Details for: IFNA21

Gene ID: 3452

Symbol: IFNA21

Ensembl ID: ENSG00000137080

Description: interferon alpha 21

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10810.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7575.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3657
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32712
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 740
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.51
    Marker Score: 295.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 866
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.33
    Marker Score: 634
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 199
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.24
    Marker Score: 3708
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.16
    Marker Score: 936
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.11
    Marker Score: 52.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 33.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.06
    Marker Score: 232
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.04
    Marker Score: 49.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.03
    Marker Score: 68
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 32.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 28
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 31
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0
    Marker Score: 29
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 31
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 25
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 41.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 25
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 30
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 18

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Other Information

**Key characteristics:** * IFNA21 is a protein of the interferon alpha/beta family. * It is expressed in high levels in the lungs during viral infection. * It is a key regulator of the immune response to viral infection. * It plays a role in the regulation of inflammation and tissue repair. **Pathways and functions:** * IFNA21 is a key regulator of the immune response to viral infection. * It is expressed in a variety of cell types, including goblet cells, neoplastic cells, abnormal cells, and intestinal stem cells. * It is a key regulator of the inflammatory response to viral infection. * It plays a role in the regulation of tissue repair. * IFNA21 is also involved in the regulation of inflammation and tissue repair. **Clinical significance:** * Mutations in IFNA21 have been linked to the development of several human diseases, including viral hepatitis, tuberculosis, and cancer. * Targeting IFNA21 has been investigated as a therapeutic strategy for these diseases. **Other important points:** * IFNA21 is a highly conserved protein, with a similar sequence in mammals and humans. * It is a potent activator of the innate immune response. * It is a key regulator of the immune response to viral infection.

Genular Protein ID: 2860170049

Symbol: IFN21_HUMAN

Name: Interferon alpha-21

UniProtKB Accession Codes:

P01568 Q14608 Q5VWD1 Q7M4Q4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 12 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 5 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6163083

Title: The structure of eight distinct cloned human leukocyte interferon cDNAs.

PubMed ID: 6163083

DOI: 10.1038/290020a0

PubMed ID: 6548765

Title: Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes.

PubMed ID: 6548765

DOI: 10.1089/jir.1984.4.609

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3803589

Title: Anomalous behavior of human leukocyte interferon subtypes on polyacrylamide gel electrophoresis in the presence of dodecyl sulfate.

PubMed ID: 3803589

DOI: 10.1016/0014-5793(87)81278-4

PubMed ID: 1634550

Title: Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.

PubMed ID: 1634550

DOI: 10.1016/s0021-9258(18)42167-9

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 8910771

Title: Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population.

PubMed ID: 8910771

DOI: 10.1089/jir.1996.16.853

Sequence Information:

  • Length: 189
  • Mass: 21741
  • Checksum: F0B6C9C392905802
  • Sequence:
    • MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG 
FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW EQSLLEKFST ELNQQLNDLE 
ACVIQEVGVE ETPLMNVDSI LAVKKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSLSKI 
FQERLRRKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.