Details for: LPAR4

Gene ID: 2846

Symbol: LPAR4

Ensembl ID: ENSG00000147145

Description: lysophosphatidic acid receptor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.9383
    Cell Significance Index: -7.3400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 7.2518
    Cell Significance Index: 103.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0667
    Cell Significance Index: -7.4800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.3446
    Cell Significance Index: 29.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9199
    Cell Significance Index: 10.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8425
    Cell Significance Index: 53.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4200
    Cell Significance Index: 5.7300
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.3466
    Cell Significance Index: 2.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2711
    Cell Significance Index: 6.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2073
    Cell Significance Index: 4.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1607
    Cell Significance Index: 2.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1467
    Cell Significance Index: 8.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0773
    Cell Significance Index: 0.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0433
    Cell Significance Index: 2.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0305
    Cell Significance Index: 0.6000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.0273
    Cell Significance Index: 0.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0080
    Cell Significance Index: 1.0200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0017
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0006
    Cell Significance Index: -0.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0028
    Cell Significance Index: -0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0032
    Cell Significance Index: -1.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0069
    Cell Significance Index: -9.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0072
    Cell Significance Index: -3.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0093
    Cell Significance Index: -0.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0098
    Cell Significance Index: -6.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0106
    Cell Significance Index: -8.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.8400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0127
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0148
    Cell Significance Index: -8.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0166
    Cell Significance Index: -7.5300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0201
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0219
    Cell Significance Index: -6.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0286
    Cell Significance Index: -5.7400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0325
    Cell Significance Index: -0.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0327
    Cell Significance Index: -5.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0354
    Cell Significance Index: -7.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0364
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0397
    Cell Significance Index: -8.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0432
    Cell Significance Index: -6.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0465
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0490
    Cell Significance Index: -8.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0494
    Cell Significance Index: -1.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0527
    Cell Significance Index: -6.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0557
    Cell Significance Index: -7.2000
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0604
    Cell Significance Index: -0.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0627
    Cell Significance Index: -6.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0724
    Cell Significance Index: -7.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0727
    Cell Significance Index: -8.3300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0767
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0802
    Cell Significance Index: -5.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0823
    Cell Significance Index: -5.0600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0880
    Cell Significance Index: -0.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0970
    Cell Significance Index: -7.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1003
    Cell Significance Index: -1.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1029
    Cell Significance Index: -7.9000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1080
    Cell Significance Index: -1.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1186
    Cell Significance Index: -4.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1239
    Cell Significance Index: -5.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1240
    Cell Significance Index: -6.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1273
    Cell Significance Index: -6.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1321
    Cell Significance Index: -3.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1359
    Cell Significance Index: -8.3300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1399
    Cell Significance Index: -1.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1424
    Cell Significance Index: -3.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1448
    Cell Significance Index: -3.7000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1613
    Cell Significance Index: -1.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1663
    Cell Significance Index: -8.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1678
    Cell Significance Index: -4.8100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1739
    Cell Significance Index: -2.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1815
    Cell Significance Index: -7.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1843
    Cell Significance Index: -8.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1854
    Cell Significance Index: -8.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2017
    Cell Significance Index: -5.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2023
    Cell Significance Index: -5.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2059
    Cell Significance Index: -2.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2090
    Cell Significance Index: -7.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2110
    Cell Significance Index: -7.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2129
    Cell Significance Index: -6.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2170
    Cell Significance Index: -7.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2254
    Cell Significance Index: -7.9200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2302
    Cell Significance Index: -3.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2305
    Cell Significance Index: -7.3400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2318
    Cell Significance Index: -2.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2366
    Cell Significance Index: -6.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2373
    Cell Significance Index: -8.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2392
    Cell Significance Index: -6.2900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2417
    Cell Significance Index: -2.6700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2477
    Cell Significance Index: -2.5000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2479
    Cell Significance Index: -3.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2494
    Cell Significance Index: -6.6700
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2501
    Cell Significance Index: -2.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2610
    Cell Significance Index: -6.5200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2669
    Cell Significance Index: -5.4300
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2697
    Cell Significance Index: -2.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2758
    Cell Significance Index: -7.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2760
    Cell Significance Index: -7.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GPCR Structure:** LPAR4 is a transmembrane receptor with seven transmembrane alpha-helices, characteristic of GPCRs. 2. **LPA Binding:** LPAR4 is activated by the binding of LPA, a bioactive lipid mediator. 3. **Signaling Pathways:** LPAR4 activates Gαq signaling, leading to the activation of Rho protein and modulation of downstream signaling events. 4. **Tissue Expression:** LPAR4 is expressed in various cell types, including kidney interstitial cells, mesangial cells, intestinal epithelial cells, and GABAergic interneurons in the cerebral cortex. **Pathways and Functions:** 1. **Gαq Signaling:** LPAR4 activates Gαq signaling, leading to the activation of Rho protein and modulation of downstream signaling events. 2. **Rho Protein Activation:** LPAR4 activation of Gαq leads to the activation of Rho protein, which regulates various cellular processes, including cell migration, proliferation, and survival. 3. **Intracellular Membrane-Bounded Organelle Regulation:** LPAR4 signaling is involved in the regulation of intracellular membrane-bounded organelle dynamics, including the endoplasmic reticulum and Golgi apparatus. 4. **Lysophosphatidic Acid Binding:** LPAR4 binding to LPA is a critical step in the activation of its signaling pathways. **Clinical Significance:** 1. **Kidney Disease:** LPAR4 has been implicated in the pathogenesis of kidney disease, including diabetic nephropathy and fibrosis. 2. **Intestinal Disease:** LPAR4 is involved in the regulation of intestinal epithelial cell function and has been implicated in the pathogenesis of intestinal diseases, including inflammatory bowel disease and cancer. 3. **Neurological Disorders:** LPAR4 signaling has been implicated in the regulation of GABAergic interneuron function and has been studied in the context of neurological disorders, including epilepsy and Parkinson's disease. 4. **Cancer:** LPAR4 has been implicated in the regulation of cell proliferation, migration, and survival in various cancer types, including breast, lung, and colon cancer. In conclusion, LPAR4 is a GPCR with widespread implications in various tissues and pathways. Its signaling pathways are involved in the regulation of cellular processes, including cell migration, proliferation, and survival. Further studies are needed to fully elucidate the role of LPAR4 in human disease and to develop therapeutic strategies targeting this receptor.

Genular Protein ID: 410705287

Symbol: LPAR4_HUMAN

Name: Lysophosphatidic acid receptor 4

UniProtKB Accession Codes:

Q99677 B2RAC7 O15132 Q502U9 Q6NSP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9073069

Title: Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.

PubMed ID: 9073069

DOI: 10.1016/s0378-1119(96)00722-6

PubMed ID: 9223435

Title: Cloning of a human heptahelical receptor closely related to the P2Y5 receptor.

PubMed ID: 9223435

DOI: 10.1006/bbrc.1997.6895

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12724320

Title: Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.

PubMed ID: 12724320

DOI: 10.1074/jbc.m302648200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

Sequence Information:

  • Length: 370
  • Mass: 41895
  • Checksum: 20857F52A3929E48
  • Sequence:
    • MGDRRFIDFQ FQDSNSSLRP RLGNATANNT CIVDDSFKYN LNGAVYSVVF ILGLITNSVS 
LFVFCFRMKM RSETAIFITN LAVSDLLFVC TLPFKIFYNF NRHWPFGDTL CKISGTAFLT 
NIYGSMLFLT CISVDRFLAI VYPFRSRTIR TRRNSAIVCA GVWILVLSGG ISASLFSTTN 
VNNATTTCFE GFSKRVWKTY LSKITIFIEV VGFIIPLILN VSCSSVVLRT LRKPATLSQI 
GTNKKKVLKM ITVHMAVFVV CFVPYNSVLF LYALVRSQAI TNCFLERFAK IMYPITLCLA 
TLNCCFDPFI YYFTLESFQK SFYINAHIRM ESLFKTETPL TTKPSLPAIQ EEVSDQTTNN 
GGELMLESTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.