Details for: MRPL22

Gene ID: 29093

Symbol: MRPL22

Ensembl ID: ENSG00000082515

Description: mitochondrial ribosomal protein L22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.8261
    Cell Significance Index: -27.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.8069
    Cell Significance Index: -29.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.8522
    Cell Significance Index: -40.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.8284
    Cell Significance Index: -42.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.9370
    Cell Significance Index: -34.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.8016
    Cell Significance Index: -40.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.3511
    Cell Significance Index: -42.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.2925
    Cell Significance Index: -34.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.4472
    Cell Significance Index: -37.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7774
    Cell Significance Index: -31.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3567
    Cell Significance Index: -31.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2812
    Cell Significance Index: -40.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.3554
    Cell Significance Index: 507.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.4557
    Cell Significance Index: 562.0300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7672
    Cell Significance Index: 14.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5646
    Cell Significance Index: 41.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3990
    Cell Significance Index: 65.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3128
    Cell Significance Index: 27.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1209
    Cell Significance Index: 9.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0008
    Cell Significance Index: 51.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9942
    Cell Significance Index: 542.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9237
    Cell Significance Index: 43.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9234
    Cell Significance Index: 126.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9226
    Cell Significance Index: 32.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8702
    Cell Significance Index: 384.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8301
    Cell Significance Index: 24.3800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7616
    Cell Significance Index: 8.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7442
    Cell Significance Index: 134.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7413
    Cell Significance Index: 87.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7224
    Cell Significance Index: 51.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6775
    Cell Significance Index: 18.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6560
    Cell Significance Index: 80.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6495
    Cell Significance Index: 48.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6196
    Cell Significance Index: 80.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5800
    Cell Significance Index: 116.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4885
    Cell Significance Index: 31.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4728
    Cell Significance Index: 60.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4426
    Cell Significance Index: 20.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4350
    Cell Significance Index: 10.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4282
    Cell Significance Index: 46.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4280
    Cell Significance Index: 84.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4181
    Cell Significance Index: 4.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4081
    Cell Significance Index: 6.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3509
    Cell Significance Index: 9.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2705
    Cell Significance Index: 17.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2643
    Cell Significance Index: 7.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2232
    Cell Significance Index: 80.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2075
    Cell Significance Index: 39.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1725
    Cell Significance Index: 8.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1703
    Cell Significance Index: 16.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1270
    Cell Significance Index: 6.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0774
    Cell Significance Index: 53.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0271
    Cell Significance Index: 20.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0206
    Cell Significance Index: 15.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0102
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0090
    Cell Significance Index: 1.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0218
    Cell Significance Index: -40.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0241
    Cell Significance Index: -0.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0266
    Cell Significance Index: -40.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0299
    Cell Significance Index: -22.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0305
    Cell Significance Index: -41.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0310
    Cell Significance Index: -0.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0316
    Cell Significance Index: -3.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0337
    Cell Significance Index: -21.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0467
    Cell Significance Index: -21.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0597
    Cell Significance Index: -33.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0741
    Cell Significance Index: -46.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0943
    Cell Significance Index: -0.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1055
    Cell Significance Index: -8.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1077
    Cell Significance Index: -30.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1421
    Cell Significance Index: -4.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1737
    Cell Significance Index: -4.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1737
    Cell Significance Index: -19.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1760
    Cell Significance Index: -4.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1799
    Cell Significance Index: -11.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1818
    Cell Significance Index: -10.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1988
    Cell Significance Index: -28.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2073
    Cell Significance Index: -43.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2204
    Cell Significance Index: -13.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2604
    Cell Significance Index: -6.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2856
    Cell Significance Index: -2.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2992
    Cell Significance Index: -23.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3318
    Cell Significance Index: -5.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3641
    Cell Significance Index: -24.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3791
    Cell Significance Index: -39.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4097
    Cell Significance Index: -7.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4311
    Cell Significance Index: -19.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4528
    Cell Significance Index: -9.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4970
    Cell Significance Index: -14.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5221
    Cell Significance Index: -19.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5328
    Cell Significance Index: -7.2700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5653
    Cell Significance Index: -7.2400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.5679
    Cell Significance Index: -3.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5819
    Cell Significance Index: -35.6800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6618
    Cell Significance Index: -4.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6925
    Cell Significance Index: -17.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7061
    Cell Significance Index: -12.1000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7678
    Cell Significance Index: -10.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7733
    Cell Significance Index: -39.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: MRPL22 is a mitochondrial ribosomal protein, specifically localized to the mitochondrial large ribosomal subunit. 2. **Ribosomal function**: MRPL22 is involved in the translation of mitochondrial mRNAs, ensuring the proper synthesis of mitochondrial proteins. 3. **Conservation across species**: MRPL22 is highly conserved across species, suggesting its essential role in mitochondrial function. 4. **Highly expressed in specific cell types**: MRPL22 is significantly expressed in cells of the pancreas, erythroid progenitors, placental trophoblasts, and epithelial cells of the nephron and esophagus. **Pathways and Functions:** 1. **Mitochondrial translation**: MRPL22 is involved in the translation of mitochondrial mRNAs, ensuring the proper synthesis of mitochondrial proteins. 2. **Mitochondrial elongation**: MRPL22 plays a role in the elongation phase of mitochondrial translation, where the ribosome reads the mRNA sequence and synthesizes the corresponding protein. 3. **Mitochondrial initiation and termination**: MRPL22 is also involved in the initiation and termination phases of mitochondrial translation, ensuring the proper assembly and disassembly of the ribosome. 4. **Metabolic pathways**: MRPL22 is involved in various metabolic pathways, including the metabolism of proteins, which is essential for energy production and cell survival. **Clinical Significance:** 1. **Mitochondrial disorders**: Mutations in the MRPL22 gene have been associated with mitochondrial disorders, such as Kearns-Sayre syndrome and MERRF syndrome. 2. **Cancer**: Elevated expression of MRPL22 has been observed in various types of cancer, including pancreatic cancer, suggesting its potential role as a tumor suppressor. 3. **Neurological disorders**: MRPL22 has been implicated in the pathogenesis of neurological disorders, such as Parkinson's disease and Alzheimer's disease, where mitochondrial dysfunction plays a key role. 4. **Infectious diseases**: MRPL22 has been shown to play a role in the response to infectious diseases, such as HIV-1, where mitochondrial dysfunction contributes to disease progression. In conclusion, MRPL22 is a critical component of the mitochondrial ribosome, essential for the proper functioning of the mitochondria. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining mitochondrial homeostasis and overall cellular health. Further research is necessary to fully elucidate the mechanisms by which MRPL22 regulates mitochondrial translation and its role in disease pathogenesis.

Genular Protein ID: 2583581361

Symbol: RM22_HUMAN

Name: 39S ribosomal protein L22, mitochondrial

UniProtKB Accession Codes:

Q9NWU5 A6NGJ8 Q5H9Q1 Q96Q51 Q9P006

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 45 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 47 PDBsum 47 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 206
  • Mass: 23641
  • Checksum: EDF999932609F05D
  • Sequence:
    • MAAAVLGQLG ALWIHNLRSR GKLALGVLPQ SYIHTSASLD ISRKWEKKNK IVYPPQLPGE 
PRRPAEIYHC RRQIKYSKDK MWYLAKLIRG MSIDQALAQL EFNDKKGAKI IKEVLLEAQD 
MAVRDHNVEF RSNLYIAEST SGRGQCLKRI RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP 
EPPKTAVAHA KEYIQQLRSR TIVHTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.