Gene STMN1 - ENSG00000117632 | NCBI Gene ID: 3925

Details for: STMN1

Gene ID: 3925

Symbol: STMN1

Ensembl ID: ENSG00000117632

Description: stathmin 1

Associated with

Nuclear signaling by erbb4
(R-HSA-1251985)
Signaling by erbb4
(R-HSA-1236394)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Axonogenesis
(GO:0007409)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Establishment of skin barrier
(GO:0061436)
Extracellular exosome
(GO:0070062)
Hepatocyte growth factor receptor signaling pathway
(GO:0048012)
Intracellular signal transduction
(GO:0035556)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule depolymerization
(GO:0007019)
Mitotic cytokinesis
(GO:0000281)
Mitotic spindle organization
(GO:0007052)
Negative regulation of guanyl-nucleotide exchange factor activity
(GO:1905098)
Negative regulation of microtubule polymerization
(GO:0031115)
Negative regulation of rho protein signal transduction
(GO:0035024)
Negative regulation of stress fiber assembly
(GO:0051497)
Negative regulation of thrombin-activated receptor signaling pathway
(GO:0070495)
Neuron projection
(GO:0043005)
Neuron projection development
(GO:0031175)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Regulation of microtubule polymerization or depolymerization
(GO:0031110)
Response to virus
(GO:0009615)
Signal transduction
(GO:0007165)
Tubulin binding
(GO:0015631)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: chromaffin cell (CL0000166)
Fold Change: 4.78
Marker Score: 6725.5
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 4.76
Marker Score: 3596
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.46
Marker Score: 5383
Cell Name: early promyelocyte (CL0002154)
Fold Change: 4.44
Marker Score: 3554
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.22
Marker Score: 55705
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.89
Marker Score: 3674
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.73
Marker Score: 22118
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.64
Marker Score: 23675
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 3.33
Marker Score: 2089
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 3.31
Marker Score: 6717
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 3.22
Marker Score: 4564
Cell Name: granulosa cell (CL0000501)
Fold Change: 3.06
Marker Score: 30817
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.01
Marker Score: 15776
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 3
Marker Score: 6255
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.98
Marker Score: 1098
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 2.97
Marker Score: 979
Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.97
Marker Score: 3509
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.9
Marker Score: 3260
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.89
Marker Score: 2717
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.88
Marker Score: 11804
Cell Name: motor neuron (CL0000100)
Fold Change: 2.81
Marker Score: 1670
Cell Name: basophil (CL0000767)
Fold Change: 2.76
Marker Score: 1310
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.75
Marker Score: 2943
Cell Name: theca cell (CL0000503)
Fold Change: 2.75
Marker Score: 1972
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.74
Marker Score: 7469
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.74
Marker Score: 1036
Cell Name: late promyelocyte (CL0002151)
Fold Change: 2.73
Marker Score: 685
Cell Name: oogonial cell (CL0000024)
Fold Change: 2.72
Marker Score: 3906
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.69
Marker Score: 903
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 2.64
Marker Score: 1246
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.64
Marker Score: 2482
Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.59
Marker Score: 87486
Cell Name: kidney cell (CL1000497)
Fold Change: 2.58
Marker Score: 1723
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.57
Marker Score: 6037.5
Cell Name: primordial germ cell (CL0000670)
Fold Change: 2.47
Marker Score: 3103
Cell Name: Unknown (CL0002371)
Fold Change: 2.47
Marker Score: 2629
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.38
Marker Score: 82610
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.38
Marker Score: 1723
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.37
Marker Score: 1855
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.36
Marker Score: 1062
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.34
Marker Score: 6665
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 2.28
Marker Score: 1116
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.26
Marker Score: 22944
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 2.26
Marker Score: 6152
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.26
Marker Score: 6701
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 2.23
Marker Score: 7465
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.22
Marker Score: 8215
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 2.2
Marker Score: 1210
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.19
Marker Score: 9118
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.18
Marker Score: 2310
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.15
Marker Score: 5154
Cell Name: Leydig cell (CL0000178)
Fold Change: 2.15
Marker Score: 2313
Cell Name: Unknown (CL0000548)
Fold Change: 2.15
Marker Score: 1564
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.12
Marker Score: 9796
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.11
Marker Score: 1090
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 2.08
Marker Score: 719
Cell Name: centroblast (CL0009112)
Fold Change: 2.08
Marker Score: 1023
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 2.07
Marker Score: 665
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.07
Marker Score: 845
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 2.06
Marker Score: 722
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.05
Marker Score: 1131
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.01
Marker Score: 3504
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.98
Marker Score: 1510
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.98
Marker Score: 3245.5
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.97
Marker Score: 1975
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.97
Marker Score: 17289
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.92
Marker Score: 451
Cell Name: granule cell (CL0000120)
Fold Change: 1.88
Marker Score: 14193
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.88
Marker Score: 559
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.87
Marker Score: 47831
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.86
Marker Score: 596
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.85
Marker Score: 9958
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.84
Marker Score: 1868
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.83
Marker Score: 682
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.82
Marker Score: 357
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 1.81
Marker Score: 505
Cell Name: glial cell (CL0000125)
Fold Change: 1.79
Marker Score: 1973
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.79
Marker Score: 7022
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.78
Marker Score: 456
Cell Name: male germ cell (CL0000015)
Fold Change: 1.78
Marker Score: 514
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.78
Marker Score: 921
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.76
Marker Score: 1171.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.75
Marker Score: 19741
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.75
Marker Score: 447
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.74
Marker Score: 2412
Cell Name: promyelocyte (CL0000836)
Fold Change: 1.73
Marker Score: 853
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.72
Marker Score: 105748
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 1.7
Marker Score: 704
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.69
Marker Score: 827
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.69
Marker Score: 4258
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.67
Marker Score: 1740
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.66
Marker Score: 2005
Cell Name: stem cell (CL0000034)
Fold Change: 1.66
Marker Score: 3934.5
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.65
Marker Score: 10027.5
Cell Name: neuron (CL0000540)
Fold Change: 1.65
Marker Score: 6706
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.62
Marker Score: 4346.5
Cell Name: macroglial cell (CL0000126)
Fold Change: 1.62
Marker Score: 3725
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.62
Marker Score: 1391
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.6
Marker Score: 1001
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.6
Marker Score: 559

Hover over a box to see details here...

**Key characteristics:** - STMN1 is a microtubule-associated protein (MAP) that is localized to the cytoplasmic face of microtubules. - It is a microtubule plus-end tracker that undergoes a conformational change upon microtubule depolymerization. - It is a key regulator of microtubule dynamics, controlling processes such as axonogenesis, cell migration, and cytokinesis. **Pathways and functions:** - STMN1 is involved in the regulation of axonal transport by promoting the disassembly of microtubules and facilitating their recycling. - It is also essential for the proper segregation of chromosomes during mitosis and nuclear transport. - In non-cancerous cells, STMN1 is generally expressed at low levels and does not significantly impact cell migration or cancer development. - However, in certain cancer cells, STMN1 is overexpressed, leading to the formation of invasive tumors. **Clinical significance:** - Mutations in the STMN1 gene have been linked to several human cancers, including breast cancer, lung cancer, and colon cancer. - Targeting STMN1 has emerged as a promising therapeutic strategy for these malignancies, as it effectively inhibits tumor growth and metastasis. - Currently, several clinical trials are investigating the use of antibodies and small molecules that block STMN1 to inhibit cancer growth and metastasis. **Conclusion:** STMN1 is a critical regulator of microtubule dynamics and cell migration. Its overexpression is associated with cancer development and progression, highlighting its importance in maintaining cellular integrity and preventing tumor formation. Understanding the role of STMN1 in cancer biology may lead to the development of novel therapeutic strategies for the treatment of various cancers.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Stathmin
A0A140VJW2_HUMAN

Genular Protein ID: 2247108991

Symbol: STMN1_HUMAN

Name: Stathmin

UniProtKB Accession Codes:

P16949 A2A2D1 B2R4E7 B7Z8N4 D3DPJ5

Database IDs:

Citations:

PubMed ID: 2760073

Title: Molecular cloning of a novel human leukemia-associated gene. Evidence of conservation in animal species.

PubMed ID: 2760073

DOI: 10.1016/s0021-9258(18)71714-6

PubMed ID: 2358074

Title: A single amino acid difference distinguishes the human and the rat sequences of stathmin, a ubiquitous intracellular phosphoprotein associated with cell regulations.

PubMed ID: 2358074

DOI: 10.1016/0014-5793(90)80266-l

PubMed ID: 1917919

Title: Characterization of the gene for a proliferation-related phosphoprotein (oncoprotein 18) expressed in high amounts in acute leukemia.

PubMed ID: 1917919

DOI: 10.1016/s0021-9258(18)55189-9

PubMed ID: 8906359

Title: Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control.

PubMed ID: 8906359

DOI: 10.1247/csf.21.237

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2546936

Title: Ca2+-dependent and cAMP-dependent control of nicotinic acetylcholine receptor phosphorylation in muscle cells.

PubMed ID: 2546936

DOI: 10.1016/s0021-9258(18)51559-3

PubMed ID: 1737801

Title: Analysis of phosphoprotein p19 by liquid chromatography/mass spectrometry. Identification of two proline-directed serine phosphorylation sites and a blocked amino terminus.

PubMed ID: 1737801

DOI: 10.1016/s0021-9258(19)50759-1

PubMed ID: 8325880

Title: Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase.

PubMed ID: 8325880

DOI: 10.1016/s0021-9258(18)82435-8

PubMed ID: 8245003

Title: Multiple signal transduction pathways induce phosphorylation of serines 16, 25, and 38 of oncoprotein 18 in T lymphocytes.

PubMed ID: 8245003

DOI: 10.1016/s0021-9258(19)74442-1

PubMed ID: 8125092

Title: Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38.

PubMed ID: 8125092

DOI: 10.1111/j.1432-1033.1994.tb18632.x

PubMed ID: 10675326

Title: Op18/stathmin caps a kinked protofilament-like tubulin tetramer.

PubMed ID: 10675326

DOI: 10.1093/emboj/19.4.572

PubMed ID: 10702243

Title: Probing the native structure of stathmin and its interaction domains with tubulin. Combined use of limited proteolysis, size exclusion chromatography, and mass spectrometry.

PubMed ID: 10702243

DOI: 10.1074/jbc.275.10.6841

PubMed ID: 11415983

Title: Phosphorylation disrupts the central helix in Op18/stathmin and suppresses binding to tubulin.

PubMed ID: 11415983

DOI: 10.1093/embo-reports/kve105

PubMed ID: 12676564

Title: Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP.

PubMed ID: 12676564

DOI: 10.1016/s0888-7543(03)00031-4

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 149
Mass: 17303
Checksum: 316426F60DABCD01
Sequence:

MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER 
RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL 
ERLREKDKHI EEVRKNKESK DPADETEAD

Genular Protein ID: 2483096200

Symbol: A0A140VJW2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJW2

Database IDs:

Sequence Information:

Length: 174
Mass: 19824
Checksum: 7F66FFAB6C32A5AB
Sequence:

MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER 
RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL 
ERLREKMYFW THGPGAHPAQ ISAEQSCLHS VPALCPALGL QSALITWSDL SHHH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: STMN1

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a novel human leukemia-associated gene. Evidence of conservation in animal species. PubMed ID: 2760073

A single amino acid difference distinguishes the human and the rat sequences of stathmin, a ubiquitous intracellular phosphoprotein associated with cell regulations. PubMed ID: 2358074

Characterization of the gene for a proliferation-related phosphoprotein (oncoprotein 18) expressed in high amounts in acute leukemia. PubMed ID: 1917919

Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control. PubMed ID: 8906359

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Ca2+-dependent and cAMP-dependent control of nicotinic acetylcholine receptor phosphorylation in muscle cells. PubMed ID: 2546936

Analysis of phosphoprotein p19 by liquid chromatography/mass spectrometry. Identification of two proline-directed serine phosphorylation sites and a blocked amino terminus. PubMed ID: 1737801

Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. PubMed ID: 8325880

Multiple signal transduction pathways induce phosphorylation of serines 16, 25, and 38 of oncoprotein 18 in T lymphocytes. PubMed ID: 8245003

Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38. PubMed ID: 8125092

Op18/stathmin caps a kinked protofilament-like tubulin tetramer. PubMed ID: 10675326

Probing the native structure of stathmin and its interaction domains with tubulin. Combined use of limited proteolysis, size exclusion chromatography, and mass spectrometry. PubMed ID: 10702243

Phosphorylation disrupts the central helix in Op18/stathmin and suppresses binding to tubulin. PubMed ID: 11415983

Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP. PubMed ID: 12676564

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. PubMed ID: 16548883

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. PubMed ID: 17924679

Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. PubMed ID: 17693683

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712