDP 
GKVKCSGPGL GAGVRARVPQ TFTVDCSQAG RAPLQVAVLG PTGVAEPVEV RDNGDGTHTV 
HYTPATDGPY TVAVKYADQE VPRSPFKIKV LPAHDASKVR ASGPGLNASG IPASLPVEFT 
IDARDAGEGL LTVQILDPEG KPKKANIRDN GDGTYTVSYL PDMSGRYTIT IKYGGDEIPY 
SPFRIHALPT GDASKCLVTV SIGGHGLGAC LGPRIQIGQE TVITVDAKAA GEGKVTCTVS 
TPDGAELDVD VVENHDGTFD IYYTAPEPGK YVITIRFGGE HIPNSPFHVL ACDPLPHEEE 
PSEVPQLRQP YAPPRPGARP THWATEEPVV PVEPMESMLR PFNLVIPFAV QKGELTGEVR 
MPSGKTARPN ITDNKDGTIT VRYAPTEKGL HQMGIKYDGN HIPGSPLQFY VDAINSRHVS 
AYGPGLSHGM VNKPATFTIV TKDAGEGGLS LAVEGPSKAE ITCKDNKDGT CTVSYLPTAP 
GDYSIIVRFD DKHIPGSPFT AKITGDDSMR TSQLNVGTST DVSLKITESD LSQLTASIRA 
PSGNEEPCLL KRLPNRHIGI SFTPKEVGEH VVSVRKSGKH VTNSPFKILV GPSEIGDASK 
VRVWGKGLSE GHTFQVAEFI VDTRNAGYGG LGLSIEGPSK VDINCEDMED GTCKVTYCPT 
EPGTYIINIK FADKHVPGSP FTVKVTGEGR MKESITRRRQ APSIATIGST CDLNLKIPGN 
WFQMVSAQER LTRTFTRSSH TYTRTERTEI SKTRGGETKR EVRVEESTQV GGDPFPAVFG 
DFLGRERLGS FGSITRQQEG EASSQDMTAQ VTSPSGKVEA AEIVEGEDSA YSVRFVPQEM 
GPHTVAVKYR GQHVPGSPFQ FTVGPLGEGG AHKVRAGGTG LERGVAGVPA EFSIWTREAG 
AGGLSIAVEG PSKAEIAFED RKDGSCGVSY VVQEPGDYEV SIKFNDEHIP DSPFVVPVAS 
LSDDARRLTV TSLQETGLKV NQPASFAVQL NGARGVIDAR VHTPSGAVEE CYVSELDSDK 
HTIRFIPHEN GVHSIDVKFN GAHIPGSPFK IRVGEQSQAG DPGLVSAYGP GLEGGTTGVS 
SEFIVNTLNA GSGALSVTID GPSKVQLDCR ECPEGHVVTY TPMAPGNYLI AIKYGGPQHI 
VGSPFKAKVT GPRLSGGHSL HETSTVLVET VTKSSSSRGS SYSSIPKFSS DASKVVTRGP 
GLSQAFVGQK NSFTVDCSKA GTNMMMVGVH GPKTPCEEVY VKHMGNRVYN VTYTVKEKGD 
YILIVKWGDE SVPGSPFKVK VP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.