Details for: PFDN4

Gene ID: 5203

Symbol: PFDN4

Ensembl ID: ENSG00000101132

Description: prefoldin subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 184.1265
    Cell Significance Index: -28.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 98.1435
    Cell Significance Index: -40.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.0834
    Cell Significance Index: -23.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.5694
    Cell Significance Index: -39.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.3032
    Cell Significance Index: -33.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.1942
    Cell Significance Index: -37.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.1188
    Cell Significance Index: -39.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.0880
    Cell Significance Index: -33.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.5817
    Cell Significance Index: -35.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5762
    Cell Significance Index: -33.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1773
    Cell Significance Index: -40.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1546
    Cell Significance Index: -21.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.2103
    Cell Significance Index: 490.6600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.6493
    Cell Significance Index: 21.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3667
    Cell Significance Index: 70.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.7021
    Cell Significance Index: 29.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.4799
    Cell Significance Index: 19.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4390
    Cell Significance Index: 396.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4313
    Cell Significance Index: 63.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7154
    Cell Significance Index: 186.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3279
    Cell Significance Index: 68.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3257
    Cell Significance Index: 171.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2510
    Cell Significance Index: 171.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2046
    Cell Significance Index: 16.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2031
    Cell Significance Index: 85.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1819
    Cell Significance Index: 32.1700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1584
    Cell Significance Index: 9.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1581
    Cell Significance Index: 632.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0618
    Cell Significance Index: 49.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9664
    Cell Significance Index: 123.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9129
    Cell Significance Index: 26.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9088
    Cell Significance Index: 111.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8344
    Cell Significance Index: 150.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8249
    Cell Significance Index: 364.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8248
    Cell Significance Index: 28.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7807
    Cell Significance Index: 92.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7759
    Cell Significance Index: 50.0600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6635
    Cell Significance Index: 7.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6277
    Cell Significance Index: 5.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5994
    Cell Significance Index: 6.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5790
    Cell Significance Index: 116.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5299
    Cell Significance Index: 39.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5057
    Cell Significance Index: 22.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3729
    Cell Significance Index: 4.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3630
    Cell Significance Index: 19.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3463
    Cell Significance Index: 68.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3417
    Cell Significance Index: 9.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3403
    Cell Significance Index: 33.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3374
    Cell Significance Index: 15.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3053
    Cell Significance Index: 19.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2846
    Cell Significance Index: 54.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2700
    Cell Significance Index: 7.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2137
    Cell Significance Index: 76.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0703
    Cell Significance Index: 3.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0576
    Cell Significance Index: 3.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0406
    Cell Significance Index: 0.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0213
    Cell Significance Index: 16.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0103
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0105
    Cell Significance Index: -19.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0133
    Cell Significance Index: -0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0220
    Cell Significance Index: -40.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0226
    Cell Significance Index: -3.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0239
    Cell Significance Index: -17.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0292
    Cell Significance Index: -44.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0317
    Cell Significance Index: -43.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0353
    Cell Significance Index: -3.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0423
    Cell Significance Index: -31.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0438
    Cell Significance Index: -27.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0584
    Cell Significance Index: -32.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0736
    Cell Significance Index: -45.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0741
    Cell Significance Index: -33.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0812
    Cell Significance Index: -23.3500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0883
    Cell Significance Index: -1.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1329
    Cell Significance Index: -4.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1593
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1911
    Cell Significance Index: -21.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2009
    Cell Significance Index: -29.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2140
    Cell Significance Index: -5.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2160
    Cell Significance Index: -12.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2172
    Cell Significance Index: -45.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2383
    Cell Significance Index: -1.4400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2684
    Cell Significance Index: -1.6800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2705
    Cell Significance Index: -1.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3160
    Cell Significance Index: -7.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3685
    Cell Significance Index: -24.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3726
    Cell Significance Index: -6.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3740
    Cell Significance Index: -28.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3817
    Cell Significance Index: -39.7400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3911
    Cell Significance Index: -2.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3929
    Cell Significance Index: -31.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4386
    Cell Significance Index: -12.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4537
    Cell Significance Index: -9.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4613
    Cell Significance Index: -9.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4769
    Cell Significance Index: -15.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4932
    Cell Significance Index: -9.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5310
    Cell Significance Index: -6.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5810
    Cell Significance Index: -25.7000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.5823
    Cell Significance Index: -3.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6288
    Cell Significance Index: -38.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6388
    Cell Significance Index: -16.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PFDN4 is a subunit of the prefoldin complex, a heterohexameric protein complex composed of six subunits, each with distinct functions. PFDN4 is a small protein with a molecular weight of approximately 10 kDa. It is highly conserved across species, suggesting its essential role in maintaining protein homeostasis. PFDN4 is also known to interact with other proteins, including chaperone-mediated protein folding proteins, such as TRIC/CCT, to facilitate protein folding. **Pathways and Functions:** PFDN4 is involved in various cellular pathways, including: 1. **Chaperone-mediated protein folding**: PFDN4 plays a crucial role in the chaperone-mediated protein folding pathway, where it interacts with TRIC/CCT to facilitate the folding of actin and tubulin proteins. 2. **Amyloid regulation**: PFDN4 is involved in the negative regulation of amyloid fibril formation, suggesting its potential role in the prevention of neurodegenerative diseases such as Alzheimer's disease. 3. **Metabolism of proteins**: PFDN4 is also involved in the metabolism of proteins, including the folding and degradation of misfolded proteins. 4. **Cooperation with prefoldin and TRIC/CCT**: PFDN4 cooperates with prefoldin and TRIC/CCT to facilitate the folding of actin and tubulin proteins. **Clinical Significance:** Dysregulation of PFDN4 has been implicated in various diseases, including: 1. **Neurodegenerative diseases**: Mutations in PFDN4 have been associated with neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 2. **Muscular dystrophy**: PFDN4 has been implicated in the pathogenesis of muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 3. **Cancer**: PFDN4 has been found to be overexpressed in various types of cancer, suggesting its potential role in cancer development and progression. In conclusion, PFDN4 is a crucial component of the prefoldin complex, essential for maintaining protein homeostasis and preventing amyloid formation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying these disorders.

Genular Protein ID: 2486934717

Symbol: PFD4_HUMAN

Name: Prefoldin subunit 4

UniProtKB Accession Codes:

Q9NQP4 Q5TD11 Q92779

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8744932

Title: Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines.

PubMed ID: 8744932

DOI: 10.18926/amo/30489

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9630229

Title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.

PubMed ID: 9630229

DOI: 10.1016/s0092-8674(00)81446-4

PubMed ID: 17936702

Title: S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.

PubMed ID: 17936702

DOI: 10.1016/j.molcel.2007.08.010

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 134
  • Mass: 15314
  • Checksum: C727F0FCB9343DC3
  • Sequence:
    • MAATMKKAAA EDVNVTFEDQ QKINKFARNT SRITELKEEI EVKKKQLQNL EDACDDIMLA 
DDDCLMIPYQ IGDVFISHSQ EETQEMLEEA KKNLQEEIDA LESRVESIQR VLADLKVQLY 
AKFGSNINLE ADES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.