Details for: MRPL51

Gene ID: 51258

Symbol: MRPL51

Ensembl ID: ENSG00000111639

Description: mitochondrial ribosomal protein L51

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 338.5511
    Cell Significance Index: -52.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 210.9261
    Cell Significance Index: -53.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 178.6392
    Cell Significance Index: -73.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.1533
    Cell Significance Index: -71.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 148.8220
    Cell Significance Index: -60.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 133.8102
    Cell Significance Index: -68.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 107.4406
    Cell Significance Index: -72.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.4676
    Cell Significance Index: -61.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.7011
    Cell Significance Index: -69.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.4910
    Cell Significance Index: -69.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.7504
    Cell Significance Index: -73.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.9508
    Cell Significance Index: -42.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 4.4696
    Cell Significance Index: 726.9400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.3366
    Cell Significance Index: 26.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8981
    Cell Significance Index: 341.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.8333
    Cell Significance Index: 132.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.7631
    Cell Significance Index: 73.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.6542
    Cell Significance Index: 1449.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6393
    Cell Significance Index: 69.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.4796
    Cell Significance Index: 51.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3422
    Cell Significance Index: 288.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3362
    Cell Significance Index: 63.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.2973
    Cell Significance Index: 107.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2288
    Cell Significance Index: 306.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2205
    Cell Significance Index: 51.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1690
    Cell Significance Index: 391.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.0872
    Cell Significance Index: 72.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9376
    Cell Significance Index: 144.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.9271
    Cell Significance Index: 20.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7750
    Cell Significance Index: 16.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6121
    Cell Significance Index: 712.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5962
    Cell Significance Index: 46.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5888
    Cell Significance Index: 18.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5160
    Cell Significance Index: 78.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4135
    Cell Significance Index: 182.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3730
    Cell Significance Index: 8.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3208
    Cell Significance Index: 93.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3115
    Cell Significance Index: 78.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2314
    Cell Significance Index: 79.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0343
    Cell Significance Index: 205.2700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9948
    Cell Significance Index: 12.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9858
    Cell Significance Index: 126.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9148
    Cell Significance Index: 41.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8534
    Cell Significance Index: 44.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6376
    Cell Significance Index: 108.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4911
    Cell Significance Index: 48.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4254
    Cell Significance Index: 11.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3743
    Cell Significance Index: 338.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2714
    Cell Significance Index: 51.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2568
    Cell Significance Index: 7.4000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2316
    Cell Significance Index: 1.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1803
    Cell Significance Index: 136.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1754
    Cell Significance Index: 35.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1471
    Cell Significance Index: 7.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1113
    Cell Significance Index: 81.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0733
    Cell Significance Index: 4.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0047
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0248
    Cell Significance Index: -18.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0279
    Cell Significance Index: -52.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0335
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0486
    Cell Significance Index: -30.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0517
    Cell Significance Index: -95.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0609
    Cell Significance Index: -93.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0712
    Cell Significance Index: -96.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0771
    Cell Significance Index: -27.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0836
    Cell Significance Index: -47.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0852
    Cell Significance Index: -54.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0888
    Cell Significance Index: -1.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1329
    Cell Significance Index: -2.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1483
    Cell Significance Index: -4.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1535
    Cell Significance Index: -69.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1730
    Cell Significance Index: -36.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2145
    Cell Significance Index: -61.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2368
    Cell Significance Index: -6.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2475
    Cell Significance Index: -28.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2618
    Cell Significance Index: -29.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3029
    Cell Significance Index: -5.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3256
    Cell Significance Index: -10.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3304
    Cell Significance Index: -26.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4482
    Cell Significance Index: -65.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4962
    Cell Significance Index: -10.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5294
    Cell Significance Index: -32.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5491
    Cell Significance Index: -62.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6617
    Cell Significance Index: -12.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6908
    Cell Significance Index: -9.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7080
    Cell Significance Index: -73.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8887
    Cell Significance Index: -9.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8899
    Cell Significance Index: -68.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9482
    Cell Significance Index: -63.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9637
    Cell Significance Index: -54.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9749
    Cell Significance Index: -5.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9798
    Cell Significance Index: -26.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9938
    Cell Significance Index: -60.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1492
    Cell Significance Index: -33.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.1533
    Cell Significance Index: -20.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2793
    Cell Significance Index: -15.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5939
    Cell Significance Index: -58.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7639
    Cell Significance Index: -78.0200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.8043
    Cell Significance Index: -27.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.8060
    Cell Significance Index: -15.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL51 is a mitochondrial ribosomal protein that belongs to the L-protein family, which is responsible for the assembly and function of the mitochondrial ribosome. The protein is composed of 39 amino acids and is encoded by the ENSG00000111639 gene. MRPL51 is specifically localized to the mitochondrial large ribosomal subunit, where it interacts with other ribosomal proteins to facilitate the translation of mitochondrial mRNAs. The protein exhibits a high degree of sequence homology with other L-proteins, suggesting its conserved role in mitochondrial translation. **Pathways and Functions:** MRPL51 is involved in several critical pathways, including: 1. **Mitochondrial Translation:** MRPL51 plays a central role in the translation of mitochondrial mRNAs, which are essential for the production of mitochondrial proteins involved in energy metabolism, oxidative stress response, and cell signaling. 2. **Mitochondrial Translation Elongation:** MRPL51 interacts with other ribosomal proteins to facilitate the elongation phase of translation, ensuring the accurate assembly of amino acids into polypeptide chains. 3. **Mitochondrial Translation Initiation:** MRPL51 is also involved in the initiation phase of translation, where it helps to recruit the ribosome to the mitochondrial mRNA and position it correctly for translation. 4. **Mitochondrial Translation Termination:** MRPL51 participates in the termination phase of translation, ensuring the release of completed polypeptides from the ribosome. **Clinical Significance:** Dysregulation of MRPL51 has been implicated in several diseases, including: 1. **Mitochondrial Diseases:** Mutations in the MRPL51 gene have been associated with mitochondrial diseases, such as Kearns-Sayre syndrome, MERRF syndrome, and myoclonic epilepsy with ragged-red fibers. 2. **Cancer:** Altered expression of MRPL51 has been observed in various types of cancer, including leukemia, lymphoma, and breast cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Neurodegenerative Diseases:** MRPL51 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction is a key contributing factor. In conclusion, MRPL51 is a critical component of the mitochondrial ribosome, essential for the accurate translation of mitochondrial mRNAs. Its dysregulation has significant implications for various diseases, highlighting the importance of maintaining mitochondrial function and overall cellular health. Further research is needed to fully elucidate the role of MRPL51 in human disease and to explore potential therapeutic interventions.

Genular Protein ID: 3161039209

Symbol: RM51_HUMAN

Name: 39S ribosomal protein L51, mitochondrial

UniProtKB Accession Codes:

Q4U2R6 Q96Q57 Q9BQ36 Q9P0N7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 6 EMDB 57 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11402041

Title: Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit.

PubMed ID: 11402041

DOI: 10.1074/jbc.m103236200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 11551941

Title: The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.

PubMed ID: 11551941

DOI: 10.1074/jbc.m106510200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 128
  • Mass: 15095
  • Checksum: 9DB4720D5B387A5D
  • Sequence:
    • MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK RAMFGVYDNI 
GILGNFEKHP KELIRGPIWL RGWKGNELQR CIRKRKMVGS RMFADDLHNL NKRIRYLYKH 
FNRHGKFR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.