Details for: PTGER2

Gene ID: 5732

Symbol: PTGER2

Ensembl ID: ENSG00000125384

Description: prostaglandin E receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.9282
    Cell Significance Index: -7.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.3288
    Cell Significance Index: -10.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.2864
    Cell Significance Index: -10.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.3003
    Cell Significance Index: -8.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.7882
    Cell Significance Index: -10.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0911
    Cell Significance Index: -7.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.5196
    Cell Significance Index: -1.4000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 5.1757
    Cell Significance Index: 13.8700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.3952
    Cell Significance Index: 7.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2400
    Cell Significance Index: -6.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1448
    Cell Significance Index: 62.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9919
    Cell Significance Index: -7.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1000
    Cell Significance Index: 20.3300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.9712
    Cell Significance Index: 10.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9542
    Cell Significance Index: 43.2500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.9345
    Cell Significance Index: 5.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6795
    Cell Significance Index: 43.8400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.6551
    Cell Significance Index: 6.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6184
    Cell Significance Index: 13.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5156
    Cell Significance Index: 60.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5148
    Cell Significance Index: 50.9300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4394
    Cell Significance Index: 2.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4045
    Cell Significance Index: 76.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3707
    Cell Significance Index: 334.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3641
    Cell Significance Index: 21.8600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.3305
    Cell Significance Index: 2.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3190
    Cell Significance Index: 34.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2785
    Cell Significance Index: 7.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2756
    Cell Significance Index: 3.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2675
    Cell Significance Index: 43.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1599
    Cell Significance Index: 11.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1111
    Cell Significance Index: 60.6800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0495
    Cell Significance Index: 0.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0430
    Cell Significance Index: 8.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0394
    Cell Significance Index: 0.6600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0219
    Cell Significance Index: 0.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0188
    Cell Significance Index: 0.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0182
    Cell Significance Index: 8.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0167
    Cell Significance Index: 0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0142
    Cell Significance Index: 0.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0065
    Cell Significance Index: 0.1400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0056
    Cell Significance Index: 0.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0033
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0032
    Cell Significance Index: -0.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0072
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0106
    Cell Significance Index: -7.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0131
    Cell Significance Index: -7.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0141
    Cell Significance Index: -10.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0144
    Cell Significance Index: -9.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0148
    Cell Significance Index: -0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0160
    Cell Significance Index: -7.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0171
    Cell Significance Index: -6.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0184
    Cell Significance Index: -2.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0219
    Cell Significance Index: -0.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0264
    Cell Significance Index: -5.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0273
    Cell Significance Index: -1.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0291
    Cell Significance Index: -8.3800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0337
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0396
    Cell Significance Index: -8.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0402
    Cell Significance Index: -5.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0466
    Cell Significance Index: -7.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0478
    Cell Significance Index: -1.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0540
    Cell Significance Index: -1.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0541
    Cell Significance Index: -9.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0563
    Cell Significance Index: -2.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0603
    Cell Significance Index: -1.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0605
    Cell Significance Index: -1.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0621
    Cell Significance Index: -9.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0659
    Cell Significance Index: -7.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0676
    Cell Significance Index: -7.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0774
    Cell Significance Index: -7.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0784
    Cell Significance Index: -9.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0789
    Cell Significance Index: -9.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0870
    Cell Significance Index: -2.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1055
    Cell Significance Index: -8.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1119
    Cell Significance Index: -8.3400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1201
    Cell Significance Index: -2.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1233
    Cell Significance Index: -5.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1285
    Cell Significance Index: -8.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1354
    Cell Significance Index: -10.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1411
    Cell Significance Index: -7.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1425
    Cell Significance Index: -8.7600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1438
    Cell Significance Index: -1.2800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1512
    Cell Significance Index: -5.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1531
    Cell Significance Index: -8.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1599
    Cell Significance Index: -2.4100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1611
    Cell Significance Index: -1.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1646
    Cell Significance Index: -7.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1691
    Cell Significance Index: -8.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1721
    Cell Significance Index: -8.9700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1778
    Cell Significance Index: -2.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1816
    Cell Significance Index: -2.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1839
    Cell Significance Index: -6.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The PTGER2 gene has several key characteristics that define its function and expression: 1. **G protein-coupled receptor**: The EP2 receptor belongs to the class A/1 rhodopsin-like receptors, which are G protein-coupled receptors that respond to ligand binding. 2. **Prostaglandin E receptor**: The EP2 receptor is specifically activated by PGE2, a prostaglandin that plays a crucial role in inflammation, immune responses, and cell proliferation. 3. **Adenylate cyclase-activating**: The EP2 receptor activates adenylate cyclase, leading to increased cAMP levels and subsequent signaling cascades. 4. **Inflammatory response**: The EP2 receptor is involved in regulating inflammatory responses, including the production of pro-inflammatory cytokines. 5. **Cell proliferation**: The EP2 receptor regulates cell proliferation in various cell types, including immune cells and smooth muscle cells. **Pathways and Functions** The PTGER2 gene is involved in several signaling pathways, including: 1. **Adenylate cyclase-activating G protein-coupled receptor signaling pathway**: The EP2 receptor activates adenylate cyclase, leading to increased cAMP levels and subsequent signaling cascades. 2. **Inflammatory response**: The EP2 receptor regulates inflammatory responses, including the production of pro-inflammatory cytokines. 3. **Cell proliferation**: The EP2 receptor regulates cell proliferation in various cell types, including immune cells and smooth muscle cells. 4. **G alpha (s) signaling events**: The EP2 receptor activates G alpha s, leading to increased cAMP levels and subsequent signaling cascades. The functions of the PTGER2 gene include: 1. **Regulation of immune responses**: The EP2 receptor regulates immune responses, including the production of pro-inflammatory cytokines. 2. **Regulation of cell proliferation**: The EP2 receptor regulates cell proliferation in various cell types, including immune cells and smooth muscle cells. 3. **Regulation of inflammation**: The EP2 receptor regulates inflammatory responses, including the production of pro-inflammatory cytokines. **Clinical Significance** The PTGER2 gene has significant clinical implications, including: 1. **Inflammatory disorders**: The EP2 receptor is involved in regulating inflammatory responses, making it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and asthma. 2. **Cancer**: The EP2 receptor is involved in regulating cell proliferation, making it a potential target for the treatment of cancer. 3. **Cardiovascular disease**: The EP2 receptor is involved in regulating inflammation and cell proliferation, making it a potential target for the treatment of cardiovascular disease. 4. **Neurological disorders**: The EP2 receptor is involved in regulating inflammation and cell proliferation, making it a potential target for the treatment of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, the PTGER2 gene encodes for the prostaglandin E2 receptor 2 (EP2), a subtype of prostaglandin E receptors that plays a crucial role in mediating the effects of prostaglandin E2. The EP2 receptor is involved in regulating inflammatory responses, cell proliferation, and immune responses, making it a potential target for the treatment of various diseases.

Genular Protein ID: 995930412

Symbol: PE2R2_HUMAN

Name: Prostaglandin E2 receptor EP2 subtype

UniProtKB Accession Codes:

P43116 D3DSC0 Q52LG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EMBL 10 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8078484

Title: Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.

PubMed ID: 8078484

PubMed ID: 10521663

Title: Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E2 receptor EP2 subtype.

PubMed ID: 10521663

DOI: 10.1016/s0378-1119(99)00323-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 358
  • Mass: 39761
  • Checksum: B3B0E2AA3CF2E363
  • Sequence:
    • MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW RGDVGCSAGR 
RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV ALAPESRACT YFAFAMTFFS 
LATMLMLFAM ALERYLSIGH PYFYQRRVSR SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ 
YCPGTWCFIR HGRTAYLQLY ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS 
GRGGPGARRR GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA 
LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS DASKQADL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.