Details for: ILF2

Gene ID: 3608

Symbol: ILF2

Ensembl ID: ENSG00000143621

Description: interleukin enhancer binding factor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.5
    Marker Score: 3656
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.82
    Marker Score: 37176
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.78
    Marker Score: 94694
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.73
    Marker Score: 3866
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.56
    Marker Score: 944
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.53
    Marker Score: 10369.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.52
    Marker Score: 16382
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.47
    Marker Score: 9511
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.45
    Marker Score: 5107
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.44
    Marker Score: 1535
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.44
    Marker Score: 2299
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.41
    Marker Score: 2577
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.39
    Marker Score: 5840.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.39
    Marker Score: 3436
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.31
    Marker Score: 2325
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.29
    Marker Score: 3890.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.28
    Marker Score: 6202
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.23
    Marker Score: 2372.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.23
    Marker Score: 3429.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.21
    Marker Score: 2657.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.21
    Marker Score: 22237
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.14
    Marker Score: 2398
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.1
    Marker Score: 3449
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.08
    Marker Score: 1389
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.08
    Marker Score: 2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.07
    Marker Score: 8919
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.05
    Marker Score: 1488
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.05
    Marker Score: 23848
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.04
    Marker Score: 1072
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.02
    Marker Score: 5503
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.01
    Marker Score: 713
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.99
    Marker Score: 7837
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.99
    Marker Score: 7374
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.99
    Marker Score: 1181
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.97
    Marker Score: 886
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.97
    Marker Score: 2118
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.96
    Marker Score: 4624
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.96
    Marker Score: 927
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.96
    Marker Score: 9623
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.95
    Marker Score: 627
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.95
    Marker Score: 3460
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.94
    Marker Score: 806
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.93
    Marker Score: 650
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.93
    Marker Score: 66847
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.92
    Marker Score: 1397.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.91
    Marker Score: 19368.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.89
    Marker Score: 3303
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.89
    Marker Score: 1427.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.89
    Marker Score: 11206
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.88
    Marker Score: 1260
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.88
    Marker Score: 922
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.87
    Marker Score: 963
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.87
    Marker Score: 1028
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.87
    Marker Score: 653
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.86
    Marker Score: 1835
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.84
    Marker Score: 2928
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.83
    Marker Score: 1959.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.83
    Marker Score: 1158
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.83
    Marker Score: 2160
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.83
    Marker Score: 1559.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.82
    Marker Score: 1437
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.81
    Marker Score: 20383
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.81
    Marker Score: 2403
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8
    Marker Score: 5343.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8
    Marker Score: 2646
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.78
    Marker Score: 15364
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.78
    Marker Score: 1674
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.77
    Marker Score: 940.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.75
    Marker Score: 503
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.73
    Marker Score: 4113.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.73
    Marker Score: 12887
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.73
    Marker Score: 1042
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.71
    Marker Score: 1429
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.69
    Marker Score: 2864
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.69
    Marker Score: 1321
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.69
    Marker Score: 420
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.68
    Marker Score: 1773
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.68
    Marker Score: 16647
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.68
    Marker Score: 1968
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.67
    Marker Score: 1616
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.67
    Marker Score: 420
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.66
    Marker Score: 563
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.66
    Marker Score: 396.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.66
    Marker Score: 3310.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.65
    Marker Score: 642
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.64
    Marker Score: 580
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.63
    Marker Score: 1972
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.62
    Marker Score: 1162
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.61
    Marker Score: 378
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.6
    Marker Score: 1203
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.6
    Marker Score: 84695
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.58
    Marker Score: 4376
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.58
    Marker Score: 2828
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.58
    Marker Score: 4994
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.58
    Marker Score: 2040
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.58
    Marker Score: 1425
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.57
    Marker Score: 1065
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.57
    Marker Score: 1514
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.56
    Marker Score: 541
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.56
    Marker Score: 1392

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Other Information

**Key characteristics:** * ILF2 is a protein of the interleukin family. * It is expressed in a variety of cell types. * It is involved in the regulation of innate immune responses. * It is a key regulator of the type I IFN response. **Pathways and functions:** * ILF2 binds to DNA sequences known as doublestranded RNA (dsRNA) and activates transcription of downstream genes. * It is involved in the regulation of the type I IFN response, which is a major antiviral pathway. * It is also involved in the regulation of inflammation and cell growth. **Clinical significance:** * Mutations in ILF2 have been linked to a number of human diseases, including cancer and viral infections. * ILF2 inhibitors are being investigated as a treatment for cancer and other diseases that are characterized by an impaired type I IFN response. **Additional information:** * ILF2 is a protein of the interleukin family. * It is a key regulator of innate immune responses. * It is expressed in a variety of cell types, including erythroid progenitor cells, mesodermal cells, fibroblasts of the mammary gland, CD8+ T cells, alpha-beta T cells, radial glial cells, pro-T cells, interstitial cells of the ovary, progenitor cell of mammary luminal epithelium, epithelial cell of the nephron, and neuroblast. * It is a highly conserved protein, with a similar sequence in mice and humans.

Genular Protein ID: 2716474421

Symbol: ILF2_HUMAN

Name: Interleukin enhancer-binding factor 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7519613

Title: Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.

PubMed ID: 7519613

DOI: 10.1016/s0021-9258(17)32048-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9442054

Title: DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45.

PubMed ID: 9442054

DOI: 10.1074/jbc.273.4.2136

PubMed ID: 10574923

Title: Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity.

PubMed ID: 10574923

DOI: 10.1074/jbc.274.49.34598

PubMed ID: 11790298

Title: Directed proteomic analysis of the human nucleolus.

PubMed ID: 11790298

DOI: 10.1016/s0960-9822(01)00650-9

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 11739746

Title: The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells.

PubMed ID: 11739746

DOI: 10.1128/mcb.22.1.343-356.2002

PubMed ID: 17890166

Title: The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G.

PubMed ID: 17890166

DOI: 10.1016/j.bbapap.2007.07.015

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18458058

Title: Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control.

PubMed ID: 18458058

DOI: 10.1128/mcb.00120-08

PubMed ID: 21123651

Title: Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense.

PubMed ID: 21123651

DOI: 10.1101/gad.1965010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26891316

Title: NF45 and NF90 Bind HIV-1 RNA and Modulate HIV Gene Expression.

PubMed ID: 26891316

DOI: 10.3390/v8020047

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31212927

Title: Cellular Interleukin Enhancer-Binding Factor 2, ILF2, Inhibits Japanese Encephalitis Virus Replication In Vitro.

PubMed ID: 31212927

DOI: 10.3390/v11060559

PubMed ID: 31878072

Title: Enterovirus 71 Represses Interleukin Enhancer-Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects.

PubMed ID: 31878072

DOI: 10.3390/v12010022

PubMed ID: 32433969

Title: NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.

PubMed ID: 32433969

DOI: 10.1016/j.celrep.2020.107660

PubMed ID: 33009960

Title: Cereblon Promotes the Ubiquitination and Proteasomal Degradation of Interleukin Enhancer-Binding Factor 2.

PubMed ID: 33009960

DOI: 10.1007/s10930-020-09918-9

Sequence Information:

  • Length: 390
  • Mass: 43062
  • Checksum: 75BAD022DCD4EE01
  • Sequence:
  • MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE TSFSEALLKR 
    NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE EVRQVGSYKK GTMTTGHNVA 
    DLVVILKILP TLEAVAALGN KVVESLRAQD PSEVLTMLTN ETGFEISSSD ATVKILITTV 
    PPNLRKLDPE LHLDIKVLQS ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL 
    TPWILDLLGH YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT 
    VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI VTPSEKAYEK 
    PPEKKEGEEE EENTEEPPQG EEEESMETQE

Genular Protein ID: 2423481106

Symbol: Q53FG3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 390
  • Mass: 43048
  • Checksum: 8822C9DF6F8E6A6C
  • Sequence:
  • MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE TSFSEALLKR 
    NQDLAPNSAE QASILSLVTK INNVVDNLIV APGTFEVQIE EVRQVGSYKK GTMTTGHNVA 
    DLVVILKILP TLEAVAALGN KVVESLRAQD PSEVLTMLTN ETGFEISSSD ATVKILITTV 
    PPNLRKLDPE LHLDIKVLQS ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL 
    TPWILDLLGH YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT 
    VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI VTPSEKAYEK 
    PPEKKEGEEE EENTEEPPQG EEEESMETQE

Genular Protein ID: 761363138

Symbol: B4DY09_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 352
  • Mass: 38910
  • Checksum: FF13423680CA025D
  • Sequence:
  • MAFPRVKPAP DETSFSEALL KRNQDLAPNS AEQASILSLV TKINNVIDNL IVAPGTFEVQ 
    IEEVRQVGSY KKGTMTTGHN VADLVVILKI LPTLEAVAAL GNKVVESLRA QDPSEVLTML 
    TNETGFEISS SDATVKILIT TVPPNLRKLD PELHLDIKVL QSALAAIRHA RWFEENASQS 
    TVKVLIRLLK DLRIRFPGFE PLTPWILDLL GHYAVMNNPT RQPLALNVAY RRCLQILAAG 
    LFLPGSVGIT DPCESGNFRV HTVMTLEQQD MVCYTAQTLV RILSHGGFRK ILGQEGDASY 
    LASEISTWDG VIVTPSEKAY EKPPEKKEGE EEEENTEEPP QGEEEESMET QE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.