Details for: RAD21

Gene ID: 5885

Symbol: RAD21

Ensembl ID: ENSG00000164754

Description: RAD21 cohesin complex component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 332.1221
    Cell Significance Index: -51.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 257.7043
    Cell Significance Index: -65.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 188.2521
    Cell Significance Index: -77.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 160.3821
    Cell Significance Index: -75.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 158.1018
    Cell Significance Index: -64.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 142.7626
    Cell Significance Index: -73.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 113.2302
    Cell Significance Index: -75.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.9659
    Cell Significance Index: -64.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.7741
    Cell Significance Index: -70.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.2495
    Cell Significance Index: -67.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.8543
    Cell Significance Index: -74.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.3306
    Cell Significance Index: -53.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.6566
    Cell Significance Index: -27.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 7.4010
    Cell Significance Index: 862.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.3166
    Cell Significance Index: 2994.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.2633
    Cell Significance Index: 117.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2060
    Cell Significance Index: 358.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.0564
    Cell Significance Index: 54.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9953
    Cell Significance Index: 235.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5960
    Cell Significance Index: 316.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2830
    Cell Significance Index: 257.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2420
    Cell Significance Index: 152.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2395
    Cell Significance Index: 170.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1913
    Cell Significance Index: 66.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1521
    Cell Significance Index: 207.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0980
    Cell Significance Index: 485.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0719
    Cell Significance Index: 585.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0632
    Cell Significance Index: 68.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0063
    Cell Significance Index: 26.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9803
    Cell Significance Index: 28.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8940
    Cell Significance Index: 88.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8649
    Cell Significance Index: 30.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6786
    Cell Significance Index: 86.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6755
    Cell Significance Index: 242.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6517
    Cell Significance Index: 17.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6459
    Cell Significance Index: 30.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5940
    Cell Significance Index: 36.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5467
    Cell Significance Index: 25.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5312
    Cell Significance Index: 33.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4882
    Cell Significance Index: 25.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4813
    Cell Significance Index: 332.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4260
    Cell Significance Index: 9.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3958
    Cell Significance Index: 27.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3445
    Cell Significance Index: 7.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2801
    Cell Significance Index: 8.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1800
    Cell Significance Index: 8.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1118
    Cell Significance Index: 14.4400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1021
    Cell Significance Index: 1.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0749
    Cell Significance Index: 5.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0502
    Cell Significance Index: 9.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0379
    Cell Significance Index: 71.4100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0316
    Cell Significance Index: 0.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0220
    Cell Significance Index: 0.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0100
    Cell Significance Index: 1.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0118
    Cell Significance Index: -21.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0151
    Cell Significance Index: -23.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0190
    Cell Significance Index: -14.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0274
    Cell Significance Index: -37.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0305
    Cell Significance Index: -0.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0319
    Cell Significance Index: -3.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0339
    Cell Significance Index: -2.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0458
    Cell Significance Index: -28.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0546
    Cell Significance Index: -1.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0665
    Cell Significance Index: -30.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0823
    Cell Significance Index: -46.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0983
    Cell Significance Index: -10.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1238
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1782
    Cell Significance Index: -37.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1854
    Cell Significance Index: -9.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2158
    Cell Significance Index: -62.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2756
    Cell Significance Index: -40.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2944
    Cell Significance Index: -3.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3447
    Cell Significance Index: -11.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3730
    Cell Significance Index: -25.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3861
    Cell Significance Index: -44.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3892
    Cell Significance Index: -6.6700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4609
    Cell Significance Index: -52.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5346
    Cell Significance Index: -3.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6314
    Cell Significance Index: -16.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6598
    Cell Significance Index: -68.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7265
    Cell Significance Index: -13.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7271
    Cell Significance Index: -57.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7464
    Cell Significance Index: -8.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7530
    Cell Significance Index: -18.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8745
    Cell Significance Index: -22.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9015
    Cell Significance Index: -12.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9043
    Cell Significance Index: -40.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9156
    Cell Significance Index: -19.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9474
    Cell Significance Index: -25.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0431
    Cell Significance Index: -24.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1152
    Cell Significance Index: -42.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1476
    Cell Significance Index: -70.3600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1637
    Cell Significance Index: -8.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3106
    Cell Significance Index: -25.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.3358
    Cell Significance Index: -38.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.3750
    Cell Significance Index: -29.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4527
    Cell Significance Index: -37.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cohesin Complex Component:** RAD21 is a key component of the cohesin complex, which is responsible for holding sister chromatids together during mitosis and meiosis. 2. **DNA Binding:** RAD21 interacts with various DNA-binding proteins, including histones, transcription factors, and chromatin remodeling complexes, to regulate gene expression and maintain genome stability. 3. **Regulation of Cell Cycle:** RAD21 plays a crucial role in regulating the cell cycle, particularly during the G2/M transition, where it acts as a negative regulator to prevent premature entry into mitosis. 4. **DNA Repair:** RAD21 is involved in the repair of double-strand breaks through sister chromatid exchange, ensuring genome stability and preventing mutations. **Pathways and Functions:** RAD21 is involved in various cellular processes, including: 1. **Apoptotic Process:** RAD21 regulates apoptosis by interacting with pro-apoptotic and anti-apoptotic proteins, influencing the balance between cell survival and death. 2. **Cell Cycle:** RAD21 regulates the cell cycle by interacting with cyclin-dependent kinases and other cell cycle regulators, ensuring proper progression through the cell cycle. 3. **DNA Repair:** RAD21 is involved in the repair of double-strand breaks through sister chromatid exchange, ensuring genome stability and preventing mutations. 4. **Transcriptional Regulation:** RAD21 interacts with transcription factors and chromatin remodeling complexes to regulate gene expression and maintain genome stability. 5. **Chromosome Segregation:** RAD21 ensures proper chromosome segregation during mitosis and meiosis by maintaining sister chromatid cohesion. **Clinical Significance:** Dysregulation of RAD21 has been implicated in various diseases, including: 1. **Cancer:** RAD21 can act as an oncogene or tumor suppressor, depending on the context, and its dysregulation has been linked to various types of cancer. 2. **Immune Disorders:** RAD21 has been implicated in immune disorders, including autoimmune diseases and immunodeficiency disorders, where it regulates immune cell function and cytokine production. 3. **Neurological Disorders:** RAD21 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates neuronal function and survival. In conclusion, RAD21 is a critical gene that plays a central role in maintaining genome stability, regulating cell cycle progression, and influencing cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms by which RAD21 regulates cellular processes and to develop therapeutic strategies targeting this gene in disease prevention and treatment.

Genular Protein ID: 2509991313

Symbol: RAD21_HUMAN

Name: Double-strand-break repair protein rad21 homolog

UniProtKB Accession Codes:

O60216 A8K0E0 Q15001 Q99568

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 EMDB 6 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8812457

Title: Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse.

PubMed ID: 8812457

DOI: 10.1006/geno.1996.0466

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10931856

Title: Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes.

PubMed ID: 10931856

DOI: 10.1083/jcb.150.3.405

PubMed ID: 11590136

Title: A potential role for human cohesin in mitotic spindle aster assembly.

PubMed ID: 11590136

DOI: 10.1074/jbc.m103364200

PubMed ID: 11931760

Title: The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase.

PubMed ID: 11931760

DOI: 10.1016/s1097-2765(02)00473-2

PubMed ID: 12417729

Title: Linking sister chromatid cohesion and apoptosis: role of rad21.

PubMed ID: 12417729

DOI: 10.1128/mcb.22.23.8267-8277.2002

PubMed ID: 10623634

Title: NXP-1, a human protein related to Rad21/Scc1/Mcd1, is a component of the nuclear matrix.

PubMed ID: 10623634

DOI: 10.1006/bbrc.1999.1969

PubMed ID: 11073952

Title: Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres.

PubMed ID: 11073952

DOI: 10.1074/jbc.m007809200

PubMed ID: 11509732

Title: Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.

PubMed ID: 11509732

DOI: 10.1126/science.1061376

PubMed ID: 11875078

Title: Caspase proteolysis of the cohesin component RAD21 promotes apoptosis.

PubMed ID: 11875078

DOI: 10.1074/jbc.m201322200

PubMed ID: 12198550

Title: A chromatin remodelling complex that loads cohesin onto human chromosomes.

PubMed ID: 12198550

DOI: 10.1038/nature01024

PubMed ID: 15837422

Title: Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.

PubMed ID: 15837422

DOI: 10.1016/j.molcel.2005.03.017

PubMed ID: 17105772

Title: The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.

PubMed ID: 17105772

DOI: 10.1242/jcs.03262

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19696148

Title: Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.

PubMed ID: 19696148

DOI: 10.1101/gad.1844309

PubMed ID: 11483345

Title: Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients.

PubMed ID: 11483345

DOI: 10.1016/s0360-3016(01)01608-x

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22628566

Title: In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex.

PubMed ID: 22628566

DOI: 10.1073/pnas.1206840109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32409525

Title: Cryo-EM structure of the human cohesin-NIPBL-DNA complex.

PubMed ID: 32409525

DOI: 10.1126/science.abb0981

PubMed ID: 22633399

Title: RAD21 mutations cause a human cohesinopathy.

PubMed ID: 22633399

DOI: 10.1016/j.ajhg.2012.04.019

PubMed ID: 25575569

Title: Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstruction.

PubMed ID: 25575569

DOI: 10.1053/j.gastro.2014.12.034

PubMed ID: 31334757

Title: Cohesin complex-associated holoprosencephaly.

PubMed ID: 31334757

DOI: 10.1093/brain/awz210

Sequence Information:

  • Length: 631
  • Mass: 71690
  • Checksum: 7D4A6EA6392BE73D
  • Sequence:
    • MFYAHFVLSK RGPLAKIWLA AHWDKKLTKA HVFECNLESS VESIISPKVK MALRTSGHLL 
LGVVRIYHRK AKYLLADCNE AFIKIKMAFR PGVVDLPEEN REAAYNAITL PEEFHDFDQP 
LPDLDDIDVA QQFSLNQSRV EEITMREEVG NISILQENDF GDFGMDDREI MREGSAFEDD 
DMLVSTTTSN LLLESEQSTS NLNEKINHLE YEDQYKDDNF GEGNDGGILD DKLISNNDGG 
IFDDPPALSE AGVMLPEQPA HDDMDEDDNV SMGGPDSPDS VDPVEPMPTM TDQTTLVPNE 
EEAFALEPID ITVKETKAKR KRKLIVDSVK ELDSKTIRAQ LSDYSDIVTT LDLAPPTKKL 
MMWKETGGVE KLFSLPAQPL WNNRLLKLFT RCLTPLVPED LRKRRKGGEA DNLDEFLKEF 
ENPEVPREDQ QQQHQQRDVI DEPIIEEPSR LQESVMEASR TNIDESAMPP PPPQGVKRKA 
GQIDPEPVMP PQQVEQMEIP PVELPPEEPP NICQLIPELE LLPEKEKEKE KEKEDDEEEE 
DEDASGGDQD QEERRWNKRT QQMLHGLQRA LAKTGAESIS LLELCRNTNR KQAAAKFYSF 
LVLKKQQAIE LTQEEPYSDI IATPGPRFHI I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.