Details for: ICAM2

Gene ID: 3384

Symbol: ICAM2

Ensembl ID: ENSG00000108622

Description: intercellular adhesion molecule 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.4770
    Cell Significance Index: -13.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.9458
    Cell Significance Index: -18.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.9957
    Cell Significance Index: -6.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.2169
    Cell Significance Index: -13.8300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 5.0738
    Cell Significance Index: 18.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7534
    Cell Significance Index: -14.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1548
    Cell Significance Index: -11.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.7700
    Cell Significance Index: 66.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7227
    Cell Significance Index: -14.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.9711
    Cell Significance Index: 57.8900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.6599
    Cell Significance Index: 9.8000
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.3902
    Cell Significance Index: 8.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1342
    Cell Significance Index: 73.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.0862
    Cell Significance Index: 12.3400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.0751
    Cell Significance Index: 2.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.0495
    Cell Significance Index: 15.1000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.9238
    Cell Significance Index: 12.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7688
    Cell Significance Index: 76.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7027
    Cell Significance Index: 14.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5829
    Cell Significance Index: 526.3300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.5300
    Cell Significance Index: 7.6000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.5233
    Cell Significance Index: 1.6000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.4846
    Cell Significance Index: 3.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4720
    Cell Significance Index: 12.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4138
    Cell Significance Index: 67.3000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.4136
    Cell Significance Index: 4.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4080
    Cell Significance Index: 44.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4063
    Cell Significance Index: 7.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3890
    Cell Significance Index: 2.3500
  • Cell Name: endothelial cell of arteriole (CL1000412)
    Fold Change: 0.3796
    Cell Significance Index: 3.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3345
    Cell Significance Index: 20.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2595
    Cell Significance Index: 30.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1014
    Cell Significance Index: 19.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0770
    Cell Significance Index: 42.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0696
    Cell Significance Index: 1.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0528
    Cell Significance Index: 9.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0332
    Cell Significance Index: 4.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0128
    Cell Significance Index: 1.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0017
    Cell Significance Index: -0.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0028
    Cell Significance Index: -0.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0037
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0074
    Cell Significance Index: -13.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0087
    Cell Significance Index: -16.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0101
    Cell Significance Index: -0.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0103
    Cell Significance Index: -7.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0104
    Cell Significance Index: -15.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0121
    Cell Significance Index: -16.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0161
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0225
    Cell Significance Index: -16.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0246
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0251
    Cell Significance Index: -14.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0280
    Cell Significance Index: -0.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0288
    Cell Significance Index: -18.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0313
    Cell Significance Index: -0.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0381
    Cell Significance Index: -17.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0387
    Cell Significance Index: -7.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0418
    Cell Significance Index: -14.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0437
    Cell Significance Index: -12.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0498
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0499
    Cell Significance Index: -8.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0644
    Cell Significance Index: -0.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0700
    Cell Significance Index: -14.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0705
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0750
    Cell Significance Index: -15.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0866
    Cell Significance Index: -10.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1027
    Cell Significance Index: -5.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1078
    Cell Significance Index: -6.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1238
    Cell Significance Index: -18.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1333
    Cell Significance Index: -15.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1383
    Cell Significance Index: -14.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1398
    Cell Significance Index: -10.7300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1647
    Cell Significance Index: -7.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1866
    Cell Significance Index: -13.9100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1981
    Cell Significance Index: -1.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2165
    Cell Significance Index: -13.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2293
    Cell Significance Index: -15.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2329
    Cell Significance Index: -10.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2361
    Cell Significance Index: -18.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2431
    Cell Significance Index: -15.3200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2685
    Cell Significance Index: -2.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2750
    Cell Significance Index: -15.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2855
    Cell Significance Index: -14.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2879
    Cell Significance Index: -9.2200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2988
    Cell Significance Index: -2.8400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3131
    Cell Significance Index: -4.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3184
    Cell Significance Index: -13.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3436
    Cell Significance Index: -15.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3694
    Cell Significance Index: -4.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3934
    Cell Significance Index: -13.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3985
    Cell Significance Index: -15.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4132
    Cell Significance Index: -15.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4133
    Cell Significance Index: -11.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4212
    Cell Significance Index: -11.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4406
    Cell Significance Index: -14.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4512
    Cell Significance Index: -12.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4560
    Cell Significance Index: -3.8300
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.4616
    Cell Significance Index: -3.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ICAM2 is a 55-kDa transmembrane glycoprotein expressed on the surface of multiple cell types, including endothelial cells, monocytes, and T-helper 22 cells. It is characterized by its ability to mediate cell-cell adhesion, regulate immune cell migration, and facilitate interactions between lymphoid and non-lymphoid cells. ICAM2 is also involved in the regulation of inflammatory responses, platelet activation, and the clearance of apoptotic cells. **Pathways and Functions:** ICAM2 is involved in various signaling pathways that modulate immune responses, including: 1. **Adaptive Immune System:** ICAM2 interacts with CD28 and CTLA-4 on T cells, regulating T-cell activation and proliferation. 2. **C-type Lectin Receptors (CLRs):** ICAM2 interacts with CLRs, such as Dectin-1, to regulate the activation of innate immune cells. 3. **Cd209 (DC-Sign) Signaling:** ICAM2 interacts with Cd209, a dendritic cell receptor, to regulate the activation of dendritic cells and the induction of immune responses. 4. **Cell-Cell Adhesion:** ICAM2 mediates adhesion between endothelial cells, monocytes, and T cells, regulating their migration and homing to sites of inflammation. **Clinical Significance:** Dysregulation of ICAM2 has been implicated in various diseases, including: 1. **Inflammatory Disorders:** ICAM2 has been implicated in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease. 2. **Immunodeficiency Diseases:** ICAM2 mutations have been associated with immunodeficiency disorders, such as X-linked lymphoproliferative disease. 3. **Cancer:** ICAM2 has been implicated in tumor progression and metastasis, particularly in lung and breast cancers. 4. **Neurological Disorders:** ICAM2 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and multiple sclerosis. In conclusion, ICAM2 plays a critical role in regulating immune responses and maintaining tissue homeostasis. Its dysregulation has significant clinical implications, highlighting the need for further research into the mechanisms of ICAM2 and its role in disease pathogenesis.

Genular Protein ID: 1453092599

Symbol: ICAM2_HUMAN

Name: Intercellular adhesion molecule 2

UniProtKB Accession Codes:

P13598 Q14600

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2497351

Title: Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1.

PubMed ID: 2497351

DOI: 10.1038/339061a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9153399

Title: Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.

PubMed ID: 9153399

DOI: 10.1038/387312a0

Sequence Information:

  • Length: 275
  • Mass: 30654
  • Checksum: C54FB34D92A6FC38
  • Sequence:
    • MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST TCNQPEVGGL 
ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE SMNSNVSVYQ PPRQVILTLQ 
PTLVAVGKSF TIECRVPTVE PLDSLTLFLF RGNETLHYET FGKAAPAPQE ATATFNSTAD 
REDGHRNFSC LAVLDLMSRG GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT 
SVLLCFIFGQ HLRQQRMGTY GVRAAWRRLP QAFRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.