Gene LPAR4 - ENSG00000147145 | NCBI Gene ID: 2846

Details for: LPAR4

Gene ID: 2846

Symbol: LPAR4

Ensembl ID: ENSG00000147145

Description: lysophosphatidic acid receptor 4

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Nucleotide-like (purinergic) receptors
(R-HSA-418038)
P2y receptors
(R-HSA-417957)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysophosphatidic acid binding
(GO:0035727)
Lysophosphatidic acid receptor activity
(GO:0070915)
Nuclear body
(GO:0016604)
Plasma membrane
(GO:0005886)
Positive regulation of rho protein signal transduction
(GO:0035025)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.74
Marker Score: 1237
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.29
Marker Score: 1562
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 854
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2
Marker Score: 871
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 485
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71828
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48052
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 460
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5352
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 372
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5287
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.84
Marker Score: 387
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 611
Cell Name: goblet cell (CL0000160)
Fold Change: 0.8
Marker Score: 5292
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1265
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 460
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2977
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.68
Marker Score: 245
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.68
Marker Score: 451.5
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.64
Marker Score: 36007
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.6
Marker Score: 1172
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.54
Marker Score: 1092
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.5
Marker Score: 938
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.44
Marker Score: 264
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.42
Marker Score: 241
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.41
Marker Score: 2436
Cell Name: mast cell (CL0000097)
Fold Change: 0.37
Marker Score: 216
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.37
Marker Score: 105
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.36
Marker Score: 550.5
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.36
Marker Score: 285
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.35
Marker Score: 237
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.33
Marker Score: 4406
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.31
Marker Score: 81
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.31
Marker Score: 2003
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3
Marker Score: 4764
Cell Name: B cell (CL0000236)
Fold Change: 0.27
Marker Score: 256
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.27
Marker Score: 170
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.27
Marker Score: 525
Cell Name: astrocyte (CL0000127)
Fold Change: 0.26
Marker Score: 228
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.26
Marker Score: 13501
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.25
Marker Score: 194
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.25
Marker Score: 5317
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.25
Marker Score: 111
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.25
Marker Score: 263
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.24
Marker Score: 155
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.21
Marker Score: 807
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.21
Marker Score: 86
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.2
Marker Score: 631
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.2
Marker Score: 95
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.2
Marker Score: 121
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.2
Marker Score: 184
Cell Name: naive T cell (CL0000898)
Fold Change: 0.18
Marker Score: 119
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.18
Marker Score: 173
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.18
Marker Score: 62
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.17
Marker Score: 104
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.17
Marker Score: 44
Cell Name: plasma cell (CL0000786)
Fold Change: 0.16
Marker Score: 180
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.16
Marker Score: 56
Cell Name: osteoblast (CL0000062)
Fold Change: 0.16
Marker Score: 86
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.15
Marker Score: 1570
Cell Name: neural cell (CL0002319)
Fold Change: 0.15
Marker Score: 74
Cell Name: keratocyte (CL0002363)
Fold Change: 0.15
Marker Score: 35
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.15
Marker Score: 74
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.15
Marker Score: 607
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.14
Marker Score: 322
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.14
Marker Score: 62
Cell Name: fibroblast (CL0000057)
Fold Change: 0.14
Marker Score: 135
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.14
Marker Score: 32
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.14
Marker Score: 137
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.13
Marker Score: 58
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.13
Marker Score: 126
Cell Name: stromal cell (CL0000499)
Fold Change: 0.12
Marker Score: 146
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.12
Marker Score: 84
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.12
Marker Score: 129
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.12
Marker Score: 71
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.12
Marker Score: 38
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.12
Marker Score: 56
Cell Name: pericyte (CL0000669)
Fold Change: 0.12
Marker Score: 70
Cell Name: neutrophil (CL0000775)
Fold Change: 0.12
Marker Score: 71
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.11
Marker Score: 103
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.11
Marker Score: 96
Cell Name: kidney cell (CL1000497)
Fold Change: 0.11
Marker Score: 75
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.11
Marker Score: 138
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.11
Marker Score: 55
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.11
Marker Score: 224
Cell Name: glial cell (CL0000125)
Fold Change: 0.11
Marker Score: 119
Cell Name: T cell (CL0000084)
Fold Change: 0.11
Marker Score: 186

Hover over a box to see details here...

**Key characteristics:** - LPAR4 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the G alpha (q) signaling pathway. - It is expressed in high levels in the kidney, mesangial cells, intestinal crypt stem cells, and cerebral cortex GABAergic interneurons. - It is a negative regulator of the LPAR/G protein-coupled receptor (GPCR) signaling pathway. **Pathways and functions:** - LPAR4 is involved in the regulation of inflammation. It is expressed in immune cells, and its expression is increased in inflammatory diseases. - It is also involved in the regulation of cell migration and differentiation. It is expressed in cells that are migrating or differentiating, and its expression is decreased when these cells are differentiated. - LPAR4 is involved in the regulation of cell migration by binding to lysophosphatidic acid (LPA), a small molecule that is produced by activated platelets and macrophages. LPA binds to LPAR4 on the surface of immune cells, and this binding activates the receptor and triggers a cascade of intracellular events that leads to the inhibition of inflammation. **Clinical significance:** - Mutations in the LPAR4 gene have been linked to several human diseases, including rheumatoid arthritis, Crohn's disease, and inflammatory bowel disease. - LPAR4 is a potential target for the treatment of these diseases. **Conclusion:** LPAR4 is a key molecule in the regulation of inflammation and cell migration. Its expression and activity are increased in inflammatory diseases, and it is a potential target for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Lysophosphatidic acid receptor 4

Genular Protein ID: 410705287

Symbol: LPAR4_HUMAN

Name: Lysophosphatidic acid receptor 4

UniProtKB Accession Codes:

Q99677 B2RAC7 O15132 Q502U9 Q6NSP5

Database IDs:

Citations:

PubMed ID: 9073069

Title: Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.

PubMed ID: 9073069

DOI: 10.1016/s0378-1119(96)00722-6

PubMed ID: 9223435

Title: Cloning of a human heptahelical receptor closely related to the P2Y5 receptor.

PubMed ID: 9223435

DOI: 10.1006/bbrc.1997.6895

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12724320

Title: Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.

PubMed ID: 12724320

DOI: 10.1074/jbc.m302648200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

Sequence Information:

Length: 370
Mass: 41895
Checksum: 20857F52A3929E48
Sequence:

MGDRRFIDFQ FQDSNSSLRP RLGNATANNT CIVDDSFKYN LNGAVYSVVF ILGLITNSVS 
LFVFCFRMKM RSETAIFITN LAVSDLLFVC TLPFKIFYNF NRHWPFGDTL CKISGTAFLT 
NIYGSMLFLT CISVDRFLAI VYPFRSRTIR TRRNSAIVCA GVWILVLSGG ISASLFSTTN 
VNNATTTCFE GFSKRVWKTY LSKITIFIEV VGFIIPLILN VSCSSVVLRT LRKPATLSQI 
GTNKKKVLKM ITVHMAVFVV CFVPYNSVLF LYALVRSQAI TNCFLERFAK IMYPITLCLA 
TLNCCFDPFI YYFTLESFQK SFYINAHIRM ESLFKTETPL TTKPSLPAIQ EEVSDQTTNN 
GGELMLESTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LPAR4

Associated with

Cells (max top 100)

Other Information

Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. PubMed ID: 9073069

Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. PubMed ID: 9223435

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. PubMed ID: 12724320

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952