Details for: H1 4

Gene ID: 3008

Symbol: H1 4

Ensembl ID: ENSG00000168298

Description: H1.4 linker histone, cluster member

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 4.64
    Marker Score: 2716
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 3.43
    Marker Score: 9686.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.43
    Marker Score: 2512
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.1
    Marker Score: 1336.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.79
    Marker Score: 4879
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.64
    Marker Score: 30675
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.64
    Marker Score: 5526
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.15
    Marker Score: 21822
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.14
    Marker Score: 2069
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.06
    Marker Score: 1616.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.02
    Marker Score: 5664
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.82
    Marker Score: 3558
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.8
    Marker Score: 1206
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.77
    Marker Score: 4327
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.77
    Marker Score: 2609
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.74
    Marker Score: 4732.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.72
    Marker Score: 861
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.71
    Marker Score: 2060
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.64
    Marker Score: 5190
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.58
    Marker Score: 1389
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.57
    Marker Score: 356
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.48
    Marker Score: 2049
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.48
    Marker Score: 408
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.44
    Marker Score: 437
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.44
    Marker Score: 473
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.43
    Marker Score: 442.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.43
    Marker Score: 2051
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.42
    Marker Score: 1332
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.41
    Marker Score: 495
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.41
    Marker Score: 74704
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.38
    Marker Score: 919
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.34
    Marker Score: 1783
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.32
    Marker Score: 11595.5
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.31
    Marker Score: 1048
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.3
    Marker Score: 799
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.27
    Marker Score: 1326
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.27
    Marker Score: 3754
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.26
    Marker Score: 439
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.26
    Marker Score: 2447
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.21
    Marker Score: 1080
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.21
    Marker Score: 67695
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.21
    Marker Score: 7150
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.18
    Marker Score: 651
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.14
    Marker Score: 834
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.13
    Marker Score: 297
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.11
    Marker Score: 7127
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.11
    Marker Score: 3025
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.1
    Marker Score: 541.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.02
    Marker Score: 695
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.01
    Marker Score: 1269
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1
    Marker Score: 1010
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71713
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47938
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.98
    Marker Score: 665
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.94
    Marker Score: 1001
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.94
    Marker Score: 458
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.93
    Marker Score: 229
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.92
    Marker Score: 319.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.92
    Marker Score: 698
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.92
    Marker Score: 666
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5243
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.92
    Marker Score: 482
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.91
    Marker Score: 1343.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2713
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.9
    Marker Score: 513
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.9
    Marker Score: 1090
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.88
    Marker Score: 644
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.87
    Marker Score: 201
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.87
    Marker Score: 650
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.87
    Marker Score: 2155
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5243
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.86
    Marker Score: 249
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.85
    Marker Score: 6353
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.85
    Marker Score: 2668
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.85
    Marker Score: 8547
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.85
    Marker Score: 418
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.84
    Marker Score: 996
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.84
    Marker Score: 415
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.83
    Marker Score: 11195
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.83
    Marker Score: 5383
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1324.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.81
    Marker Score: 880
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.81
    Marker Score: 3310
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8
    Marker Score: 716
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8
    Marker Score: 798
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.79
    Marker Score: 648
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.79
    Marker Score: 1112.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.76
    Marker Score: 1241
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.75
    Marker Score: 317
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.75
    Marker Score: 294
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.75
    Marker Score: 192
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.75
    Marker Score: 1309

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Other Information

**Key characteristics:** - H1.4 is a heterochronic gene, meaning it is expressed in different cell types and developmental stages. - It is a member of the H1 family of histone proteins, characterized by their ability to form higher-order chromatin structures. - H1.4 is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. **Pathways and functions:** - H1.4 is involved in both positive and negative regulation of gene expression. - It forms complexes with RNA polymerase II, which is responsible for transcribing mRNA from DNA. - H1.4 helps to recruit RNA polymerase II to specific DNA sequences, facilitating the initiation of transcription. - It also interacts with DNA damage response proteins, such as ATM and ATR, which are involved in DNA repair and cell cycle regulation. - H1.4 plays a role in apoptosis by promoting the disassembly of chromatin and facilitating the activation of pro-apoptotic genes. - It is also involved in cell cycle regulation by binding to DNA damage response proteins and preventing the initiation of DNA replication. **Clinical significance:** - Mutations in H1.4 have been linked to several human cancers, including lymphoma and leukemia. - Targeting H1.4 has emerged as a promising therapeutic strategy for these malignancies. - Small molecule inhibitors of H1.4 have been shown to inhibit cancer cell growth and metastasis, suggesting that it could be used as a therapeutic agent.

Genular Protein ID: 3552312055

Symbol: H14_HUMAN

Name: Histone H1.4

UniProtKB Accession Codes:

P10412 Q4VB25

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 EMDB 20 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PDB 27 PDBsum 24 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3782055

Title: Human spleen histone H1. Isolation and amino acid sequence of a main variant, H1b.

PubMed ID: 3782055

DOI: 10.1093/oxfordjournals.jbchem.a121722

PubMed ID: 10997781

Title: The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.

PubMed ID: 10997781

DOI: 10.1023/a:1009262819961

PubMed ID: 15469825

Title: Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

PubMed ID: 15469825

DOI: 10.1016/j.molcel.2004.08.031

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27723750

Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.

PubMed ID: 27723750

DOI: 10.1038/nchembio.2180

PubMed ID: 28475857

Title: Mutations in epigenetic regulation genes are a major cause of overgrowth with intellectual disability.

PubMed ID: 28475857

DOI: 10.1016/j.ajhg.2017.03.010

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 219
  • Mass: 21865
  • Checksum: 1720FECCCBEBCC7F
  • Sequence:
    • MSETAPAAPA APAPAEKTPV KKKARKSAGA AKRKASGPPV SELITKAVAA SKERSGVSLA 
ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKA 
KKAGAAKAKK PAGAAKKPKK ATGAATPKKS AKKTPKKAKK PAAAAGAKKA KSPKKAKAAK 
PKKAPKSPAK AKAVKPKAAK PKTAKPKAAK PKKAAAKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.