Details for: DNAJC4

Gene ID: 3338

Symbol: DNAJC4

Ensembl ID: ENSG00000110011

Description: DnaJ heat shock protein family (Hsp40) member C4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 157.0604
    Cell Significance Index: -24.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.6050
    Cell Significance Index: -25.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.9554
    Cell Significance Index: -14.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.7816
    Cell Significance Index: -27.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.2115
    Cell Significance Index: -28.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.6618
    Cell Significance Index: -27.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3552
    Cell Significance Index: -26.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9107
    Cell Significance Index: -27.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8567
    Cell Significance Index: -21.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9354
    Cell Significance Index: -15.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.3349
    Cell Significance Index: 388.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3110
    Cell Significance Index: 107.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3127
    Cell Significance Index: 17.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2667
    Cell Significance Index: 163.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2649
    Cell Significance Index: 34.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2188
    Cell Significance Index: 78.6300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0759
    Cell Significance Index: 8.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0329
    Cell Significance Index: 46.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0229
    Cell Significance Index: 13.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9538
    Cell Significance Index: 117.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9501
    Cell Significance Index: 130.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9130
    Cell Significance Index: 47.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8964
    Cell Significance Index: 66.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8648
    Cell Significance Index: 19.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8192
    Cell Significance Index: 447.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8127
    Cell Significance Index: 56.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7844
    Cell Significance Index: 92.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7696
    Cell Significance Index: 54.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7569
    Cell Significance Index: 136.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6644
    Cell Significance Index: 599.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6585
    Cell Significance Index: 291.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6163
    Cell Significance Index: 12.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6120
    Cell Significance Index: 9.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5128
    Cell Significance Index: 24.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5119
    Cell Significance Index: 11.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4940
    Cell Significance Index: 12.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4316
    Cell Significance Index: 11.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4190
    Cell Significance Index: 12.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3603
    Cell Significance Index: 58.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3441
    Cell Significance Index: 6.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3432
    Cell Significance Index: 3.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3372
    Cell Significance Index: 64.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3231
    Cell Significance Index: 3.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3080
    Cell Significance Index: 39.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2072
    Cell Significance Index: 5.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1801
    Cell Significance Index: 9.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1735
    Cell Significance Index: 6.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1160
    Cell Significance Index: 23.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0757
    Cell Significance Index: 12.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0651
    Cell Significance Index: 1.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0587
    Cell Significance Index: 11.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0449
    Cell Significance Index: 32.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0176
    Cell Significance Index: 0.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0123
    Cell Significance Index: 4.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0056
    Cell Significance Index: 0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0051
    Cell Significance Index: 3.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0045
    Cell Significance Index: 0.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0011
    Cell Significance Index: 0.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0009
    Cell Significance Index: 0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0009
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0100
    Cell Significance Index: -1.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0135
    Cell Significance Index: -24.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0168
    Cell Significance Index: -25.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0198
    Cell Significance Index: -26.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0248
    Cell Significance Index: -18.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0305
    Cell Significance Index: -19.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0319
    Cell Significance Index: -0.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0333
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0397
    Cell Significance Index: -22.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0514
    Cell Significance Index: -23.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0550
    Cell Significance Index: -34.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0723
    Cell Significance Index: -20.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0799
    Cell Significance Index: -2.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1233
    Cell Significance Index: -17.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1271
    Cell Significance Index: -8.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1389
    Cell Significance Index: -29.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1661
    Cell Significance Index: -4.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1699
    Cell Significance Index: -3.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1850
    Cell Significance Index: -14.2000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1923
    Cell Significance Index: -4.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2119
    Cell Significance Index: -16.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2553
    Cell Significance Index: -26.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3293
    Cell Significance Index: -20.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3479
    Cell Significance Index: -19.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3624
    Cell Significance Index: -24.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3625
    Cell Significance Index: -18.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3841
    Cell Significance Index: -23.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3999
    Cell Significance Index: -11.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4023
    Cell Significance Index: -4.1700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4218
    Cell Significance Index: -2.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4480
    Cell Significance Index: -18.3600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4904
    Cell Significance Index: -3.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5262
    Cell Significance Index: -5.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5336
    Cell Significance Index: -9.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5629
    Cell Significance Index: -24.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6041
    Cell Significance Index: -30.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6067
    Cell Significance Index: -22.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6068
    Cell Significance Index: -10.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6503
    Cell Significance Index: -22.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DNAJC4 exhibits several key characteristics that contribute to its function as a molecular chaperone. These include: 1. **Heat shock protein (Hsp) domain**: DNAJC4 contains a characteristic Hsp40 domain, which is essential for its chaperone activity. 2. **Chaperone activity**: DNAJC4 has been shown to interact with and facilitate the folding of client proteins, thereby preventing protein misfolding and aggregation. 3. **Ubiquitin ligase activity**: DNAJC4 possesses ubiquitin ligase activity, which allows it to regulate protein degradation and transport. 4. **Protein binding**: DNAJC4 interacts with a variety of client proteins, including heat shock proteins, kinases, and transcription factors. **Pathways and Functions** DNAJC4 is involved in several cellular pathways that are essential for maintaining protein homeostasis and cellular function. These include: 1. **Protein folding pathway**: DNAJC4 plays a crucial role in facilitating the folding of client proteins, thereby preventing protein misfolding and aggregation. 2. **Protein degradation pathway**: DNAJC4 regulates protein degradation through its ubiquitin ligase activity, which targets misfolded or damaged proteins for degradation. 3. **Protein transport pathway**: DNAJC4 facilitates the transport of client proteins to their correct subcellular locations, thereby maintaining cellular homeostasis. 4. **Response to unfolded protein pathway**: DNAJC4 is activated in response to unfolded protein stress, where it helps to mitigate the effects of protein misfolding and aggregation. **Clinical Significance** Dysregulation of DNAJC4 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: DNAJC4 has been shown to be involved in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: DNAJC4 has been found to be overexpressed in certain types of cancer, where it may contribute to tumorigenesis and cancer progression. 3. **Metabolic disorders**: DNAJC4 has been implicated in metabolic disorders, such as type 2 diabetes, where it may contribute to insulin resistance and glucose metabolism dysregulation. In conclusion, DNAJC4 is a critical component of the molecular chaperone network that plays a vital role in maintaining protein homeostasis and cellular function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its role in human health and disease.

Genular Protein ID: 117790385

Symbol: DNJC4_HUMAN

Name: DnaJ homolog subfamily C member 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9473517

Title: Characterisation of a new human and murine member of the DnaJ family of proteins.

PubMed ID: 9473517

DOI: 10.1006/bbrc.1997.8091

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 241
  • Mass: 27593
  • Checksum: EA186D2FA6C2E179
  • Sequence:
  • MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE 
    LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT 
    HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ 
    MHLNFMDEKD RIITAFYNEA RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG 
    P

Genular Protein ID: 2707881494

Symbol: Q86VG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 229
  • Mass: 25914
  • Checksum: CD70F24B1506E19C
  • Sequence:
  • RLLGAAAGQR SRPSTYYELL GVHPGASTEE VKRAFFSKSK ELHPDRDPGN PSLHSRFVEL 
    SEAYRVLSRE QSRRSYDDQL RSGSPPKSPR TTVHDKSAHQ THSSWTPPNA QYWSQFHSVR 
    PQGPQLRQQQ HKQNKQVLGY CLLLMLAGMG LHYIAFRKVK QMHLNFMDEK DRIITAFYNE 
    ARARARSVPA LFCSLLPVQE PHFGIPIPTT QVPSPPGPTE ASFSRSDNG

Genular Protein ID: 3461885187

Symbol: J3KNJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 249
  • Mass: 28240
  • Checksum: 5C4D54E954570440
  • Sequence:
  • MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE 
    LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT 
    HSSSWTPPNA QYWSQFHSVR PQGPQLRQQQ HKQNKQVLGY CLLLMLAGMG LHYIAFRKVK 
    QMHLNFMDEK DRIITAFYNE ARARARSVPA LFCSLLPVQE PHFGIPIPTT QVPSPPGPTE 
    ASFSRSDNG

Genular Protein ID: 4117256336

Symbol: Q6PIN0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 311
  • Mass: 35040
  • Checksum: 1713A13C1CE3B20E
  • Sequence:
  • MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE 
    LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT 
    HSSSWTPPNA QYWSQFHSVR PQGPQLRQQQ HKQNKQVLGY CLLLMLAGMG LHYIAFRKVK 
    QMHLNFMDEK DRIITAFYNE ARARARSVPA LFCSLLPVQE PHFGIPIPTT QVPSPPGPTE 
    ASFSRSDNGY GSGSRHHPSQ PKAPRSCPGA PAPEGLTWMG PAVRSRFASF PGRPAPRNAR 
    NKVIRRKKKK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.