Details for: RAD23B

Gene ID: 5887

Symbol: RAD23B

Ensembl ID: ENSG00000119318

Description: RAD23 homolog B, nucleotide excision repair protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 337.7796
    Cell Significance Index: -52.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 225.4938
    Cell Significance Index: -57.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 149.3637
    Cell Significance Index: -61.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 133.4623
    Cell Significance Index: -54.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 132.1055
    Cell Significance Index: -62.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 118.3354
    Cell Significance Index: -60.8700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 93.0223
    Cell Significance Index: -62.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.3034
    Cell Significance Index: -54.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.6449
    Cell Significance Index: -61.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.3627
    Cell Significance Index: -51.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.9970
    Cell Significance Index: -63.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.7808
    Cell Significance Index: -48.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.3276
    Cell Significance Index: -26.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.7753
    Cell Significance Index: 154.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.7640
    Cell Significance Index: 63.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4847
    Cell Significance Index: 33.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.3120
    Cell Significance Index: 60.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2645
    Cell Significance Index: 449.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.0580
    Cell Significance Index: 52.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9141
    Cell Significance Index: 383.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6006
    Cell Significance Index: 260.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3934
    Cell Significance Index: 48.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2966
    Cell Significance Index: 67.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2539
    Cell Significance Index: 70.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2031
    Cell Significance Index: 1086.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1808
    Cell Significance Index: 145.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1753
    Cell Significance Index: 211.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1701
    Cell Significance Index: 89.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0529
    Cell Significance Index: 28.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0503
    Cell Significance Index: 78.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0407
    Cell Significance Index: 134.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0164
    Cell Significance Index: 555.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0085
    Cell Significance Index: 47.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9852
    Cell Significance Index: 135.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9290
    Cell Significance Index: 333.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9272
    Cell Significance Index: 26.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9137
    Cell Significance Index: 47.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9084
    Cell Significance Index: 401.6400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8981
    Cell Significance Index: 5.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8822
    Cell Significance Index: 21.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7443
    Cell Significance Index: 20.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7026
    Cell Significance Index: 32.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6624
    Cell Significance Index: 6.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6365
    Cell Significance Index: 62.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6019
    Cell Significance Index: 42.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5482
    Cell Significance Index: 24.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5205
    Cell Significance Index: 61.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4528
    Cell Significance Index: 77.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3437
    Cell Significance Index: 9.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3023
    Cell Significance Index: 5.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2885
    Cell Significance Index: 17.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2357
    Cell Significance Index: 30.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2141
    Cell Significance Index: 394.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1864
    Cell Significance Index: 350.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1710
    Cell Significance Index: 11.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1636
    Cell Significance Index: 103.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1574
    Cell Significance Index: 10.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1435
    Cell Significance Index: 220.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1301
    Cell Significance Index: 6.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1096
    Cell Significance Index: 2.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0922
    Cell Significance Index: 10.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0861
    Cell Significance Index: 39.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0696
    Cell Significance Index: 13.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0575
    Cell Significance Index: 2.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0554
    Cell Significance Index: 75.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0480
    Cell Significance Index: 1.1100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0215
    Cell Significance Index: 0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0092
    Cell Significance Index: 6.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0061
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0209
    Cell Significance Index: -1.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0308
    Cell Significance Index: -0.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0338
    Cell Significance Index: -24.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0392
    Cell Significance Index: -5.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0393
    Cell Significance Index: -24.5300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0707
    Cell Significance Index: -1.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0748
    Cell Significance Index: -7.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0819
    Cell Significance Index: -46.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1217
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1421
    Cell Significance Index: -29.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1669
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1851
    Cell Significance Index: -21.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1858
    Cell Significance Index: -53.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1924
    Cell Significance Index: -8.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1934
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2067
    Cell Significance Index: -23.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2602
    Cell Significance Index: -3.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2757
    Cell Significance Index: -8.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2863
    Cell Significance Index: -10.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2923
    Cell Significance Index: -34.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3063
    Cell Significance Index: -8.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4428
    Cell Significance Index: -2.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4471
    Cell Significance Index: -46.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5087
    Cell Significance Index: -30.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5418
    Cell Significance Index: -13.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6200
    Cell Significance Index: -7.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6366
    Cell Significance Index: -50.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6474
    Cell Significance Index: -11.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6827
    Cell Significance Index: -20.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7175
    Cell Significance Index: -7.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Nucleotide Excision Repair (NER) Protein**: RAD23B is a NER protein that recognizes and repairs UV-induced DNA damage, including cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). 2. **Incision Complex Formation**: RAD23B regulates the formation of the incision complex, a critical step in the NER pathway, by interacting with other proteins such as XPC and ERCC1. 3. **Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process**: RAD23B is involved in the regulation of proteasome-mediated ubiquitin-dependent protein catabolic process, which is essential for protein quality control and genome stability. 4. **Cellular Response to Interleukin-7**: RAD23B is also involved in the cellular response to interleukin-7, a cytokine that regulates immune cell development and function. **Pathways and Functions:** RAD23B is integrated into various cellular pathways, including: 1. **Asparagine N-Linked Glycosylation**: RAD23B interacts with proteins involved in asparagine N-linked glycosylation, a post-translational modification process that regulates protein function and stability. 2. **Cytosol**: RAD23B is localized to the cytosol, where it interacts with other proteins and regulates various cellular processes. 3. **Damaged DNA Binding**: RAD23B recognizes and binds to damaged DNA, facilitating the recruitment of other repair proteins. 4. **Deubiquitination**: RAD23B is involved in deubiquitination, a process that regulates protein degradation and ubiquitination. 5. **DNA Damage Recognition in GG-NER**: RAD23B is essential for the recognition of DNA damage in the global genome nucleotide excision repair (GG-NER) pathway. **Clinical Significance:** RAD23B dysfunction or mutations have been implicated in various diseases, including: 1. **Cancer**: RAD23B mutations have been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Disorders**: RAD23B has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Developmental Disorders**: RAD23B mutations have been associated with developmental disorders, including craniosynostosis and congenital heart defects. In conclusion, RAD23B is a critical component of the nucleotide excision repair pathway, regulating incision complex formation, proteasome-mediated ubiquitin-dependent protein catabolic process, and cellular response to interleukin-7. Its dysfunction or mutations have been implicated in various diseases, highlighting the importance of RAD23B in maintaining genome stability and tissue homeostasis. Further research is needed to fully elucidate the function and clinical significance of RAD23B.

Genular Protein ID: 852016860

Symbol: RD23B_HUMAN

Name: UV excision repair protein RAD23 homolog B

UniProtKB Accession Codes:

P54727 B3KWK8 G5E9P0 Q7Z5K8 Q8WUB0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CPTAC 7 CPTC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8168482

Title: Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

PubMed ID: 8168482

DOI: 10.1002/j.1460-2075.1994.tb06452.x

PubMed ID: 15064313

Title: Expression of a novel RAD23B mRNA splice variant in the human testis.

PubMed ID: 15064313

DOI: 10.1002/j.1939-4640.2004.tb02801.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9372924

Title: Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.

PubMed ID: 9372924

DOI: 10.1128/mcb.17.12.6924

PubMed ID: 9734359

Title: Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.

PubMed ID: 9734359

DOI: 10.1016/s1097-2765(00)80132-x

PubMed ID: 10488153

Title: Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome.

PubMed ID: 10488153

DOI: 10.1074/jbc.274.39.28019

PubMed ID: 10915768

Title: Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.

PubMed ID: 10915768

DOI: 10.1093/hmg/9.12.1795

PubMed ID: 10873465

Title: Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.

PubMed ID: 10873465

DOI: 10.1006/jmbi.2000.3857

PubMed ID: 11279143

Title: Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.

PubMed ID: 11279143

DOI: 10.1074/jbc.m100855200

PubMed ID: 12509299

Title: A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex.

PubMed ID: 12509299

DOI: 10.1016/s1568-7864(01)00008-8

PubMed ID: 12509233

Title: The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH.

PubMed ID: 12509233

DOI: 10.1016/s1568-7864(02)00031-9

PubMed ID: 12547395

Title: DNA bending by the human damage recognition complex XPC-HR23B.

PubMed ID: 12547395

DOI: 10.1016/s1568-7864(02)00222-7

PubMed ID: 12815074

Title: A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein.

PubMed ID: 12815074

DOI: 10.1101/gad.260003

PubMed ID: 15358861

Title: A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins.

PubMed ID: 15358861

DOI: 10.1073/pnas.0405663101

PubMed ID: 16253613

Title: Studies on the intracellular localization of hHR23B.

PubMed ID: 16253613

DOI: 10.1016/j.bbrc.2005.09.192

PubMed ID: 15964821

Title: Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.

PubMed ID: 15964821

DOI: 10.1128/mcb.25.13.5664-5674.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16712842

Title: Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B.

PubMed ID: 16712842

DOI: 10.1016/j.febslet.2006.05.012

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19435460

Title: Variably modulated gating of the 26S proteasome by ATP and polyubiquitin.

PubMed ID: 19435460

DOI: 10.1042/bj20090528

PubMed ID: 19941824

Title: Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning.

PubMed ID: 19941824

DOI: 10.1016/j.molcel.2009.09.035

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20028083

Title: Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct.

PubMed ID: 20028083

DOI: 10.1021/bi901575h

PubMed ID: 20798892

Title: Stimulation of DNA glycosylase activities by XPC Protein Complex: Roles of protein-protein interactions.

PubMed ID: 20798892

DOI: 10.4061/2010/805698

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30455355

Title: Physiological and pathophysiological characteristics of ataxin-3 isoforms.

PubMed ID: 30455355

DOI: 10.1074/jbc.ra118.005801

PubMed ID: 12832454

Title: Binding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5a.

PubMed ID: 12832454

DOI: 10.1074/jbc.m304628200

PubMed ID: 14585839

Title: Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B.

PubMed ID: 14585839

DOI: 10.1074/jbc.m309448200

PubMed ID: 15885096

Title: Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B.

PubMed ID: 15885096

DOI: 10.1111/j.1742-4658.2005.04667.x

Sequence Information:

  • Length: 409
  • Mass: 43171
  • Checksum: C026C78273BCB289
  • Sequence:
    • MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK 
EYKIDEKNFV VVMVTKPKAV STPAPATTQQ SAPASTTAVT SSTTTTVAQA PTPVPALAPT 
STPASITPAS ATASSEPAPA SAAKQEKPAE KPAETPVATS PTATDSTSGD SSRSNLFEDA 
TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD 
PPQAASTGAP QSSAVAAAAA TTTATTTTTS SGGHPLEFLR NQPQFQQMRQ IIQQNPSLLP 
ALLQQIGREN PQLLQQISQH QEHFIQMLNE PVQEAGGQGG GGGGGSGGIA EAGSGHMNYI 
QVTPQEKEAI ERLKALGFPE GLVIQAYFAC EKNENLAANF LLQQNFDED

Genular Protein ID: 1930210971

Symbol: B7Z4W4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z4W4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 2 InterPro 9 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 2 RuleBase 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 388
  • Mass: 40713
  • Checksum: 68B1658E6A767753
  • Sequence:
    • MVKALKEKIE SEKGKDAFPV AGQKLIYAGK ILNDDTALKE YKIDEKNFVV VMVTKPKAVS 
TPAPATTQQS APASTTAVTS STTTTVAQAP TPVPALAPTS TPASITPASA TASSEPAPAS 
AAKQEKPAEK PAETPVATSP TATDSTSGDS SRSNLFEDAT SALVTGQSYE NMVTEIMSMG 
YEREQVIAAL RASFNNPDRA VEYLLMGIPG DRESQAVVDP PQAASTGAPQ SSAVAAAAAT 
TTATTTTTSS GGHPLEFLRN QPQFQQMRQI IQQNPSLLPA LLQQIGRENP QLLQQISQHQ 
EHFIQMLNEP VQEAGGQGGG GGGGSGGIAE AGSGHMNYIQ VTPQEKEAIE RLKALGFPEG 
LVIQAYFACE KNENLAANFL LQQNFDED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.