Details for: PGAM1

Gene ID: 5223

Symbol: PGAM1

Ensembl ID: ENSG00000171314

Description: phosphoglycerate mutase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 452.6658
    Cell Significance Index: -70.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 243.0578
    Cell Significance Index: -61.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 177.9110
    Cell Significance Index: -73.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 163.8864
    Cell Significance Index: -66.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 156.8660
    Cell Significance Index: -74.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 141.9559
    Cell Significance Index: -73.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 111.1439
    Cell Significance Index: -74.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 69.9351
    Cell Significance Index: -66.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.8302
    Cell Significance Index: -72.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.8898
    Cell Significance Index: -74.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.2345
    Cell Significance Index: -52.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1627
    Cell Significance Index: -37.9400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 8.9039
    Cell Significance Index: 68.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8413
    Cell Significance Index: -19.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.5661
    Cell Significance Index: 397.2500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 7.2252
    Cell Significance Index: 60.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.0012
    Cell Significance Index: 146.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.1522
    Cell Significance Index: 65.9800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.9684
    Cell Significance Index: 32.2700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.7872
    Cell Significance Index: 23.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6981
    Cell Significance Index: 318.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9468
    Cell Significance Index: 116.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9460
    Cell Significance Index: 316.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8825
    Cell Significance Index: 15.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8162
    Cell Significance Index: 84.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8139
    Cell Significance Index: 33.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.7851
    Cell Significance Index: 112.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7414
    Cell Significance Index: 239.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7038
    Cell Significance Index: 21.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6144
    Cell Significance Index: 56.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5777
    Cell Significance Index: 21.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5448
    Cell Significance Index: 189.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5311
    Cell Significance Index: 276.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4061
    Cell Significance Index: 73.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3354
    Cell Significance Index: 590.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3314
    Cell Significance Index: 36.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2324
    Cell Significance Index: 87.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0209
    Cell Significance Index: 557.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9999
    Cell Significance Index: 128.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9177
    Cell Significance Index: 43.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8752
    Cell Significance Index: 173.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8730
    Cell Significance Index: 23.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8631
    Cell Significance Index: 55.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8480
    Cell Significance Index: 170.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8206
    Cell Significance Index: 61.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7983
    Cell Significance Index: 20.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6461
    Cell Significance Index: 5.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5188
    Cell Significance Index: 67.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4762
    Cell Significance Index: 5.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4479
    Cell Significance Index: 12.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4404
    Cell Significance Index: 43.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3515
    Cell Significance Index: 126.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3302
    Cell Significance Index: 95.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2566
    Cell Significance Index: 5.5600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.2497
    Cell Significance Index: 2.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2370
    Cell Significance Index: 45.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2156
    Cell Significance Index: 36.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1742
    Cell Significance Index: 268.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1220
    Cell Significance Index: 3.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1115
    Cell Significance Index: 209.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1107
    Cell Significance Index: 150.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1079
    Cell Significance Index: 198.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0679
    Cell Significance Index: 51.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0392
    Cell Significance Index: 28.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0281
    Cell Significance Index: 0.4700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0172
    Cell Significance Index: 0.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0084
    Cell Significance Index: 7.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0245
    Cell Significance Index: -18.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0279
    Cell Significance Index: -2.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0471
    Cell Significance Index: -29.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0558
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0577
    Cell Significance Index: -36.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0635
    Cell Significance Index: -28.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0851
    Cell Significance Index: -48.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1016
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1347
    Cell Significance Index: -28.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1661
    Cell Significance Index: -1.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2569
    Cell Significance Index: -7.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2768
    Cell Significance Index: -18.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2894
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3181
    Cell Significance Index: -36.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3191
    Cell Significance Index: -10.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3207
    Cell Significance Index: -46.6200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3580
    Cell Significance Index: -4.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3946
    Cell Significance Index: -10.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4004
    Cell Significance Index: -46.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4822
    Cell Significance Index: -29.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5063
    Cell Significance Index: -28.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5595
    Cell Significance Index: -14.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5628
    Cell Significance Index: -43.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6102
    Cell Significance Index: -48.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6315
    Cell Significance Index: -65.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8408
    Cell Significance Index: -5.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8723
    Cell Significance Index: -15.4200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.1153
    Cell Significance Index: -12.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.1624
    Cell Significance Index: -60.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2059
    Cell Significance Index: -73.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2455
    Cell Significance Index: -36.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2851
    Cell Significance Index: -27.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3427
    Cell Significance Index: -60.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PGAM1 is a cytosolic enzyme that catalyzes the reversible conversion of 3-phosphoglycerate to 2-phosphoglycerate, a crucial step in glycolysis and gluconeogenesis. This enzyme is characterized by its high affinity for 2,3-bisphosphoglycerate (2,3-BPG), a byproduct of glycolysis, which significantly enhances its activity. PGAM1 is also known to interact with various proteins, including protein kinases and B7Z9E5, a protein involved in immune system regulation. **Pathways and Functions:** PGAM1 plays a pivotal role in several metabolic and immune-related pathways, including: 1. **Glycolysis**: PGAM1 is essential for the conversion of 3-phosphoglycerate to 2-phosphoglycerate, a critical step in glycolysis, the primary energy-producing pathway in cells. 2. **Gluconeogenesis**: PGAM1 also participates in gluconeogenesis, the process of generating glucose from non-carbohydrate sources, by catalyzing the conversion of 2-phosphoglycerate to 3-phosphoglycerate. 3. **Immune System**: PGAM1 has been implicated in immune system function, particularly in the regulation of neutrophil degranulation and the production of reactive oxygen species during a respiratory burst. 4. **Cytosolic Metabolism**: PGAM1 is also involved in the regulation of glycolytic process and pentose-phosphate shunt, two critical pathways involved in cytosolic metabolism. **Clinical Significance:** Dysregulation of PGAM1 has been linked to various diseases, including: 1. **Metabolic Disorders**: Altered PGAM1 activity has been associated with metabolic disorders, such as diabetes and metabolic syndrome, which are characterized by impaired glucose metabolism and increased risk of developing cardiovascular diseases. 2. **Immune System Dysregulation**: PGAM1 has been implicated in immune system dysregulation, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where PGAM1 activity is altered. 3. **Cancer**: PGAM1 has been found to be overexpressed in certain types of cancer, including breast cancer, where it may contribute to tumor progression and metastasis. In conclusion, PGAM1 is a multifunctional enzyme that plays a critical role in metabolism and immune system function. Its dysregulation has been linked to various diseases, highlighting the importance of PGAM1 in maintaining cellular homeostasis and overall health. Further research is needed to fully elucidate the mechanisms underlying PGAM1's functions and to explore its potential as a therapeutic target for diseases related to metabolic and immune system dysregulation.

Genular Protein ID: 2285623325

Symbol: PGAM1_HUMAN

Name: BPG-dependent PGAM 1

UniProtKB Accession Codes:

P18669 Q9BWC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2846553

Title: Isolation of a cDNA encoding the B isozyme of human phosphoglycerate mutase (PGAM) and characterization of the PGAM gene family.

PubMed ID: 2846553

DOI: 10.1016/s0021-9258(18)37476-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2846554

Title: Sequence of the human erythrocyte phosphoglycerate mutase by microsequencer and mass spectrometry.

PubMed ID: 2846554

DOI: 10.1016/s0021-9258(18)37477-5

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22157007

Title: Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation.

PubMed ID: 22157007

DOI: 10.1074/jbc.m111.317404

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15883004

Title: Crystal structure of human B-type phosphoglycerate mutase bound with citrate.

PubMed ID: 15883004

DOI: 10.1016/j.bbrc.2005.03.243

PubMed ID: 23653202

Title: Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.

PubMed ID: 23653202

DOI: 10.1038/ncomms2759

Sequence Information:

  • Length: 254
  • Mass: 28804
  • Checksum: 6DC0852BEBB22409
  • Sequence:
    • MAAYKLVLIR HGESAWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ 
KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD 
VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR 
VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR 
KAMEAVAAQG KAKK

Genular Protein ID: 1672518575

Symbol: B7Z9E5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z9E5

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSR 2 Pfam 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 129
  • Mass: 14550
  • Checksum: FB00DA2EAD508C66
  • Sequence:
    • MEPDHPFYSN ISKDRRYADH TEDQLPSCES LKDTIARALP FWNEEIVPQI KEGKRVLIAA 
HGNSLRGIVK HLEGLSEEAI MELNLPTGIP IVYELDKNLK PIKPMQFLGD EETVRKAMEA 
VAAQGKAKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.