Details for: DNAJC4

Gene ID: 3338

Symbol: DNAJC4

Ensembl ID: ENSG00000110011

Description: DnaJ heat shock protein family (Hsp40) member C4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.06
    Marker Score: 4342
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2
    Marker Score: 1448
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.81
    Marker Score: 3160
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.81
    Marker Score: 4510.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.72
    Marker Score: 3916
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.71
    Marker Score: 19845
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.68
    Marker Score: 12487
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.64
    Marker Score: 2715
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.56
    Marker Score: 4171
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.54
    Marker Score: 493
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.49
    Marker Score: 5856
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.47
    Marker Score: 1768
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.45
    Marker Score: 81179
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.44
    Marker Score: 503
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.41
    Marker Score: 1202
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.41
    Marker Score: 3839
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.39
    Marker Score: 765
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.38
    Marker Score: 2259
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.37
    Marker Score: 661
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.36
    Marker Score: 541
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.34
    Marker Score: 1354
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.34
    Marker Score: 1970
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.34
    Marker Score: 13545.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.34
    Marker Score: 5761
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.3
    Marker Score: 8460
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.29
    Marker Score: 4974
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.29
    Marker Score: 1522
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.29
    Marker Score: 601
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.28
    Marker Score: 2494.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.28
    Marker Score: 854
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.28
    Marker Score: 12837.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.28
    Marker Score: 44166
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.27
    Marker Score: 3193
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.26
    Marker Score: 526
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.26
    Marker Score: 615
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.25
    Marker Score: 623
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.25
    Marker Score: 465
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.23
    Marker Score: 289
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.22
    Marker Score: 1757
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.22
    Marker Score: 1725
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.2
    Marker Score: 15878.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.2
    Marker Score: 825
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.19
    Marker Score: 4881
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.19
    Marker Score: 2697
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.18
    Marker Score: 2812
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.18
    Marker Score: 340
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.18
    Marker Score: 271
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.17
    Marker Score: 1248
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.17
    Marker Score: 1195
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.16
    Marker Score: 2430
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.16
    Marker Score: 619
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.16
    Marker Score: 368
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.16
    Marker Score: 1228
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.16
    Marker Score: 399.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.16
    Marker Score: 1086
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.15
    Marker Score: 500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.14
    Marker Score: 1020
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.14
    Marker Score: 665
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.13
    Marker Score: 767
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.12
    Marker Score: 15053
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.11
    Marker Score: 3295
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.11
    Marker Score: 1966
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.1
    Marker Score: 1113
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1
    Marker Score: 577
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.09
    Marker Score: 4044
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.09
    Marker Score: 1171
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.09
    Marker Score: 2954
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.08
    Marker Score: 374
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.08
    Marker Score: 375
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.07
    Marker Score: 1136
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.07
    Marker Score: 622
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.07
    Marker Score: 358
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.06
    Marker Score: 1803
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.06
    Marker Score: 1410
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.05
    Marker Score: 5058
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.05
    Marker Score: 396
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.04
    Marker Score: 538
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.04
    Marker Score: 1301
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.04
    Marker Score: 1164
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.04
    Marker Score: 975.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.03
    Marker Score: 293
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.03
    Marker Score: 993
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.03
    Marker Score: 1831.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 16026.5
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.02
    Marker Score: 246
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.02
    Marker Score: 769
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.01
    Marker Score: 674
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.01
    Marker Score: 11405
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.01
    Marker Score: 1427
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1
    Marker Score: 988
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71605
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47828.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.98
    Marker Score: 2716
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30372
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.98
    Marker Score: 1013
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.98
    Marker Score: 646
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.97
    Marker Score: 407
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.97
    Marker Score: 232
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.97
    Marker Score: 594
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.97
    Marker Score: 1538

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Other Information

**Key characteristics:** - DNAJC4 is a protein of approximately 120 kDa. - It is a chaperone that helps to prevent misfolding and aggregation of other proteins. - It is found in the nucleus, cytoplasm, and mitochondria of cells. - It is expressed in a variety of cell types, including pancreatic acinar cell, CD34-positive, CD38-negative hematopoietic stem cell, B-1 B cell, CD14-positive monocyte, acinar cell of salivary gland, blood cell, basal cell of epithelium of trachea, kidney collecting duct intercalated cell, kidney loop of Henle thick ascending limb epithelial cell, erythroid progenitor cell. **Pathways and functions:** - DNAJC4 is a chaperone that helps to prevent misfolding and aggregation of other proteins. - It is involved in the folding and trafficking of proteins to their proper destinations. - It is also involved in the regulation of protein-protein interactions. - It is a key regulator of protein homeostasis and has been shown to play a role in disease. **Clinical significance:** - Mutations in DNAJC4 have been linked to a number of human diseases, including amyotrophic lateral sclerosis, Werner syndrome, and cancer. - DNAJC4 is a potential therapeutic target for these diseases.

Genular Protein ID: 117790385

Symbol: DNJC4_HUMAN

Name: DnaJ homolog subfamily C member 4

UniProtKB Accession Codes:

Q9NNZ3 O14716

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9473517

Title: Characterisation of a new human and murine member of the DnaJ family of proteins.

PubMed ID: 9473517

DOI: 10.1006/bbrc.1997.8091

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 241
  • Mass: 27593
  • Checksum: EA186D2FA6C2E179
  • Sequence:
    • MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE 
LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT 
HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ 
MHLNFMDEKD RIITAFYNEA RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG 
P

Genular Protein ID: 4117256336

Symbol: Q6PIN0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PIN0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 311
  • Mass: 35040
  • Checksum: 1713A13C1CE3B20E
  • Sequence:
    • MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE 
LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT 
HSSSWTPPNA QYWSQFHSVR PQGPQLRQQQ HKQNKQVLGY CLLLMLAGMG LHYIAFRKVK 
QMHLNFMDEK DRIITAFYNE ARARARSVPA LFCSLLPVQE PHFGIPIPTT QVPSPPGPTE 
ASFSRSDNGY GSGSRHHPSQ PKAPRSCPGA PAPEGLTWMG PAVRSRFASF PGRPAPRNAR 
NKVIRRKKKK K

Genular Protein ID: 3461885187

Symbol: J3KNJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KNJ8

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 249
  • Mass: 28240
  • Checksum: 5C4D54E954570440
  • Sequence:
    • MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE 
LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT 
HSSSWTPPNA QYWSQFHSVR PQGPQLRQQQ HKQNKQVLGY CLLLMLAGMG LHYIAFRKVK 
QMHLNFMDEK DRIITAFYNE ARARARSVPA LFCSLLPVQE PHFGIPIPTT QVPSPPGPTE 
ASFSRSDNG

Genular Protein ID: 2707881494

Symbol: Q86VG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86VG4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 229
  • Mass: 25914
  • Checksum: CD70F24B1506E19C
  • Sequence:
    • RLLGAAAGQR SRPSTYYELL GVHPGASTEE VKRAFFSKSK ELHPDRDPGN PSLHSRFVEL 
SEAYRVLSRE QSRRSYDDQL RSGSPPKSPR TTVHDKSAHQ THSSWTPPNA QYWSQFHSVR 
PQGPQLRQQQ HKQNKQVLGY CLLLMLAGMG LHYIAFRKVK QMHLNFMDEK DRIITAFYNE 
ARARARSVPA LFCSLLPVQE PHFGIPIPTT QVPSPPGPTE ASFSRSDNG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.