Details for: PIN4

Gene ID: 5303

Symbol: PIN4

Ensembl ID: ENSG00000102309

Description: peptidylprolyl cis/trans isomerase, NIMA-interacting 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 237.4872
    Cell Significance Index: -36.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.5908
    Cell Significance Index: -38.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 110.1596
    Cell Significance Index: -45.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 101.8591
    Cell Significance Index: -48.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.9132
    Cell Significance Index: -46.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 71.7413
    Cell Significance Index: -48.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.8626
    Cell Significance Index: -45.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.1884
    Cell Significance Index: -35.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2135
    Cell Significance Index: -48.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.8939
    Cell Significance Index: -33.4600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.5876
    Cell Significance Index: 20.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9740
    Cell Significance Index: 1782.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4932
    Cell Significance Index: 69.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4296
    Cell Significance Index: 64.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2965
    Cell Significance Index: 35.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2137
    Cell Significance Index: 218.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2073
    Cell Significance Index: 18.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1909
    Cell Significance Index: 163.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1666
    Cell Significance Index: 143.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0624
    Cell Significance Index: 580.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0356
    Cell Significance Index: 53.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0100
    Cell Significance Index: 29.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9859
    Cell Significance Index: 195.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9467
    Cell Significance Index: 153.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9310
    Cell Significance Index: 24.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8673
    Cell Significance Index: 40.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8578
    Cell Significance Index: 172.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8438
    Cell Significance Index: 373.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8119
    Cell Significance Index: 6.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7979
    Cell Significance Index: 102.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7826
    Cell Significance Index: 50.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7747
    Cell Significance Index: 54.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7404
    Cell Significance Index: 25.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6411
    Cell Significance Index: 13.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6357
    Cell Significance Index: 47.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6138
    Cell Significance Index: 14.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5726
    Cell Significance Index: 36.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5695
    Cell Significance Index: 31.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5604
    Cell Significance Index: 12.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5348
    Cell Significance Index: 69.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4552
    Cell Significance Index: 23.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3761
    Cell Significance Index: 134.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3389
    Cell Significance Index: 39.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3174
    Cell Significance Index: 19.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2786
    Cell Significance Index: 7.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2736
    Cell Significance Index: 52.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2618
    Cell Significance Index: 44.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2509
    Cell Significance Index: 2.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1058
    Cell Significance Index: 1.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0995
    Cell Significance Index: 9.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0707
    Cell Significance Index: 1.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0405
    Cell Significance Index: 30.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0184
    Cell Significance Index: 13.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0152
    Cell Significance Index: 28.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0073
    Cell Significance Index: 11.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -9.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0078
    Cell Significance Index: -10.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0138
    Cell Significance Index: -8.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0168
    Cell Significance Index: -0.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0209
    Cell Significance Index: -13.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0237
    Cell Significance Index: -1.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0269
    Cell Significance Index: -0.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0420
    Cell Significance Index: -4.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0442
    Cell Significance Index: -20.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0444
    Cell Significance Index: -1.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0584
    Cell Significance Index: -32.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0652
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1113
    Cell Significance Index: -23.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1197
    Cell Significance Index: -13.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1222
    Cell Significance Index: -3.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1223
    Cell Significance Index: -35.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1712
    Cell Significance Index: -19.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2112
    Cell Significance Index: -30.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2669
    Cell Significance Index: -5.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3194
    Cell Significance Index: -8.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3473
    Cell Significance Index: -23.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3591
    Cell Significance Index: -28.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3729
    Cell Significance Index: -6.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3877
    Cell Significance Index: -5.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4053
    Cell Significance Index: -46.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4435
    Cell Significance Index: -11.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4451
    Cell Significance Index: -46.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4480
    Cell Significance Index: -5.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5037
    Cell Significance Index: -22.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5537
    Cell Significance Index: -16.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5869
    Cell Significance Index: -15.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6144
    Cell Significance Index: -6.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6457
    Cell Significance Index: -24.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6567
    Cell Significance Index: -8.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6803
    Cell Significance Index: -4.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7766
    Cell Significance Index: -47.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7889
    Cell Significance Index: -18.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7929
    Cell Significance Index: -19.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8313
    Cell Significance Index: -23.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8705
    Cell Significance Index: -16.0900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8815
    Cell Significance Index: -5.4300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.8938
    Cell Significance Index: -5.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9146
    Cell Significance Index: -23.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Peptidylprolyl cis/trans isomerase activity:** PIN4 possesses the ability to catalyze the cis-trans isomerization of peptidylprolyl bonds in proteins, which is essential for protein folding and stability. 2. **NIMA-interacting protein:** PIN4 interacts with the NIMA protein, which is involved in cell cycle regulation, spindle pole assembly, and cytokinesis. 3. **Multiple cellular expressions:** PIN4 is highly expressed in various cell types, including erythroid progenitor cells, epithelial cells of the nephron, and embryonic stem cells. 4. **Mitochondrial and nuclear localization:** PIN4 is localized to both the mitochondrial matrix and the nucleus, suggesting its involvement in both mitochondrial and nuclear functions. **Pathways and Functions:** 1. **Cell cycle regulation:** PIN4's interaction with NIMA suggests its role in regulating the cell cycle, particularly in the G2/M phase. 2. **Spindle pole assembly:** PIN4 is involved in spindle pole assembly, which is crucial for proper mitotic spindle formation and cytokinesis. 3. **Mitochondrial function:** PIN4's localization to the mitochondrial matrix suggests its involvement in mitochondrial function, including energy production and reactive oxygen species (ROS) regulation. 4. **Protein folding and modification:** PIN4's peptidylprolyl cis/trans isomerase activity is essential for protein folding and modification, which is critical for maintaining protein homeostasis. 5. **RNA processing:** PIN4's involvement in RNA processing suggests its role in regulating gene expression and RNA stability. **Clinical Significance:** 1. **Cancer:** Alterations in PIN4 expression have been linked to various cancers, including breast, lung, and colon cancer. PIN4's role in cell cycle regulation and spindle pole assembly makes it a potential target for cancer therapy. 2. **Neurological disorders:** PIN4's involvement in mitochondrial function and protein folding suggests its potential role in neurological disorders, such as Parkinson's disease and Alzheimer's disease. 3. **Reproductive health:** PIN4's expression in embryonic stem cells and decidual cells highlights its potential role in reproductive health and fertility. 4. **Kidney disease:** PIN4's expression in kidney cells and collecting duct intercalated cells suggests its potential role in kidney function and disease. In conclusion, PIN4 is a multifunctional protein involved in various cellular processes, including cell cycle regulation, spindle pole assembly, mitochondrial function, protein folding, and RNA processing. Its expression patterns and cellular roles highlight the importance of PIN4 in maintaining cellular homeostasis and development. Further research is needed to fully understand the clinical significance of PIN4 and its potential applications in human disease.

Genular Protein ID: 1050859036

Symbol: PIN4_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

UniProtKB Accession Codes:

Q9Y237 A8E0G6 B3KXM0 F5H1P5 Q0D2H3 Q3MHV0 Q52M21 Q5HYW6 Q6IRW4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10364457

Title: Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases.

PubMed ID: 10364457

DOI: 10.1006/bbrc.1999.0828

PubMed ID: 10100858

Title: Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase.

PubMed ID: 10100858

DOI: 10.1016/s0014-5793(99)00239-2

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16522211

Title: Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation.

PubMed ID: 16522211

DOI: 10.1186/1471-2199-7-9

PubMed ID: 17875217

Title: The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae.

PubMed ID: 17875217

DOI: 10.1186/1741-7007-5-37

PubMed ID: 12860119

Title: Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14.

PubMed ID: 12860119

DOI: 10.1016/s0022-2836(03)00713-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12144781

Title: The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding.

PubMed ID: 12144781

DOI: 10.1016/s0022-2836(02)00615-0

PubMed ID: 19369196

Title: Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage.

PubMed ID: 19369196

DOI: 10.1074/mcp.m900147-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10966801

Title: NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein.

PubMed ID: 10966801

DOI: 10.1006/jmbi.2000.4013

PubMed ID: 11162102

Title: Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14.

PubMed ID: 11162102

DOI: 10.1006/jmbi.2000.4293

Sequence Information:

  • Length: 131
  • Mass: 13810
  • Checksum: 787C15BDB0701258
  • Sequence:
    • MPPKGKSGSG KAGKGGAASG SDSADKKAQG PKGGGNAVKV RHILCEKHGK IMEAMEKLKS 
GMRFNEVAAQ YSEDKARQGG DLGWMTRGSM VGPFQEAAFA LPVSGMDKPV FTDPPVKTKF 
GYHIIMVEGR K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.