PSMC1 | ENSG00000100764 | NCBI 5700

Details for: PSMC1

Gene ID: 5700

Symbol: PSMC1

Ensembl ID: ENSG00000100764

Description: proteasome 26S subunit, ATPase 1

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Asparagine n-linked glycosylation
(R-HSA-446203)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-HSA-532668)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 220.3861
Cell Significance Index: -34.2800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 141.3007
Cell Significance Index: -35.8400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 109.9412
Cell Significance Index: -45.2900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 102.9076
Cell Significance Index: -48.5900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 102.6813
Cell Significance Index: -41.7200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 91.5462
Cell Significance Index: -47.0900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 72.8888
Cell Significance Index: -48.9100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 43.8757
Cell Significance Index: -41.8900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 37.2844
Cell Significance Index: -45.9700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.3693
Cell Significance Index: -48.8100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.4862
Cell Significance Index: -30.7700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.8320
Cell Significance Index: -33.2700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.9823
Cell Significance Index: -17.4700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 3.7501
Cell Significance Index: 31.5000
Cell Name: kidney cell (CL1000497)
Fold Change: 2.5525
Cell Significance Index: 20.3800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.9056
Cell Significance Index: 26.0000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.6613
Cell Significance Index: 57.7300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.5932
Cell Significance Index: 17.3200
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.5600
Cell Significance Index: 41.0200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.5383
Cell Significance Index: 32.2000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4819
Cell Significance Index: 40.3400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.3831
Cell Significance Index: 170.0700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3678
Cell Significance Index: 246.5800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.2619
Cell Significance Index: 11.6200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2562
Cell Significance Index: 81.0500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1393
Cell Significance Index: 30.4200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0879
Cell Significance Index: 176.9300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.0762
Cell Significance Index: 80.2100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.0157
Cell Significance Index: 139.4800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.0087
Cell Significance Index: 47.4100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0051
Cell Significance Index: 52.2100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0040
Cell Significance Index: 46.8100
Cell Name: lactocyte (CL0002325)
Fold Change: 0.9985
Cell Significance Index: 129.0100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9900
Cell Significance Index: 437.7200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.9752
Cell Significance Index: 8.3800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.9726
Cell Significance Index: 279.8600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.9077
Cell Significance Index: 116.3600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8137
Cell Significance Index: 57.5500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7680
Cell Significance Index: 419.4500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.7448
Cell Significance Index: 21.3500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7187
Cell Significance Index: 144.1800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.7167
Cell Significance Index: 12.6700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6447
Cell Significance Index: 76.0300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.6398
Cell Significance Index: 33.5900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.6232
Cell Significance Index: 7.0800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5791
Cell Significance Index: 40.0500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5593
Cell Significance Index: 35.2500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5578
Cell Significance Index: 110.7000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4884
Cell Significance Index: 10.5800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.4835
Cell Significance Index: 14.2000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4650
Cell Significance Index: 88.5000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3248
Cell Significance Index: 116.5000
Cell Name: peg cell (CL4033014)
Fold Change: 0.3181
Cell Significance Index: 7.3500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3004
Cell Significance Index: 8.6600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2723
Cell Significance Index: 46.4900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2699
Cell Significance Index: 243.7200
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.2496
Cell Significance Index: 6.0900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2288
Cell Significance Index: 22.6400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1428
Cell Significance Index: 3.9900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1255
Cell Significance Index: 5.6900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0242
Cell Significance Index: 18.3600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0213
Cell Significance Index: 15.6000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0146
Cell Significance Index: 27.4700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0056
Cell Significance Index: 8.6000
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0038
Cell Significance Index: 6.9800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0002
Cell Significance Index: 0.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0026
Cell Significance Index: -1.9100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0048
Cell Significance Index: -0.0800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0130
Cell Significance Index: -17.7300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0157
Cell Significance Index: -9.7800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0239
Cell Significance Index: -15.1800
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0277
Cell Significance Index: -0.3300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0449
Cell Significance Index: -3.4500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0454
Cell Significance Index: -4.6400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0509
Cell Significance Index: -23.1100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0549
Cell Significance Index: -30.9700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0602
Cell Significance Index: -1.6100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0741
Cell Significance Index: -4.1600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0761
Cell Significance Index: -16.0300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1395
Cell Significance Index: -16.2600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1759
Cell Significance Index: -20.1600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1918
Cell Significance Index: -6.7400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2145
Cell Significance Index: -31.1800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2382
Cell Significance Index: -12.4100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2480
Cell Significance Index: -28.3100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2906
Cell Significance Index: -4.9800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3077
Cell Significance Index: -7.8600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3305
Cell Significance Index: -22.2200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3531
Cell Significance Index: -11.3100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3571
Cell Significance Index: -28.2800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3656
Cell Significance Index: -3.7900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3722
Cell Significance Index: -6.8800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4522
Cell Significance Index: -47.0800
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.4902
Cell Significance Index: -7.9100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5081
Cell Significance Index: -3.0700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5145
Cell Significance Index: -7.7100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5840
Cell Significance Index: -17.2000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5963
Cell Significance Index: -12.7000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6014
Cell Significance Index: -15.4600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6611
Cell Significance Index: -29.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The PSMC1 gene is a unique member of the 26S proteasome subunit family, characterized by its high degree of similarity to other subunits, but with distinct features that distinguish it from other subunits. Some key characteristics of the PSMC1 gene include: * High expression levels in various cell types, including placental villous trophoblast, epithelial cells of nephron, enteric neurons, and cortical thymic epithelial cells. * Conserved ATPase activity, which is essential for the degradation of proteins. * Ability to interact with other subunits of the 26S proteasome to form a functional complex. * Involvement in various cellular processes, including cell cycle regulation, apoptosis, and immune response. **Pathways and Functions** The PSMC1 gene is involved in various cellular pathways, including: * **Ubiquitin-proteasome pathway (UPP)**: The PSMC1 gene plays a crucial role in the UPP, which is responsible for the degradation of proteins that are no longer needed or damaged. * **Cell cycle regulation**: The PSMC1 gene is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it helps to degrade proteins that are necessary for cell cycle progression. * **Apoptosis**: The PSMC1 gene is involved in the regulation of apoptosis, where it helps to degrade proteins that are necessary for cell survival. * **Immune response**: The PSMC1 gene is involved in the regulation of the immune response, particularly in the context of antigen presentation and processing. The PSMC1 gene also interacts with other proteins and pathways, including: * **NEDD8**: The PSMC1 gene interacts with NEDD8, a ubiquitin-like protein that plays a crucial role in the UPP. * **ATP**: The PSMC1 gene is dependent on ATP for its activity, which is essential for the degradation of proteins. * **WNT/β-catenin signaling**: The PSMC1 gene interacts with the WNT/β-catenin signaling pathway, which is involved in cell proliferation and differentiation. **Clinical Significance** The PSMC1 gene has been implicated in various diseases, including: * **Cancer**: The PSMC1 gene has been found to be overexpressed in various types of cancer, including breast cancer and lung cancer. * **Neurodegenerative diseases**: The PSMC1 gene has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. * **Immunological disorders**: The PSMC1 gene has been implicated in immunological disorders, including autoimmune diseases and immunodeficiency disorders. Overall, the PSMC1 gene plays a critical role in various cellular processes, including cell cycle regulation, apoptosis, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of the PSMC1 gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome regulatory subunit 4

Genular Protein ID: 1048963960

Symbol: PRS4_HUMAN

Name: 26S proteasome regulatory subunit 4

UniProtKB Accession Codes:

P62191 B4DR63 P49014 Q03527 Q6IAW0 Q6NW36 Q96AZ3

Database IDs:

Citations:

PubMed ID: 1429620

Title: Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family.

PubMed ID: 1429620

DOI: 10.1016/s0021-9258(18)50002-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 11734547

Title: Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex.

PubMed ID: 11734547

DOI: 10.1093/hmg/10.24.2821

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15358861

Title: A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins.

PubMed ID: 15358861

DOI: 10.1073/pnas.0405663101

PubMed ID: 15831487

Title: Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases.

PubMed ID: 15831487

DOI: 10.1128/mcb.25.9.3842-3853.2005

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17370265

Title: Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.

PubMed ID: 17370265

DOI: 10.1002/pmic.200600410

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 35861243

Title: PSMC1 variant causes a novel neurological syndrome.

PubMed ID: 35861243

DOI: 10.1111/cge.14195

Sequence Information:

Length: 440
Mass: 49185
Checksum: ACA80782F4F96F49
Sequence:

MGQSQSGGHG PGGGKKDDKD KKKKYEPPVP TRVGKKKKKT KGPDAASKLP LVTPHTQCRL 
KLLKLERIKD YLLMEEEFIR NQEQMKPLEE KQEEERSKVD DLRGTPMSVG TLEEIIDDNH 
AIVSTSVGSE HYVSILSFVD KDLLEPGCSV LLNHKVHAVI GVLMDDTDPL VTVMKVEKAP 
QETYADIGGL DNQIQEIKES VELPLTHPEY YEEMGIKPPK GVILYGPPGT GKTLLAKAVA 
NQTSATFLRV VGSELIQKYL GDGPKLVREL FRVAEEHAPS IVFIDEIDAI GTKRYDSNSG 
GEREIQRTML ELLNQLDGFD SRGDVKVIMA TNRIETLDPA LIRPGRIDRK IEFPLPDEKT 
KKRIFQIHTS RMTLADDVTL DDLIMAKDDL SGADIKAICT EAGLMALRER RMKVTNEDFK 
KSKENVLYKK QEGTPEGLYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMC1

Associated with

Cells (max top 100)

Other Information

Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family. PubMed ID: 1429620

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex. PubMed ID: 11734547

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins. PubMed ID: 15358861

Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. PubMed ID: 15831487

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. PubMed ID: 17370265

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805

Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. PubMed ID: 25807930

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

PSMC1 variant causes a novel neurological syndrome. PubMed ID: 35861243