Details for: HSP90AB1

Gene ID: 3326

Symbol: HSP90AB1

Ensembl ID: ENSG00000096384

Description: heat shock protein 90 alpha family class B member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1358.2223
    Cell Significance Index: -211.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 712.1022
    Cell Significance Index: -180.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 602.6737
    Cell Significance Index: -248.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 525.0123
    Cell Significance Index: -213.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 509.1685
    Cell Significance Index: -240.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 464.4962
    Cell Significance Index: -238.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 359.3175
    Cell Significance Index: -241.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 223.3036
    Cell Significance Index: -213.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 187.0708
    Cell Significance Index: -230.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 72.1352
    Cell Significance Index: -193.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 64.7804
    Cell Significance Index: -198.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 61.0357
    Cell Significance Index: -240.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 34.8444
    Cell Significance Index: -76.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.0981
    Cell Significance Index: 289.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 8.3619
    Cell Significance Index: 393.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.2043
    Cell Significance Index: 105.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.0450
    Cell Significance Index: 279.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.6965
    Cell Significance Index: 202.3800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 7.5523
    Cell Significance Index: 44.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.3621
    Cell Significance Index: 386.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.9950
    Cell Significance Index: 960.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.4776
    Cell Significance Index: 796.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.3494
    Cell Significance Index: 813.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.1890
    Cell Significance Index: 168.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.0876
    Cell Significance Index: 1097.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.9248
    Cell Significance Index: 3235.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.7598
    Cell Significance Index: 99.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.5336
    Cell Significance Index: 585.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.3106
    Cell Significance Index: 1905.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.1320
    Cell Significance Index: 44.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.0623
    Cell Significance Index: 46.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.9284
    Cell Significance Index: 69.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.8647
    Cell Significance Index: 273.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.7775
    Cell Significance Index: 445.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.4460
    Cell Significance Index: 256.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.2916
    Cell Significance Index: 212.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.2844
    Cell Significance Index: 75.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.2520
    Cell Significance Index: 645.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.6616
    Cell Significance Index: 24.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5386
    Cell Significance Index: 118.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.4542
    Cell Significance Index: 150.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1578
    Cell Significance Index: 773.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.1549
    Cell Significance Index: 367.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0829
    Cell Significance Index: 417.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.0025
    Cell Significance Index: 53.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.9570
    Cell Significance Index: 109.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6061
    Cell Significance Index: 444.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6000
    Cell Significance Index: 454.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3201
    Cell Significance Index: 16.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1844
    Cell Significance Index: 30.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1509
    Cell Significance Index: 14.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1488
    Cell Significance Index: 134.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1234
    Cell Significance Index: 0.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1207
    Cell Significance Index: 4.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0757
    Cell Significance Index: 14.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0451
    Cell Significance Index: 0.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0036
    Cell Significance Index: 6.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1027
    Cell Significance Index: -76.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1146
    Cell Significance Index: -11.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1234
    Cell Significance Index: -167.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1323
    Cell Significance Index: -244.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1475
    Cell Significance Index: -227.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1645
    Cell Significance Index: -4.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.2179
    Cell Significance Index: -150.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2202
    Cell Significance Index: -137.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2379
    Cell Significance Index: -151.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3178
    Cell Significance Index: -179.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4357
    Cell Significance Index: -197.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5363
    Cell Significance Index: -112.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.7384
    Cell Significance Index: -212.4600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.8000
    Cell Significance Index: -12.1500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.8809
    Cell Significance Index: -6.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1014
    Cell Significance Index: -74.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1492
    Cell Significance Index: -91.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.3003
    Cell Significance Index: -189.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3242
    Cell Significance Index: -74.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.3525
    Cell Significance Index: -157.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4086
    Cell Significance Index: -161.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.6159
    Cell Significance Index: -41.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.7961
    Cell Significance Index: -81.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.8504
    Cell Significance Index: -11.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.9325
    Cell Significance Index: -210.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.9572
    Cell Significance Index: -33.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.0769
    Cell Significance Index: -49.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.1371
    Cell Significance Index: -164.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1770
    Cell Significance Index: -137.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.2481
    Cell Significance Index: -234.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.3593
    Cell Significance Index: -65.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.9403
    Cell Significance Index: -84.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -3.0431
    Cell Significance Index: -81.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -3.0725
    Cell Significance Index: -212.4800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -3.1479
    Cell Significance Index: -27.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -3.2625
    Cell Significance Index: -60.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.4905
    Cell Significance Index: -214.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -3.6227
    Cell Significance Index: -103.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -3.6563
    Cell Significance Index: -97.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.7197
    Cell Significance Index: -50.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.8538
    Cell Significance Index: -123.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -3.9548
    Cell Significance Index: -206.0000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -4.2579
    Cell Significance Index: -32.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HSP90AB1 is a member of the HSP90 family, which is characterized by the presence of a conserved ATP-binding domain. The protein is a homodimer and exhibits chaperone activity, facilitating the proper folding and stability of its client proteins. HSP90AB1 has been implicated in various cellular processes, including cell cycle regulation, apoptosis, and immune responses. It also interacts with several signaling pathways, including the aryl hydrocarbon receptor signaling pathway and the NF-κB pathway. **Pathways and Functions** HSP90AB1 is involved in a wide range of cellular processes, including: 1. **Cell cycle regulation**: HSP90AB1 interacts with the cyclin-dependent kinase 4 (CDK4) and regulates its activity, influencing cell cycle progression. 2. **Apoptosis**: HSP90AB1 can inhibit apoptosis by interacting with pro-apoptotic proteins, such as BAX and BAK. 3. **Immune responses**: HSP90AB1 is involved in the regulation of immune responses, including the activation of T cells and the production of cytokines. 4. **Signaling pathways**: HSP90AB1 interacts with several signaling pathways, including the aryl hydrocarbon receptor signaling pathway and the NF-κB pathway. 5. **Protein folding**: HSP90AB1 facilitates the proper folding of its client proteins, ensuring their stability and function. **Clinical Significance** The clinical significance of HSP90AB1 is an area of active research. The protein has been implicated in several diseases, including: 1. **Cancer**: HSP90AB1 is overexpressed in several types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with poor prognosis and metastasis. 2. **Autoimmune diseases**: HSP90AB1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurodegenerative diseases**: HSP90AB1 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: HSP90AB1 has been implicated in the regulation of immune responses to viral infections, such as respiratory syncytial virus (RSV) and SARS-CoV-2. In summary, HSP90AB1 is a multifunctional protein that plays a critical role in various cellular processes, including cell cycle regulation, apoptosis, and immune responses. Its dysregulation has been implicated in several diseases, highlighting the potential for therapeutic targeting of this protein in the treatment of cancer and other diseases.

Genular Protein ID: 1368812127

Symbol: HS90B_HUMAN

Name: Heat shock protein HSP 90-beta

UniProtKB Accession Codes:

P08238 B2R5P0 Q5T9W7 Q9NQW0 Q9NTK6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EMBL 16 EMDB 19 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 72 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 29 PIR 2 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 21 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3301534

Title: Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family.

PubMed ID: 3301534

DOI: 10.1016/0378-1119(87)90012-6

PubMed ID: 2768249

Title: Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene.

PubMed ID: 2768249

DOI: 10.1016/s0021-9258(18)63803-7

PubMed ID: 2469626

Title: Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens.

PubMed ID: 2469626

DOI: 10.1016/0378-1119(88)90182-5

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2492519

Title: Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II.

PubMed ID: 2492519

DOI: 10.1016/s0021-9258(19)81631-9

PubMed ID: 8180474

Title: A cosmid clone at the D6S182 locus on human chromosome 6p12 contains the 90-kDa heat shock protein beta gene (HSP90 beta).

PubMed ID: 8180474

DOI: 10.1007/bf00292342

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 7588731

Title: Mechanism of dimer formation of the 90-kDa heat-shock protein.

PubMed ID: 7588731

DOI: 10.1111/j.1432-1033.1995.001_1.x

PubMed ID: 9482106

Title: Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.

PubMed ID: 9482106

DOI: 10.1038/sj.onc.1201570

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15581363

Title: Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex.

PubMed ID: 15581363

DOI: 10.1021/bi048736m

PubMed ID: 15358771

Title: Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.

PubMed ID: 15358771

DOI: 10.1074/jbc.m407687200

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16580629

Title: SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis.

PubMed ID: 16580629

DOI: 10.1016/j.bbrc.2006.03.090

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16478993

Title: GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.

PubMed ID: 16478993

DOI: 10.1128/mcb.26.5.1722-1730.2006

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18042044

Title: Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.

PubMed ID: 18042044

DOI: 10.1042/bj20071338

PubMed ID: 18620420

Title: Role of the cochaperone Tpr2 in Hsp90 chaperoning.

PubMed ID: 18620420

DOI: 10.1021/bi800770g

PubMed ID: 18239673

Title: Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation.

PubMed ID: 18239673

DOI: 10.1038/cdd.2008.5

PubMed ID: 18400751

Title: Conserved conformational changes in the ATPase cycle of human Hsp90.

PubMed ID: 18400751

DOI: 10.1074/jbc.m800540200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18320024

Title: The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.

PubMed ID: 18320024

DOI: 10.1371/journal.pone.0001737

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 18663603

Title: Guidelines for the nomenclature of the human heat shock proteins.

PubMed ID: 18663603

DOI: 10.1007/s12192-008-0068-7

PubMed ID: 19696785

Title: Hsp90 is regulated by a switch point in the C-terminal domain.

PubMed ID: 19696785

DOI: 10.1038/embor.2009.153

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20599762

Title: Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1.

PubMed ID: 20599762

DOI: 10.1016/j.bbrc.2010.06.112

PubMed ID: 20353823

Title: Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.

PubMed ID: 20353823

DOI: 10.1016/j.cellsig.2010.03.012

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21949862

Title: The soluble recombinant Neisseria meningitidis adhesin NadA(Delta351-405) stimulates human monocytes by binding to extracellular Hsp90.

PubMed ID: 21949862

DOI: 10.1371/journal.pone.0025089

PubMed ID: 22022502

Title: An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.

PubMed ID: 22022502

DOI: 10.1371/journal.pone.0026044

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22828320

Title: Investigation on PLK2 and PLK3 substrate recognition.

PubMed ID: 22828320

DOI: 10.1016/j.bbapap.2012.07.003

PubMed ID: 22843495

Title: Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.

PubMed ID: 22843495

DOI: 10.1093/hmg/dds303

PubMed ID: 22066472

Title: Human heat shock protein (Hsp) 90 interferes with Neisseria meningitidis adhesin A (NadA)-mediated adhesion and invasion.

PubMed ID: 22066472

DOI: 10.1111/j.1462-5822.2011.01722.x

PubMed ID: 22848402

Title: Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif.

PubMed ID: 22848402

DOI: 10.1371/journal.pone.0040795

PubMed ID: 23585225

Title: LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung.

PubMed ID: 23585225

DOI: 10.1152/ajplung.00419.2012

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23428871

Title: Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.

PubMed ID: 23428871

DOI: 10.1128/mcb.01246-12

PubMed ID: 23431407

Title: Distinct roles of molecular chaperones HSP90alpha and HSP90beta in the biogenesis of KCNQ4 channels.

PubMed ID: 23431407

DOI: 10.1371/journal.pone.0057282

PubMed ID: 24613385

Title: Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.

PubMed ID: 24613385

DOI: 10.1016/j.bbrc.2014.02.124

PubMed ID: 24880080

Title: SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.

PubMed ID: 24880080

DOI: 10.1016/j.canlet.2014.05.014

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24681825

Title: The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.

PubMed ID: 24681825

DOI: 10.18632/oncotarget.1850

PubMed ID: 25486457

Title: Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast.

PubMed ID: 25486457

DOI: 10.1016/j.bbamcr.2014.11.026

PubMed ID: 25973397

Title: Hsp90, the concertmaster: tuning transcription.

PubMed ID: 25973397

DOI: 10.3389/fonc.2015.00100

PubMed ID: 26517842

Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.

PubMed ID: 26517842

DOI: 10.1371/journal.pone.0141786

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27295069

Title: Hsp90: Friends, clients and natural foes.

PubMed ID: 27295069

DOI: 10.1016/j.biochi.2016.05.018

PubMed ID: 26991466

Title: Review: The HSP90 molecular chaperone-an enigmatic ATPase.

PubMed ID: 26991466

DOI: 10.1002/bip.22835

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 15217611

Title: Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.

PubMed ID: 15217611

DOI: 10.1016/j.chembiol.2004.03.033

PubMed ID: 15159550

Title: 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.

PubMed ID: 15159550

DOI: 10.1073/pnas.0305969101

Sequence Information:

  • Length: 724
  • Mass: 83264
  • Checksum: A93118C214D03810
  • Sequence:
    • MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT 
DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG 
ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGEPIGRGTK 
VILHLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE 
DKDDEEKPKI EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE 
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK NNIKLYVRRV 
FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI LKVIRKNIVK KCLELFSELA 
EDKENYKKFY EAFSKNLKLG IHEDSTNRRR LSELLRYHTS QSGDEMTSLS EYVSRMKETQ 
KSIYYITGES KEQVANSAFV ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG 
LELPEDEEEK KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA 
NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA VKDLVVLLFE 
TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVAAEEP NAAVPDEIPP LEGDEDASRM 
EEVD

Genular Protein ID: 392832538

Symbol: Q6PK50_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PK50

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 12 Gene3D 2 IntAct 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 351
  • Mass: 40295
  • Checksum: 5CA7AFC5181A33A5
  • Sequence:
    • MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT 
DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG 
ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGEPIGRGTK 
VILHLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE 
DKDDEEKPKI EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE 
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFEKKKKK K

Genular Protein ID: 1863577633

Symbol: B4DGL0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGL0

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 DNASU 1 DisGeNET 1 EMBL 2 GO 13 Gene3D 4 HAMAP 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 714
  • Mass: 82170
  • Checksum: 1C7927E5F1D9509F
  • Sequence:
    • MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRCESLT 
DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG 
VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGDPIGRGTK VILHLKEDQT 
EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE DKDDEEKPKI 
EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE YGEFYKSLTN 
DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK NNIKLYVRRV FIMDSCDELI 
PEYLNFIRGV VDSEDLPLNI SREMLQQSKI LKVIRKNIVK KCLELFSELA EDKENYKKFY 
EAFSKNLKLG IHEDSTNRRR LSELLRYHTS QSGDEMTSLS EYVSRMKETQ KSIYYITGES 
KEQVANSAFV ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG LELPEDEEEK 
KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA NMERIMKAQA 
LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA VKDLVVLLFE TALLSSGFSL 
EDPQTHSNRI YRMIKLGLGI DEDEVAAEEP NAAVPDEIPP LEGDEDASRM EEVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.