Details for: PIN4
Gene ID: 5303
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PIN4
Ensembl ID: ENSG00000102309
Description: peptidylprolyl cis/trans isomerase, NIMA-interacting 4
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 22.44rCSI 26.79%PRS 39.03
-
CSI 22rCSI 19.05%PRS 25.46
-
CSI 13.36rCSI 12.27%PRS 26.75
-
CSI 12.85rCSI 12.62%PRS 35.12
-
CSI 12.68rCSI 16.86%PRS 24.73
-
CSI 12.08rCSI 19.21%PRS 19.05
-
CSI 11.66rCSI 23.09%PRS 51.93
-
CSI 11.38rCSI 28.18%PRS 20.9
-
CSI 11.06rCSI 17.09%PRS 21.07
-
CSI 10.78rCSI 16.27%PRS 23.08
-
CSI 10.65rCSI 28.1%PRS 26.93
-
CSI 10.02rCSI 10.22%PRS 32.27
-
CSI 8.76rCSI 15.45%PRS 29.3
-
CSI 7.92rCSI 12.65%PRS 24.71
-
CSI 7.77rCSI 85.07%PRS 39.21
-
CSI 7.58rCSI 10.33%PRS 19.76
-
CSI 7.48rCSI 7.82%PRS 23.46
-
CSI 7.4rCSI 16.8%PRS 29.79
-
CSI 6.63rCSI 5.83%PRS 16.4
-
CSI 6.55rCSI 7.91%PRS 27.39
-
CSI 6.42rCSI 14.34%PRS 26.53
-
CSI 6.33rCSI 16.02%PRS 27.7
-
CSI 6.17rCSI 16.11%PRS 33.87
-
CSI 5.78rCSI 31.17%PRS 37.85
-
CSI 5.44rCSI 4.32%PRS 40.29
-
CSI 5.2rCSI 14.83%PRS 37.52
-
CSI 5.19rCSI 7.94%PRS 29.4
-
CSI 5.04rCSI 7.96%PRS 22.65
-
CSI 5.03rCSI 17.31%PRS 63.3
-
CSI 4.87rCSI 3.96%PRS 23.7
-
CSI 4.83rCSI 4.29%PRS 22.74
-
CSI 4.62rCSI 7.09%PRS 30.3
-
CSI 4.59rCSI 26.29%PRS 33.26
-
CSI 4.52rCSI 7.82%PRS 17.22
-
CSI 4.47rCSI 17.86%PRS 46.06
-
CSI 4.44rCSI 9.96%PRS 13.98
-
CSI 4.4rCSI 3.06%PRS 27.29
-
CSI 4.36rCSI 10.06%PRS 18.17
-
CSI 4.35rCSI 5.98%PRS 43.32
-
CSI 4.22rCSI 6.55%PRS 33.32
-
CSI 4.14rCSI 5.66%PRS 25.47
-
CSI 4.03rCSI 3.03%PRS 24.21
-
CSI 3.92rCSI 24.51%PRS 17.54
-
CSI 3.8rCSI 3.79%PRS 19.3
-
CSI 3.76rCSI 5.14%PRS 25.09
-
CSI 3.67rCSI 10.56%PRS 40.65
-
CSI 3.64rCSI 6.43%PRS 13.24
-
CSI 3.62rCSI 15.9%PRS 40.91
-
CSI 3.59rCSI 35.27%PRS 54.99
-
CSI 3.44rCSI 3.54%PRS 36.24
-
CSI 3.4rCSI 8.27%PRS 13.1
-
CSI 3.39rCSI 4.44%PRS 32.28
-
CSI 3.21rCSI 18.88%PRS 14
-
CSI 3.16rCSI 6.52%PRS 33.45
-
CSI 3.14rCSI 6.96%PRS 20.8
-
CSI 3.13rCSI 6.28%PRS 16.61
-
CSI 3.12rCSI 4.58%PRS 20.74
-
CSI 3.11rCSI 6.04%PRS 23.16
-
CSI 3.02rCSI 4.41%PRS 23.89
-
CSI 2.96rCSI 5.27%PRS 37.01
-
CSI 2.95rCSI 2.85%PRS 16.45
-
CSI 2.81rCSI 2.18%PRS 21.75
-
CSI 2.8rCSI 2.13%PRS 29.99
-
CSI 2.75rCSI 4.41%PRS 57.29
-
CSI 2.75rCSI 4.45%PRS 22.72
-
CSI 2.74rCSI 10.34%PRS 13.83
-
CSI 2.69rCSI 2%PRS 33.28
-
CSI 2.61rCSI 2.25%PRS 34.28
-
CSI 2.59rCSI 4.17%PRS 33.82
-
CSI 2.52rCSI 2.7%PRS 20.77
-
CSI 2.48rCSI 1.72%PRS 31.97
-
CSI 2.48rCSI 1.85%PRS 35.61
-
CSI 2.39rCSI 2.54%PRS 37.98
-
CSI 2.38rCSI 2.48%PRS 23.12
-
CSI 2.34rCSI 6.91%PRS 26.49
-
CSI 2.32rCSI 4.16%PRS 20.86
-
CSI 2.3rCSI 5.4%PRS 32.15
-
CSI 2.3rCSI 6.6%PRS 34.07
-
CSI 2.3rCSI 3.41%PRS 26.52
-
CSI 2.28rCSI 2.06%PRS 20.49
-
CSI 2.28rCSI 2.9%PRS 26.02
-
CSI 2.26rCSI 2.65%PRS 25.84
-
CSI 2.23rCSI 10.23%PRS 49.58
-
CSI 2.23rCSI 2.77%PRS 12.52
-
CSI 2.22rCSI 2.14%PRS 23.34
-
CSI 2.2rCSI 3.76%PRS 45.11
-
CSI 2.2rCSI 3.04%PRS 31.19
-
CSI 2.13rCSI 3.32%PRS 49.98
-
CSI 2.12rCSI 2.22%PRS 23.94
-
CSI 2.09rCSI 2.19%PRS 21.06
-
CSI 2.05rCSI 4.92%PRS 39.66
-
CSI 2.05rCSI 1.8%PRS 26.13
-
CSI 2.04rCSI 2.94%PRS 35.32
-
CSI 2.04rCSI 1.35%PRS 27.05
-
CSI 2rCSI 1.89%PRS 23.7
-
CSI 1.98rCSI 10.15%PRS 66.81
-
CSI 1.96rCSI 7.64%PRS 30.66
-
CSI 1.95rCSI 1.88%PRS 44.87
-
CSI 1.95rCSI 2.76%PRS 20.89
-
CSI 1.94rCSI 1.91%PRS 24.26
-
CSI 0.1rCSI 0.3%PRS 49.9%
-
CSI 0.1rCSI 0.5%PRS 33.3%
-
CSI 0.1rCSI 0.2%PRS 34.3%
-
CSI 0.2rCSI 0.5%PRS 16.1%
-
CSI 0.2rCSI 2.5%PRS 42.3%
-
CSI 0.3rCSI 6.0%PRS 11.9%
-
CSI 0.3rCSI 2.8%PRS 54.1%
-
CSI 0.4rCSI 2.4%PRS 57.4%
-
CSI 0.4rCSI 1.8%PRS 43.4%
-
CSI 0.4rCSI 2.8%PRS 42.9%
-
CSI 0.4rCSI 1.4%PRS 43.0%
-
CSI 0.4rCSI 1.7%PRS 53.2%
-
CSI 0.4rCSI 3.0%PRS 67.6%
-
CSI 0.4rCSI 5.8%PRS 52.1%
-
CSI 0.4rCSI 1.0%PRS 43.3%
-
CSI 0.4rCSI 1.7%PRS 38.7%
-
CSI 0.4rCSI 1.3%PRS 15.3%
-
CSI 0.4rCSI 2.7%PRS 54.5%
-
CSI 0.4rCSI 1.1%PRS 17.1%
-
CSI 0.5rCSI 1.2%PRS 29.2%
-
CSI 0.5rCSI 8.8%PRS 84.7%
-
CSI 0.5rCSI 1.5%PRS 14.2%
-
CSI 0.5rCSI 1.7%PRS 36.3%
-
CSI 0.5rCSI 12.0%PRS 12.9%
-
CSI 0.5rCSI 1.1%PRS 44.4%
-
CSI 0.5rCSI 2.3%PRS 21.9%
-
CSI 0.5rCSI 0.8%PRS 17.2%
-
CSI 0.5rCSI 1.6%PRS 25.3%
-
CSI 0.6rCSI 1.5%PRS 36.6%
-
CSI 0.6rCSI 1.7%PRS 49.3%
-
CSI 0.6rCSI 1.3%PRS 30.1%
-
CSI 0.6rCSI 1.6%PRS 34.8%
-
CSI 0.6rCSI 1.0%PRS 13.4%
-
CSI 0.6rCSI 0.9%PRS 36.2%
-
CSI 0.6rCSI 0.9%PRS 20.8%
-
CSI 0.6rCSI 2.0%PRS 31.4%
-
CSI 0.7rCSI 2.8%PRS 40.5%
-
CSI 0.7rCSI 3.2%PRS 30.4%
-
CSI 0.7rCSI 2.7%PRS 38.1%
-
CSI 0.7rCSI 1.6%PRS 33.4%
-
CSI 0.7rCSI 2.5%PRS 63.0%
-
CSI 0.7rCSI 1.7%PRS 35.7%
-
CSI 0.7rCSI 1.6%PRS 23.2%
-
CSI 0.7rCSI 1.9%PRS 22.9%
-
CSI 0.7rCSI 2.5%PRS 38.6%
-
CSI 0.7rCSI 2.4%PRS 35.3%
-
CSI 0.8rCSI 2.4%PRS 23.4%
-
CSI 0.8rCSI 1.1%PRS 31.5%
-
CSI 0.8rCSI 2.2%PRS 17.4%
-
CSI 0.8rCSI 2.5%PRS 18.4%
-
CSI 0.8rCSI 1.6%PRS 46.6%
-
CSI 0.8rCSI 5.7%PRS 55.9%
-
CSI 0.8rCSI 1.3%PRS 17.3%
-
CSI 0.8rCSI 1.8%PRS 33.7%
-
CSI 0.8rCSI 3.7%PRS 20.8%
-
CSI 0.9rCSI 4.2%PRS 76.6%
-
CSI 0.9rCSI 2.2%PRS 28.7%
-
CSI 0.9rCSI 11.3%PRS 61.3%
-
CSI 0.9rCSI 1.4%PRS 14.6%
-
CSI 0.9rCSI 1.2%PRS 34.0%
-
CSI 0.9rCSI 1.3%PRS 25.7%
-
CSI 0.9rCSI 1.0%PRS 25.3%
-
CSI 0.9rCSI 1.8%PRS 23.6%
-
CSI 1.0rCSI 1.7%PRS 19.2%
-
CSI 1.0rCSI 1.7%PRS 22.0%
-
CSI 1.0rCSI 1.3%PRS 34.4%
-
CSI 1.0rCSI 1.4%PRS 25.3%
-
CSI 1.0rCSI 2.2%PRS 26.0%
-
CSI 1.0rCSI 2.6%PRS 21.0%
-
CSI 1.0rCSI 3.6%PRS 12.6%
-
CSI 1.0rCSI 1.3%PRS 42.3%
-
CSI 1.0rCSI 1.4%PRS 17.5%
-
CSI 1.0rCSI 1.6%PRS 39.3%
-
CSI 1.0rCSI 4.2%PRS 20.6%
-
CSI 1.1rCSI 5.4%PRS 67.4%
-
CSI 1.1rCSI 10.1%PRS 72.1%
-
CSI 1.1rCSI 0.9%PRS 22.7%
-
CSI 1.1rCSI 2.4%PRS 34.0%
-
CSI 1.1rCSI 2.1%PRS 47.4%
-
CSI 1.1rCSI 1.9%PRS 30.6%
-
CSI 1.1rCSI 1.8%PRS 26.8%
-
CSI 1.1rCSI 1.4%PRS 29.3%
-
CSI 1.1rCSI 1.3%PRS 16.7%
-
CSI 1.1rCSI 1.4%PRS 26.1%
-
CSI 1.2rCSI 2.2%PRS 43.1%
-
CSI 1.2rCSI 27.9%PRS 41.6%
-
CSI 1.2rCSI 1.4%PRS 32.4%
-
CSI 1.2rCSI 6.1%PRS 29.9%
-
CSI 1.2rCSI 0.9%PRS 21.1%
-
CSI 1.2rCSI 1.9%PRS 22.7%
-
CSI 1.2rCSI 1.1%PRS 28.5%
-
CSI 1.2rCSI 1.8%PRS 25.6%
-
CSI 1.2rCSI 4.0%PRS 27.0%
-
CSI 1.3rCSI 3.0%PRS 33.7%
-
CSI 1.3rCSI 1.7%PRS 51.0%
-
CSI 1.3rCSI 2.9%PRS 43.3%
-
CSI 1.3rCSI 2.0%PRS 28.9%
-
CSI 1.3rCSI 1.6%PRS 24.0%
-
CSI 1.3rCSI 2.3%PRS 18.6%
-
CSI 1.3rCSI 1.9%PRS 29.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1050859036
Symbol: PIN4_HUMAN
Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10364457
Title: Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases.
PubMed ID: 10364457
PubMed ID: 10100858
Title: Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase.
PubMed ID: 10100858
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16522211
Title: Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation.
PubMed ID: 16522211
PubMed ID: 17875217
Title: The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae.
PubMed ID: 17875217
PubMed ID: 12860119
Title: Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14.
PubMed ID: 12860119
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12144781
Title: The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding.
PubMed ID: 12144781
PubMed ID: 19369196
Title: Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage.
PubMed ID: 19369196
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 10966801
Title: NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein.
PubMed ID: 10966801
PubMed ID: 11162102
Title: Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14.
PubMed ID: 11162102
Sequence Information:
- Length: 131
- Mass: 13810
- Checksum: 787C15BDB0701258
- Sequence:
MPPKGKSGSG KAGKGGAASG SDSADKKAQG PKGGGNAVKV RHILCEKHGK IMEAMEKLKS GMRFNEVAAQ YSEDKARQGG DLGWMTRGSM VGPFQEAAFA LPVSGMDKPV FTDPPVKTKF GYHIIMVEGR K