Details for: PGAM1

Gene ID: 5223

Symbol: PGAM1

Ensembl ID: ENSG00000171314

Description: phosphoglycerate mutase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.4
    Marker Score: 5313
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.81
    Marker Score: 3597
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.61
    Marker Score: 3224
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.32
    Marker Score: 6750
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.11
    Marker Score: 24290
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.89
    Marker Score: 161599
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.86
    Marker Score: 28353
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.84
    Marker Score: 32990.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.72
    Marker Score: 1554
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.66
    Marker Score: 1414
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.65
    Marker Score: 22823
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.61
    Marker Score: 16695.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.53
    Marker Score: 3583
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.51
    Marker Score: 7147
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.48
    Marker Score: 32698
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.47
    Marker Score: 10653.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.41
    Marker Score: 5036
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.4
    Marker Score: 6525
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.4
    Marker Score: 4668
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.37
    Marker Score: 2230
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.37
    Marker Score: 15405.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.35
    Marker Score: 7417
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.33
    Marker Score: 1839
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.33
    Marker Score: 5806
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.32
    Marker Score: 691
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.29
    Marker Score: 1440
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.29
    Marker Score: 6792.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.29
    Marker Score: 2446
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.27
    Marker Score: 3853
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.26
    Marker Score: 3998
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.23
    Marker Score: 22418
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.22
    Marker Score: 1161
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.22
    Marker Score: 3080
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.21
    Marker Score: 8198.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.21
    Marker Score: 8680.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.18
    Marker Score: 6024
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.17
    Marker Score: 8865
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.16
    Marker Score: 2174
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.16
    Marker Score: 1895
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.15
    Marker Score: 721
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.12
    Marker Score: 1545
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.12
    Marker Score: 12562
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.11
    Marker Score: 5319
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.11
    Marker Score: 4958
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.1
    Marker Score: 1209
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.09
    Marker Score: 5109
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.09
    Marker Score: 2528
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.09
    Marker Score: 15531.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.08
    Marker Score: 2337
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.08
    Marker Score: 2241
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.08
    Marker Score: 2198
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.07
    Marker Score: 6045
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.07
    Marker Score: 1998.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.06
    Marker Score: 972
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.06
    Marker Score: 9872
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.04
    Marker Score: 5467
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.03
    Marker Score: 1354
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.02
    Marker Score: 1277
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2
    Marker Score: 2949
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2
    Marker Score: 8578
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2
    Marker Score: 2944.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.99
    Marker Score: 813
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.96
    Marker Score: 6151
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.96
    Marker Score: 5326
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.95
    Marker Score: 2520
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.95
    Marker Score: 2588
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.95
    Marker Score: 66224
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.95
    Marker Score: 1155
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.93
    Marker Score: 49537
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.93
    Marker Score: 1131
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.92
    Marker Score: 666
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.91
    Marker Score: 2030
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.91
    Marker Score: 3327
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.9
    Marker Score: 1580
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.9
    Marker Score: 1263
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.9
    Marker Score: 3389
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.9
    Marker Score: 3145
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.89
    Marker Score: 536
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.89
    Marker Score: 1782
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.89
    Marker Score: 1108
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.89
    Marker Score: 816
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.89
    Marker Score: 3695
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.88
    Marker Score: 939
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.88
    Marker Score: 2902
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.88
    Marker Score: 1571
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.87
    Marker Score: 25164
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.87
    Marker Score: 2141
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.87
    Marker Score: 529
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.86
    Marker Score: 4229
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.85
    Marker Score: 609.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.83
    Marker Score: 1009
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.81
    Marker Score: 890
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.81
    Marker Score: 406
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.8
    Marker Score: 1283
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.79
    Marker Score: 678
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.79
    Marker Score: 821
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.78
    Marker Score: 2229
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.78
    Marker Score: 4650
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.78
    Marker Score: 690
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.77
    Marker Score: 1164

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Other Information

**Key Characteristics:** PGAM1 is a cytosolic enzyme that catalyzes the reversible conversion of 3-phosphoglycerate to 2-phosphoglycerate, a crucial step in glycolysis and gluconeogenesis. This enzyme is characterized by its high affinity for 2,3-bisphosphoglycerate (2,3-BPG), a byproduct of glycolysis, which significantly enhances its activity. PGAM1 is also known to interact with various proteins, including protein kinases and B7Z9E5, a protein involved in immune system regulation. **Pathways and Functions:** PGAM1 plays a pivotal role in several metabolic and immune-related pathways, including: 1. **Glycolysis**: PGAM1 is essential for the conversion of 3-phosphoglycerate to 2-phosphoglycerate, a critical step in glycolysis, the primary energy-producing pathway in cells. 2. **Gluconeogenesis**: PGAM1 also participates in gluconeogenesis, the process of generating glucose from non-carbohydrate sources, by catalyzing the conversion of 2-phosphoglycerate to 3-phosphoglycerate. 3. **Immune System**: PGAM1 has been implicated in immune system function, particularly in the regulation of neutrophil degranulation and the production of reactive oxygen species during a respiratory burst. 4. **Cytosolic Metabolism**: PGAM1 is also involved in the regulation of glycolytic process and pentose-phosphate shunt, two critical pathways involved in cytosolic metabolism. **Clinical Significance:** Dysregulation of PGAM1 has been linked to various diseases, including: 1. **Metabolic Disorders**: Altered PGAM1 activity has been associated with metabolic disorders, such as diabetes and metabolic syndrome, which are characterized by impaired glucose metabolism and increased risk of developing cardiovascular diseases. 2. **Immune System Dysregulation**: PGAM1 has been implicated in immune system dysregulation, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where PGAM1 activity is altered. 3. **Cancer**: PGAM1 has been found to be overexpressed in certain types of cancer, including breast cancer, where it may contribute to tumor progression and metastasis. In conclusion, PGAM1 is a multifunctional enzyme that plays a critical role in metabolism and immune system function. Its dysregulation has been linked to various diseases, highlighting the importance of PGAM1 in maintaining cellular homeostasis and overall health. Further research is needed to fully elucidate the mechanisms underlying PGAM1's functions and to explore its potential as a therapeutic target for diseases related to metabolic and immune system dysregulation.

Genular Protein ID: 2285623325

Symbol: PGAM1_HUMAN

Name: BPG-dependent PGAM 1

UniProtKB Accession Codes:

P18669 Q9BWC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 15 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2846553

Title: Isolation of a cDNA encoding the B isozyme of human phosphoglycerate mutase (PGAM) and characterization of the PGAM gene family.

PubMed ID: 2846553

DOI: 10.1016/s0021-9258(18)37476-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2846554

Title: Sequence of the human erythrocyte phosphoglycerate mutase by microsequencer and mass spectrometry.

PubMed ID: 2846554

DOI: 10.1016/s0021-9258(18)37477-5

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22157007

Title: Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation.

PubMed ID: 22157007

DOI: 10.1074/jbc.m111.317404

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15883004

Title: Crystal structure of human B-type phosphoglycerate mutase bound with citrate.

PubMed ID: 15883004

DOI: 10.1016/j.bbrc.2005.03.243

PubMed ID: 23653202

Title: Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.

PubMed ID: 23653202

DOI: 10.1038/ncomms2759

Sequence Information:

  • Length: 254
  • Mass: 28804
  • Checksum: 6DC0852BEBB22409
  • Sequence:
    • MAAYKLVLIR HGESAWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ 
KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD 
VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR 
VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR 
KAMEAVAAQG KAKK

Genular Protein ID: 1672518575

Symbol: B7Z9E5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z9E5

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSR 2 Pfam 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 129
  • Mass: 14550
  • Checksum: FB00DA2EAD508C66
  • Sequence:
    • MEPDHPFYSN ISKDRRYADH TEDQLPSCES LKDTIARALP FWNEEIVPQI KEGKRVLIAA 
HGNSLRGIVK HLEGLSEEAI MELNLPTGIP IVYELDKNLK PIKPMQFLGD EETVRKAMEA 
VAAQGKAKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.