Details for: CWC15
Gene ID: 51503
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CWC15
Ensembl ID: ENSG00000150316
Description: CWC15 spliceosome associated protein homolog
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 21.75rCSI 16.46%PRS 51.51
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CSI 21.7rCSI 20.89%PRS 40.53
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CSI 19.6rCSI 31.17%PRS 33.93
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CSI 13.55rCSI 22.31%PRS 45.1
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CSI 13.46rCSI 25.45%PRS 63.83
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CSI 13.04rCSI 16.37%PRS 49.08
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CSI 12.35rCSI 12.71%PRS 57.16
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CSI 12.01rCSI 53.39%PRS 38.49
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CSI 11.18rCSI 10.1%PRS 36.73
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CSI 11.1rCSI 35.63%PRS 48.1
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CSI 10.66rCSI 34.59%PRS 43.37
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CSI 10.35rCSI 12.5%PRS 46.97
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CSI 9.86rCSI 19.17%PRS 41.73
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CSI 9.47rCSI 8.63%PRS 54.47
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CSI 9.34rCSI 26.79%PRS 56.6
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CSI 8.89rCSI 7.9%PRS 39.14
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CSI 8.71rCSI 13.28%PRS 37.02
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CSI 8.63rCSI 11.48%PRS 44.23
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CSI 8.54rCSI 12.61%PRS 56.98
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CSI 8.3rCSI 8.69%PRS 37.51
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CSI 8.02rCSI 6.01%PRS 53.95
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CSI 7.97rCSI 9.92%PRS 50.87
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CSI 7.88rCSI 40.69%PRS 63.83
-
CSI 7.73rCSI 19.13%PRS 38.09
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CSI 7.56rCSI 82.82%PRS 56.94
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CSI 7.53rCSI 7.86%PRS 40.49
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CSI 7.02rCSI 5.68%PRS 40.41
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CSI 7rCSI 6.88%PRS 54.69
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CSI 6.96rCSI 12.29%PRS 25.06
-
CSI 6.85rCSI 11.09%PRS 38.76
-
CSI 6.84rCSI 6.72%PRS 42.18
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CSI 6.82rCSI 19.39%PRS 40.13
-
CSI 6.78rCSI 5.02%PRS 34.31
-
CSI 6.62rCSI 17.56%PRS 53.26
-
CSI 6.59rCSI 9.01%PRS 44.45
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CSI 6.44rCSI 6.21%PRS 31.41
-
CSI 6.4rCSI 5.92%PRS 60.06
-
CSI 6.28rCSI 4.37%PRS 47.76
-
CSI 6.16rCSI 8.4%PRS 34.33
-
CSI 5.82rCSI 14.74%PRS 47.74
-
CSI 5.81rCSI 25.21%PRS 55.71
-
CSI 5.79rCSI 7.74%PRS 41.67
-
CSI 5.77rCSI 8.01%PRS 39.65
-
CSI 5.6rCSI 10.68%PRS 56.39
-
CSI 5.43rCSI 31.57%PRS 51.07
-
CSI 5.31rCSI 15.66%PRS 44.23
-
CSI 5.3rCSI 7.26%PRS 37.13
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CSI 5.06rCSI 8.12%PRS 69.24
-
CSI 5.03rCSI 11.11%PRS 29.68
-
CSI 5rCSI 26.99%PRS 54.99
-
CSI 4.99rCSI 9.41%PRS 49.33
-
CSI 4.97rCSI 6.05%PRS 47.15
-
CSI 4.89rCSI 3.4%PRS 52.25
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CSI 4.82rCSI 6.44%PRS 62.37
-
CSI 4.8rCSI 5.02%PRS 39.76
-
CSI 4.78rCSI 5%PRS 70.79
-
CSI 4.72rCSI 23.67%PRS 50.28
-
CSI 4.64rCSI 12.01%PRS 36.57
-
CSI 4.64rCSI 3.85%PRS 38.47
-
CSI 4.62rCSI 7.3%PRS 40.9
-
CSI 4.57rCSI 3.96%PRS 43.67
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CSI 4.54rCSI 5.85%PRS 26.88
-
CSI 4.43rCSI 4.64%PRS 42.31
-
CSI 4.33rCSI 3.8%PRS 30.22
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CSI 4.25rCSI 3.36%PRS 28.89
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CSI 4.16rCSI 5.17%PRS 42.39
-
CSI 4.11rCSI 5.61%PRS 42.56
-
CSI 4.11rCSI 3.34%PRS 40.88
-
CSI 4.09rCSI 9.45%PRS 32.82
-
CSI 3.93rCSI 3.3%PRS 44.99
-
CSI 3.92rCSI 3.6%PRS 46.8
-
CSI 3.86rCSI 5.57%PRS 49.86
-
CSI 3.82rCSI 5.28%PRS 45.59
-
CSI 3.79rCSI 2.98%PRS 45.88
-
CSI 3.78rCSI 2.52%PRS 44.01
-
CSI 3.78rCSI 8.37%PRS 37.25
-
CSI 3.77rCSI 10.92%PRS 42.47
-
CSI 3.72rCSI 2.98%PRS 61.14
-
CSI 3.69rCSI 2.46%PRS 66.06
-
CSI 3.6rCSI 10.29%PRS 54.64
-
CSI 3.52rCSI 7.74%PRS 43.62
-
CSI 3.51rCSI 5.39%PRS 43.35
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CSI 3.47rCSI 5.09%PRS 40.19
-
CSI 3.46rCSI 9.14%PRS 46.91
-
CSI 3.45rCSI 3.95%PRS 62.53
-
CSI 3.37rCSI 4.17%PRS 35.99
-
CSI 3.32rCSI 2.91%PRS 49.35
-
CSI 3.32rCSI 3.52%PRS 55.28
-
CSI 3.28rCSI 2.74%PRS 62.38
-
CSI 3.26rCSI 4.68%PRS 47.39
-
CSI 3.05rCSI 4.48%PRS 36.69
-
CSI 2.98rCSI 16.03%PRS 55.78
-
CSI 2.97rCSI 3.69%PRS 24.61
-
CSI 2.96rCSI 2.22%PRS 72.85
-
CSI 2.94rCSI 2.06%PRS 41.65
-
CSI 2.91rCSI 5.47%PRS 60.02
-
CSI 2.85rCSI 3.89%PRS 67.72
-
CSI 2.81rCSI 2.36%PRS 56.77
-
CSI 2.81rCSI 2.59%PRS 40.99
-
CSI 2.79rCSI 2.89%PRS 45.41
-
CSI 0.1rCSI 0.8%PRS 52.0%
-
CSI 0.1rCSI 3.5%PRS 81.9%
-
CSI 0.2rCSI 1.8%PRS 66.1%
-
CSI 0.2rCSI 1.2%PRS 63.3%
-
CSI 0.2rCSI 4.0%PRS 75.9%
-
CSI 0.3rCSI 2.5%PRS 68.6%
-
CSI 0.3rCSI 5.0%PRS 88.0%
-
CSI 0.3rCSI 4.1%PRS 66.8%
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CSI 0.3rCSI 4.4%PRS 73.7%
-
CSI 0.4rCSI 6.5%PRS 74.9%
-
CSI 0.4rCSI 1.2%PRS 29.1%
-
CSI 0.4rCSI 2.8%PRS 60.2%
-
CSI 0.4rCSI 3.9%PRS 81.6%
-
CSI 0.4rCSI 4.1%PRS 67.8%
-
CSI 0.4rCSI 1.5%PRS 53.4%
-
CSI 0.4rCSI 4.6%PRS 60.8%
-
CSI 0.4rCSI 2.1%PRS 66.6%
-
CSI 0.5rCSI 1.3%PRS 48.7%
-
CSI 0.5rCSI 3.0%PRS 65.2%
-
CSI 0.5rCSI 0.9%PRS 26.0%
-
CSI 0.5rCSI 3.2%PRS 76.2%
-
CSI 0.5rCSI 0.8%PRS 55.5%
-
CSI 0.6rCSI 3.1%PRS 72.7%
-
CSI 0.6rCSI 1.0%PRS 38.4%
-
CSI 0.6rCSI 2.0%PRS 50.4%
-
CSI 0.6rCSI 3.1%PRS 51.0%
-
CSI 0.6rCSI 0.8%PRS 58.5%
-
CSI 0.6rCSI 0.9%PRS 49.2%
-
CSI 0.7rCSI 1.0%PRS 41.5%
-
CSI 0.7rCSI 1.8%PRS 55.5%
-
CSI 0.7rCSI 1.6%PRS 25.2%
-
CSI 0.7rCSI 4.4%PRS 71.5%
-
CSI 0.7rCSI 2.2%PRS 27.1%
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CSI 0.7rCSI 1.7%PRS 52.4%
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CSI 0.7rCSI 1.4%PRS 57.7%
-
CSI 0.7rCSI 2.9%PRS 55.6%
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CSI 0.8rCSI 3.4%PRS 76.4%
-
CSI 0.8rCSI 1.4%PRS 30.9%
-
CSI 0.8rCSI 2.8%PRS 76.7%
-
CSI 0.8rCSI 1.9%PRS 57.1%
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CSI 0.8rCSI 4.0%PRS 82.4%
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CSI 0.8rCSI 1.2%PRS 56.0%
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CSI 0.8rCSI 2.7%PRS 72.3%
-
CSI 0.9rCSI 3.5%PRS 61.7%
-
CSI 0.9rCSI 2.5%PRS 57.9%
-
CSI 0.9rCSI 1.3%PRS 53.5%
-
CSI 0.9rCSI 0.8%PRS 63.7%
-
CSI 0.9rCSI 6.5%PRS 67.1%
-
CSI 0.9rCSI 1.7%PRS 69.5%
-
CSI 0.9rCSI 1.6%PRS 67.1%
-
CSI 0.9rCSI 4.1%PRS 59.6%
-
CSI 1.0rCSI 1.5%PRS 48.6%
-
CSI 1.0rCSI 2.2%PRS 49.6%
-
CSI 1.0rCSI 3.9%PRS 59.7%
-
CSI 1.0rCSI 2.3%PRS 38.9%
-
CSI 1.0rCSI 1.6%PRS 40.5%
-
CSI 1.0rCSI 1.8%PRS 38.9%
-
CSI 1.1rCSI 2.5%PRS 66.3%
-
CSI 1.1rCSI 2.9%PRS 62.8%
-
CSI 1.1rCSI 1.7%PRS 38.0%
-
CSI 1.1rCSI 0.8%PRS 42.9%
-
CSI 1.1rCSI 4.1%PRS 74.4%
-
CSI 1.1rCSI 2.8%PRS 36.6%
-
CSI 1.1rCSI 3.9%PRS 72.7%
-
CSI 1.2rCSI 2.1%PRS 55.7%
-
CSI 1.2rCSI 1.6%PRS 52.5%
-
CSI 1.2rCSI 2.3%PRS 39.7%
-
CSI 1.2rCSI 2.3%PRS 74.3%
-
CSI 1.2rCSI 6.1%PRS 76.2%
-
CSI 1.2rCSI 1.9%PRS 46.3%
-
CSI 1.2rCSI 2.6%PRS 54.9%
-
CSI 1.2rCSI 2.7%PRS 54.5%
-
CSI 1.3rCSI 3.7%PRS 58.9%
-
CSI 1.3rCSI 1.7%PRS 50.3%
-
CSI 1.3rCSI 2.1%PRS 31.7%
-
CSI 1.3rCSI 1.4%PRS 37.8%
-
CSI 1.3rCSI 1.5%PRS 25.9%
-
CSI 1.3rCSI 2.9%PRS 45.9%
-
CSI 1.3rCSI 3.1%PRS 45.7%
-
CSI 1.3rCSI 1.5%PRS 50.6%
-
CSI 1.4rCSI 4.9%PRS 58.7%
-
CSI 1.4rCSI 1.6%PRS 59.7%
-
CSI 1.4rCSI 2.8%PRS 62.3%
-
CSI 1.4rCSI 2.0%PRS 42.6%
-
CSI 1.4rCSI 2.6%PRS 55.7%
-
CSI 1.4rCSI 2.1%PRS 50.5%
-
CSI 1.5rCSI 2.5%PRS 49.0%
-
CSI 1.5rCSI 6.3%PRS 56.7%
-
CSI 1.5rCSI 1.8%PRS 53.0%
-
CSI 1.5rCSI 1.6%PRS 43.7%
-
CSI 1.5rCSI 2.4%PRS 34.5%
-
CSI 1.5rCSI 25.2%PRS 73.8%
-
CSI 1.5rCSI 4.2%PRS 54.6%
-
CSI 1.5rCSI 2.6%PRS 65.9%
-
CSI 1.5rCSI 2.7%PRS 48.1%
-
CSI 1.5rCSI 1.3%PRS 48.4%
-
CSI 1.5rCSI 3.2%PRS 35.7%
-
CSI 1.6rCSI 1.1%PRS 49.3%
-
CSI 1.6rCSI 1.3%PRS 55.9%
-
CSI 1.7rCSI 3.7%PRS 59.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4076398363
Symbol: CWC15_HUMAN
Name: Spliceosome-associated protein CWC15 homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10873569
Title: Characterization of five novel human genes in the 11q13-q22 region.
PubMed ID: 10873569
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 10931946
Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
PubMed ID: 10931946
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20176811
Title: Molecular architecture of the human Prp19/CDC5L complex.
PubMed ID: 20176811
DOI: 10.1128/mcb.01505-09
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28502770
Title: An Atomic Structure of the Human Spliceosome.
PubMed ID: 28502770
PubMed ID: 28076346
Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
PubMed ID: 28076346
DOI: 10.1038/nature21079
PubMed ID: 33509932
Title: Structure of the activated human minor spliceosome.
PubMed ID: 33509932
Sequence Information:
- Length: 229
- Mass: 26624
- Checksum: B21E6EEF46C4427C
- Sequence:
MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA PEEVRNRDFR RELEERERAA AREKNRDRPT REHTTSSSVS KKPRLDQIPA ANLDADDPLT DEEDEDFEEE SDDDDTAALL AELEKIKKER AEEQARKEQE QKAEEERIRM ENILSGNPLL NLTGPSQPQA NFKVKRRWDD DVVFKNCAKG VDDQKKDKRF VNDTLRSEFH KKFMEKYIK