Details for: ICAM2

Gene ID: 3384

Symbol: ICAM2

Ensembl ID: ENSG00000108622

Description: intercellular adhesion molecule 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.38
    Marker Score: 6335
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.61
    Marker Score: 9176
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.5
    Marker Score: 2151
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.29
    Marker Score: 2156
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.05
    Marker Score: 4096
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.97
    Marker Score: 477
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.92
    Marker Score: 22303.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.89
    Marker Score: 1131
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.87
    Marker Score: 8000
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.84
    Marker Score: 3585
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.83
    Marker Score: 5331
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.78
    Marker Score: 415
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.77
    Marker Score: 1508
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.65
    Marker Score: 3234
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.64
    Marker Score: 1583.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.54
    Marker Score: 81384
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.51
    Marker Score: 483
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.49
    Marker Score: 1089
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.48
    Marker Score: 1596
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.47
    Marker Score: 1061
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167909
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.46
    Marker Score: 9336
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.45
    Marker Score: 1458
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.45
    Marker Score: 1288
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.45
    Marker Score: 1297
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.44
    Marker Score: 4529
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.43
    Marker Score: 594
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.42
    Marker Score: 3475
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.42
    Marker Score: 2401.5
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.4
    Marker Score: 1269
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.4
    Marker Score: 1400.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.38
    Marker Score: 689
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.36
    Marker Score: 344
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.35
    Marker Score: 314
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.31
    Marker Score: 456
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.26
    Marker Score: 909
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.25
    Marker Score: 2366
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.24
    Marker Score: 3484
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.22
    Marker Score: 2093.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.21
    Marker Score: 876
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.2
    Marker Score: 4904
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.18
    Marker Score: 495
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.17
    Marker Score: 2816
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.16
    Marker Score: 11740
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.15
    Marker Score: 404
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.15
    Marker Score: 356
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.14
    Marker Score: 1519
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.11
    Marker Score: 337
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.11
    Marker Score: 750
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.11
    Marker Score: 1153
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.1
    Marker Score: 235
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.09
    Marker Score: 1602
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.08
    Marker Score: 378
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.08
    Marker Score: 1100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.07
    Marker Score: 463
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.07
    Marker Score: 1868
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.06
    Marker Score: 269
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.06
    Marker Score: 1888
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.06
    Marker Score: 1494
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.04
    Marker Score: 326
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.03
    Marker Score: 26505
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.03
    Marker Score: 664
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.02
    Marker Score: 898
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.01
    Marker Score: 736.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71706.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47936
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.99
    Marker Score: 228
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.96
    Marker Score: 592
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.96
    Marker Score: 541
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.94
    Marker Score: 883
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.92
    Marker Score: 931
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.91
    Marker Score: 1011
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.91
    Marker Score: 9038
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.91
    Marker Score: 546
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2713
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5124
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.87
    Marker Score: 716
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.87
    Marker Score: 777
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5268
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.87
    Marker Score: 815
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.86
    Marker Score: 229.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.86
    Marker Score: 189
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.85
    Marker Score: 47630
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.85
    Marker Score: 369
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.84
    Marker Score: 203
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.84
    Marker Score: 657
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.82
    Marker Score: 988.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.82
    Marker Score: 430
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.81
    Marker Score: 2010.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.8
    Marker Score: 470
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.79
    Marker Score: 305
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.76
    Marker Score: 317
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.76
    Marker Score: 482.5

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Other Information

**Key characteristics:** * ICAM2 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the immunoglobulin superfamily. * It is expressed in high levels on endothelial cells, which are key cells in the immune system. * ICAM2 is also expressed on immune cells, such as T-helper 22 cells and CD14-positive monocytes. **Pathways and functions:** * ICAM2 is involved in cell adhesion through its interaction with integrins on the cell surface. * It also plays a role in cell signaling pathways, including the C-type lectin receptors (clrs) and Cd209 (dc-sign) signaling pathways. * ICAM2 is involved in the regulation of inflammation and immune responses. * It is expressed on blood cells, and its expression on endothelial cells is essential for the migration and adhesion of immune cells to sites of infection. **Clinical significance:** * Mutations in the ICAM2 gene have been linked to human diseases, including asthma, rheumatoid arthritis, and cancer. * ICAM2 is a potential target for therapeutic interventions in these diseases. * By blocking ICAM2 signaling, it has been shown to inhibit inflammation and tumor growth. **Additional notes:** * ICAM2 is a highly conserved protein with homologs in other species. * It is a promising target for cancer immunotherapy due to its expression on tumor cells and its role in cell adhesion and signaling. * Further research is needed to explore the potential clinical applications of ICAM2 inhibitors in the treatment of inflammatory and cancer diseases.

Genular Protein ID: 1453092599

Symbol: ICAM2_HUMAN

Name: Intercellular adhesion molecule 2

UniProtKB Accession Codes:

P13598 Q14600

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2497351

Title: Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1.

PubMed ID: 2497351

DOI: 10.1038/339061a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9153399

Title: Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.

PubMed ID: 9153399

DOI: 10.1038/387312a0

Sequence Information:

  • Length: 275
  • Mass: 30654
  • Checksum: C54FB34D92A6FC38
  • Sequence:
    • MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST TCNQPEVGGL 
ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE SMNSNVSVYQ PPRQVILTLQ 
PTLVAVGKSF TIECRVPTVE PLDSLTLFLF RGNETLHYET FGKAAPAPQE ATATFNSTAD 
REDGHRNFSC LAVLDLMSRG GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT 
SVLLCFIFGQ HLRQQRMGTY GVRAAWRRLP QAFRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.