Details for: MIR130B

Gene ID: 406920

Symbol: MIR130B

Ensembl ID: ENSG00000283871

Description: microRNA 130b

Associated with

  • Extracellular space
    (GO:0005615)
  • Inflammatory response
    (GO:0006954)
  • Lipoprotein transport
    (GO:0042953)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of cholesterol efflux
    (GO:0090370)
  • Negative regulation of macrophage derived foam cell differentiation
    (GO:0010745)
  • Negative regulation of monooxygenase activity
    (GO:0032769)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.2032
    Cell Significance Index: 1.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0378
    Cell Significance Index: 7.5900
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.0004
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0444
    Cell Significance Index: -1.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0467
    Cell Significance Index: -1.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0478
    Cell Significance Index: -1.5200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0481
    Cell Significance Index: -0.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0505
    Cell Significance Index: -1.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0510
    Cell Significance Index: -1.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0562
    Cell Significance Index: -1.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0596
    Cell Significance Index: -1.1800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0623
    Cell Significance Index: -0.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0637
    Cell Significance Index: -1.5900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0708
    Cell Significance Index: -1.3900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0726
    Cell Significance Index: -0.6400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0791
    Cell Significance Index: -1.5800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0834
    Cell Significance Index: -1.7000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0866
    Cell Significance Index: -0.8000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0869
    Cell Significance Index: -1.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0890
    Cell Significance Index: -1.5400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0949
    Cell Significance Index: -0.9000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1118
    Cell Significance Index: -1.6700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1151
    Cell Significance Index: -1.5100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1189
    Cell Significance Index: -1.5700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1202
    Cell Significance Index: -1.5700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1214
    Cell Significance Index: -1.1300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1229
    Cell Significance Index: -1.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1244
    Cell Significance Index: -1.4700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1258
    Cell Significance Index: -1.5300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1259
    Cell Significance Index: -1.3500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1265
    Cell Significance Index: -1.4000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1356
    Cell Significance Index: -1.5400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1369
    Cell Significance Index: -1.5300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1403
    Cell Significance Index: -1.5400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1405
    Cell Significance Index: -1.4600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1418
    Cell Significance Index: -1.6700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1430
    Cell Significance Index: -1.5500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1464
    Cell Significance Index: -1.6300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1499
    Cell Significance Index: -1.6400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1578
    Cell Significance Index: -1.6100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1634
    Cell Significance Index: -1.6100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1662
    Cell Significance Index: -2.1700
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.1697
    Cell Significance Index: -1.6700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1753
    Cell Significance Index: -2.1300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1754
    Cell Significance Index: -1.9500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1765
    Cell Significance Index: -1.4600
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.1818
    Cell Significance Index: -1.9200
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.1889
    Cell Significance Index: -1.9400
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.1921
    Cell Significance Index: -2.0500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2088
    Cell Significance Index: -2.2700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.2105
    Cell Significance Index: -2.2800
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.2989
    Cell Significance Index: -2.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **MicroRNA structure and function:** MIR130B is a 22-nucleotide long non-coding RNA that belongs to the microRNA family. Its primary function is to regulate gene expression by binding to the 3'-untranslated region (3'-UTR) of target mRNAs, leading to mRNA degradation or translational repression. 2. **Cellular expression:** MIR130B is highly expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, lymphoid lineage-restricted progenitor cells, pericytes, cardiac endothelial cells, cardiac muscle myoblasts, and fibroblasts of cardiac tissue. 3. **Pathway involvement:** MIR130B is involved in several biological pathways, including extracellular space, inflammatory response, lipoprotein transport, and negative regulation of cholesterol efflux, macrophage-derived foam cell differentiation, and monooxygenase activity. **Pathways and Functions:** 1. **Inflammatory response:** MIR130B regulates the expression of genes involved in inflammation, such as cytokines and chemokines, to modulate the immune response. 2. **Lipoprotein transport:** MIR130B influences the expression of genes involved in lipid metabolism, including those involved in cholesterol efflux and uptake. 3. **Negative regulation of cholesterol efflux:** MIR130B inhibits the expression of genes involved in cholesterol efflux, leading to reduced cholesterol efflux from macrophages and increased foam cell formation. 4. **Negative regulation of macrophage-derived foam cell differentiation:** MIR130B inhibits the expression of genes involved in foam cell differentiation, reducing the formation of foam cells in the arterial wall. 5. **Negative regulation of monooxygenase activity:** MIR130B regulates the expression of genes involved in monooxygenase activity, which is essential for lipid metabolism and cardiovascular health. **Clinical Significance:** 1. **Cardiovascular disease:** MIR130B dysregulation has been implicated in various cardiovascular diseases, including atherosclerosis, hypertension, and cardiac hypertrophy. 2. **Immune regulation:** MIR130B plays a crucial role in regulating immune responses, and its dysregulation may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** MIR130B has been implicated in cancer development and progression, particularly in cardiovascular-related cancers, such as cardiac cancer. 4. **Pharmacological applications:** MIR130B is a potential target for the development of novel therapeutic strategies for cardiovascular and immune-related diseases. In conclusion, microRNA 130b plays a critical role in regulating various biological processes, including inflammation, lipid metabolism, and immune response. Its dysregulation has been implicated in various cardiovascular and immune-related diseases, making it a potential target for the development of novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms of MIR130B and its clinical significance in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.