Details for: SDF4

Gene ID: 51150

Symbol: SDF4

Ensembl ID: ENSG00000078808

Description: stromal cell derived factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 315.9853
    Cell Significance Index: -49.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 200.0446
    Cell Significance Index: -50.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 143.7319
    Cell Significance Index: -59.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.5256
    Cell Significance Index: -57.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 118.6441
    Cell Significance Index: -48.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 108.5762
    Cell Significance Index: -55.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.7721
    Cell Significance Index: -57.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.0085
    Cell Significance Index: -48.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.3024
    Cell Significance Index: -53.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.0189
    Cell Significance Index: -48.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.7961
    Cell Significance Index: -54.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3813
    Cell Significance Index: -41.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1233
    Cell Significance Index: -15.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.0230
    Cell Significance Index: 2729.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8178
    Cell Significance Index: 84.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.7885
    Cell Significance Index: 52.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6057
    Cell Significance Index: 220.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2182
    Cell Significance Index: 156.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1415
    Cell Significance Index: 59.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1341
    Cell Significance Index: 30.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0779
    Cell Significance Index: 194.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0051
    Cell Significance Index: 45.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9821
    Cell Significance Index: 536.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9785
    Cell Significance Index: 159.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9427
    Cell Significance Index: 115.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8449
    Cell Significance Index: 83.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7911
    Cell Significance Index: 16.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7613
    Cell Significance Index: 152.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7098
    Cell Significance Index: 313.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7055
    Cell Significance Index: 33.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7044
    Cell Significance Index: 9.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6852
    Cell Significance Index: 51.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6385
    Cell Significance Index: 16.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5489
    Cell Significance Index: 108.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5312
    Cell Significance Index: 90.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5123
    Cell Significance Index: 13.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4921
    Cell Significance Index: 31.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4319
    Cell Significance Index: 12.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4110
    Cell Significance Index: 21.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3751
    Cell Significance Index: 134.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3448
    Cell Significance Index: 65.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3319
    Cell Significance Index: 42.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3186
    Cell Significance Index: 22.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2921
    Cell Significance Index: 202.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2242
    Cell Significance Index: 3.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2016
    Cell Significance Index: 2.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1287
    Cell Significance Index: 15.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1264
    Cell Significance Index: 2.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1157
    Cell Significance Index: 4.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0149
    Cell Significance Index: 0.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0059
    Cell Significance Index: 0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0003
    Cell Significance Index: -0.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0215
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0216
    Cell Significance Index: -16.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0222
    Cell Significance Index: -2.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0287
    Cell Significance Index: -52.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0361
    Cell Significance Index: -55.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0400
    Cell Significance Index: -24.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0433
    Cell Significance Index: -58.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0434
    Cell Significance Index: -1.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0544
    Cell Significance Index: -34.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0671
    Cell Significance Index: -37.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0706
    Cell Significance Index: -0.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0884
    Cell Significance Index: -40.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1080
    Cell Significance Index: -2.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1257
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1455
    Cell Significance Index: -16.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1473
    Cell Significance Index: -42.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1579
    Cell Significance Index: -33.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1834
    Cell Significance Index: -3.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1997
    Cell Significance Index: -23.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2079
    Cell Significance Index: -30.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2255
    Cell Significance Index: -14.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2587
    Cell Significance Index: -15.9000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2612
    Cell Significance Index: -2.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2692
    Cell Significance Index: -20.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2708
    Cell Significance Index: -9.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2952
    Cell Significance Index: -19.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3259
    Cell Significance Index: -7.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3689
    Cell Significance Index: -42.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4646
    Cell Significance Index: -11.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4933
    Cell Significance Index: -12.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5110
    Cell Significance Index: -53.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5429
    Cell Significance Index: -3.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5450
    Cell Significance Index: -30.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6236
    Cell Significance Index: -13.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6337
    Cell Significance Index: -50.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7014
    Cell Significance Index: -12.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7293
    Cell Significance Index: -32.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7353
    Cell Significance Index: -45.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7611
    Cell Significance Index: -13.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8971
    Cell Significance Index: -33.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9325
    Cell Significance Index: -18.2000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.9493
    Cell Significance Index: -10.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9995
    Cell Significance Index: -50.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.0232
    Cell Significance Index: -41.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0821
    Cell Significance Index: -30.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics:** SDF4 is a member of the chemokine family, which is characterized by its ability to induce chemotaxis in target cells. It is a ligand for the CXCR4 receptor, which is expressed on various cell types, including hematopoietic cells, epithelial cells, and immune cells. SDF4 is primarily produced by stromal cells, but it can also be expressed in other cell types, including embryonic stem cells and smooth muscle cells. **Pathways and functions:** SDF4 is involved in several signaling pathways, including: 1. **Calcium-ion regulated exocytosis**: SDF4 is involved in the regulation of calcium-mediated exocytosis, which is essential for cellular signaling and communication. 2. **Cerebellum development**: SDF4 plays a crucial role in the development of the cerebellum, which is essential for motor coordination and learning. 3. **Cell migration and differentiation**: SDF4 promotes cell migration and differentiation in various cell types, including hematopoietic cells and epithelial cells. 4. **Endoplasmic reticulum and Golgi lumen**: SDF4 is involved in the regulation of endoplasmic reticulum and Golgi lumen functions, which are essential for protein synthesis and secretion. **Proteins and binding partners:** SDF4 is a ligand for the CXCR4 receptor, which is a G-protein-coupled receptor that activates various signaling pathways. SDF4 also binds to other proteins, including CAB45, a calcium-binding protein that regulates calcium-mediated signaling. **Significantly expressed cells:** SDF4 is expressed in various cell types, including: 1. **Hematopoietic oligopotent progenitor cells**: SDF4 promotes the migration and differentiation of these cells. 2. **Embryonic stem cells**: SDF4 is involved in the regulation of embryonic stem cell self-renewal and differentiation. 3. **Smooth muscle fibers of the ileum**: SDF4 regulates the migration and differentiation of these cells. 4. **Mucosal type mast cells**: SDF4 promotes the migration and activation of these cells. **Clinical significance:** Dysregulation of SDF4 has been implicated in various diseases, including: 1. **Cancer**: SDF4 is involved in tumor metastasis and angiogenesis. 2. **Neurological disorders**: SDF4 is involved in the regulation of cerebellum development and function. 3. **Inflammatory diseases**: SDF4 is involved in the regulation of immune responses and inflammation. 4. **Gastrointestinal diseases**: SDF4 is involved in the regulation of gut homeostasis and inflammation. In conclusion, SDF4 is a multifunctional chemokine that plays a crucial role in various cellular processes, including cell migration, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of SDF4 and its clinical significance.

Genular Protein ID: 929538897

Symbol: CAB45_HUMAN

Name: 45 kDa calcium-binding protein

UniProtKB Accession Codes:

Q9BRK5 B1AME5 B1AME6 B2RDF1 B4DSM1 Q53G52 Q53HQ9 Q8NBQ3 Q96AA1 Q9NZP7 Q9UN53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChEBI 26 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 2 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9254016

Title: Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs.

PubMed ID: 9254016

DOI: 10.3109/10425179709034038

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17442889

Title: A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini.

PubMed ID: 17442889

DOI: 10.1091/mbc.e06-10-0950

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 362
  • Mass: 41807
  • Checksum: 440C6990149AAE2C
  • Sequence:
    • MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN REENEILPPD 
HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR RKLMVIFSKV DVNTDRKISA 
KEMQRWIMEK TAEHFQEAME ESKTHFRAVD PDGDGHVSWD EYKVKFLASK GHSEKEVADA 
IRLNEELKVD EETQEVLENL KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE 
IVRDLDQDGD KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA 
EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK LVDYARSVHE 
EF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.