Details for: HSPB7

Gene ID: 27129

Symbol: HSPB7

Ensembl ID: ENSG00000173641

Description: heat shock protein family B (small) member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.5924
    Cell Significance Index: -9.2500
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 11.0790
    Cell Significance Index: 31.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 9.8544
    Cell Significance Index: 240.4400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 9.0027
    Cell Significance Index: 145.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.5009
    Cell Significance Index: 268.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.2142
    Cell Significance Index: 32.6900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.9897
    Cell Significance Index: 10.4700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.4740
    Cell Significance Index: 21.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4422
    Cell Significance Index: 37.0700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.9728
    Cell Significance Index: 12.2500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.5031
    Cell Significance Index: 2.1900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3567
    Cell Significance Index: 5.1300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.3328
    Cell Significance Index: 2.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2271
    Cell Significance Index: 6.0900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0956
    Cell Significance Index: 1.4300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0926
    Cell Significance Index: 1.2100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0910
    Cell Significance Index: 0.9500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0699
    Cell Significance Index: 0.8700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0642
    Cell Significance Index: 0.7500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0256
    Cell Significance Index: 0.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0234
    Cell Significance Index: 1.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0152
    Cell Significance Index: 28.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0145
    Cell Significance Index: 6.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0032
    Cell Significance Index: 0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0002
    Cell Significance Index: 0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0038
    Cell Significance Index: -2.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0050
    Cell Significance Index: -6.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0063
    Cell Significance Index: -0.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0131
    Cell Significance Index: -0.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0132
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0147
    Cell Significance Index: -4.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0173
    Cell Significance Index: -9.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0177
    Cell Significance Index: -9.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0198
    Cell Significance Index: -7.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0238
    Cell Significance Index: -3.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0317
    Cell Significance Index: -4.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0368
    Cell Significance Index: -6.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0455
    Cell Significance Index: -9.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0461
    Cell Significance Index: -9.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0489
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0508
    Cell Significance Index: -10.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0551
    Cell Significance Index: -6.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0584
    Cell Significance Index: -9.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0598
    Cell Significance Index: -3.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0599
    Cell Significance Index: -6.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0674
    Cell Significance Index: -1.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0676
    Cell Significance Index: -8.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0727
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0760
    Cell Significance Index: -8.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0836
    Cell Significance Index: -6.6200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0873
    Cell Significance Index: -1.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0958
    Cell Significance Index: -2.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1034
    Cell Significance Index: -2.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1052
    Cell Significance Index: -1.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1104
    Cell Significance Index: -7.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1190
    Cell Significance Index: -8.8700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1432
    Cell Significance Index: -1.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1441
    Cell Significance Index: -3.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1457
    Cell Significance Index: -9.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1466
    Cell Significance Index: -9.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1556
    Cell Significance Index: -6.7700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1589
    Cell Significance Index: -0.7600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1669
    Cell Significance Index: -2.0300
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1740
    Cell Significance Index: -1.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1800
    Cell Significance Index: -9.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1806
    Cell Significance Index: -8.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1807
    Cell Significance Index: -10.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1813
    Cell Significance Index: -2.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1840
    Cell Significance Index: -2.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1866
    Cell Significance Index: -8.7700
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1898
    Cell Significance Index: -2.7000
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1911
    Cell Significance Index: -1.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2056
    Cell Significance Index: -9.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2110
    Cell Significance Index: -3.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2174
    Cell Significance Index: -5.8100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2577
    Cell Significance Index: -3.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2578
    Cell Significance Index: -7.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2630
    Cell Significance Index: -10.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2658
    Cell Significance Index: -7.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2697
    Cell Significance Index: -9.9000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2760
    Cell Significance Index: -1.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2840
    Cell Significance Index: -9.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2920
    Cell Significance Index: -10.2600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3032
    Cell Significance Index: -9.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3039
    Cell Significance Index: -9.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3064
    Cell Significance Index: -5.2500
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3118
    Cell Significance Index: -1.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3130
    Cell Significance Index: -9.9700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.3204
    Cell Significance Index: -3.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3260
    Cell Significance Index: -8.1300
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: -0.3276
    Cell Significance Index: -2.4100
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.3358
    Cell Significance Index: -1.8200
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.3383
    Cell Significance Index: -2.1100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.3390
    Cell Significance Index: -1.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3455
    Cell Significance Index: -9.8600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.3660
    Cell Significance Index: -1.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** HSPB7 is expressed in a wide range of cell types, including cardiac myocytes, dendritic cells, skeletal muscle fibers, and lymphocytes, indicating its involvement in various cellular processes. 2. **Cytoskeletal Regulation:** HSPB7 interacts with actin filaments, influencing cytoskeletal dynamics and cell shape, which is essential for cardiac muscle contraction and immune cell function. 3. **Protein Binding:** HSPB7 exhibits high affinity for various proteins, including filamins, which are crucial for maintaining protein interactions and preventing protein aggregation. 4. **Heat Shock Response:** HSPB7 is induced by heat shock, oxidative stress, and other forms of cellular stress, highlighting its role in responding to cellular stressors. **Pathways and Functions:** 1. **Actin Cytoskeleton Regulation:** HSPB7 interacts with actin filaments, modulating cytoskeletal dynamics and cell shape, which is essential for cardiac muscle contraction and immune cell function. 2. **Aggresome Formation:** HSPB7 is involved in the formation of aggresomes, which are protein aggregates that are degraded by autophagy, helping to maintain protein homeostasis. 3. **Protein Binding and Regulation:** HSPB7 binds to various proteins, regulating protein interactions and preventing protein aggregation, which is essential for maintaining cellular homeostasis. 4. **Regulation of Heart Contraction:** HSPB7 is involved in regulating cardiac muscle contraction, which is essential for maintaining cardiac function. **Clinical Significance:** 1. **Cardiac Disease:** HSPB7 has been implicated in cardiac disease, including heart failure, where its expression is reduced, leading to impaired cardiac function. 2. **Immune System:** HSPB7 plays a crucial role in immune function, particularly in dendritic cells and lymphocytes, where its expression is essential for proper immune cell function. 3. **Neurodegenerative Diseases:** HSPB7 has been implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), where its expression is reduced, leading to impaired motor function. 4. **Cancer:** HSPB7 has been implicated in cancer, where its expression is often reduced, leading to impaired cellular homeostasis and increased tumor growth. In conclusion, HSPB7 is a crucial heat shock protein that plays a significant role in maintaining protein homeostasis, regulating cytoskeletal dynamics, and modulating protein interactions. Its expression in various cell types highlights its importance in multiple physiological and pathological processes, including cardiac disease, immune system function, neurodegenerative diseases, and cancer. Further research is needed to fully elucidate the role of HSPB7 in these processes and to explore its potential as a therapeutic target.

Genular Protein ID: 2907665282

Symbol: HSPB7_HUMAN

Name: Heat shock protein beta-7

UniProtKB Accession Codes:

Q9UBY9 B3KQ37 C9K0Y0 Q9NU17

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10593960

Title: Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues.

PubMed ID: 10593960

DOI: 10.1074/jbc.274.51.36592

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19464326

Title: HSPB7 is a SC35 speckle resident small heat shock protein.

PubMed ID: 19464326

DOI: 10.1016/j.bbamcr.2009.05.005

Sequence Information:

  • Length: 170
  • Mass: 18611
  • Checksum: 0A6F47931AE67B3E
  • Sequence:
    • MSHRTSSTFR AERSFHSSSS SSSSSTSSSA SRALPAQDPP MEKALSMFSD DFGSFMRPHS 
EPLAFPARPG GAGNIKTLGD AYEFAVDVRD FSPEDIIVTT SNNHIEVRAE KLAADGTVMN 
TFAHKCQLPE DVDPTSVTSA LREDGSLTIR ARRHPHTEHV QQTFRTEIKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.