Details for: RPS25

Gene ID: 6230

Symbol: RPS25

Ensembl ID: ENSG00000118181

Description: ribosomal protein S25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 682.3198
    Cell Significance Index: -281.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 669.4529
    Cell Significance Index: -271.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 601.6657
    Cell Significance Index: -284.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 565.1990
    Cell Significance Index: -290.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 425.3213
    Cell Significance Index: -285.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 288.0985
    Cell Significance Index: -275.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 65.4368
    Cell Significance Index: 1631.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.0502
    Cell Significance Index: -104.6100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 18.6238
    Cell Significance Index: 282.8600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 16.9872
    Cell Significance Index: 99.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 15.9248
    Cell Significance Index: 418.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.8756
    Cell Significance Index: 1621.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 15.5890
    Cell Significance Index: 398.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 11.3617
    Cell Significance Index: 533.9900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.4254
    Cell Significance Index: 133.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.2241
    Cell Significance Index: 116.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.6677
    Cell Significance Index: 170.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.9057
    Cell Significance Index: 255.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.7595
    Cell Significance Index: 183.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.7253
    Cell Significance Index: 1127.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.6881
    Cell Significance Index: 1193.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.2767
    Cell Significance Index: 191.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.2006
    Cell Significance Index: 579.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.6754
    Cell Significance Index: 943.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.5598
    Cell Significance Index: 1362.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.4842
    Cell Significance Index: 557.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.3286
    Cell Significance Index: 3240.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.0137
    Cell Significance Index: 827.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.9964
    Cell Significance Index: 76.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.8206
    Cell Significance Index: 874.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.5262
    Cell Significance Index: 3564.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.1220
    Cell Significance Index: 330.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.1141
    Cell Significance Index: 150.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.0221
    Cell Significance Index: 263.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.9562
    Cell Significance Index: 134.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.6585
    Cell Significance Index: 217.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.6513
    Cell Significance Index: 161.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.3305
    Cell Significance Index: 80.0400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.5179
    Cell Significance Index: 21.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.4522
    Cell Significance Index: 589.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.2291
    Cell Significance Index: 2444.1400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 2.1000
    Cell Significance Index: 29.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7027
    Cell Significance Index: 1537.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.5689
    Cell Significance Index: 179.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3265
    Cell Significance Index: 12.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9746
    Cell Significance Index: 185.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9539
    Cell Significance Index: 189.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.7417
    Cell Significance Index: 543.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1532
    Cell Significance Index: 7.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1412
    Cell Significance Index: 3.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0879
    Cell Significance Index: 3.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0327
    Cell Significance Index: -6.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0517
    Cell Significance Index: -38.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0765
    Cell Significance Index: -144.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1511
    Cell Significance Index: -278.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1815
    Cell Significance Index: -279.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1938
    Cell Significance Index: -121.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2088
    Cell Significance Index: -74.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2239
    Cell Significance Index: -11.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2248
    Cell Significance Index: -15.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2392
    Cell Significance Index: -325.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2571
    Cell Significance Index: -144.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2645
    Cell Significance Index: -26.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3604
    Cell Significance Index: -14.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3643
    Cell Significance Index: -231.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5422
    Cell Significance Index: -246.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5444
    Cell Significance Index: -43.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6698
    Cell Significance Index: -141.0700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7326
    Cell Significance Index: -12.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9082
    Cell Significance Index: -57.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.9217
    Cell Significance Index: -149.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.9588
    Cell Significance Index: -7.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1738
    Cell Significance Index: -133.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3577
    Cell Significance Index: -43.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4859
    Cell Significance Index: -83.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.6132
    Cell Significance Index: -84.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.6641
    Cell Significance Index: -241.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.9246
    Cell Significance Index: -32.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.3771
    Cell Significance Index: -59.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.6141
    Cell Significance Index: -272.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -2.8581
    Cell Significance Index: -24.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.4066
    Cell Significance Index: -261.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.0377
    Cell Significance Index: -247.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.1432
    Cell Significance Index: -248.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.3199
    Cell Significance Index: -93.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -4.3580
    Cell Significance Index: -51.9500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -4.3739
    Cell Significance Index: -91.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -4.5231
    Cell Significance Index: -158.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.9136
    Cell Significance Index: -84.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -5.3010
    Cell Significance Index: -79.4300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.3312
    Cell Significance Index: -29.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.3400
    Cell Significance Index: -236.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -5.3709
    Cell Significance Index: -32.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -5.4031
    Cell Significance Index: -155.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.4186
    Cell Significance Index: -73.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -5.4269
    Cell Significance Index: -41.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.5325
    Cell Significance Index: -162.9600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -5.9914
    Cell Significance Index: -43.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.0739
    Cell Significance Index: -222.9700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -6.2942
    Cell Significance Index: -52.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPS25 is a conserved protein, encoded by the RPS25 gene (ENSG00000118181), and is highly expressed in various cell types, including professional antigen-presenting cells, skeletal muscle satellite cells, epithelial cells of exocrine pancreas, and tracheobronchial smooth muscle cells. The protein is a member of the ribosomal protein S family, which is essential for the assembly and function of the 40S ribosomal subunit. **Pathways and Functions** RPS25 is involved in multiple cellular pathways, including: 1. **Translation initiation**: RPS25 is a key component of the eIF2G-elongation factor 1α (eEF1A) complex, which binds to the mRNA cap and recruits the small ribosomal subunit to the mRNA. 2. **Cap-dependent translation initiation**: RPS25 interacts with the cap-binding complex (CBC) and eIF4E, facilitating the recruitment of the small ribosomal subunit to the mRNA. 3. **Cytoplasmic translation**: RPS25 is a structural component of the 40S ribosomal subunit, which is responsible for translating mRNAs into proteins. 4. **Amino acid metabolism**: RPS25 is involved in the regulation of amino acid metabolism, particularly in response to amino acid deficiency, where it interacts with eIF2α (Gcn2). 5. **Viral infection**: RPS25 has been implicated in the translation of viral mRNAs, including those of influenza viruses. **Clinical Significance** RPS25 has been associated with various diseases, including: 1. **Influenza infection**: RPS25 has been shown to be a target of the influenza virus, facilitating its translation into proteins. 2. **SARS-CoV-2 infection**: Similar to influenza, RPS25 has been implicated in the translation of SARS-CoV-2 mRNAs. 3. **Neurological disorders**: RPS25 has been associated with neurological disorders, such as Alzheimer's disease, where it plays a role in the regulation of protein synthesis. 4. **Cancer**: RPS25 has been found to be overexpressed in certain types of cancer, including breast cancer, where it may contribute to tumorigenesis. In conclusion, RPS25 is a critical component of the 40S ribosomal subunit, playing a central role in translation initiation, elongation, and termination. Its involvement in various cellular pathways and diseases highlights its importance in maintaining cellular homeostasis and regulating protein synthesis. Further research is needed to elucidate the precise mechanisms by which RPS25 contributes to disease pathogenesis and to explore its potential as a therapeutic target.

Genular Protein ID: 3507771066

Symbol: RS25_HUMAN

Name: 40S ribosomal protein S25

UniProtKB Accession Codes:

P62851 B2R4M7 P25111

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 77 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 93 PDBsum 93 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1748303

Title: Cloning and sequencing a cDNA encoding human ribosomal protein S25.

PubMed ID: 1748303

DOI: 10.1016/0378-1119(91)90335-9

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 125
  • Mass: 13742
  • Checksum: B8E05F04FCF2F1A9
  • Sequence:
    • MPPKDDKKKK DAGKSAKKDK DPVNKSGGKA KKKKWSKGKV RDKLNNLVLF DKATYDKLCK 
EVPNYKLITP AVVSERLKIR GSLARAALQE LLSKGLIKLV SKHRAQVIYT RNTKGGDAPA 
AGEDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.