Details for: MRPL42

Gene ID: 28977

Symbol: MRPL42

Ensembl ID: ENSG00000198015

Description: mitochondrial ribosomal protein L42

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 203.6064
    Cell Significance Index: -31.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 134.0859
    Cell Significance Index: -34.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 111.8225
    Cell Significance Index: -46.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.1961
    Cell Significance Index: -44.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.4291
    Cell Significance Index: -37.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.0421
    Cell Significance Index: -43.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 66.1454
    Cell Significance Index: -44.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.5604
    Cell Significance Index: -37.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.8049
    Cell Significance Index: -41.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.4502
    Cell Significance Index: -38.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1376
    Cell Significance Index: -37.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2239
    Cell Significance Index: -44.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.8640
    Cell Significance Index: 566.8400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.2156
    Cell Significance Index: 17.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8487
    Cell Significance Index: 50.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8243
    Cell Significance Index: 296.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5948
    Cell Significance Index: 55.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5768
    Cell Significance Index: 14.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4270
    Cell Significance Index: 19.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3961
    Cell Significance Index: 762.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3063
    Cell Significance Index: 34.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1415
    Cell Significance Index: 226.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1207
    Cell Significance Index: 137.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0895
    Cell Significance Index: 29.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0646
    Cell Significance Index: 191.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9591
    Cell Significance Index: 131.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9317
    Cell Significance Index: 52.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8018
    Cell Significance Index: 41.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7827
    Cell Significance Index: 157.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6592
    Cell Significance Index: 15.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6356
    Cell Significance Index: 47.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5999
    Cell Significance Index: 215.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5960
    Cell Significance Index: 263.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5629
    Cell Significance Index: 6.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5544
    Cell Significance Index: 12.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5379
    Cell Significance Index: 25.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5289
    Cell Significance Index: 11.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5175
    Cell Significance Index: 24.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4976
    Cell Significance Index: 32.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4509
    Cell Significance Index: 31.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4417
    Cell Significance Index: 3.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4314
    Cell Significance Index: 50.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3903
    Cell Significance Index: 24.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3815
    Cell Significance Index: 23.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3701
    Cell Significance Index: 47.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3591
    Cell Significance Index: 10.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3334
    Cell Significance Index: 25.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2929
    Cell Significance Index: 37.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2670
    Cell Significance Index: 12.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2632
    Cell Significance Index: 13.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2205
    Cell Significance Index: 6.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2131
    Cell Significance Index: 40.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2034
    Cell Significance Index: 34.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1017
    Cell Significance Index: 10.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0815
    Cell Significance Index: 2.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0503
    Cell Significance Index: 1.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0424
    Cell Significance Index: 1.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0262
    Cell Significance Index: 49.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0200
    Cell Significance Index: 15.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0180
    Cell Significance Index: 13.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0129
    Cell Significance Index: 0.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0210
    Cell Significance Index: -28.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0260
    Cell Significance Index: -16.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0330
    Cell Significance Index: -14.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0420
    Cell Significance Index: -23.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0509
    Cell Significance Index: -7.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0530
    Cell Significance Index: -5.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0935
    Cell Significance Index: -19.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0974
    Cell Significance Index: -1.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1091
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1133
    Cell Significance Index: -12.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1301
    Cell Significance Index: -37.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1750
    Cell Significance Index: -11.7700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1779
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2018
    Cell Significance Index: -23.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2019
    Cell Significance Index: -5.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2507
    Cell Significance Index: -5.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2562
    Cell Significance Index: -2.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2980
    Cell Significance Index: -13.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2987
    Cell Significance Index: -7.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3176
    Cell Significance Index: -25.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3307
    Cell Significance Index: -7.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3639
    Cell Significance Index: -6.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3832
    Cell Significance Index: -10.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3945
    Cell Significance Index: -41.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4088
    Cell Significance Index: -15.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4168
    Cell Significance Index: -21.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4809
    Cell Significance Index: -7.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5419
    Cell Significance Index: -15.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5745
    Cell Significance Index: -14.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5895
    Cell Significance Index: -36.1400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7424
    Cell Significance Index: -7.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7447
    Cell Significance Index: -21.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7680
    Cell Significance Index: -4.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8019
    Cell Significance Index: -10.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8603
    Cell Significance Index: -15.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL42 is a mitochondrial ribosomal protein that belongs to the L42 family of ribosomal proteins. It is encoded by the ENSG00000198015 gene and is significantly expressed in cells with high energy demands, such as hepatocytes, erythroid progenitor cells, and kidney epithelial cells. MRPL42 is localized to the mitochondrial large and small ribosomal subunits, where it plays a crucial role in the translation of mRNAs into proteins. The protein has a high degree of sequence homology with other mitochondrial ribosomal proteins, suggesting a conserved function across species. **Pathways and Functions:** MRPL42 is involved in various cellular pathways, including: 1. **Mitochondrial translation**: MRPL42 plays a critical role in the translation of mRNAs into proteins within the mitochondria. It is a key component of the mitochondrial large and small ribosomal subunits, where it interacts with other ribosomal proteins to facilitate translation. 2. **Mitochondrial inner membrane**: MRPL42 is localized to the mitochondrial inner membrane, where it contributes to the maintenance of mitochondrial structure and function. 3. **Metabolism of proteins**: MRPL42 is involved in the metabolism of proteins, including the regulation of protein synthesis and degradation. 4. **RNA binding**: MRPL42 has been shown to bind to RNA molecules, suggesting a role in RNA processing and regulation. **Clinical Significance:** Dysregulation of MRPL42 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: MRPL42 has been linked to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction is a key contributing factor. 2. **Metabolic disorders**: MRPL42 has been implicated in metabolic disorders, such as diabetes and obesity, where mitochondrial dysfunction plays a critical role in the development of these diseases. 3. **Cancer**: MRPL42 has been shown to be overexpressed in various types of cancer, suggesting a potential role in tumorigenesis. 4. **Cardiovascular disease**: MRPL42 has been linked to cardiovascular disease, where mitochondrial dysfunction contributes to the development of cardiovascular disease. In conclusion, MRPL42 is a critical component of the mitochondrial ribosome, playing a vital role in mitochondrial function and disease. Further research is needed to fully understand the mechanisms by which MRPL42 regulates mitochondrial function and to identify potential therapeutic targets for diseases associated with MRPL42 dysfunction.

Genular Protein ID: 1298922834

Symbol: RM42_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y6G3 Q6FID1 Q96Q48 Q9P0S1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 57 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 11551941

Title: The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.

PubMed ID: 11551941

DOI: 10.1074/jbc.m106510200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 142
  • Mass: 16661
  • Checksum: AED9ECFA653F870A
  • Sequence:
    • MAVAAVKWVM SKRTILKHLF PVQNGALYCV CHKSTYSPLP DDYNCNVELA LTSDGRTIVC 
YHPSVDIPYE HTKPIPRPDP VHNNEETHDQ VLKTRLEEKV EHLEEGPMIE QLSKMFFTTK 
HRWYPHGRYH RCRKNLNPPK DR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.