Details for: TRMT112

Gene ID: 51504

Symbol: TRMT112

Ensembl ID: ENSG00000173113

Description: tRNA methyltransferase activator subunit 11-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 419.2993
    Cell Significance Index: -65.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 265.4120
    Cell Significance Index: -67.3200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 229.8108
    Cell Significance Index: -94.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 206.2241
    Cell Significance Index: -83.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 195.6483
    Cell Significance Index: -92.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 177.8822
    Cell Significance Index: -91.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 138.0133
    Cell Significance Index: -92.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 89.3225
    Cell Significance Index: -85.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 69.3374
    Cell Significance Index: -85.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.9886
    Cell Significance Index: -94.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.1128
    Cell Significance Index: -70.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.0624
    Cell Significance Index: -40.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.1384
    Cell Significance Index: 161.4100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.6774
    Cell Significance Index: 45.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.4912
    Cell Significance Index: 310.5900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.0467
    Cell Significance Index: 51.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.9830
    Cell Significance Index: 83.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.8992
    Cell Significance Index: 42.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4381
    Cell Significance Index: 472.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.4042
    Cell Significance Index: 92.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.1789
    Cell Significance Index: 149.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.0176
    Cell Significance Index: 355.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.7059
    Cell Significance Index: 30.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.6352
    Cell Significance Index: 1439.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.5047
    Cell Significance Index: 307.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.4812
    Cell Significance Index: 86.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2112
    Cell Significance Index: 398.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1560
    Cell Significance Index: 160.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0784
    Cell Significance Index: 61.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0497
    Cell Significance Index: 906.2300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.8983
    Cell Significance Index: 16.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8078
    Cell Significance Index: 231.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7993
    Cell Significance Index: 41.5700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.7787
    Cell Significance Index: 10.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6385
    Cell Significance Index: 46.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6143
    Cell Significance Index: 114.1700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.6135
    Cell Significance Index: 9.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3382
    Cell Significance Index: 172.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2988
    Cell Significance Index: 68.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2976
    Cell Significance Index: 22.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2347
    Cell Significance Index: 79.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2157
    Cell Significance Index: 1097.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1410
    Cell Significance Index: 53.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0094
    Cell Significance Index: 9.3000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.0065
    Cell Significance Index: 7.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9716
    Cell Significance Index: 158.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9528
    Cell Significance Index: 13.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9043
    Cell Significance Index: 46.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6683
    Cell Significance Index: 66.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6655
    Cell Significance Index: 12.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6535
    Cell Significance Index: 17.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5432
    Cell Significance Index: 92.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5030
    Cell Significance Index: 26.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4165
    Cell Significance Index: 79.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3417
    Cell Significance Index: 258.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3220
    Cell Significance Index: 63.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3154
    Cell Significance Index: 19.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2926
    Cell Significance Index: 6.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1709
    Cell Significance Index: 2.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0938
    Cell Significance Index: 18.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0248
    Cell Significance Index: 18.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0092
    Cell Significance Index: -5.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0105
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0257
    Cell Significance Index: -19.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0315
    Cell Significance Index: -59.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0359
    Cell Significance Index: -12.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0573
    Cell Significance Index: -105.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0677
    Cell Significance Index: -104.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0794
    Cell Significance Index: -107.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0937
    Cell Significance Index: -52.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1205
    Cell Significance Index: -76.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1500
    Cell Significance Index: -4.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1551
    Cell Significance Index: -32.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1819
    Cell Significance Index: -82.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2280
    Cell Significance Index: -26.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2377
    Cell Significance Index: -6.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2517
    Cell Significance Index: -6.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2571
    Cell Significance Index: -73.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3543
    Cell Significance Index: -12.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4698
    Cell Significance Index: -53.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5496
    Cell Significance Index: -15.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5570
    Cell Significance Index: -63.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5592
    Cell Significance Index: -81.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6752
    Cell Significance Index: -18.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7040
    Cell Significance Index: -55.7600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.7923
    Cell Significance Index: -4.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8075
    Cell Significance Index: -36.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9027
    Cell Significance Index: -93.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9128
    Cell Significance Index: -5.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9451
    Cell Significance Index: -30.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0593
    Cell Significance Index: -65.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0851
    Cell Significance Index: -60.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2348
    Cell Significance Index: -94.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2446
    Cell Significance Index: -83.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3180
    Cell Significance Index: -22.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4245
    Cell Significance Index: -87.3400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.4699
    Cell Significance Index: -11.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5064
    Cell Significance Index: -44.3700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.5459
    Cell Significance Index: -12.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.5784
    Cell Significance Index: -16.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRMT112 is a multifunctional protein that exhibits a diverse range of enzymatic activities. Some of the key characteristics of TRMT112 include: - **Protein Methyltransferase Activity**: TRMT112 possesses protein methyltransferase activity, which enables it to transfer methyl groups to specific amino acid residues in proteins. - **Trna (m2g10) Methyltransferase Activity**: TRMT112 also exhibits trna (m2g10) methyltransferase activity, which is involved in the methylation of tRNA molecules. - **Protein Methyltransferase Activator Activity**: TRMT112 acts as a protein methyltransferase activator, facilitating the activity of other protein methyltransferases. - **Expression in Specific Cell Types**: TRMT112 is specifically expressed in various cell types, including hematopoietic oligopotent progenitor cells, embryonic stem cells, and mucosal type mast cells. **Pathways and Functions** TRMT112 is involved in various cellular pathways, including: - **Biological Oxidations**: TRMT112 plays a role in the regulation of biological oxidations, which are essential for the proper functioning of various cellular processes. - **Cytoplasm and Cytosol**: TRMT112 is localized to the cytoplasm and cytosol, where it interacts with other proteins and RNAs to regulate cellular processes. - **Eukaryotic Translation Termination**: TRMT112 is involved in the regulation of eukaryotic translation termination, which is essential for the proper functioning of protein synthesis. - **Maturation of LSU-rrna and SSU-rrna**: TRMT112 plays a role in the maturation of LSU-rrna and SSU-rrna, which are essential for the proper functioning of ribosomes. - **Metabolism**: TRMT112 is involved in various metabolic pathways, including the metabolism of proteins, RNA, and compounds. **Clinical Significance** The dysregulation of TRMT112 has been implicated in various human diseases, including: - **Hematological Disorders**: TRMT112 deficiency has been linked to hematological disorders, including anemia and leukemia. - **Cancer**: TRMT112 has been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma. - **Neurological Disorders**: TRMT112 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TRMT112 is a multifunctional protein that plays a crucial role in the regulation of various cellular processes, including RNA processing, protein modification, and metabolism. The dysregulation of TRMT112 has been implicated in various human diseases, highlighting the importance of this gene in maintaining cellular homeostasis.

Genular Protein ID: 2821251509

Symbol: TR112_HUMAN

Name: Multifunctional methyltransferase subunit TRM112-like protein

UniProtKB Accession Codes:

Q9UI30 B2R539 J3KNG5 Q3MHC7 Q8N2Z4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 7 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 6 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18539146

Title: HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.

PubMed ID: 18539146

DOI: 10.1016/j.febslet.2008.05.045

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20308323

Title: Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival.

PubMed ID: 20308323

DOI: 10.1128/mcb.01604-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25851604

Title: The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.

PubMed ID: 25851604

DOI: 10.1091/mbc.e15-02-0073

PubMed ID: 31632689

Title: Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112.

PubMed ID: 31632689

DOI: 10.1038/s41421-019-0119-5

PubMed ID: 32217665

Title: The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.

PubMed ID: 32217665

DOI: 10.1101/gad.333369.119

PubMed ID: 34948388

Title: Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor.

PubMed ID: 34948388

DOI: 10.3390/ijms222413593

PubMed ID: 33428944

Title: Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima.

PubMed ID: 33428944

DOI: 10.1016/j.jbc.2021.100270

PubMed ID: 34669960

Title: THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates.

PubMed ID: 34669960

DOI: 10.1093/nar/gkab927

PubMed ID: 35033535

Title: The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation.

PubMed ID: 35033535

DOI: 10.1016/j.jbc.2022.101590

PubMed ID: 31328227

Title: The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.

PubMed ID: 31328227

DOI: 10.1093/nar/gkz619

PubMed ID: 31636962

Title: Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase.

PubMed ID: 31636962

DOI: 10.1038/s41421-019-0121-y

PubMed ID: 31061526

Title: KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.

PubMed ID: 31061526

DOI: 10.1038/s41594-019-0219-9

PubMed ID: 32969463

Title: Structural insight into HEMK2-TRMT112-mediated glutamine methylation.

PubMed ID: 32969463

DOI: 10.1042/bcj20200594

Sequence Information:

  • Length: 125
  • Mass: 14199
  • Checksum: A943569364D4FFEA
  • Sequence:
    • MKLLTHNLLS SHVRGVGSRG FPLRLQATEV RICPVEFNPN FVARMIPKVE WSAFLEAADN 
LRLIQVPKGP VEGYEENEEF LRTMHHLLLE VEVIEGTLQC PESGRMFPIS RGIPNMLLSE 
EETES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.