Details for: TRBV16

Gene ID: 28571

Symbol: TRBV16

Ensembl ID: ENSG00000275243

Description: T cell receptor beta variable 16

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,817
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,582
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,660
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,734
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.12
    Marker Score: 192
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.07
    Marker Score: 158
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.04
    Marker Score: 64
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.02
    Marker Score: 38
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 54
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 223
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 41
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 6

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV16 is a member of the T cell receptor beta (TRBV) gene family, which encodes the variable region of the T cell receptor (TCR) beta chain. The TCR beta chain is a critical component of the TCR complex, responsible for recognizing and binding to specific antigens. TRBV16 is characterized by its unique sequence and structure, which enables it to interact with the TCR alpha chain and other co-receptors to form a functional TCR complex. The gene's expression is highly specific, with a restricted pattern of cell-type restricted expression, suggesting a specialized role in immune function. **Pathways and Functions:** TRBV16 is involved in several key pathways, including: 1. **Adaptive Immune Response:** TRBV16 plays a crucial role in the adaptive immune response, enabling alpha-beta T cells to recognize and respond to specific antigens. 2. **Cell Surface Receptor Signaling Pathway:** The TCR complex, including TRBV16, interacts with co-receptors and signaling molecules to initiate a signaling cascade that regulates T cell activation, proliferation, and differentiation. 3. **Plasma Membrane:** TRBV16 is embedded in the plasma membrane, where it interacts with other TCR complexes and co-receptors to regulate immune responses. 4. **T Cell Receptor Complex:** TRBV16 is an essential component of the TCR complex, which is composed of the TCR alpha, beta, gamma, and delta chains, as well as co-receptors and regulatory molecules. **Clinical Significance:** The TRBV16 gene has significant clinical implications, particularly in the context of immune-related disorders. Dysregulation of TRBV16 expression or function has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Alterations in TRBV16 expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where the immune system mistakenly attacks healthy tissues. 2. **Cancer:** TRBV16 has been identified as a potential biomarker for certain types of cancer, including lymphoma and leukemia, where aberrant T cell activation and proliferation contribute to tumorigenesis. 3. **Infectious Diseases:** TRBV16 plays a critical role in the immune response to infections, such as HIV and tuberculosis, where dysregulation of T cell function contributes to disease progression. In conclusion, the TRBV16 gene is a vital component of the adaptive immune system, with significant implications for our understanding of immune function and disease. Further research is needed to fully elucidate the mechanisms by which TRBV16 regulates immune responses and to explore its potential as a therapeutic target for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.