Details for: HOXB9

Gene ID: 3219

Symbol: HOXB9

Ensembl ID: ENSG00000170689

Description: homeobox B9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 9.1061
    Cell Significance Index: 70.7700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 6.5269
    Cell Significance Index: 37.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7885
    Cell Significance Index: -7.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.7100
    Cell Significance Index: 94.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.2231
    Cell Significance Index: 17.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7114
    Cell Significance Index: 77.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1995
    Cell Significance Index: 72.0100
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.0902
    Cell Significance Index: 8.6600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.0895
    Cell Significance Index: 12.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0552
    Cell Significance Index: 171.6200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.0179
    Cell Significance Index: 3.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6198
    Cell Significance Index: 42.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5926
    Cell Significance Index: 18.9800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.5719
    Cell Significance Index: 7.9400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.5342
    Cell Significance Index: 5.7900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.4683
    Cell Significance Index: 5.6000
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.4669
    Cell Significance Index: 3.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2734
    Cell Significance Index: 52.0300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.2604
    Cell Significance Index: 1.8700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1857
    Cell Significance Index: 2.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1432
    Cell Significance Index: 2.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1412
    Cell Significance Index: 127.5300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.0938
    Cell Significance Index: 0.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0936
    Cell Significance Index: 9.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0882
    Cell Significance Index: 4.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0653
    Cell Significance Index: 1.8800
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.0578
    Cell Significance Index: 0.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0394
    Cell Significance Index: 0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0381
    Cell Significance Index: 1.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0376
    Cell Significance Index: 20.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0158
    Cell Significance Index: 11.5500
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0055
    Cell Significance Index: 0.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0035
    Cell Significance Index: -0.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0120
    Cell Significance Index: -6.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0124
    Cell Significance Index: -0.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0139
    Cell Significance Index: -2.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0174
    Cell Significance Index: -0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0183
    Cell Significance Index: -3.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0189
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0237
    Cell Significance Index: -0.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0246
    Cell Significance Index: -0.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0290
    Cell Significance Index: -2.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0295
    Cell Significance Index: -3.6300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0314
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0343
    Cell Significance Index: -2.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0395
    Cell Significance Index: -5.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0447
    Cell Significance Index: -5.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0458
    Cell Significance Index: -1.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0497
    Cell Significance Index: -1.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0504
    Cell Significance Index: -1.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0505
    Cell Significance Index: -5.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0552
    Cell Significance Index: -6.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0759
    Cell Significance Index: -5.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0780
    Cell Significance Index: -1.9500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0846
    Cell Significance Index: -1.1500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0928
    Cell Significance Index: -1.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0992
    Cell Significance Index: -6.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1003
    Cell Significance Index: -1.0900
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.1019
    Cell Significance Index: -0.7000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1052
    Cell Significance Index: -1.1100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1093
    Cell Significance Index: -1.0600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1104
    Cell Significance Index: -1.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1105
    Cell Significance Index: -5.1500
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1202
    Cell Significance Index: -1.1500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1214
    Cell Significance Index: -1.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1234
    Cell Significance Index: -1.8600
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: -0.1284
    Cell Significance Index: -1.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1334
    Cell Significance Index: -1.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1465
    Cell Significance Index: -6.8900
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1465
    Cell Significance Index: -1.5900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1526
    Cell Significance Index: -1.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1545
    Cell Significance Index: -2.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1556
    Cell Significance Index: -4.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1576
    Cell Significance Index: -5.7900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1600
    Cell Significance Index: -1.5200
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1622
    Cell Significance Index: -1.5200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1771
    Cell Significance Index: -1.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1798
    Cell Significance Index: -1.5100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1811
    Cell Significance Index: -2.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1836
    Cell Significance Index: -2.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1852
    Cell Significance Index: -2.7800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1860
    Cell Significance Index: -1.1600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1874
    Cell Significance Index: -1.1000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1876
    Cell Significance Index: -2.6700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1884
    Cell Significance Index: -2.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1981
    Cell Significance Index: -3.9500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2007
    Cell Significance Index: -2.3600
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.2011
    Cell Significance Index: -1.0900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2048
    Cell Significance Index: -2.3700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2053
    Cell Significance Index: -1.8500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2088
    Cell Significance Index: -3.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2090
    Cell Significance Index: -4.0800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2098
    Cell Significance Index: -2.2900
  • Cell Name: MHC-II-positive classical monocyte (CL0002470)
    Fold Change: -0.2145
    Cell Significance Index: -1.1400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2205
    Cell Significance Index: -2.0100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2275
    Cell Significance Index: -3.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXB9 is a transcription factor that belongs to the homeobox gene family, which consists of highly conserved DNA-binding proteins. The HOXB9 gene is specifically expressed in various cell types, including microglial cells, blood vessel endothelial cells, epithelial cells of the nephron, and neural cells. Its expression is tightly regulated by transcriptional and post-transcriptional mechanisms, which allow for precise control of its activity during development and in adult tissues. **Pathways and Functions:** HOXB9 is involved in several developmental and immunological pathways, including: 1. **Anterior/posterior pattern specification:** HOXB9 plays a crucial role in the specification of the anterior/posterior axis during embryogenesis, which is essential for the proper formation of the body plan. 2. **Cell chemotaxis:** HOXB9 is involved in the regulation of cell migration and chemotaxis, which is essential for the development and maintenance of tissues and organs. 3. **Chromatin remodeling:** HOXB9 interacts with chromatin-modifying complexes to regulate gene expression and chromatin structure. 4. **DNA-binding transcription factor activity:** HOXB9 acts as a transcription factor to regulate the expression of target genes involved in various developmental and physiological processes. 5. **Regulation of transcription by RNA polymerase II:** HOXB9 regulates the expression of target genes by interacting with the RNA polymerase II transcription machinery. **Clinical Significance:** HOXB9 has been implicated in various diseases, including: 1. **Cancer:** HOXB9 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer, where it promotes tumor progression and metastasis. 2. **Neurological disorders:** HOXB9 has been implicated in the pathogenesis of neurological disorders, such as autism spectrum disorder, schizophrenia, and Alzheimer's disease. 3. **Immune regulation:** HOXB9 has been shown to regulate the expression of genes involved in immune cell development and function, highlighting its potential role in immune-related diseases. 4. **Developmental disorders:** HOXB9 has been implicated in developmental disorders, such as congenital heart defects and skeletal abnormalities, where it plays a crucial role in the development and patterning of tissues and organs. In conclusion, HOXB9 is a multifunctional gene that plays a crucial role in various developmental and immunological processes. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the mechanisms of HOXB9 regulation and its potential therapeutic applications. **Proteins and Interacting Partners:** HOXB9 interacts with several proteins, including HXB9_HUMAN (Homeobox protein Hox-B9) and B3KPJ1_HUMAN, which are involved in various cellular processes, including transcriptional regulation, chromatin remodeling, and cell migration. **Significantly Expressed Cells:** HOXB9 is expressed in various cell types, including microglial cells, blood vessel endothelial cells, epithelial cells of the nephron, granulocyte monocyte progenitor cells, and neural cells. Its expression is tightly regulated by transcriptional and post-transcriptional mechanisms, which allow for precise control of its activity during development and in adult tissues. **Signaling Pathways:** HOXB9 is involved in several signaling pathways, including: 1. **Wnt/β-catenin signaling:** HOXB9 interacts with β-catenin to regulate the expression of target genes involved in development and cell migration. 2. **Notch signaling:** HOXB9 interacts with Notch receptors to regulate the expression of target genes involved in development and cell fate determination. 3. **PI3K/AKT signaling:** HOXB9 interacts with PI3K/AKT to regulate the expression of target genes involved in cell survival and proliferation. **Regulation of HOXB9:** HOXB9 is regulated by various mechanisms, including: 1. **Transcriptional regulation:** HOXB9 is regulated by transcriptional factors, such as Sox2 and Oct4, which control its expression during embryogenesis and in adult tissues. 2. **Post-transcriptional regulation:** HOXB9 is regulated by post-transcriptional mechanisms, such as microRNA-mediated repression, which control its expression and activity in adult tissues. 3. **Epigenetic regulation:** HOXB9 is regulated by epigenetic mechanisms, such as DNA methylation and histone modification, which control its expression and activity during development and in adult tissues.

Genular Protein ID: 1823756018

Symbol: HXB9_HUMAN

Name: Homeobox protein Hox-B9

UniProtKB Accession Codes:

P17482 B2RDB7 Q9H1I1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2570724

Title: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

PubMed ID: 2570724

DOI: 10.1111/j.1432-0436.1989.tb00598.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 250
  • Mass: 28059
  • Checksum: F06ECBC08FBBED2C
  • Sequence:
    • MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC SFQPKAPVFG 
ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE PAPRGEAAPG QGQAAVKAEP 
LLGAPGELLK QGTPEYSLET SAGREAVLSN QRPGYGDNKI CEGSEDKERP DQTNPSANWL 
HARSSRKKRC PYTKYQTLEL EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM 
KKMNKEQGKE

Genular Protein ID: 3400371376

Symbol: B3KPJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPJ1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 ProteomicsDB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 128
  • Mass: 13592
  • Checksum: D5F9919379C97723
  • Sequence:
    • MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC SFQPKAPVFG 
ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE PAPRGGAAQT GHARVQFGNF 
GGQGGRAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.