Details for: ARL6IP4

Gene ID: 51329

Symbol: ARL6IP4

Ensembl ID: ENSG00000182196

Description: ARF like GTPase 6 interacting protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 475.8102
    Cell Significance Index: -74.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 277.3185
    Cell Significance Index: -70.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 215.7254
    Cell Significance Index: -87.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 201.1554
    Cell Significance Index: -94.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 185.8626
    Cell Significance Index: -95.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 142.4543
    Cell Significance Index: -95.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 92.4856
    Cell Significance Index: -88.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 71.2597
    Cell Significance Index: -87.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.1343
    Cell Significance Index: -70.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.7681
    Cell Significance Index: -93.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.3966
    Cell Significance Index: -68.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 14.4658
    Cell Significance Index: 531.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2310
    Cell Significance Index: -24.5800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 7.7995
    Cell Significance Index: 109.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.5348
    Cell Significance Index: 41.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.5012
    Cell Significance Index: 80.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.3735
    Cell Significance Index: 463.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.1918
    Cell Significance Index: 148.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.1408
    Cell Significance Index: 386.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.9435
    Cell Significance Index: 77.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9417
    Cell Significance Index: 530.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9380
    Cell Significance Index: 138.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.8751
    Cell Significance Index: 1570.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6230
    Cell Significance Index: 137.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5541
    Cell Significance Index: 75.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.4518
    Cell Significance Index: 158.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.2088
    Cell Significance Index: 285.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2004
    Cell Significance Index: 259.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1485
    Cell Significance Index: 160.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1433
    Cell Significance Index: 58.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9839
    Cell Significance Index: 877.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9196
    Cell Significance Index: 40.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8823
    Cell Significance Index: 241.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8612
    Cell Significance Index: 131.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6511
    Cell Significance Index: 268.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6157
    Cell Significance Index: 159.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5548
    Cell Significance Index: 54.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5343
    Cell Significance Index: 17.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2481
    Cell Significance Index: 22.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2341
    Cell Significance Index: 244.9200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9953
    Cell Significance Index: 10.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8166
    Cell Significance Index: 6.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7949
    Cell Significance Index: 22.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6283
    Cell Significance Index: 126.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6119
    Cell Significance Index: 116.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4997
    Cell Significance Index: 22.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3517
    Cell Significance Index: 6.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3430
    Cell Significance Index: 237.2600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2622
    Cell Significance Index: 1.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2435
    Cell Significance Index: 6.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1781
    Cell Significance Index: 134.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1491
    Cell Significance Index: 5.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1411
    Cell Significance Index: 50.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1313
    Cell Significance Index: 96.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0690
    Cell Significance Index: 11.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0672
    Cell Significance Index: 3.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0597
    Cell Significance Index: 53.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0453
    Cell Significance Index: 1.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0412
    Cell Significance Index: 0.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0275
    Cell Significance Index: -2.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0383
    Cell Significance Index: -72.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0486
    Cell Significance Index: -89.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0587
    Cell Significance Index: -90.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0720
    Cell Significance Index: -97.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0950
    Cell Significance Index: -70.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1003
    Cell Significance Index: -5.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1272
    Cell Significance Index: -80.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1405
    Cell Significance Index: -79.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1631
    Cell Significance Index: -101.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1720
    Cell Significance Index: -78.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1991
    Cell Significance Index: -12.5500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2745
    Cell Significance Index: -3.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3257
    Cell Significance Index: -93.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4265
    Cell Significance Index: -6.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4325
    Cell Significance Index: -11.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4575
    Cell Significance Index: -96.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4927
    Cell Significance Index: -20.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5292
    Cell Significance Index: -60.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5489
    Cell Significance Index: -43.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5512
    Cell Significance Index: -64.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5925
    Cell Significance Index: -86.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6369
    Cell Significance Index: -20.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6541
    Cell Significance Index: -14.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6988
    Cell Significance Index: -20.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7225
    Cell Significance Index: -55.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8227
    Cell Significance Index: -50.5700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8287
    Cell Significance Index: -5.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8893
    Cell Significance Index: -92.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0717
    Cell Significance Index: -72.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.1413
    Cell Significance Index: -59.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1927
    Cell Significance Index: -66.9300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.2189
    Cell Significance Index: -25.4200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.2664
    Cell Significance Index: -7.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.4084
    Cell Significance Index: -11.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4124
    Cell Significance Index: -19.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5345
    Cell Significance Index: -38.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.5518
    Cell Significance Index: -41.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5533
    Cell Significance Index: -95.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7492
    Cell Significance Index: -51.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8230
    Cell Significance Index: -80.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARL6IP4 is a gene with a relatively low expression level, predominantly found in cells of hematopoietic origin, including polychromatophilic erythroblasts and hematopoietic oligopotent progenitor cells. Its expression is also notable in cells of the immune system, such as mucosal-type mast cells and alpha-beta intraepithelial T cells. The protein AR6P4, encoded by ARL6IP4, exhibits a unique ability to interact with ADP-ribosylation factor-like proteins, thereby participating in the regulation of various cellular processes. **Pathways and Functions:** ARL6IP4 is involved in several key cellular pathways, including mRNA processing, nuclear speck formation, and protein binding. The gene's involvement in mRNA processing is particularly noteworthy, as it plays a crucial role in the regulation of RNA splicing, a process essential for the production of functional mRNA. Additionally, ARL6IP4's interaction with nuclear specks, structures that regulate gene expression and cell cycle progression, highlights its role in maintaining cellular homeostasis. The protein's ability to bind to RNA and other proteins underscores its importance in regulating cellular processes. **Clinical Significance:** While the clinical significance of ARL6IP4 remains to be fully elucidated, its involvement in hematopoietic cells and immune system cells suggests a potential role in diseases affecting these tissues. For example, alterations in ARL6IP4 expression or function may contribute to the development of hematological disorders, such as leukemia or lymphoma. Furthermore, the gene's involvement in immune system cells highlights its potential role in autoimmune diseases or immune-mediated disorders. Further research is necessary to fully understand the clinical significance of ARL6IP4 and to explore its therapeutic potential. In conclusion, ARL6IP4 is a gene of significant interest, with a multifaceted role in various cellular processes. Its involvement in mRNA processing, nuclear speck formation, and protein binding underscores its importance in maintaining cellular homeostasis. While the clinical significance of ARL6IP4 remains to be fully elucidated, its potential role in hematological disorders and immune-mediated diseases suggests a need for further research in this area.

Genular Protein ID: 269516115

Symbol: AR6P4_HUMAN

Name: ADP-ribosylation factor-like protein 6-interacting protein 4

UniProtKB Accession Codes:

Q66PJ3 A4UCR8 B3V0L0 B3V0L1 Q4F966 Q504R8 Q96BI2 Q9NR05 Q9P2R9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 7 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 RefSeq 7 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 19582790

Title: SRrp37, a novel splicing regulator located in the nuclear speckles and nucleoli, interacts with SC35 and modulates alternative pre-mRNA splicing in vivo.

PubMed ID: 19582790

DOI: 10.1002/jcb.22255

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11884129

Title: An SR-protein induced by HSVI binding to cells functioning as a splicing inhibitor of viral pre-mRNA.

PubMed ID: 11884129

DOI: 10.1006/jmbi.2001.5318

PubMed ID: 10708573

Title: Molecular cloning and expression analysis of a putative nuclear protein, SR-25.

PubMed ID: 10708573

DOI: 10.1006/bbrc.2000.2301

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18772245

Title: Screening of human SNP database identifies recoding sites of A-to-I RNA editing.

PubMed ID: 18772245

DOI: 10.1261/rna.816908

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 237
  • Mass: 26375
  • Checksum: D2D0FE5374CFB802
  • Sequence:
    • MAHVGSRKRS RSRSRSRGRG SEKRKKKSRK DTSRNCSAST SQGRKASTAP GAEASPSPCI 
TERSKQKARR RTRSSSSSSS SSSSSSSSSS SSSSSSSSDG RKKRGKYKDK RRKKKKKRKK 
LKKKGKEKAE AQQVEALPGP SLDQWHRSAG EEEDGPVLTD EQKSRIQAMK PMTKEEWDAR 
QSIIRKVVDP ETGRTRLIKG DGEVLEEIVT KERHREINKQ ATRGDCLAFQ MRAGLLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.