RAB8A | ENSG00000167461 | NCBI 4218

Details for: RAB8A

Gene ID: 4218

Symbol: RAB8A

Ensembl ID: ENSG00000167461

Description: RAB8A, member RAS oncogene family

Associated with

Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Cargo trafficking to the periciliary membrane
(R-HSA-5620920)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
G2/m transition
(R-HSA-69275)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mitotic g2-g2/m phases
(R-HSA-453274)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post-translational protein modification
(R-HSA-597592)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab geranylgeranylation
(R-HSA-8873719)
Rab regulation of trafficking
(R-HSA-9007101)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Tbc/rabgaps
(R-HSA-8854214)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Vesicle-mediated transport
(R-HSA-5653656)
Vxpx cargo-targeting to cilium
(R-HSA-5620916)
Autophagy
(GO:0006914)
Axonogenesis
(GO:0007409)
Cellular response to insulin stimulus
(GO:0032869)
Centriole
(GO:0005814)
Centrosome
(GO:0005813)
Ciliary basal body
(GO:0036064)
Ciliary base
(GO:0097546)
Ciliary membrane
(GO:0060170)
Cilium
(GO:0005929)
Cilium assembly
(GO:0060271)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Endocytic recycling
(GO:0032456)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Exocytosis
(GO:0006887)
Extracellular exosome
(GO:0070062)
Gdp binding
(GO:0019003)
Glutamatergic synapse
(GO:0098978)
Golgi membrane
(GO:0000139)
Golgi organization
(GO:0007030)
Golgi vesicle fusion to target membrane
(GO:0048210)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Lysosome
(GO:0005764)
Midbody
(GO:0030496)
Myosin v binding
(GO:0031489)
Neuronal cell body
(GO:0043025)
Neurotransmitter receptor transport, endosome to postsynaptic membrane
(GO:0098887)
Neurotransmitter receptor transport to postsynaptic membrane
(GO:0098969)
Non-motile cilium
(GO:0097730)
Phagocytic vesicle
(GO:0045335)
Phagocytic vesicle membrane
(GO:0030670)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein localization to cilium
(GO:0061512)
Protein localization to plasma membrane
(GO:0072659)
Protein tyrosine kinase binding
(GO:1990782)
Recycling endosome membrane
(GO:0055038)
Regulation of autophagy
(GO:0010506)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of protein transport
(GO:0051223)
Small gtpase binding
(GO:0031267)
Synaptic vesicle
(GO:0008021)
Trans-golgi network membrane
(GO:0032588)
Trans-golgi network transport vesicle
(GO:0030140)
Vesicle-mediated transport in synapse
(GO:0099003)
Vesicle docking involved in exocytosis
(GO:0006904)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 165.9967
Cell Significance Index: -25.8200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 87.9187
Cell Significance Index: -22.3000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 84.2097
Cell Significance Index: -34.6900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 72.0470
Cell Significance Index: -34.0200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 68.8395
Cell Significance Index: -35.4100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 50.9149
Cell Significance Index: -34.1700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.5865
Cell Significance Index: -32.7800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.5985
Cell Significance Index: -33.9300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.8989
Cell Significance Index: -21.1600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.8481
Cell Significance Index: -24.1100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.2045
Cell Significance Index: 142.2200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.0873
Cell Significance Index: 125.3100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.7640
Cell Significance Index: 191.8700
Cell Name: peg cell (CL4033014)
Fold Change: 1.5229
Cell Significance Index: 35.1900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2724
Cell Significance Index: 17.3600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.9771
Cell Significance Index: 18.0600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.9746
Cell Significance Index: 114.9300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.7968
Cell Significance Index: 23.4000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7762
Cell Significance Index: 40.3200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7338
Cell Significance Index: 132.2900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7260
Cell Significance Index: 33.8500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6746
Cell Significance Index: 92.6400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6738
Cell Significance Index: 31.6700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6688
Cell Significance Index: 365.2600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6501
Cell Significance Index: 44.9600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6485
Cell Significance Index: 79.7400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6415
Cell Significance Index: 17.4600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.6316
Cell Significance Index: 13.2200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6036
Cell Significance Index: 27.3600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5890
Cell Significance Index: 260.4300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5434
Cell Significance Index: 15.6600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5025
Cell Significance Index: 81.7300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4667
Cell Significance Index: 46.1700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4544
Cell Significance Index: 32.1400
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.4369
Cell Significance Index: 3.6700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3861
Cell Significance Index: 10.3100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3573
Cell Significance Index: 12.4200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2980
Cell Significance Index: 38.2000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2851
Cell Significance Index: 2.6300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2728
Cell Significance Index: 20.3400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2326
Cell Significance Index: 46.1700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1976
Cell Significance Index: 5.3000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1636
Cell Significance Index: 21.1400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1544
Cell Significance Index: 4.0600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1499
Cell Significance Index: 30.0700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1299
Cell Significance Index: 117.2500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0672
Cell Significance Index: 12.7900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0373
Cell Significance Index: 13.4000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0090
Cell Significance Index: 0.1500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0060
Cell Significance Index: -4.5600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0078
Cell Significance Index: -0.8000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0087
Cell Significance Index: -0.1300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0092
Cell Significance Index: -17.3800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0119
Cell Significance Index: -8.7000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0221
Cell Significance Index: -40.7900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0273
Cell Significance Index: -42.0400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0321
Cell Significance Index: -43.5900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0396
Cell Significance Index: -0.4500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0407
Cell Significance Index: -30.1200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0442
Cell Significance Index: -28.0700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0471
Cell Significance Index: -5.4000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0574
Cell Significance Index: -32.3800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0588
Cell Significance Index: -2.0700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0616
Cell Significance Index: -38.5000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0625
Cell Significance Index: -0.6800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0661
Cell Significance Index: -30.0000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0672
Cell Significance Index: -11.4700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0732
Cell Significance Index: -1.5600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1025
Cell Significance Index: -29.5000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1100
Cell Significance Index: -2.8100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1100
Cell Significance Index: -6.9300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1542
Cell Significance Index: -4.3100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1576
Cell Significance Index: -18.3700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1750
Cell Significance Index: -25.4400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1779
Cell Significance Index: -4.7600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1837
Cell Significance Index: -3.9800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1915
Cell Significance Index: -40.3300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2236
Cell Significance Index: -7.1600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2904
Cell Significance Index: -17.8500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3185
Cell Significance Index: -33.1600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3225
Cell Significance Index: -25.5400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3366
Cell Significance Index: -9.6500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3500
Cell Significance Index: -19.6400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3579
Cell Significance Index: -3.7100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3808
Cell Significance Index: -29.2200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4224
Cell Significance Index: -28.4000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4672
Cell Significance Index: -24.5300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5207
Cell Significance Index: -21.3400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5337
Cell Significance Index: -15.7200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5617
Cell Significance Index: -34.4400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5975
Cell Significance Index: -3.6100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.5994
Cell Significance Index: -30.2900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.6255
Cell Significance Index: -8.0100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7277
Cell Significance Index: -32.1900
Cell Name: kidney cell (CL1000497)
Fold Change: -0.7377
Cell Significance Index: -5.8900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7692
Cell Significance Index: -13.5900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.7857
Cell Significance Index: -11.8400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7871
Cell Significance Index: -28.9000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8575
Cell Significance Index: -32.4700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.8598
Cell Significance Index: -30.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Small GTPase**: RAB8A belongs to the RAS superfamily of small GTPases, which are key regulators of cellular signaling pathways. 2. **Membrane Trafficking**: RAB8A is involved in regulating membrane trafficking, including endocytic recycling, exocytosis, and cargo trafficking to the periciliary membrane. 3. **Cilia Assembly**: RAB8A plays a crucial role in cilia assembly and maintenance, particularly in non-motile cilia. 4. **Cellular Response to Insulin Stimulus**: RAB8A is involved in regulating the cellular response to insulin stimulus, which is essential for glucose metabolism and energy homeostasis. 5. **Protein Localization**: RAB8A regulates the localization of proteins to the cilium and plasma membrane, which is critical for maintaining cellular homeostasis and function. **Pathways and Functions:** 1. **Anchoring of the Basal Body to the Plasma Membrane**: RAB8A regulates the anchoring of the basal body to the plasma membrane, which is essential for cilia assembly and maintenance. 2. **Autophagy**: RAB8A is involved in regulating autophagy, a process by which cells recycle damaged or dysfunctional components. 3. **Axonogenesis**: RAB8A plays a crucial role in axonogenesis, the process by which neurons generate axons. 4. **Cargo Trafficking to the Periciliary Membrane**: RAB8A regulates the trafficking of cargo to the periciliary membrane, which is essential for maintaining cilia function. 5. **Cell Cycle**: RAB8A is involved in regulating the cell cycle, particularly in the G2/M transition. 6. **Ciliary Basal Body**: RAB8A regulates the ciliary basal body, a structure essential for cilia assembly and maintenance. 7. **Endocytic Recycling**: RAB8A is involved in regulating endocytic recycling, a process by which cells recycle membrane components. 8. **Golgi Organization**: RAB8A regulates Golgi organization, which is essential for maintaining cellular homeostasis and function. 9. **Protein Secretion**: RAB8A is involved in regulating protein secretion, a process by which cells release proteins into the extracellular space. 10. **Synaptic Vesicle**: RAB8A regulates the trafficking of synaptic vesicles, which is essential for maintaining neuronal function. **Clinical Significance:** 1. **Cancer**: Dysregulation of RAB8A has been implicated in various cancers, including breast, lung, and colon cancer. 2. **Autoimmune Disorders**: RAB8A has been implicated in autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. 3. **Neurological Conditions**: RAB8A has been implicated in neurological conditions, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 4. **Immune Cell Function**: RAB8A is essential for maintaining immune cell function, particularly in hematopoietic cells and immune cells. In conclusion, RAB8A is a crucial regulator of various cellular processes, including membrane trafficking, autophagy, and cilia assembly. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining cellular homeostasis and function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ras-related protein Rab-8A

Genular Protein ID: 2630077428

Symbol: RAB8A_HUMAN

Name: Ras-related protein Rab-8A

UniProtKB Accession Codes:

P61006 B4DEK7 P24407 Q6FHV5

Database IDs:

Citations:

PubMed ID: 8294494

Title: A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells.

PubMed ID: 8294494

DOI: 10.1083/jcb.124.1.101

PubMed ID: 1886711

Title: The MEL gene: a new member of the RAB/YPT class of RAS-related genes.

PubMed ID: 1886711

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8375503

Title: Isoprenylation of Rab proteins possessing a C-terminal CaaX motif.

PubMed ID: 8375503

DOI: 10.1016/0014-5793(93)80897-4

PubMed ID: 12221131

Title: A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport.

PubMed ID: 12221131

DOI: 10.1091/mbc.e02-03-0143

PubMed ID: 15837803

Title: Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.

PubMed ID: 15837803

DOI: 10.1083/jcb.200501162

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18329369

Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

PubMed ID: 18329369

DOI: 10.1016/j.cell.2008.01.012

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20643351

Title: Pitchfork regulates primary cilia disassembly and left-right asymmetry.

PubMed ID: 20643351

DOI: 10.1016/j.devcel.2010.06.005

PubMed ID: 20890297

Title: A molecular network for de novo generation of the apical surface and lumen.

PubMed ID: 20890297

DOI: 10.1038/ncb2106

PubMed ID: 19864458

Title: MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.

PubMed ID: 19864458

DOI: 10.1091/mbc.e09-06-0535

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22159412

Title: Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.

PubMed ID: 22159412

DOI: 10.1242/jcs.085407

PubMed ID: 21282656

Title: Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.

PubMed ID: 21282656

DOI: 10.1073/pnas.1010754108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21255211

Title: Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.

PubMed ID: 21255211

DOI: 10.1111/j.1600-0854.2011.01165.x

PubMed ID: 21844891

Title: A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.

PubMed ID: 21844891

DOI: 10.1038/cr.2011.134

PubMed ID: 22543976

Title: OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome.

PubMed ID: 22543976

DOI: 10.1093/hmg/dds163

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26209634

Title: Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.

PubMed ID: 26209634

DOI: 10.1074/jbc.m115.669242

PubMed ID: 25860027

Title: GSK3beta-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.

PubMed ID: 25860027

DOI: 10.1371/journal.pbio.1002129

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

PubMed ID: 27103069

Title: Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

PubMed ID: 27103069

DOI: 10.15252/embj.201593350

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 30398148

Title: A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

PubMed ID: 30398148

DOI: 10.7554/elife.40202

PubMed ID: 30209220

Title: LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.

PubMed ID: 30209220

DOI: 10.1073/pnas.1812196115

PubMed ID: 32344433

Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.

PubMed ID: 32344433

DOI: 10.1083/jcb.201811014

PubMed ID: 21378754

Title: A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.

PubMed ID: 21378754

DOI: 10.1038/emboj.2011.60

PubMed ID: 27552051

Title: bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.

PubMed ID: 27552051

DOI: 10.7554/elife.18675

Sequence Information:

Length: 207
Mass: 23668
Checksum: AA52DBF54A2CD056
Sequence:

MAKTYDYLFK LLLIGDSGVG KTCVLFRFSE DAFNSTFIST IGIDFKIRTI ELDGKRIKLQ 
IWDTAGQERF RTITTAYYRG AMGIMLVYDI TNEKSFDNIR NWIRNIEEHA SADVEKMILG 
NKCDVNDKRQ VSKERGEKLA LDYGIKFMET SAKANINVEN AFFTLARDIK AKMDKKLEGN 
SPQGSNQGVK ITPDQQKRSS FFRCVLL

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Details for: RAB8A

Associated with

Cells (max top 100)

Other Information

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. PubMed ID: 8294494

The MEL gene: a new member of the RAB/YPT class of RAS-related genes. PubMed ID: 1886711

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isoprenylation of Rab proteins possessing a C-terminal CaaX motif. PubMed ID: 8375503

A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. PubMed ID: 12221131

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. PubMed ID: 15837803

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. PubMed ID: 18329369

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Pitchfork regulates primary cilia disassembly and left-right asymmetry. PubMed ID: 20643351

A molecular network for de novo generation of the apical surface and lumen. PubMed ID: 20890297

MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling. PubMed ID: 19864458

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein. PubMed ID: 22159412

Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. PubMed ID: 21282656

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. PubMed ID: 21255211

A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. PubMed ID: 21844891

OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome. PubMed ID: 22543976

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology. PubMed ID: 26209634

GSK3beta-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PubMed ID: 25860027

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. PubMed ID: 26824392

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. PubMed ID: 27103069

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. PubMed ID: 29125462

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. PubMed ID: 30398148

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. PubMed ID: 30209220

GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508. PubMed ID: 32344433

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. PubMed ID: 21378754

bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. PubMed ID: 27552051