Details for: PAM
Gene ID: 5066
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PAM
Ensembl ID: ENSG00000145730
Description: peptidylglycine alpha-amidating monooxygenase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 67.05rCSI 70.25%PRS 50.52
-
CSI 66.34rCSI 82.53%PRS 29.92
-
CSI 61.78rCSI 79.64%PRS 32.45
-
CSI 56.07rCSI 66.97%PRS 31.4
-
CSI 49.52rCSI 71.05%PRS 38.64
-
CSI 45.82rCSI 37.02%PRS 58
-
CSI 42.38rCSI 68.16%PRS 33.66
-
CSI 40.95rCSI 70.83%PRS 38.26
-
CSI 38.8rCSI 65.13%PRS 31.56
-
CSI 32.85rCSI 32.31%PRS 49.97
-
CSI 27.84rCSI 60.4%PRS 37.53
-
CSI 24.5rCSI 59.55%PRS 30.57
-
CSI 24.11rCSI 64.2%PRS 39.41
-
CSI 23.17rCSI 72.48%PRS 35.12
-
CSI 21.95rCSI 54.34%PRS 45.47
-
CSI 21.93rCSI 48.29%PRS 62.07
-
CSI 19.79rCSI 43.73%PRS 35.56
-
CSI 19.61rCSI 70.56%PRS 30.39
-
CSI 18.96rCSI 61.02%PRS 46.61
-
CSI 18.86rCSI 41.75%PRS 44.96
-
CSI 18.85rCSI 64.58%PRS 38.6
-
CSI 18.61rCSI 27.23%PRS 50.73
-
CSI 18.38rCSI 73.15%PRS 62.75
-
CSI 18.26rCSI 17.93%PRS 62.9
-
CSI 18.11rCSI 68.44%PRS 32.41
-
CSI 17.64rCSI 24.1%PRS 49.95
-
CSI 17.12rCSI 34.37%PRS 37.28
-
CSI 16.11rCSI 90.12%PRS 59.04
-
CSI 16.08rCSI 38.46%PRS 36.61
-
CSI 16.08rCSI 38.65%PRS 57.41
-
CSI 15.94rCSI 46.19%PRS 38.75
-
CSI 15.93rCSI 19.7%PRS 43.31
-
CSI 15.33rCSI 23.56%PRS 48.37
-
CSI 15.27rCSI 15.94%PRS 48.02
-
CSI 15.12rCSI 28.38%PRS 66.39
-
CSI 14.74rCSI 34.02%PRS 38.69
-
CSI 14.69rCSI 21.54%PRS 58.88
-
CSI 13.85rCSI 37.02%PRS 40.2
-
CSI 13.79rCSI 26.04%PRS 57.81
-
CSI 13.51rCSI 17.34%PRS 42.71
-
CSI 12.93rCSI 17.91%PRS 51.85
-
CSI 12.1rCSI 56.4%PRS 69.56
-
CSI 11.94rCSI 27.24%PRS 40.81
-
CSI 11.93rCSI 16.91%PRS 44.38
-
CSI 11.83rCSI 31.21%PRS 55.41
-
CSI 11.44rCSI 8.9%PRS 64.82
-
CSI 11.33rCSI 19.86%PRS 39.84
-
CSI 11.32rCSI 19.99%PRS 30.53
-
CSI 11.13rCSI 14.28%PRS 45.38
-
CSI 11.02rCSI 8.71%PRS 35.21
-
CSI 10.72rCSI 33.51%PRS 32.79
-
CSI 10.69rCSI 51.19%PRS 48.29
-
CSI 10.49rCSI 39.59%PRS 39.18
-
CSI 10.42rCSI 13.26%PRS 53.13
-
CSI 10.36rCSI 8.93%PRS 55.6
-
CSI 10.14rCSI 7.51%PRS 41.01
-
CSI 10.14rCSI 32.9%PRS 49.99
-
CSI 10.14rCSI 13.86%PRS 52.53
-
CSI 10.13rCSI 26.4%PRS 46.83
-
CSI 10.07rCSI 74.01%PRS 35.44
-
CSI 9.95rCSI 11.51%PRS 37.68
-
CSI 9.94rCSI 10.42%PRS 44.5
-
CSI 9.84rCSI 8.64%PRS 52.6
-
CSI 9.83rCSI 69.53%PRS 40.33
-
CSI 9.78rCSI 14.94%PRS 48.01
-
CSI 9.73rCSI 20.19%PRS 45.42
-
CSI 9.72rCSI 11.65%PRS 66.35
-
CSI 9.16rCSI 45.15%PRS 59.35
-
CSI 9.08rCSI 56.74%PRS 40.02
-
CSI 9.07rCSI 40.3%PRS 46.3
-
CSI 8.91rCSI 12.38%PRS 46.81
-
CSI 8.88rCSI 20.3%PRS 46.95
-
CSI 8.85rCSI 29.64%PRS 35.36
-
CSI 8.8rCSI 26.12%PRS 58.7
-
CSI 8.74rCSI 14.95%PRS 67.89
-
CSI 8.65rCSI 15.54%PRS 40.84
-
CSI 8.5rCSI 8.2%PRS 38.18
-
CSI 8.49rCSI 11.55%PRS 60.24
-
CSI 8.43rCSI 84.16%PRS 13.79
-
CSI 8.42rCSI 9.23%PRS 51.45
-
CSI 8.4rCSI 8.78%PRS 46.63
-
CSI 8.38rCSI 8.07%PRS 47.81
-
CSI 8.37rCSI 6.37%PRS 59.04
-
CSI 8.34rCSI 6.92%PRS 46.04
-
CSI 8.23rCSI 6.18%PRS 51.2
-
CSI 8.21rCSI 16.66%PRS 29.83
-
CSI 8.16rCSI 26.1%PRS 44.57
-
CSI 8.14rCSI 16.72%PRS 41.13
-
CSI 8.12rCSI 68.36%PRS 42.03
-
CSI 8.1rCSI 9.4%PRS 57.5
-
CSI 8rCSI 7.98%PRS 41.6
-
CSI 7.95rCSI 12.68%PRS 41.18
-
CSI 7.92rCSI 29.67%PRS 40.46
-
CSI 7.91rCSI 6.43%PRS 48.03
-
CSI 7.9rCSI 6.95%PRS 36.57
-
CSI 7.87rCSI 32.05%PRS 44.42
-
CSI 7.58rCSI 9.44%PRS 58.72
-
CSI 7.57rCSI 19.74%PRS 46.75
-
CSI 7.51rCSI 8.68%PRS 41.64
-
CSI 7.34rCSI 15.16%PRS 52.89
-
CSI 0.2rCSI 2.5%PRS 63.4%
-
CSI 0.5rCSI 0.7%PRS 64.9%
-
CSI 0.5rCSI 2.5%PRS 58.8%
-
CSI 0.8rCSI 12.8%PRS 77.8%
-
CSI 0.8rCSI 5.1%PRS 81.4%
-
CSI 0.9rCSI 4.4%PRS 46.8%
-
CSI 1.1rCSI 6.1%PRS 58.2%
-
CSI 1.1rCSI 1.5%PRS 43.5%
-
CSI 1.2rCSI 3.2%PRS 62.8%
-
CSI 1.2rCSI 13.0%PRS 48.0%
-
CSI 1.2rCSI 4.2%PRS 77.9%
-
CSI 1.3rCSI 3.9%PRS 75.4%
-
CSI 1.3rCSI 3.2%PRS 53.1%
-
CSI 1.4rCSI 3.8%PRS 61.7%
-
CSI 1.4rCSI 6.4%PRS 65.4%
-
CSI 1.4rCSI 2.1%PRS 56.7%
-
CSI 1.4rCSI 3.0%PRS 67.9%
-
CSI 1.4rCSI 8.2%PRS 44.4%
-
CSI 1.5rCSI 4.9%PRS 54.8%
-
CSI 1.5rCSI 6.0%PRS 68.0%
-
CSI 1.6rCSI 8.8%PRS 63.9%
-
CSI 1.7rCSI 6.6%PRS 40.5%
-
CSI 1.8rCSI 7.8%PRS 69.6%
-
CSI 1.8rCSI 7.8%PRS 40.6%
-
CSI 1.8rCSI 19.4%PRS 66.9%
-
CSI 1.8rCSI 8.6%PRS 44.7%
-
CSI 1.9rCSI 4.1%PRS 57.1%
-
CSI 1.9rCSI 3.4%PRS 46.0%
-
CSI 1.9rCSI 11.1%PRS 32.9%
-
CSI 1.9rCSI 6.7%PRS 59.6%
-
CSI 1.9rCSI 5.0%PRS 69.5%
-
CSI 2.1rCSI 8.0%PRS 56.6%
-
CSI 2.1rCSI 2.6%PRS 52.3%
-
CSI 2.1rCSI 17.8%PRS 47.6%
-
CSI 2.1rCSI 5.5%PRS 49.7%
-
CSI 2.1rCSI 8.3%PRS 65.1%
-
CSI 2.2rCSI 1.7%PRS 46.5%
-
CSI 2.2rCSI 13.2%PRS 67.8%
-
CSI 2.3rCSI 13.0%PRS 59.2%
-
CSI 2.3rCSI 6.6%PRS 65.6%
-
CSI 2.3rCSI 17.5%PRS 42.5%
-
CSI 2.4rCSI 4.8%PRS 46.4%
-
CSI 2.5rCSI 4.9%PRS 65.6%
-
CSI 2.6rCSI 2.8%PRS 45.6%
-
CSI 2.6rCSI 11.6%PRS 44.9%
-
CSI 2.7rCSI 11.3%PRS 67.7%
-
CSI 2.7rCSI 15.5%PRS 49.0%
-
CSI 2.7rCSI 4.4%PRS 55.3%
-
CSI 2.8rCSI 6.5%PRS 71.6%
-
CSI 2.8rCSI 4.0%PRS 60.8%
-
CSI 2.8rCSI 22.6%PRS 41.9%
-
CSI 2.8rCSI 6.1%PRS 66.2%
-
CSI 2.8rCSI 17.6%PRS 31.1%
-
CSI 2.8rCSI 2.0%PRS 56.5%
-
CSI 2.9rCSI 17.9%PRS 74.7%
-
CSI 3.0rCSI 14.9%PRS 80.6%
-
CSI 3.0rCSI 69.6%PRS 70.2%
-
CSI 3.1rCSI 31.8%PRS 41.5%
-
CSI 3.1rCSI 4.9%PRS 40.5%
-
CSI 3.1rCSI 74.3%PRS 31.9%
-
CSI 3.1rCSI 74.6%PRS 31.0%
-
CSI 3.3rCSI 4.5%PRS 40.6%
-
CSI 3.4rCSI 19.2%PRS 76.5%
-
CSI 3.6rCSI 14.1%PRS 24.7%
-
CSI 3.6rCSI 5.8%PRS 48.7%
-
CSI 3.7rCSI 11.9%PRS 49.5%
-
CSI 3.7rCSI 74.9%PRS 41.1%
-
CSI 3.7rCSI 75.1%PRS 39.8%
-
CSI 3.7rCSI 10.7%PRS 49.8%
-
CSI 3.8rCSI 6.0%PRS 56.9%
-
CSI 4.0rCSI 10.8%PRS 56.1%
-
CSI 4.0rCSI 11.3%PRS 46.9%
-
CSI 4.0rCSI 5.4%PRS 52.5%
-
CSI 4.0rCSI 16.4%PRS 58.7%
-
CSI 4.1rCSI 13.4%PRS 36.2%
-
CSI 4.2rCSI 23.5%PRS 33.9%
-
CSI 4.2rCSI 12.9%PRS 59.1%
-
CSI 4.2rCSI 7.4%PRS 55.9%
-
CSI 4.3rCSI 6.3%PRS 42.8%
-
CSI 4.3rCSI 11.0%PRS 56.0%
-
CSI 4.3rCSI 4.6%PRS 61.7%
-
CSI 4.4rCSI 2.9%PRS 58.3%
-
CSI 4.4rCSI 4.6%PRS 53.3%
-
CSI 4.4rCSI 8.7%PRS 68.7%
-
CSI 4.4rCSI 5.3%PRS 67.8%
-
CSI 4.4rCSI 22.8%PRS 81.5%
-
CSI 4.5rCSI 13.3%PRS 45.5%
-
CSI 4.5rCSI 19.5%PRS 63.5%
-
CSI 4.5rCSI 8.2%PRS 40.9%
-
CSI 4.6rCSI 4.3%PRS 48.2%
-
CSI 4.6rCSI 7.2%PRS 45.2%
-
CSI 4.6rCSI 29.7%PRS 52.9%
-
CSI 4.7rCSI 22.0%PRS 71.6%
-
CSI 4.8rCSI 13.3%PRS 44.1%
-
CSI 4.9rCSI 23.5%PRS 46.4%
-
CSI 5.0rCSI 25.5%PRS 51.1%
-
CSI 5.0rCSI 8.0%PRS 51.5%
-
CSI 5.0rCSI 6.1%PRS 55.5%
-
CSI 5.0rCSI 27.4%PRS 69.1%
-
CSI 5.0rCSI 71.4%PRS 39.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1786306581
Symbol: AMD_HUMAN
Name: Peptidyl-alpha-hydroxyglycine alpha-amidating lyase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2357221
Title: Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells.
PubMed ID: 2357221
PubMed ID: 7999037
Title: Isolation and functional expression of human pancreatic peptidylglycine alpha-amidating monooxygenase.
PubMed ID: 7999037
PubMed ID: 12699694
Title: Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase.
PubMed ID: 12699694
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9110174
PubMed ID: 8144680
Title: Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase.
PubMed ID: 8144680
PubMed ID: 10574929
Title: The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase.
PubMed ID: 10574929
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 973
- Mass: 108332
- Checksum: 8A089B657F56EE39
- Sequence:
MAGRVPSLLV LLVFPSSCLA FRSPLSVFKR FKETTRPFSN ECLGTTRPVV PIDSSDFALD IRMPGVTPKQ SDTYFCMSMR IPVDEEAFVI DFKPRASMDT VHHMLLFGCN MPSSTGSYWF CDEGTCTDKA NILYAWARNA PPTRLPKGVG FRVGGETGSK YFVLQVHYGD ISAFRDNNKD CSGVSLHLTR LPQPLIAGMY LMMSVDTVIP AGEKVVNSDI SCHYKNYPMH VFAYRVHTHH LGKVVSGYRV RNGQWTLIGR QSPQLPQAFY PVGHPVDVSF GDLLAARCVF TGEGRTEATH IGGTSSDEMC NLYIMYYMEA KHAVSFMTCT QNVAPDMFRT IPPEANIPIP VKSDMVMMHE HHKETEYKDK IPLLQQPKRE EEEVLDQGDF YSLLSKLLGE REDVVHVHKY NPTEKAESES DLVAEIANVV QKKDLGRSDA REGAEHERGN AILVRDRIHK FHRLVSTLRP PESRVFSLQQ PPPGEGTWEP EHTGDFHMEE ALDWPGVYLL PGQVSGVALD PKNNLVIFHR GDHVWDGNSF DSKFVYQQIG LGPIEEDTIL VIDPNNAAVL QSSGKNLFYL PHGLSIDKDG NYWVTDVALH QVFKLDPNNK EGPVLILGRS MQPGSDQNHF CQPTDVAVDP GTGAIYVSDG YCNSRIVQFS PSGKFITQWG EESSGSSPLP GQFTVPHSLA LVPLLGQLCV ADRENGRIQC FKTDTKEFVR EIKHSSFGRN VFAISYIPGL LFAVNGKPHF GDQEPVQGFV MNFSNGEIID IFKPVRKHFD MPHDIVASED GTVYIGDAHT NTVWKFTLTE KLEHRSVKKA GIEVQEIKEA EAVVETKMEN KPTSSELQKM QEKQKLIKEP GSGVPVVLIT TLLVIPVVVL LAIAIFIRWK KSRAFGDSEH KLETSSGRVL GRFRGKGSGG LNLGNFFASR KGYSRKGFDR LSTEGSDQEK EDDGSESEEE YSAPLPALAP SSS
Genular Protein ID: 3701901209
Symbol: A0A804HIQ0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 867
- Mass: 96329
- Checksum: DF0EE46ABC089E76
- Sequence:
MAGRVPSLLV LLVFPSSCLA FRSPLSVFKR FKETTRPFSN ECLGTTRPVV PIDSSDFALD IRMPGVTPKQ SDTYFCMSMR IPVDEEAFVI DFKPRASMDT VHHMLLFGCN MPSSTGSYWF CDEGTCTDKA NILYAWARNA PPTRLPKGVG FRVGGETGSK YFVLQVHYGD ISAFRDNNKD CSGVSLHLTR LPQPLIAGMY LMMSVDTVIP AGEKVVNSDI SCHYKNYPMH VFAYRVHTHH LGKVVSGYRV RNGQWTLIGR QSPQLPQAFY PVGHPVDVSF GDLLAARCVF TGEGRTEATH IGGTSSDEMC NLYIMYYMEA KHAVSFMTCT QNVAPDMFRT IPPEANIPIP VKSDMVMMHE HHKETEYKDK IPLLQQPKRE EEEVLDQDFH MEEALDWPGV YLLPGQVSGV ALDPKNNLVI FHRGDHVWDG NSFDSKFVYQ QIGLGPIEED TILVIDPNNA AVLQSSGKNL FYLPHGLSID KDGNYWVTDV ALHQVFKLDP NNKEGPVLIL GRSMQPGSDQ NHFCQPTDVA VDPGTGAIYV SDGYCNSRIV QFSPSGKFIT QWGEESSGSS PLPGQFTVPH SLALVPLLGQ LCVADRENGR IQCFKTDTKE FVREIKHSSF GRNVFAISYI PGLLFAVNGK PHFGDQEPVQ GFVMNFSNGE IIDIFKPVRK HFDMPHDIVA SEDGTVYIGD AHTNTVWKFT LTEKLEHRSV KKAGIEVQEI KEAEAVVETK MENKPTSSEL QKMQEKQKLI KEPGSGVPVV LITTLLVIPV VVLLAIAIFI RWKKSRAFGA DSEHKLETSS GRVLGRFRGK GSGGLNLGNF FASRKGYSRK GFDRLSTEGS DQEKEDDGSE SEEEYSAPLP ALAPSSS
Genular Protein ID: 3320701115
Symbol: O43832_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7590286
Title: Human peptidylglycine alpha-amidating monooxygenase transcripts derived by alternative mRNA splicing of an unreported exon.
PubMed ID: 7590286
Sequence Information:
- Length: 97
- Mass: 11020
- Checksum: 3A7402A2126CF9CE
- Sequence:
AESESDLVAE IANVVQKKDL GRSDAREGAE HERGNAILVR DRIHKFHRLV STLRPPESRV FSLQQPPPGE GTWEPEHTGA RREDMKCFQC KEMISVQ