Details for: GHITM

Gene ID: 27069

Symbol: GHITM

Ensembl ID: ENSG00000165678

Description: growth hormone inducible transmembrane protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 311.7421
    Cell Significance Index: -48.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 213.4887
    Cell Significance Index: -54.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 193.7140
    Cell Significance Index: -79.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 154.1972
    Cell Significance Index: -72.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 140.8283
    Cell Significance Index: -72.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 108.7296
    Cell Significance Index: -72.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 68.6782
    Cell Significance Index: -65.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.0423
    Cell Significance Index: -61.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.7680
    Cell Significance Index: -57.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.5882
    Cell Significance Index: -73.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1403
    Cell Significance Index: -37.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.7214
    Cell Significance Index: 195.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2235
    Cell Significance Index: 103.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9313
    Cell Significance Index: 90.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9141
    Cell Significance Index: 345.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5790
    Cell Significance Index: 194.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5494
    Cell Significance Index: 212.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5326
    Cell Significance Index: 45.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5191
    Cell Significance Index: 41.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4983
    Cell Significance Index: 111.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4295
    Cell Significance Index: 92.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3746
    Cell Significance Index: 750.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3341
    Cell Significance Index: 35.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2940
    Cell Significance Index: 165.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2922
    Cell Significance Index: 152.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2537
    Cell Significance Index: 11.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2349
    Cell Significance Index: 159.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2170
    Cell Significance Index: 538.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1171
    Cell Significance Index: 70.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0136
    Cell Significance Index: 27.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9385
    Cell Significance Index: 66.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9358
    Cell Significance Index: 187.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8370
    Cell Significance Index: 43.4800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7586
    Cell Significance Index: 8.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7135
    Cell Significance Index: 70.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6942
    Cell Significance Index: 19.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6915
    Cell Significance Index: 24.0300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5887
    Cell Significance Index: 4.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5734
    Cell Significance Index: 15.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5618
    Cell Significance Index: 11.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5537
    Cell Significance Index: 90.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5317
    Cell Significance Index: 6.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4675
    Cell Significance Index: 88.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4472
    Cell Significance Index: 8.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4471
    Cell Significance Index: 6.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4022
    Cell Significance Index: 20.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2836
    Cell Significance Index: 56.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2822
    Cell Significance Index: 101.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2750
    Cell Significance Index: 46.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1600
    Cell Significance Index: 117.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1105
    Cell Significance Index: 83.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1032
    Cell Significance Index: 2.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0642
    Cell Significance Index: 1.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0629
    Cell Significance Index: 2.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0239
    Cell Significance Index: -17.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0362
    Cell Significance Index: -3.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0389
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0407
    Cell Significance Index: -25.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0438
    Cell Significance Index: -80.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0524
    Cell Significance Index: -80.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0550
    Cell Significance Index: -34.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0639
    Cell Significance Index: -86.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0828
    Cell Significance Index: -46.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1147
    Cell Significance Index: -52.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1263
    Cell Significance Index: -26.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1699
    Cell Significance Index: -19.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1945
    Cell Significance Index: -55.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2097
    Cell Significance Index: -16.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2193
    Cell Significance Index: -9.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2485
    Cell Significance Index: -7.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3510
    Cell Significance Index: -40.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3560
    Cell Significance Index: -51.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3844
    Cell Significance Index: -9.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4136
    Cell Significance Index: -48.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4276
    Cell Significance Index: -9.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4810
    Cell Significance Index: -10.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4834
    Cell Significance Index: -29.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5052
    Cell Significance Index: -14.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5300
    Cell Significance Index: -36.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5381
    Cell Significance Index: -5.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5513
    Cell Significance Index: -37.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5966
    Cell Significance Index: -45.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6670
    Cell Significance Index: -9.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6908
    Cell Significance Index: -71.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7003
    Cell Significance Index: -17.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7185
    Cell Significance Index: -8.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8736
    Cell Significance Index: -24.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9276
    Cell Significance Index: -52.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1482
    Cell Significance Index: -33.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1873
    Cell Significance Index: -72.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2023
    Cell Significance Index: -53.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.4102
    Cell Significance Index: -11.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4419
    Cell Significance Index: -24.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.4424
    Cell Significance Index: -54.6200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.4853
    Cell Significance Index: -11.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5933
    Cell Significance Index: -58.4900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.6386
    Cell Significance Index: -9.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.7372
    Cell Significance Index: -56.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GHITM is a transmembrane protein that is induced by growth hormone (GH) signaling. It is primarily expressed in cells that are involved in calcium homeostasis, such as kidney collecting duct intercalated cells and blood cells. The GHITM protein has been shown to regulate mitochondrial calcium ion transport, which is critical for maintaining cellular calcium homeostasis. This protein also plays a role in regulating the release of cytochrome c from mitochondria, which is essential for preventing apoptosis. One of the unique features of GHITM is its ability to regulate mitochondrial ATP synthesis coupled electron transport. This process is essential for maintaining energy homeostasis in cells. Additionally, GHITM has been shown to interact with other proteins, such as calmodulin, which is involved in calcium signaling pathways. **Pathways and Functions** GHITM is involved in several cellular pathways, including: 1. **Apoptotic process**: GHITM regulates the release of cytochrome c from mitochondria, which is essential for preventing apoptosis. 2. **Calcium ion transport**: GHITM regulates mitochondrial calcium ion transport, which is critical for maintaining cellular calcium homeostasis. 3. **Mitochondrial inner membrane organization**: GHITM plays a role in regulating the organization of the mitochondrial inner membrane, which is essential for maintaining mitochondrial function. 4. **Extracellular exosome**: GHITM has been shown to interact with extracellular exosomes, which are small vesicles that are involved in intercellular communication. **Functions** The main function of GHITM is to regulate mitochondrial calcium ion transport and prevent apoptosis. GHITM also plays a role in regulating mitochondrial ATP synthesis coupled electron transport, which is essential for maintaining energy homeostasis in cells. Additionally, GHITM has been shown to interact with other proteins, such as calmodulin, which is involved in calcium signaling pathways. **Clinical Significance** The discovery of GHITM has significant implications for our understanding of cellular calcium homeostasis and apoptosis. Dysregulation of GHITM has been implicated in various diseases, including cancer and neurodegenerative disorders. Further research is needed to fully understand the role of GHITM in human disease and to develop therapeutic strategies that target this protein. In addition, GHITM has potential therapeutic applications in the treatment of diseases such as cancer, where dysregulation of mitochondrial calcium ion transport is a hallmark of tumor progression. GHITM may also have a role in the treatment of neurodegenerative disorders, such as Alzheimer's disease, where mitochondrial dysfunction is a key feature of the disease. In conclusion, GHITM is a critical protein that plays a key role in regulating mitochondrial calcium ion transport and preventing apoptosis. Further research is needed to fully understand the role of GHITM in human disease and to develop therapeutic strategies that target this protein.

Genular Protein ID: 2179852690

Symbol: GHITM_HUMAN

Name: Growth hormone-inducible transmembrane protein

UniProtKB Accession Codes:

Q9H3K2 A8K9Z9 D3DWE0 O95894 Q5VT95 Q9H0P2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 10 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 2 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18417609

Title: Identification of a novel protein MICS1 that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c.

PubMed ID: 18417609

DOI: 10.1091/mbc.e07-12-1205

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32977469

Title: Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery.

PubMed ID: 32977469

DOI: 10.3390/cells9102147

PubMed ID: 36321428

Title: TMBIM5 is the Ca2+ /H+ antiporter of mammalian mitochondria.

PubMed ID: 36321428

DOI: 10.15252/embr.202254978

PubMed ID: 35912435

Title: Regulation of mitochondrial proteostasis by the proton gradient.

PubMed ID: 35912435

DOI: 10.15252/embj.2021110476

Sequence Information:

  • Length: 345
  • Mass: 37205
  • Checksum: 808FAED86A9CD98E
  • Sequence:
    • MLAARLVCLR TLPSRVFHPA FTKASPVVKN SITKNQWLLT PSREYATKTR IGIRRGRTGQ 
ELKEAALEPS MEKIFKIDQM GRWFVAGGAA VGLGALCYYG LGLSNEIGAI EKAVIWPQYV 
KDRIHSTYMY LAGSIGLTAL SAIAISRTPV LMNFMMRGSW VTIGVTFAAM VGAGMLVRSI 
PYDQSPGPKH LAWLLHSGVM GAVVAPLTIL GGPLLIRAAW YTAGIVGGLS TVAMCAPSEK 
FLNMGAPLGV GLGLVFVSSL GSMFLPPTTV AGATLYSVAM YGGLVLFSMF LLYDTQKVIK 
RAEVSPMYGV QKYDPINSML SIYMDTLNIF MRVATMLATG GNRKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.