Details for: CWC15

Gene ID: 51503

Symbol: CWC15

Ensembl ID: ENSG00000150316

Description: CWC15 spliceosome associated protein homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 262.7210
    Cell Significance Index: -40.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.4725
    Cell Significance Index: -38.4200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 128.1474
    Cell Significance Index: -52.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.1049
    Cell Significance Index: -55.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.8565
    Cell Significance Index: -44.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.2338
    Cell Significance Index: -50.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.3356
    Cell Significance Index: -55.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.7930
    Cell Significance Index: -45.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.5367
    Cell Significance Index: -49.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.5253
    Cell Significance Index: -41.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.4793
    Cell Significance Index: -53.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6264
    Cell Significance Index: -35.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2969
    Cell Significance Index: -15.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.5384
    Cell Significance Index: 528.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8015
    Cell Significance Index: 47.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6521
    Cell Significance Index: 44.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6368
    Cell Significance Index: 85.2600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.6019
    Cell Significance Index: 12.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3788
    Cell Significance Index: 28.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2935
    Cell Significance Index: 177.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2468
    Cell Significance Index: 202.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2227
    Cell Significance Index: 57.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2003
    Cell Significance Index: 27.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1932
    Cell Significance Index: 527.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1859
    Cell Significance Index: 83.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1856
    Cell Significance Index: 213.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0988
    Cell Significance Index: 57.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0971
    Cell Significance Index: 599.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0592
    Cell Significance Index: 130.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9917
    Cell Significance Index: 46.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9174
    Cell Significance Index: 117.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9049
    Cell Significance Index: 57.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8294
    Cell Significance Index: 28.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8176
    Cell Significance Index: 96.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7368
    Cell Significance Index: 47.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7254
    Cell Significance Index: 37.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6960
    Cell Significance Index: 89.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6442
    Cell Significance Index: 48.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5595
    Cell Significance Index: 25.3600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5482
    Cell Significance Index: 5.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4286
    Cell Significance Index: 85.9800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3615
    Cell Significance Index: 5.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3038
    Cell Significance Index: 8.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3003
    Cell Significance Index: 59.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2870
    Cell Significance Index: 49.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1682
    Cell Significance Index: 60.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1136
    Cell Significance Index: 11.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1101
    Cell Significance Index: 1.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0687
    Cell Significance Index: 1.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0606
    Cell Significance Index: 2.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0309
    Cell Significance Index: 22.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0204
    Cell Significance Index: 15.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0161
    Cell Significance Index: 0.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0131
    Cell Significance Index: 0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0102
    Cell Significance Index: -6.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0113
    Cell Significance Index: -0.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0135
    Cell Significance Index: -2.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0139
    Cell Significance Index: -9.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0268
    Cell Significance Index: -49.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0310
    Cell Significance Index: -3.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0311
    Cell Significance Index: -19.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0319
    Cell Significance Index: -0.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0324
    Cell Significance Index: -49.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0450
    Cell Significance Index: -25.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0454
    Cell Significance Index: -61.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0504
    Cell Significance Index: -3.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0530
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0573
    Cell Significance Index: -6.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0724
    Cell Significance Index: -32.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0947
    Cell Significance Index: -19.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1151
    Cell Significance Index: -1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1317
    Cell Significance Index: -19.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1728
    Cell Significance Index: -4.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1866
    Cell Significance Index: -10.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1879
    Cell Significance Index: -54.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1941
    Cell Significance Index: -2.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2448
    Cell Significance Index: -7.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2494
    Cell Significance Index: -6.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3045
    Cell Significance Index: -24.1200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3174
    Cell Significance Index: -4.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3485
    Cell Significance Index: -7.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4422
    Cell Significance Index: -50.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5103
    Cell Significance Index: -53.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5170
    Cell Significance Index: -39.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5363
    Cell Significance Index: -9.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5464
    Cell Significance Index: -36.7400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.5946
    Cell Significance Index: -4.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6656
    Cell Significance Index: -12.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6858
    Cell Significance Index: -20.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8791
    Cell Significance Index: -53.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8982
    Cell Significance Index: -39.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9455
    Cell Significance Index: -12.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0098
    Cell Significance Index: -17.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0352
    Cell Significance Index: -26.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0835
    Cell Significance Index: -41.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1528
    Cell Significance Index: -6.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1757
    Cell Significance Index: -43.1600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.1853
    Cell Significance Index: -7.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CWC15 is a highly conserved protein that shares sequence homology with other spliceosome-associated proteins. Its expression is widespread, with significant levels detected in polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, embryonic stem cells, and various types of epithelial cells. CWC15's unique characteristics include its association with the spliceosome, a complex involved in the processing of RNA, and its involvement in the regulation of alternative splicing events. **Pathways and Functions:** CWC15's primary function is to regulate RNA processing, specifically in the context of spliceosome-mediated events. Its involvement in the catalytic step 2 of the U2-type spliceosome highlights its role in the recognition and excision of introns from pre-mRNA. Furthermore, CWC15's association with the Prp19 complex, a key component of the spliceosome, underscores its importance in the regulation of alternative splicing events. Additionally, CWC15's involvement in the metabolism of RNA and its role in the regulation of protein binding and RNA binding suggest its broader implications in RNA processing and translation. **Clinical Significance:** The clinical significance of CWC15 is multifaceted. Its expression in hematopoietic and epithelial cells suggests its potential role in the development and maintenance of these cell types. Aberrant expression of CWC15 has been linked to various diseases, including hematological malignancies and epithelial cancers. Furthermore, CWC15's involvement in RNA processing and alternative splicing events highlights its potential role in the diagnosis and treatment of diseases characterized by aberrant RNA processing, such as cancer and neurodegenerative disorders. **Conclusion:** In conclusion, CWC15 is a multifaceted protein with significant implications in RNA processing and its regulation. Its widespread expression and association with the spliceosome highlight its potential role in the development and maintenance of various cell types. Further research is necessary to elucidate the mechanisms by which CWC15 regulates RNA processing and its clinical significance in human health and disease. **Future Directions:** Future studies should aim to elucidate the mechanisms by which CWC15 regulates RNA processing and its clinical significance in human health and disease. Specifically, investigations into the molecular mechanisms underlying CWC15's involvement in the regulation of alternative splicing events and its role in the development and maintenance of hematopoietic and epithelial cells are warranted. Additionally, the application of CWC15 as a diagnostic or therapeutic target in diseases characterized by aberrant RNA processing, such as cancer and neurodegenerative disorders, warrants further investigation.

Genular Protein ID: 4076398363

Symbol: CWC15_HUMAN

Name: Spliceosome-associated protein CWC15 homolog

UniProtKB Accession Codes:

Q9P013 B2RC17 Q05BV9 Q05DM1 Q9UI29

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 23 Ensembl 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10873569

Title: Characterization of five novel human genes in the 11q13-q22 region.

PubMed ID: 10873569

DOI: 10.1006/bbrc.2000.2910

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20176811

Title: Molecular architecture of the human Prp19/CDC5L complex.

PubMed ID: 20176811

DOI: 10.1128/mcb.01505-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

Sequence Information:

  • Length: 229
  • Mass: 26624
  • Checksum: B21E6EEF46C4427C
  • Sequence:
    • MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA PEEVRNRDFR 
RELEERERAA AREKNRDRPT REHTTSSSVS KKPRLDQIPA ANLDADDPLT DEEDEDFEEE 
SDDDDTAALL AELEKIKKER AEEQARKEQE QKAEEERIRM ENILSGNPLL NLTGPSQPQA 
NFKVKRRWDD DVVFKNCAKG VDDQKKDKRF VNDTLRSEFH KKFMEKYIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.