PSMD2 | ENSG00000175166 | NCBI 5708

Details for: PSMD2

Gene ID: 5708

Symbol: PSMD2

Ensembl ID: ENSG00000175166

Description: proteasome 26S subunit ubiquitin receptor, non-ATPase 2

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 208.5567
Cell Significance Index: -32.4400
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 168.1889
Cell Significance Index: -42.6600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 113.2651
Cell Significance Index: -53.4800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 104.2197
Cell Significance Index: -42.3400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 99.0114
Cell Significance Index: -50.9300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 44.8079
Cell Significance Index: -42.7800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 38.2171
Cell Significance Index: -47.1200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.5850
Cell Significance Index: -41.7500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.0586
Cell Significance Index: -51.5300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.3134
Cell Significance Index: -37.8200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 3.5138
Cell Significance Index: 409.5000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.1797
Cell Significance Index: 219.9000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.7025
Cell Significance Index: 439.5400
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.3318
Cell Significance Index: 35.0200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2209
Cell Significance Index: 150.1200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.1495
Cell Significance Index: 10.5900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.1069
Cell Significance Index: 38.4700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0808
Cell Significance Index: 194.8400
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.0526
Cell Significance Index: 574.8400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9770
Cell Significance Index: 134.1700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9350
Cell Significance Index: 48.7100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8950
Cell Significance Index: 41.7300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.8396
Cell Significance Index: 17.5800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8171
Cell Significance Index: 22.2400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7940
Cell Significance Index: 21.2000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7870
Cell Significance Index: 40.8800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7773
Cell Significance Index: 50.1500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.7641
Cell Significance Index: 56.9500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.7294
Cell Significance Index: 20.9100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7276
Cell Significance Index: 321.6800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7240
Cell Significance Index: 85.3800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.7024
Cell Significance Index: 36.8800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6592
Cell Significance Index: 30.9800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6474
Cell Significance Index: 129.8600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.6393
Cell Significance Index: 6.9500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.5237
Cell Significance Index: 67.1400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4629
Cell Significance Index: 32.7400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4237
Cell Significance Index: 9.1800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4201
Cell Significance Index: 41.5600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.4129
Cell Significance Index: 257.8600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4112
Cell Significance Index: 78.2600
Cell Name: lactocyte (CL0002325)
Fold Change: 0.3997
Cell Significance Index: 51.6400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3755
Cell Significance Index: 74.5100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.3530
Cell Significance Index: 4.0100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3472
Cell Significance Index: 240.1200
Cell Name: germ cell (CL0000586)
Fold Change: 0.3265
Cell Significance Index: 2.4700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2773
Cell Significance Index: 7.4300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2544
Cell Significance Index: 7.4700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2199
Cell Significance Index: 78.8600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2167
Cell Significance Index: 13.6600
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.1978
Cell Significance Index: 1.7000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1797
Cell Significance Index: 30.6800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1767
Cell Significance Index: 5.0900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0600
Cell Significance Index: 2.1100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0197
Cell Significance Index: 14.4500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0141
Cell Significance Index: 0.6400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0037
Cell Significance Index: 3.3500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0035
Cell Significance Index: -2.6200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0041
Cell Significance Index: -7.7400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0151
Cell Significance Index: -11.1800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0161
Cell Significance Index: -0.2700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0171
Cell Significance Index: -0.8600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0180
Cell Significance Index: -33.2700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0203
Cell Significance Index: -31.2600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0307
Cell Significance Index: -1.8900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0322
Cell Significance Index: -43.8500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0374
Cell Significance Index: -23.7800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0449
Cell Significance Index: -4.5900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0568
Cell Significance Index: -32.0600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0716
Cell Significance Index: -32.5100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0890
Cell Significance Index: -18.7400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1498
Cell Significance Index: -43.1100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1748
Cell Significance Index: -20.0300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1916
Cell Significance Index: -14.7000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2481
Cell Significance Index: -36.0600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2733
Cell Significance Index: -5.8200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2825
Cell Significance Index: -11.5800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2928
Cell Significance Index: -7.4800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3379
Cell Significance Index: -18.9600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3870
Cell Significance Index: -5.2800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4067
Cell Significance Index: -27.3500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4085
Cell Significance Index: -7.0000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4177
Cell Significance Index: -47.6800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4302
Cell Significance Index: -34.0700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4839
Cell Significance Index: -50.3900
Cell Name: peg cell (CL4033014)
Fold Change: -0.5908
Cell Significance Index: -13.6500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5944
Cell Significance Index: -36.4400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5946
Cell Significance Index: -10.9900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6388
Cell Significance Index: -20.4600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6961
Cell Significance Index: -18.6200
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.7179
Cell Significance Index: -10.0700
Cell Name: kidney cell (CL1000497)
Fold Change: -0.7302
Cell Significance Index: -5.8300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.7547
Cell Significance Index: -45.3100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8704
Cell Significance Index: -38.5000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.9204
Cell Significance Index: -16.2700
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.9285
Cell Significance Index: -5.6100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.0162
Cell Significance Index: -26.1200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.0167
Cell Significance Index: -38.5000
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.0394
Cell Significance Index: -25.3600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.0528
Cell Significance Index: -31.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The PSMD2 gene is a non-coding gene that encodes for a regulatory subunit of the 26S proteasome. The 26S proteasome is a complex composed of 20S proteasome core particles and 19S regulatory particles, with the PSMD2 subunit playing a key role in the recognition and processing of ubiquitinated proteins. The PSMD2 subunit is involved in the ubiquitin-proteasome pathway (UPP), which is a critical mechanism for regulating protein degradation and cell cycle progression. **Pathways and Functions** The PSMD2 gene is involved in various cellular processes, including: 1. **Apoptosis**: The 26S proteasome, with PSMD2 as a key component, regulates apoptosis (programmed cell death) by degrading pro-apoptotic proteins. 2. **Cell Cycle Progression**: The UPP, involving PSMD2, regulates cell cycle progression by degrading proteins that inhibit or promote cell cycle entry and exit. 3. **Immune Response**: The 26S proteasome, with PSMD2, plays a crucial role in regulating immune responses by degrading proteins involved in the activation and inactivation of immune cells. 4. **Antigen Processing and Presentation**: The UPP, involving PSMD2, is involved in the processing and presentation of antigens to T-cells, a critical step in the immune response. 5. **Protein Degradation**: The 26S proteasome, with PSMD2, regulates protein degradation by degrading ubiquitinated proteins. **Clinical Significance** Dysregulation of the PSMD2 gene has been associated with various diseases, including: 1. **Cancer**: Mutations in PSMD2 have been linked to various cancers, including breast, ovarian, and lung cancer. 2. **Autoimmune Disorders**: Alterations in PSMD2 have been associated with autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Developmental Abnormalities**: Mutations in PSMD2 have been linked to developmental abnormalities, including neural tube defects and congenital heart defects. 4. **Neurological Disorders**: Alterations in PSMD2 have been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the PSMD2 gene plays a critical role in regulating protein degradation, cell cycle progression, and immune responses. Dysregulation of the PSMD2 gene has been associated with various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and overall health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome non-ATPase regulatory subunit 2

Genular Protein ID: 1118580233

Symbol: PSMD2_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 2

UniProtKB Accession Codes:

Q13200 B4DX07 B4DXY1 E7EW34 E9PCS3 Q12932 Q15321 Q53XQ4 Q96I12

Database IDs:

Citations:

PubMed ID: 8774743

Title: cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.

PubMed ID: 8774743

DOI: 10.1111/j.1432-1033.1996.0912u.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9126987

Title: Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease.

PubMed ID: 9126987

PubMed ID: 7601280

Title: A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death domain'.

PubMed ID: 7601280

DOI: 10.1016/0014-5793(95)00534-g

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28539385

Title: Phosphatase UBLCP1 controls proteasome assembly.

PubMed ID: 28539385

DOI: 10.1098/rsob.170042

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 908
Mass: 100200
Checksum: FAD71E7B26101BE3
Sequence:

MEEGGRDKAP VQPQQSPAAA PGGTDEKPSG KERRDAGDKD KEQELSEEDK QLQDELEMLV 
ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR PHYGKLKEIY ENMAPGENKR 
FAADIISVLA MTMSGERECL KYRLVGSQEE LASWGHEYVR HLAGEVAKEW QELDDAEKVQ 
REPLLTLVKE IVPYNMAHNA EHEACDLLME IEQVDMLEKD IDENAYAKVC LYLTSCVNYV 
PEPENSALLR CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR 
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK THLENNRFGG 
SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY KNKDHGMLSA AASLGMILLW 
DVDGGLTQID KYLYSSEDYI KSGALLACGI VNSGVRNECD PALALLSDYV LHNSNTMRLG 
SIFGLGLAYA GSNREDVLTL LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ 
TIMEKSETEL KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY 
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ GVAVLGIALI 
AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS NPRLNILDTL SKFSHDADPE 
VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP 
YHSDRQLMSQ VAVAGLLTVL VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL 
PVSVRVGQAV DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL 
RKNPNYDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMD2

Associated with

Cells (max top 100)

Other Information

cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11. PubMed ID: 8774743

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease. PubMed ID: 9126987

A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death domain'. PubMed ID: 7601280

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. PubMed ID: 17924679

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Phosphatase UBLCP1 controls proteasome assembly. PubMed ID: 28539385

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858