Details for: H1 4

Gene ID: 3008

Symbol: H1 4

Ensembl ID: ENSG00000168298

Description: H1.4 linker histone, cluster member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.2187
    Cell Significance Index: -10.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.4248
    Cell Significance Index: -15.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.1745
    Cell Significance Index: -20.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.6282
    Cell Significance Index: -21.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.6658
    Cell Significance Index: -21.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.8099
    Cell Significance Index: -18.2600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 6.0409
    Cell Significance Index: 32.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8631
    Cell Significance Index: -19.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8711
    Cell Significance Index: -11.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.3398
    Cell Significance Index: 215.4700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.5331
    Cell Significance Index: 35.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.3516
    Cell Significance Index: 447.5200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.0527
    Cell Significance Index: 21.8400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.6921
    Cell Significance Index: 17.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6090
    Cell Significance Index: 159.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5867
    Cell Significance Index: 82.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4596
    Cell Significance Index: 172.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2387
    Cell Significance Index: 36.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0987
    Cell Significance Index: 119.5000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.0403
    Cell Significance Index: 7.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0164
    Cell Significance Index: 165.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9019
    Cell Significance Index: 25.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8457
    Cell Significance Index: 38.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8203
    Cell Significance Index: 6.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7475
    Cell Significance Index: 17.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7444
    Cell Significance Index: 672.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7365
    Cell Significance Index: 18.4100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.6022
    Cell Significance Index: 5.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6005
    Cell Significance Index: 7.6900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5812
    Cell Significance Index: 4.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5668
    Cell Significance Index: 39.2000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5371
    Cell Significance Index: 8.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5337
    Cell Significance Index: 9.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5152
    Cell Significance Index: 92.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3685
    Cell Significance Index: 19.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3623
    Cell Significance Index: 17.0300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2783
    Cell Significance Index: 2.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2385
    Cell Significance Index: 47.3400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.1994
    Cell Significance Index: 0.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1931
    Cell Significance Index: 10.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1736
    Cell Significance Index: 6.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1413
    Cell Significance Index: 2.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1001
    Cell Significance Index: 54.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0975
    Cell Significance Index: 43.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0907
    Cell Significance Index: 12.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0868
    Cell Significance Index: 2.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0761
    Cell Significance Index: 9.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0554
    Cell Significance Index: 0.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0540
    Cell Significance Index: 2.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0521
    Cell Significance Index: 0.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0484
    Cell Significance Index: 1.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0386
    Cell Significance Index: 4.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0296
    Cell Significance Index: 10.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0148
    Cell Significance Index: 1.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0041
    Cell Significance Index: 7.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0031
    Cell Significance Index: 2.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0089
    Cell Significance Index: -13.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0160
    Cell Significance Index: -21.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0172
    Cell Significance Index: -0.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0194
    Cell Significance Index: -14.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0230
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0232
    Cell Significance Index: -17.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0239
    Cell Significance Index: -1.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0293
    Cell Significance Index: -18.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0309
    Cell Significance Index: -0.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0338
    Cell Significance Index: -19.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0351
    Cell Significance Index: -15.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0383
    Cell Significance Index: -11.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0403
    Cell Significance Index: -25.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0453
    Cell Significance Index: -9.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0533
    Cell Significance Index: -1.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0562
    Cell Significance Index: -5.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0691
    Cell Significance Index: -7.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0824
    Cell Significance Index: -14.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0848
    Cell Significance Index: -2.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0898
    Cell Significance Index: -1.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1101
    Cell Significance Index: -16.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1101
    Cell Significance Index: -23.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1131
    Cell Significance Index: -7.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1450
    Cell Significance Index: -18.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1484
    Cell Significance Index: -15.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1790
    Cell Significance Index: -9.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1876
    Cell Significance Index: -1.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2039
    Cell Significance Index: -16.1500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2469
    Cell Significance Index: -3.4600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.2551
    Cell Significance Index: -1.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2649
    Cell Significance Index: -19.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2770
    Cell Significance Index: -16.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3050
    Cell Significance Index: -3.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3282
    Cell Significance Index: -7.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3293
    Cell Significance Index: -9.4400
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3507
    Cell Significance Index: -2.5500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3710
    Cell Significance Index: -2.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3782
    Cell Significance Index: -7.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3844
    Cell Significance Index: -9.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3856
    Cell Significance Index: -2.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Histone H1.4 is a conserved linker histone that associates with nucleosomes, forming a scaffold for chromatin assembly. It is characterized by its ability to bind to DNA and histone proteins, influencing chromatin structure and transcriptional regulation. H1.4 is also involved in the regulation of DNA recombination and repair, as well as the formation of senescence-associated heterochromatin foci (SAHF). Its expression is tightly regulated, with significant expression in immune cells, including B cells, T cells, and germ cells. **Pathways and Functions:** H1.4 is involved in various cellular pathways, including: 1. **Apoptosis and Programmed Cell Death**: H1.4 plays a role in regulating the apoptotic process, influencing the formation of chromatin and the activation of caspases. 2. **Chromatin Remodeling**: H1.4 interacts with chromatin-associated proteins, influencing the regulation of transcription and DNA recombination. 3. **DNA Damage Response**: H1.4 is involved in the regulation of DNA damage response, influencing the formation of SAHF and the activation of DNA repair pathways. 4. **Cellular Senescence**: H1.4 is involved in the regulation of cellular senescence, influencing the formation of SAHF and the activation of senescence-associated pathways. **Clinical Significance:** The dysregulation of H1.4 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases**: H1.4 dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where chromatin structure and function are disrupted. 2. **Cancer**: H1.4 dysregulation has been implicated in cancer, influencing the regulation of transcription and DNA recombination. 3. **Immune-Mediated Disorders**: H1.4 dysregulation has been linked to immune-mediated disorders, such as multiple sclerosis and type 1 diabetes, where chromatin structure and function are disrupted. In conclusion, Histone H1.4 is a critical regulator of chromatin structure and function, with significant implications for immune responses and programmed cell death. Further research is needed to fully elucidate the role of H1.4 in regulating cellular responses and its potential therapeutic applications in immune-related disorders.

Genular Protein ID: 3552312055

Symbol: H14_HUMAN

Name: Histone H1.4

UniProtKB Accession Codes:

P10412 Q4VB25

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 EMDB 21 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PDB 24 PDBsum 24 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3782055

Title: Human spleen histone H1. Isolation and amino acid sequence of a main variant, H1b.

PubMed ID: 3782055

DOI: 10.1093/oxfordjournals.jbchem.a121722

PubMed ID: 10997781

Title: The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.

PubMed ID: 10997781

DOI: 10.1023/a:1009262819961

PubMed ID: 15469825

Title: Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

PubMed ID: 15469825

DOI: 10.1016/j.molcel.2004.08.031

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27723750

Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.

PubMed ID: 27723750

DOI: 10.1038/nchembio.2180

PubMed ID: 28475857

Title: Mutations in epigenetic regulation genes are a major cause of overgrowth with intellectual disability.

PubMed ID: 28475857

DOI: 10.1016/j.ajhg.2017.03.010

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 219
  • Mass: 21865
  • Checksum: 1720FECCCBEBCC7F
  • Sequence:
    • MSETAPAAPA APAPAEKTPV KKKARKSAGA AKRKASGPPV SELITKAVAA SKERSGVSLA 
ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKA 
KKAGAAKAKK PAGAAKKPKK ATGAATPKKS AKKTPKKAKK PAAAAGAKKA KSPKKAKAAK 
PKKAPKSPAK AKAVKPKAAK PKTAKPKAAK PKKAAAKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.