Details for: HSP90AB1

Gene ID: 3326

Symbol: HSP90AB1

Ensembl ID: ENSG00000096384

Description: heat shock protein 90 alpha family class B member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.42
    Marker Score: 4093.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.31
    Marker Score: 4155.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.25
    Marker Score: 4203
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.95
    Marker Score: 168548
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.75
    Marker Score: 9962
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.74
    Marker Score: 1748
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.64
    Marker Score: 7142
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.41
    Marker Score: 3160.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.34
    Marker Score: 77106
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.29
    Marker Score: 5589
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.29
    Marker Score: 56542
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.24
    Marker Score: 3208
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.22
    Marker Score: 5099
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.16
    Marker Score: 10162.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.15
    Marker Score: 41089
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.13
    Marker Score: 17235
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.1
    Marker Score: 3491.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.04
    Marker Score: 2853
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.04
    Marker Score: 3808.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.02
    Marker Score: 4295.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.95
    Marker Score: 209103
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.93
    Marker Score: 1767
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.9
    Marker Score: 20495
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.87
    Marker Score: 7265
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.87
    Marker Score: 10845
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.85
    Marker Score: 3020
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.84
    Marker Score: 2050
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.81
    Marker Score: 2457
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.77
    Marker Score: 28081.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.77
    Marker Score: 43789
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.75
    Marker Score: 11844
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.74
    Marker Score: 1924
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.71
    Marker Score: 887
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.71
    Marker Score: 15916
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.7
    Marker Score: 24099
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.64
    Marker Score: 2639
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.61
    Marker Score: 17755
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.59
    Marker Score: 3473
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.57
    Marker Score: 48033
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.54
    Marker Score: 5807
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.54
    Marker Score: 1830
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.52
    Marker Score: 3128.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.49
    Marker Score: 30316
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.48
    Marker Score: 3431
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.46
    Marker Score: 3098
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.43
    Marker Score: 2011
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.42
    Marker Score: 2882
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.42
    Marker Score: 1532
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.41
    Marker Score: 1419
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.4
    Marker Score: 3036.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.38
    Marker Score: 117163
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.36
    Marker Score: 6721
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.36
    Marker Score: 3733.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.35
    Marker Score: 21861
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.34
    Marker Score: 19820
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.33
    Marker Score: 3585
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.32
    Marker Score: 3616
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.32
    Marker Score: 879
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.31
    Marker Score: 1155
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.31
    Marker Score: 6723
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.3
    Marker Score: 2188.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.3
    Marker Score: 827
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.29
    Marker Score: 1083
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.29
    Marker Score: 4062
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.29
    Marker Score: 8816
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.27
    Marker Score: 2787
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.26
    Marker Score: 4487
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.26
    Marker Score: 2469
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.25
    Marker Score: 1120.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.25
    Marker Score: 1681
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.24
    Marker Score: 4591
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.24
    Marker Score: 5489
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.24
    Marker Score: 4561
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.24
    Marker Score: 2035
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.23
    Marker Score: 1962.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.22
    Marker Score: 3776
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.21
    Marker Score: 3676
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.21
    Marker Score: 1604
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.21
    Marker Score: 3868
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.21
    Marker Score: 8868
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.21
    Marker Score: 1171
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.21
    Marker Score: 1812
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 3.2
    Marker Score: 2007
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.19
    Marker Score: 2815.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.19
    Marker Score: 3077
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.18
    Marker Score: 1446
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.18
    Marker Score: 7210
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.17
    Marker Score: 12233.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.16
    Marker Score: 5025
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.16
    Marker Score: 2488
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.15
    Marker Score: 7950
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.15
    Marker Score: 828
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.14
    Marker Score: 7978
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.14
    Marker Score: 9156
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.13
    Marker Score: 19963
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.12
    Marker Score: 1343
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.12
    Marker Score: 716
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 3.12
    Marker Score: 1081
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.12
    Marker Score: 1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.11
    Marker Score: 24297.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - It is a chaperone protein that helps to protect other proteins from aggregation and degradation. - It is a key regulator of autophagy, a process by which cells break down and recycle their own components. - It is also involved in the regulation of cell cycle progression and the response to stress. - It is a regulator of inflammation and immune responses. **Pathways and functions:** - HSP90AB1 is involved in the regulation of autophagy. - It is also involved in the regulation of cell cycle progression, including the G1/S transition. - It is involved in the response to stress, including heat shock and oxidative stress. - It is also involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in HSP90AB1 have been linked to a number of human diseases, including cancer, neurodegenerative disorders, and metabolic diseases. - Targeting HSP90AB1 has been explored as a therapeutic strategy for these diseases. **Additional notes:** - HSP90AB1 is a highly conserved protein, with a sequence that is found in organisms from yeast to humans. - It is a multi-functional protein that can interact with a variety of other proteins. - It is a key regulator of cellular metabolism and stress response.

Genular Protein ID: 1368812127

Symbol: HS90B_HUMAN

Name: Heat shock protein HSP 90-beta

UniProtKB Accession Codes:

P08238 B2R5P0 Q5T9W7 Q9NQW0 Q9NTK6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 EMBL 16 EMDB 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 73 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 28 PIR 2 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 19 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3301534

Title: Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family.

PubMed ID: 3301534

DOI: 10.1016/0378-1119(87)90012-6

PubMed ID: 2768249

Title: Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene.

PubMed ID: 2768249

DOI: 10.1016/s0021-9258(18)63803-7

PubMed ID: 2469626

Title: Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens.

PubMed ID: 2469626

DOI: 10.1016/0378-1119(88)90182-5

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2492519

Title: Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II.

PubMed ID: 2492519

DOI: 10.1016/s0021-9258(19)81631-9

PubMed ID: 8180474

Title: A cosmid clone at the D6S182 locus on human chromosome 6p12 contains the 90-kDa heat shock protein beta gene (HSP90 beta).

PubMed ID: 8180474

DOI: 10.1007/bf00292342

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 7588731

Title: Mechanism of dimer formation of the 90-kDa heat-shock protein.

PubMed ID: 7588731

DOI: 10.1111/j.1432-1033.1995.001_1.x

PubMed ID: 9482106

Title: Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.

PubMed ID: 9482106

DOI: 10.1038/sj.onc.1201570

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15581363

Title: Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex.

PubMed ID: 15581363

DOI: 10.1021/bi048736m

PubMed ID: 15358771

Title: Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.

PubMed ID: 15358771

DOI: 10.1074/jbc.m407687200

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16580629

Title: SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis.

PubMed ID: 16580629

DOI: 10.1016/j.bbrc.2006.03.090

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16478993

Title: GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.

PubMed ID: 16478993

DOI: 10.1128/mcb.26.5.1722-1730.2006

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18042044

Title: Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.

PubMed ID: 18042044

DOI: 10.1042/bj20071338

PubMed ID: 18620420

Title: Role of the cochaperone Tpr2 in Hsp90 chaperoning.

PubMed ID: 18620420

DOI: 10.1021/bi800770g

PubMed ID: 18239673

Title: Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation.

PubMed ID: 18239673

DOI: 10.1038/cdd.2008.5

PubMed ID: 18400751

Title: Conserved conformational changes in the ATPase cycle of human Hsp90.

PubMed ID: 18400751

DOI: 10.1074/jbc.m800540200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18320024

Title: The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.

PubMed ID: 18320024

DOI: 10.1371/journal.pone.0001737

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19696785

Title: Hsp90 is regulated by a switch point in the C-terminal domain.

PubMed ID: 19696785

DOI: 10.1038/embor.2009.153

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20599762

Title: Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1.

PubMed ID: 20599762

DOI: 10.1016/j.bbrc.2010.06.112

PubMed ID: 20353823

Title: Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.

PubMed ID: 20353823

DOI: 10.1016/j.cellsig.2010.03.012

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21949862

Title: The soluble recombinant Neisseria meningitidis adhesin NadA(Delta351-405) stimulates human monocytes by binding to extracellular Hsp90.

PubMed ID: 21949862

DOI: 10.1371/journal.pone.0025089

PubMed ID: 22022502

Title: An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.

PubMed ID: 22022502

DOI: 10.1371/journal.pone.0026044

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22828320

Title: Investigation on PLK2 and PLK3 substrate recognition.

PubMed ID: 22828320

DOI: 10.1016/j.bbapap.2012.07.003

PubMed ID: 22843495

Title: Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.

PubMed ID: 22843495

DOI: 10.1093/hmg/dds303

PubMed ID: 22066472

Title: Human heat shock protein (Hsp) 90 interferes with Neisseria meningitidis adhesin A (NadA)-mediated adhesion and invasion.

PubMed ID: 22066472

DOI: 10.1111/j.1462-5822.2011.01722.x

PubMed ID: 22848402

Title: Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif.

PubMed ID: 22848402

DOI: 10.1371/journal.pone.0040795

PubMed ID: 23585225

Title: LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung.

PubMed ID: 23585225

DOI: 10.1152/ajplung.00419.2012

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23428871

Title: Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.

PubMed ID: 23428871

DOI: 10.1128/mcb.01246-12

PubMed ID: 23431407

Title: Distinct roles of molecular chaperones HSP90alpha and HSP90beta in the biogenesis of KCNQ4 channels.

PubMed ID: 23431407

DOI: 10.1371/journal.pone.0057282

PubMed ID: 24613385

Title: Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.

PubMed ID: 24613385

DOI: 10.1016/j.bbrc.2014.02.124

PubMed ID: 24880080

Title: SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.

PubMed ID: 24880080

DOI: 10.1016/j.canlet.2014.05.014

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24681825

Title: The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.

PubMed ID: 24681825

DOI: 10.18632/oncotarget.1850

PubMed ID: 25486457

Title: Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast.

PubMed ID: 25486457

DOI: 10.1016/j.bbamcr.2014.11.026

PubMed ID: 25973397

Title: Hsp90, the concertmaster: tuning transcription.

PubMed ID: 25973397

DOI: 10.3389/fonc.2015.00100

PubMed ID: 26517842

Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.

PubMed ID: 26517842

DOI: 10.1371/journal.pone.0141786

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27295069

Title: Hsp90: Friends, clients and natural foes.

PubMed ID: 27295069

DOI: 10.1016/j.biochi.2016.05.018

PubMed ID: 26991466

Title: Review: The HSP90 molecular chaperone-an enigmatic ATPase.

PubMed ID: 26991466

DOI: 10.1002/bip.22835

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 15217611

Title: Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.

PubMed ID: 15217611

DOI: 10.1016/j.chembiol.2004.03.033

PubMed ID: 15159550

Title: 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.

PubMed ID: 15159550

DOI: 10.1073/pnas.0305969101

Sequence Information:

  • Length: 724
  • Mass: 83264
  • Checksum: A93118C214D03810
  • Sequence:
    • MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT 
DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG 
ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGEPIGRGTK 
VILHLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE 
DKDDEEKPKI EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE 
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK NNIKLYVRRV 
FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI LKVIRKNIVK KCLELFSELA 
EDKENYKKFY EAFSKNLKLG IHEDSTNRRR LSELLRYHTS QSGDEMTSLS EYVSRMKETQ 
KSIYYITGES KEQVANSAFV ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG 
LELPEDEEEK KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA 
NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA VKDLVVLLFE 
TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVAAEEP NAAVPDEIPP LEGDEDASRM 
EEVD

Genular Protein ID: 392832538

Symbol: Q6PK50_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PK50

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 7 Gene3D 2 GenomeRNAi 1 IntAct 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 351
  • Mass: 40295
  • Checksum: 5CA7AFC5181A33A5
  • Sequence:
    • MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT 
DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG 
ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGEPIGRGTK 
VILHLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE 
DKDDEEKPKI EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE 
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFEKKKKK K

Genular Protein ID: 1863577633

Symbol: B4DGL0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGL0

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 8 Gene3D 4 GenomeRNAi 1 HAMAP 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 714
  • Mass: 82170
  • Checksum: 1C7927E5F1D9509F
  • Sequence:
    • MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRCESLT 
DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG 
VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGDPIGRGTK VILHLKEDQT 
EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE DKDDEEKPKI 
EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE YGEFYKSLTN 
DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK NNIKLYVRRV FIMDSCDELI 
PEYLNFIRGV VDSEDLPLNI SREMLQQSKI LKVIRKNIVK KCLELFSELA EDKENYKKFY 
EAFSKNLKLG IHEDSTNRRR LSELLRYHTS QSGDEMTSLS EYVSRMKETQ KSIYYITGES 
KEQVANSAFV ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG LELPEDEEEK 
KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA NMERIMKAQA 
LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA VKDLVVLLFE TALLSSGFSL 
EDPQTHSNRI YRMIKLGLGI DEDEVAAEEP NAAVPDEIPP LEGDEDASRM EEVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.