Details for: TRBJ2 6

Gene ID: 28623

Symbol: TRBJ2 6

Ensembl ID: ENSG00000211770

Description: T cell receptor beta joining 2-6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 12.7247
    Cell Significance Index: 248.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.1373
    Cell Significance Index: 51.7700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.5765
    Cell Significance Index: 7.5700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5370
    Cell Significance Index: 7.8300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0275
    Cell Significance Index: 0.1500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0133
    Cell Significance Index: 0.1400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0075
    Cell Significance Index: 0.0700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0024
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0040
    Cell Significance Index: -0.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0132
    Cell Significance Index: -0.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0195
    Cell Significance Index: -0.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0199
    Cell Significance Index: -0.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0199
    Cell Significance Index: -0.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0228
    Cell Significance Index: -0.5800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0228
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0265
    Cell Significance Index: -0.4300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0272
    Cell Significance Index: -0.3300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0276
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0281
    Cell Significance Index: -0.5200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0281
    Cell Significance Index: -0.2400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0301
    Cell Significance Index: -0.4000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0306
    Cell Significance Index: -0.3500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0330
    Cell Significance Index: -0.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0330
    Cell Significance Index: -0.3600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0348
    Cell Significance Index: -0.3100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0380
    Cell Significance Index: -0.3600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0390
    Cell Significance Index: -0.3200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0408
    Cell Significance Index: -0.4800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0415
    Cell Significance Index: -0.4600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0448
    Cell Significance Index: -0.5100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0466
    Cell Significance Index: -0.5400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0470
    Cell Significance Index: -0.4800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0483
    Cell Significance Index: -0.5400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0487
    Cell Significance Index: -0.4500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0498
    Cell Significance Index: -0.5300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0503
    Cell Significance Index: -0.5300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0507
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0510
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0511
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0513
    Cell Significance Index: -0.4800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0516
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0520
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0522
    Cell Significance Index: -0.5300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0533
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0535
    Cell Significance Index: -0.5400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0539
    Cell Significance Index: -0.6200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0541
    Cell Significance Index: -0.5400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0545
    Cell Significance Index: -0.4700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0569
    Cell Significance Index: -0.4900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0580
    Cell Significance Index: -0.4900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0607
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0645
    Cell Significance Index: -0.5300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0676
    Cell Significance Index: -0.5400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0694
    Cell Significance Index: -0.5400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0697
    Cell Significance Index: -0.6100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0711
    Cell Significance Index: -0.6000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0726
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0753
    Cell Significance Index: -0.6100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0756
    Cell Significance Index: -0.5200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2034
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Function:** The TRBJ2-6 gene is involved in the formation of T cell receptors, which are essential for recognizing and binding to antigens. 2. **Cellular Expression:** This gene is expressed in multiple cell types, including B cells, natural killer cells, thymocytes, and plasma cells, indicating its broad role in the immune system. 3. **Molecular Mechanism:** The TRBJ2-6 gene contributes to the assembly and maturation of T cell receptors, which are composed of alpha, beta, and gamma chains. 4. **Regulatory Role:** The TRBJ2-6 gene is part of the T cell receptor complex and plays a regulatory role in the adaptive immune response. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBJ2-6 gene is involved in the adaptive immune response, which is characterized by specific and targeted responses to pathogens and antigens. 2. **T Cell Receptor Complex:** This gene is part of the T cell receptor complex, which assembles and matures to form functional T cell receptors. 3. **Immune Cell Regulation:** The TRBJ2-6 gene regulates the function of immune cells, including T cells, B cells, and natural killer cells. 4. **Antigen Recognition:** The TRBJ2-6 gene contributes to the recognition of antigens by T cells, which is essential for the activation of immune responses. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in the TRBJ2-6 gene can lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Autoimmune Diseases:** Dysregulation of the TRBJ2-6 gene has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** The TRBJ2-6 gene is involved in the regulation of immune responses to cancer cells, and dysregulation can contribute to tumorigenesis. 4. **Vaccine Development:** Understanding the role of the TRBJ2-6 gene in the adaptive immune response can inform the development of novel vaccines and immunotherapies. In conclusion, the TRBJ2-6 gene plays a critical role in the adaptive immune response, and its dysregulation can have significant consequences for human health. Further research is necessary to fully elucidate the mechanisms by which this gene regulates immune responses and to explore its potential as a therapeutic target for immunodeficiency disorders and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.