Details for: FLNC

Gene ID: 2318

Symbol: FLNC

Ensembl ID: ENSG00000128591

Description: filamin C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 30.4408
    Cell Significance Index: -12.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.6395
    Cell Significance Index: -12.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 7.1871
    Cell Significance Index: 175.3600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 5.4043
    Cell Significance Index: 87.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.2974
    Cell Significance Index: 176.3000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.7218
    Cell Significance Index: 9.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.3289
    Cell Significance Index: 19.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8289
    Cell Significance Index: 17.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7837
    Cell Significance Index: 8.5200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7567
    Cell Significance Index: 12.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7207
    Cell Significance Index: 18.5300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.7012
    Cell Significance Index: 7.3200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.6641
    Cell Significance Index: 3.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3959
    Cell Significance Index: 11.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3823
    Cell Significance Index: 5.4800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3080
    Cell Significance Index: 3.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0362
    Cell Significance Index: 4.9700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0335
    Cell Significance Index: 0.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0326
    Cell Significance Index: 0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0312
    Cell Significance Index: 14.1400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0246
    Cell Significance Index: 0.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0100
    Cell Significance Index: 1.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0090
    Cell Significance Index: 4.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0065
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0028
    Cell Significance Index: 5.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0051
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0082
    Cell Significance Index: -1.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0082
    Cell Significance Index: -15.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0093
    Cell Significance Index: -3.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0098
    Cell Significance Index: -15.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0160
    Cell Significance Index: -10.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0163
    Cell Significance Index: -2.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0164
    Cell Significance Index: -0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0169
    Cell Significance Index: -12.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0173
    Cell Significance Index: -12.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0208
    Cell Significance Index: -11.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0227
    Cell Significance Index: -4.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0228
    Cell Significance Index: -6.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0234
    Cell Significance Index: -13.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0377
    Cell Significance Index: -6.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0410
    Cell Significance Index: -2.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0496
    Cell Significance Index: -9.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0583
    Cell Significance Index: -8.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0673
    Cell Significance Index: -7.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0695
    Cell Significance Index: -8.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0774
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0778
    Cell Significance Index: -13.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0887
    Cell Significance Index: -8.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0951
    Cell Significance Index: -12.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0986
    Cell Significance Index: -10.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1020
    Cell Significance Index: -4.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1038
    Cell Significance Index: -11.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1082
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1116
    Cell Significance Index: -12.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1138
    Cell Significance Index: -6.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1189
    Cell Significance Index: -8.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1201
    Cell Significance Index: -3.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1268
    Cell Significance Index: -1.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1308
    Cell Significance Index: -7.3400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1344
    Cell Significance Index: -2.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1479
    Cell Significance Index: -11.7100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1504
    Cell Significance Index: -1.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1594
    Cell Significance Index: -9.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1652
    Cell Significance Index: -12.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1739
    Cell Significance Index: -4.8600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1899
    Cell Significance Index: -2.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1903
    Cell Significance Index: -1.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1905
    Cell Significance Index: -12.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1994
    Cell Significance Index: -10.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2035
    Cell Significance Index: -10.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2074
    Cell Significance Index: -9.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2094
    Cell Significance Index: -9.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2097
    Cell Significance Index: -5.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2121
    Cell Significance Index: -9.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2185
    Cell Significance Index: -5.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2209
    Cell Significance Index: -7.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2301
    Cell Significance Index: -12.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2305
    Cell Significance Index: -14.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2325
    Cell Significance Index: -6.2300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2364
    Cell Significance Index: -3.4000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2452
    Cell Significance Index: -3.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2982
    Cell Significance Index: -13.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3012
    Cell Significance Index: -7.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3128
    Cell Significance Index: -10.8700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3241
    Cell Significance Index: -4.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3248
    Cell Significance Index: -8.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3252
    Cell Significance Index: -6.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3426
    Cell Significance Index: -8.5700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3505
    Cell Significance Index: -4.9800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3509
    Cell Significance Index: -5.3300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3510
    Cell Significance Index: -2.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3512
    Cell Significance Index: -13.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3547
    Cell Significance Index: -13.0200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3631
    Cell Significance Index: -5.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3665
    Cell Significance Index: -12.8400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3681
    Cell Significance Index: -2.2800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3693
    Cell Significance Index: -1.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FLNC is a large, multi-domain protein that belongs to the filamin family. It consists of 17 repeats of a 35-amino acid motif, which is rich in proline and hydrophobic residues. This modular structure allows FLNC to interact with various proteins and cellular structures, including actin filaments, ankyrins, and costameres. FLNC is also characterized by its high degree of homology with other filamins, including filamin A and filamin B. This homology is thought to be responsible for FLNC's ability to regulate cell-cell and cell-extracellular matrix interactions. **Pathways and Functions:** FLNC plays a critical role in regulating various cellular processes, including: 1. **Actin filament binding:** FLNC interacts with actin filaments to regulate their dynamics and organization. This interaction is essential for maintaining cellular structure and function. 2. **Ankyrin binding:** FLNC binds to ankyrins, which are proteins that anchor integral membrane proteins to the cytoskeleton. This interaction is critical for maintaining cell-cell adhesion and signaling. 3. **Cell-cell communication:** FLNC regulates cell-cell communication by interacting with adhesion molecules and signaling proteins. 4. **Cell-extracellular matrix interactions:** FLNC regulates cell-extracellular matrix interactions by interacting with extracellular matrix proteins and receptors. 5. **Cytoskeleton organization:** FLNC regulates cytoskeleton organization by interacting with microtubules and microfilaments. **Clinical Significance:** Dysregulation of FLNC has been implicated in various diseases, including: 1. **Muscular dystrophy:** Mutations in the FLNC gene have been associated with limb-girdle muscular dystrophy type 1A (LGMD1A). 2. **Cancer:** FLNC has been implicated in cancer progression and metastasis, particularly in breast and ovarian cancer. 3. **Cardiovascular disorders:** FLNC has been implicated in cardiovascular disorders, including heart failure and atherosclerosis. 4. **Neurological disorders:** FLNC has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. **Therapeutic Applications:** FLNC's dysregulation has been targeted for therapeutic intervention in various diseases. For example, small molecule inhibitors of FLNC have been developed to treat muscular dystrophy and cancer. Additionally, gene therapy approaches have been explored to restore FLNC function in patients with genetic mutations. In conclusion, FLNC is a critical component of the cytoskeleton that plays a vital role in maintaining cellular integrity, structure, and function. Its dysregulation has been implicated in various diseases, and therapeutic interventions targeting FLNC are being explored. Further research is needed to fully understand the role of FLNC in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 352016895

Symbol: FLNC_HUMAN

Name: Filamin-C

UniProtKB Accession Codes:

Q14315 B2ZZ88 O95303 Q07985 Q9NS12 Q9NYE5 Q9UMR8 Q9Y503

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 2 EvolutionaryTrace 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 8 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9791010

Title: Molecular cloning of human ABPL, an actin-binding protein homologue.

PubMed ID: 9791010

DOI: 10.1006/bbrc.1998.9506

PubMed ID: 11153914

Title: Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.

PubMed ID: 11153914

DOI: 10.1007/s004390000414

PubMed ID: 10658210

Title: Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation.

PubMed ID: 10658210

DOI: 10.1002/(sici)1097-0169(200002)45:2<149::aid-cm6>3.0.co;2-g

PubMed ID: 10629222

Title: Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein.

PubMed ID: 10629222

DOI: 10.1083/jcb.148.1.115

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 7689010

Title: Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7.

PubMed ID: 7689010

DOI: 10.1093/hmg/2.6.761

PubMed ID: 10984498

Title: FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle.

PubMed ID: 10984498

DOI: 10.1074/jbc.m007493200

PubMed ID: 11038172

Title: Indications for a novel muscular dystrophy pathway: gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin.

PubMed ID: 11038172

DOI: 10.1083/jcb.151.2.235

PubMed ID: 11102480

Title: Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.

PubMed ID: 11102480

DOI: 10.1523/jneurosci.20-23-08736.2000

PubMed ID: 11171996

Title: Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines.

PubMed ID: 11171996

DOI: 10.1073/pnas.98.4.1595

PubMed ID: 11739414

Title: The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.

PubMed ID: 11739414

DOI: 10.1083/jcb.200104005

PubMed ID: 11252955

Title: Filamins as integrators of cell mechanics and signalling.

PubMed ID: 11252955

DOI: 10.1038/35052082

PubMed ID: 12438262

Title: Identification of silencing of nine genes in human gastric cancers.

PubMed ID: 12438262

PubMed ID: 11842093

Title: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

PubMed ID: 11842093

DOI: 10.1074/jbc.m200712200

PubMed ID: 12525170

Title: The limits of promiscuity: isoform-specific dimerization of filamins.

PubMed ID: 12525170

DOI: 10.1021/bi026501+

PubMed ID: 15929027

Title: A mutation in the dimerization domain of filamin C causes a novel type of autosomal dominant myofibrillar myopathy.

PubMed ID: 15929027

DOI: 10.1086/431959

PubMed ID: 16076904

Title: The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.

PubMed ID: 16076904

DOI: 10.1242/jcs.02484

PubMed ID: 16501887

Title: The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins.

PubMed ID: 16501887

DOI: 10.1007/s00018-005-5533-1

PubMed ID: 16631741

Title: Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.

PubMed ID: 16631741

DOI: 10.1016/j.yexcr.2006.03.015

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20554076

Title: The sarcomeric Z-disc component myopodin is a multiadapter protein that interacts with filamin and alpha-actinin.

PubMed ID: 20554076

DOI: 10.1016/j.ejcb.2010.04.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21223964

Title: Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C.

PubMed ID: 21223964

DOI: 10.1016/j.yexcr.2011.01.002

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22972877

Title: F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.

PubMed ID: 22972877

DOI: 10.1161/circresaha.112.271007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 34405687

Title: Filamin C cardiomyopathy variants cause protein and lysosome accumulation.

PubMed ID: 34405687

DOI: 10.1161/circresaha.120.317076

PubMed ID: 15642266

Title: Structural basis for vertebrate filamin dimerization.

PubMed ID: 15642266

DOI: 10.1016/j.str.2004.10.014

PubMed ID: 17379241

Title: Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer.

PubMed ID: 17379241

DOI: 10.1016/j.jmb.2007.02.018

PubMed ID: 19074766

Title: Migfilin, a molecular switch in regulation of integrin activation.

PubMed ID: 19074766

DOI: 10.1074/jbc.m807719200

PubMed ID: 21620354

Title: Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy.

PubMed ID: 21620354

DOI: 10.1016/j.ajhg.2011.04.021

PubMed ID: 25351925

Title: Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy.

PubMed ID: 25351925

DOI: 10.1038/ncomms6326

PubMed ID: 26666891

Title: Mutations in FLNC are Associated with Familial Restrictive Cardiomyopathy.

PubMed ID: 26666891

DOI: 10.1002/humu.22942

Sequence Information:

  • Length: 2725
  • Mass: 291022
  • Checksum: B7C8516C2366E75D
  • Sequence:
    • MMNNSGYSDA GLGLGDETDE MPSTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVGKRLTDL 
QRDLSDGLRL IALLEVLSQK RMYRKFHPRP NFRQMKLENV SVALEFLERE HIKLVSIDSK 
AIVDGNLKLI LGLIWTLILH YSISMPMWED EDDEDARKQT PKQRLLGWIQ NKVPQLPITN 
FNRDWQDGKA LGALVDNCAP GLCPDWEAWD PNQPVENARE AMQQADDWLG VPQVIAPEEI 
VDPNVDEHSV MTYLSQFPKA KLKPGAPVRS KQLNPKKAIA YGPGIEPQGN TVLQPAHFTV 
QTVDAGVGEV LVYIEDPEGH TEEAKVVPNN DKDRTYAVSY VPKVAGLHKV TVLFAGQNIE 
RSPFEVNVGM ALGDANKVSA RGPGLEPVGN VANKPTYFDI YTAGAGTGDV AVVIVDPQGR 
RDTVEVALED KGDSTFRCTY RPAMEGPHTV HVAFAGAPIT RSPFPVHVSE ACNPNACRAS 
GRGLQPKGVR VKEVADFKVF TKGAGSGELK VTVKGPKGTE EPVKVREAGD GVFECEYYPV 
VPGKYVVTIT WGGYAIPRSP FEVQVSPEAG VQKVRAWGPG LETGQVGKSA DFVVEAIGTE 
VGTLGFSIEG PSQAKIECDD KGDGSCDVRY WPTEPGEYAV HVICDDEDIR DSPFIAHILP 
APPDCFPDKV KAFGPGLEPT GCIVDKPAEF TIDARAAGKG DLKLYAQDAD GCPIDIKVIP 
NGDGTFRCSY VPTKPIKHTI IISWGGVNVP KSPFRVNVGE GSHPERVKVY GPGVEKTGLK 
ANEPTYFTVD CSEAGQGDVS IGIKCAPGVV GPAEADIDFD IIKNDNDTFT VKYTPPGAGR 
YTIMVLFANQ EIPASPFHIK VDPSHDASKV KAEGPGLNRT GVEVGKPTHF TVLTKGAGKA 
KLDVQFAGTA KGEVVRDFEI IDNHDYSYTV KYTAVQQGNM AVTVTYGGDP VPKSPFVVNV 
APPLDLSKIK VQGLNSKVAV GQEQAFSVNT RGAGGQGQLD VRMTSPSRRP IPCKLEPGGG 
AEAQAVRYMP PEEGPYKVDI TYDGHPVPGS PFAVEGVLPP DPSKVCAYGP GLKGGLVGTP 
APFSIDTKGA GTGGLGLTVE GPCEAKIECQ DNGDGSCAVS YLPTEPGEYT INILFAEAHI 
PGSPFKATIR PVFDPSKVRA SGPGLERGKV GEAATFTVDC SEAGEAELTI EILSDAGVKA 
EVLIHNNADG TYHITYSPAF PGTYTITIKY GGHPVPKFPT RVHVQPAVDT SGVKVSGPGV 
EPHGVLREVT TEFTVDARSL TATGGNHVTA RVLNPSGAKT DTYVTDNGDG TYRVQYTAYE 
EGVHLVEVLY DEVAVPKSPF RVGVTEGCDP TRVRAFGPGL EGGLVNKANR FTVETRGAGT 
GGLGLAIEGP SEAKMSCKDN KDGSCTVEYI PFTPGDYDVN ITFGGRPIPG SPFRVPVKDV 
VDPGKVKCSG PGLGAGVRAR VPQTFTVDCS QAGRAPLQVA VLGPTGVAEP VEVRDNGDGT 
HTVHYTPATD GPYTVAVKYA DQEVPRSPFK IKVLPAHDAS KVRASGPGLN ASGIPASLPV 
EFTIDARDAG EGLLTVQILD PEGKPKKANI RDNGDGTYTV SYLPDMSGRY TITIKYGGDE 
IPYSPFRIHA LPTGDASKCL VTVSIGGHGL GACLGPRIQI GQETVITVDA KAAGEGKVTC 
TVSTPDGAEL DVDVVENHDG TFDIYYTAPE PGKYVITIRF GGEHIPNSPF HVLACDPLPH 
EEEPSEVPQL RQPYAPPRPG ARPTHWATEE PVVPVEPMES MLRPFNLVIP FAVQKGELTG 
EVRMPSGKTA RPNITDNKDG TITVRYAPTE KGLHQMGIKY DGNHIPGSPL QFYVDAINSR 
HVSAYGPGLS HGMVNKPATF TIVTKDAGEG GLSLAVEGPS KAEITCKDNK DGTCTVSYLP 
TAPGDYSIIV RFDDKHIPGS PFTAKITGDD SMRTSQLNVG TSTDVSLKIT ESDLSQLTAS 
IRAPSGNEEP CLLKRLPNRH IGISFTPKEV GEHVVSVRKS GKHVTNSPFK ILVGPSEIGD 
ASKVRVWGKG LSEGHTFQVA EFIVDTRNAG YGGLGLSIEG PSKVDINCED MEDGTCKVTY 
CPTEPGTYII NIKFADKHVP GSPFTVKVTG EGRMKESITR RRQAPSIATI GSTCDLNLKI 
PGNWFQMVSA QERLTRTFTR SSHTYTRTER TEISKTRGGE TKREVRVEES TQVGGDPFPA 
VFGDFLGRER LGSFGSITRQ QEGEASSQDM TAQVTSPSGK VEAAEIVEGE DSAYSVRFVP 
QEMGPHTVAV KYRGQHVPGS PFQFTVGPLG EGGAHKVRAG GTGLERGVAG VPAEFSIWTR 
EAGAGGLSIA VEGPSKAEIA FEDRKDGSCG VSYVVQEPGD YEVSIKFNDE HIPDSPFVVP 
VASLSDDARR LTVTSLQETG LKVNQPASFA VQLNGARGVI DARVHTPSGA VEECYVSELD 
SDKHTIRFIP HENGVHSIDV KFNGAHIPGS PFKIRVGEQS QAGDPGLVSA YGPGLEGGTT 
GVSSEFIVNT LNAGSGALSV TIDGPSKVQL DCRECPEGHV VTYTPMAPGN YLIAIKYGGP 
QHIVGSPFKA KVTGPRLSGG HSLHETSTVL VETVTKSSSS RGSSYSSIPK FSSDASKVVT 
RGPGLSQAFV GQKNSFTVDC SKAGTNMMMV GVHGPKTPCE EVYVKHMGNR VYNVTYTVKE 
KGDYILIVKW GDESVPGSPF KVKVP

Genular Protein ID: 1780613659

Symbol: Q59H94_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H94

Database IDs:

ARBA 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 1342
  • Mass: 142815
  • Checksum: CE776D873FA591CA
  • Sequence:
    • GLAIEGPSEA KMSCKDNKDG SCTVEYIPFT PGDYDVNITF GGRPIPGSPF RVPVKDVVDP 
GKVKCSGPGL GAGVRARVPQ TFTVDCSQAG RAPLQVAVLG PTGVAEPVEV RDNGDGTHTV 
HYTPATDGPY TVAVKYADQE VPRSPFKIKV LPAHDASKVR ASGPGLNASG IPASLPVEFT 
IDARDAGEGL LTVQILDPEG KPKKANIRDN GDGTYTVSYL PDMSGRYTIT IKYGGDEIPY 
SPFRIHALPT GDASKCLVTV SIGGHGLGAC LGPRIQIGQE TVITVDAKAA GEGKVTCTVS 
TPDGAELDVD VVENHDGTFD IYYTAPEPGK YVITIRFGGE HIPNSPFHVL ACDPLPHEEE 
PSEVPQLRQP YAPPRPGARP THWATEEPVV PVEPMESMLR PFNLVIPFAV QKGELTGEVR 
MPSGKTARPN ITDNKDGTIT VRYAPTEKGL HQMGIKYDGN HIPGSPLQFY VDAINSRHVS 
AYGPGLSHGM VNKPATFTIV TKDAGEGGLS LAVEGPSKAE ITCKDNKDGT CTVSYLPTAP 
GDYSIIVRFD DKHIPGSPFT AKITGDDSMR TSQLNVGTST DVSLKITESD LSQLTASIRA 
PSGNEEPCLL KRLPNRHIGI SFTPKEVGEH VVSVRKSGKH VTNSPFKILV GPSEIGDASK 
VRVWGKGLSE GHTFQVAEFI VDTRNAGYGG LGLSIEGPSK VDINCEDMED GTCKVTYCPT 
EPGTYIINIK FADKHVPGSP FTVKVTGEGR MKESITRRRQ APSIATIGST CDLNLKIPGN 
WFQMVSAQER LTRTFTRSSH TYTRTERTEI SKTRGGETKR EVRVEESTQV GGDPFPAVFG 
DFLGRERLGS FGSITRQQEG EASSQDMTAQ VTSPSGKVEA AEIVEGEDSA YSVRFVPQEM 
GPHTVAVKYR GQHVPGSPFQ FTVGPLGEGG AHKVRAGGTG LERGVAGVPA EFSIWTREAG 
AGGLSIAVEG PSKAEIAFED RKDGSCGVSY VVQEPGDYEV SIKFNDEHIP DSPFVVPVAS 
LSDDARRLTV TSLQETGLKV NQPASFAVQL NGARGVIDAR VHTPSGAVEE CYVSELDSDK 
HTIRFIPHEN GVHSIDVKFN GAHIPGSPFK IRVGEQSQAG DPGLVSAYGP GLEGGTTGVS 
SEFIVNTLNA GSGALSVTID GPSKVQLDCR ECPEGHVVTY TPMAPGNYLI AIKYGGPQHI 
VGSPFKAKVT GPRLSGGHSL HETSTVLVET VTKSSSSRGS SYSSIPKFSS DASKVVTRGP 
GLSQAFVGQK NSFTVDCSKA GTNMMMVGVH GPKTPCEEVY VKHMGNRVYN VTYTVKEKGD 
YILIVKWGDE SVPGSPFKVK VP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.