RPS18 | ENSG00000231500 | NCBI 6222

Details for: RPS18

Gene ID: 6222

Symbol: RPS18

Ensembl ID: ENSG00000231500

Description: ribosomal protein S18

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)
Small ribosomal subunit
(GO:0015935)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 852.6620
Cell Significance Index: -346.4000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 843.7238
Cell Significance Index: -347.5700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 738.4310
Cell Significance Index: -348.6300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 707.4270
Cell Significance Index: -363.8900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 521.8159
Cell Significance Index: -350.1500
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 94.7704
Cell Significance Index: 2363.3000
Cell Name: theca cell (CL0000503)
Fold Change: 37.2458
Cell Significance Index: 218.8200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 35.6159
Cell Significance Index: -95.4100
Cell Name: pro-T cell (CL0000827)
Fold Change: 23.0853
Cell Significance Index: 589.7600
Cell Name: abnormal cell (CL0001061)
Fold Change: 19.4524
Cell Significance Index: 1987.0600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 17.0605
Cell Significance Index: 801.8300
Cell Name: granulosa cell (CL0000501)
Fold Change: 16.8219
Cell Significance Index: 442.3300
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 15.1612
Cell Significance Index: 130.2800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 14.3625
Cell Significance Index: 300.6300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 14.2406
Cell Significance Index: 251.6500
Cell Name: peg cell (CL4033014)
Fold Change: 13.4702
Cell Significance Index: 311.2100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 13.1310
Cell Significance Index: 376.4100
Cell Name: lactocyte (CL0002325)
Fold Change: 12.8563
Cell Significance Index: 1660.9500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 12.8014
Cell Significance Index: 145.4300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 12.6401
Cell Significance Index: 893.9600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 12.3223
Cell Significance Index: 133.9600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 11.9075
Cell Significance Index: 413.7800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 11.8758
Cell Significance Index: 152.0900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 11.6092
Cell Significance Index: 71.4400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 10.6981
Cell Significance Index: 797.3200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 10.4130
Cell Significance Index: 1430.0000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 10.3983
Cell Significance Index: 1874.4900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 10.3359
Cell Significance Index: 4569.7500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 10.2808
Cell Significance Index: 1264.1200
Cell Name: odontoblast (CL0000060)
Fold Change: 9.8288
Cell Significance Index: 1259.9900
Cell Name: cell in vitro (CL0001034)
Fold Change: 9.1882
Cell Significance Index: 5017.8700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 8.7660
Cell Significance Index: 1033.7800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 7.9900
Cell Significance Index: 6047.7900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 7.6043
Cell Significance Index: 490.5900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 6.8787
Cell Significance Index: 202.0200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 6.5896
Cell Significance Index: 345.9800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 6.2585
Cell Significance Index: 291.8000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.6357
Cell Significance Index: 153.4000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 4.3633
Cell Significance Index: 40.1800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 4.3426
Cell Significance Index: 741.5200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 4.1757
Cell Significance Index: 3770.3100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.1316
Cell Significance Index: 57.8800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 2.1699
Cell Significance Index: 1590.9600
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.0580
Cell Significance Index: 14.7800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.0423
Cell Significance Index: 405.3100
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 1.8982
Cell Significance Index: 5.0800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.8659
Cell Significance Index: 84.5800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.3706
Cell Significance Index: 108.5600
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 1.3382
Cell Significance Index: 27.9100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.2359
Cell Significance Index: 141.5900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2315
Cell Significance Index: 234.3700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9581
Cell Significance Index: 49.7700
Cell Name: kidney cell (CL1000497)
Fold Change: 0.7540
Cell Significance Index: 6.0200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3592
Cell Significance Index: 9.5900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0224
Cell Significance Index: 3.6500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0218
Cell Significance Index: 2.1600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0713
Cell Significance Index: -134.2500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1510
Cell Significance Index: -278.5400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1726
Cell Significance Index: -127.8300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1906
Cell Significance Index: -293.4500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2564
Cell Significance Index: -348.6400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3043
Cell Significance Index: -15.3800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.3512
Cell Significance Index: -198.0400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.4530
Cell Significance Index: -90.8700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.4606
Cell Significance Index: -292.5000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.4693
Cell Significance Index: -168.3200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.5141
Cell Significance Index: -321.0300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5240
Cell Significance Index: -21.4700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.6794
Cell Significance Index: -308.3500
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.7698
Cell Significance Index: -13.2700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -1.2251
Cell Significance Index: -258.0300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.2501
Cell Significance Index: -70.1500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.5477
Cell Significance Index: -54.3900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.5686
Cell Significance Index: -50.2400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -2.0837
Cell Significance Index: -302.9000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -2.4969
Cell Significance Index: -285.0200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.5916
Cell Significance Index: -163.3400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.8139
Cell Significance Index: -70.3400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -2.9278
Cell Significance Index: -49.0000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -2.9455
Cell Significance Index: -203.7000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.1060
Cell Significance Index: -323.4100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -3.6301
Cell Significance Index: -21.9300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -4.0392
Cell Significance Index: -242.4900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -4.3120
Cell Significance Index: -330.9000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -4.6736
Cell Significance Index: -70.0300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -4.7774
Cell Significance Index: -292.9000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -5.0072
Cell Significance Index: -108.4800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -5.4201
Cell Significance Index: -73.9500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -5.9763
Cell Significance Index: -172.1900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -6.5350
Cell Significance Index: -167.9800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -6.5451
Cell Significance Index: -192.7800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -6.6727
Cell Significance Index: -347.5700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -6.8002
Cell Significance Index: -116.5400
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -7.0911
Cell Significance Index: -44.0600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -7.1701
Cell Significance Index: -317.1500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -7.5687
Cell Significance Index: -277.8400
Cell Name: preadipocyte (CL0002334)
Fold Change: -7.9917
Cell Significance Index: -155.9800
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -8.2471
Cell Significance Index: -44.9700
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -8.3674
Cell Significance Index: -107.7600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -8.6425
Cell Significance Index: -327.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RPS18 is a small, acidic protein with a molecular weight of approximately 18 kDa. It is a structural component of the 40S ribosomal subunit, which is responsible for the translation of mRNA into proteins. RPS18 is highly conserved across species, suggesting its essential role in eukaryotic translation. The protein has a unique ability to interact with eIFs and the mRNA cap-binding complex, facilitating the initiation of translation. **Pathways and Functions** RPS18 is involved in various cellular processes, including: 1. **Translation Initiation**: RPS18 binds to the mRNA cap-binding complex and eIFs, recruiting the 40S subunit to the mRNA and facilitating the start of translation. 2. **Axon Guidance**: RPS18 has been implicated in axon guidance, a critical process in neuronal development and regeneration. 3. **Cap-dependent Translation Initiation**: RPS18 plays a key role in cap-dependent translation initiation, where it helps to recruit the 40S subunit to the mRNA. 4. **Cytoplasmic Translation**: RPS18 is involved in cytoplasmic translation, where it facilitates the translation of mRNAs into proteins. 5. **Regulation of Protein Synthesis**: RPS18 has been shown to regulate protein synthesis by interacting with eIFs and other translation initiation factors. **Clinical Significance** RPS18 has been implicated in various diseases, including: 1. **Influenza Infection**: RPS18 has been shown to be involved in the translation of influenza mRNAs, highlighting its potential role in the pathogenesis of influenza. 2. **SARS-CoV-2 Infection**: RPS18 has been implicated in the translation of SARS-CoV-2 mRNAs, suggesting its potential role in the pathogenesis of COVID-19. 3. **Cancer**: RPS18 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. 4. **Neurological Disorders**: RPS18 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, RPS18 is a critical component of the 40S ribosomal subunit, playing a vital role in translation initiation and cytoplasmic translation. Its involvement in various cellular processes and diseases highlights its importance in understanding the mechanisms of translation and its potential as a therapeutic target for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S18

Genular Protein ID: 233484360

Symbol: RS18_HUMAN

Name: 40S ribosomal protein S18

UniProtKB Accession Codes:

P62269 P25232 Q5SUJ3 Q6IPF8

Database IDs:

Citations:

PubMed ID: 8441687

Title: The human homolog of ribosomal protein S18.

PubMed ID: 8441687

DOI: 10.1093/nar/21.3.745

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

Length: 152
Mass: 17719
Checksum: 4DAF0662C3F37F22
Sequence:

MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT 
EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA NGLDNKLRED LERLKKIRAH 
RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPS18

Associated with

Cells (max top 100)

Other Information

The human homolog of ribosomal protein S18. PubMed ID: 8441687

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399