Details for: HOXB9

Gene ID: 3219

Symbol: HOXB9

Ensembl ID: ENSG00000170689

Description: homeobox B9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6835
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.47
    Marker Score: 2484
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.48
    Marker Score: 3088
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.33
    Marker Score: 313
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.13
    Marker Score: 1469
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.03
    Marker Score: 498
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.98
    Marker Score: 369
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 659.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5293
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.85
    Marker Score: 339.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.83
    Marker Score: 1317
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.82
    Marker Score: 1364
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.82
    Marker Score: 546
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.8
    Marker Score: 1906
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.79
    Marker Score: 1122
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.75
    Marker Score: 1898
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 473
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 449
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.67
    Marker Score: 131
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2797
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.66
    Marker Score: 1160
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.65
    Marker Score: 660
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.63
    Marker Score: 667
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.58
    Marker Score: 576
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.57
    Marker Score: 395
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.55
    Marker Score: 319
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.55
    Marker Score: 527
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.54
    Marker Score: 148.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.53
    Marker Score: 1667
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.51
    Marker Score: 1379.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.47
    Marker Score: 217
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.45
    Marker Score: 2991
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 429
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.42
    Marker Score: 1021
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.42
    Marker Score: 103
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.36
    Marker Score: 105
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.34
    Marker Score: 214
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.32
    Marker Score: 466
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 134.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.32
    Marker Score: 229
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.31
    Marker Score: 532
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3
    Marker Score: 261
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.27
    Marker Score: 1311
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.26
    Marker Score: 464
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.25
    Marker Score: 76
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 474
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.23
    Marker Score: 119
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.22
    Marker Score: 115
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2
    Marker Score: 105
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.2
    Marker Score: 77
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.19
    Marker Score: 243
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.19
    Marker Score: 100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 169
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.19
    Marker Score: 287
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.19
    Marker Score: 456
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.18
    Marker Score: 190
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 284.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.17
    Marker Score: 188
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 95
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 332
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.16
    Marker Score: 67
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.16
    Marker Score: 111
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.16
    Marker Score: 149
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.16
    Marker Score: 92
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.15
    Marker Score: 306
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 80
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.15
    Marker Score: 107
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 353.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.15
    Marker Score: 250
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.15
    Marker Score: 37

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Other Information

**Key characteristics:** - HOXB9 is a homeobox gene, which are a family of transcription factors that are involved in a variety of cellular processes, including tissue development, differentiation, and migration. - It is a highly conserved gene, with a similar sequence in humans and other vertebrates. - HOXB9 is expressed in a wide range of cell types, including microglial cells, blood vessel endothelial cells, epithelial cells of the nephron, granulocyte monocyte progenitor cells, nephron tubule epithelial cells, monocyte, early T lineage precursor, neural cells, and cerebral cortex GABAergic interneurons. **Pathways and functions:** - HOXB9 is involved in a variety of cellular processes, including anterior/posterior pattern specification, cell chemotaxis, chromatin remodeling, and embryonic skeletal system morphogenesis. - In the context of anterior/posterior pattern specification, HOXB9 is expressed in the developing neural tube and is required for the specification of the anterior-posterior axis of the embryo. - In cell chemotaxis, HOXB9 is expressed in endothelial cells and is required for the migration of endothelial cells along the developing blood-brain barrier. - In chromatin remodeling, HOXB9 is involved in the regulation of gene expression by binding to DNA and facilitating the interaction of transcription factors. - In embryonic skeletal system morphogenesis, HOXB9 is involved in the formation of the neural tube and the specification of the somatogenic and epiblastal layers of the embryo. **Clinical significance:** HOXB9 mutations have been linked to a number of human diseases, including autism, intellectual disability, and cancer. These mutations can disrupt the function of HOXB9, leading to the development of these diseases.

Genular Protein ID: 1823756018

Symbol: HXB9_HUMAN

Name: Homeobox protein Hox-B9

UniProtKB Accession Codes:

P17482 B2RDB7 Q9H1I1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2570724

Title: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

PubMed ID: 2570724

DOI: 10.1111/j.1432-0436.1989.tb00598.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 250
  • Mass: 28059
  • Checksum: F06ECBC08FBBED2C
  • Sequence:
    • MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC SFQPKAPVFG 
ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE PAPRGEAAPG QGQAAVKAEP 
LLGAPGELLK QGTPEYSLET SAGREAVLSN QRPGYGDNKI CEGSEDKERP DQTNPSANWL 
HARSSRKKRC PYTKYQTLEL EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM 
KKMNKEQGKE

Genular Protein ID: 3400371376

Symbol: B3KPJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPJ1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Genevisible 1 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 ProteomicsDB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 128
  • Mass: 13592
  • Checksum: D5F9919379C97723
  • Sequence:
    • MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC SFQPKAPVFG 
ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE PAPRGGAAQT GHARVQFGNF 
GGQGGRAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.