Gene RPS25 - ENSG00000118181 | NCBI Gene ID: 6230

Details for: RPS25

Gene ID: 6230

Symbol: RPS25

Ensembl ID: ENSG00000118181

Description: ribosomal protein S25

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Small ribosomal subunit
(GO:0015935)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 9.48
Marker Score: 4894
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 8.32
Marker Score: 5563
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 6.44
Marker Score: 3630
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 6.27
Marker Score: 1838
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.94
Marker Score: 29196
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.58
Marker Score: 11698
Cell Name: classical monocyte (CL0000860)
Fold Change: 5.55
Marker Score: 23072
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.48
Marker Score: 3975
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.36
Marker Score: 2756
Cell Name: mature T cell (CL0002419)
Fold Change: 5.34
Marker Score: 52846
Cell Name: malignant cell (CL0001064)
Fold Change: 5.26
Marker Score: 70641
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.21
Marker Score: 15212
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.2
Marker Score: 6767
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 5.13
Marker Score: 3622
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.1
Marker Score: 8741
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.97
Marker Score: 169090
Cell Name: theca cell (CL0000503)
Fold Change: 4.94
Marker Score: 3540
Cell Name: radial glial cell (CL0000681)
Fold Change: 4.9
Marker Score: 1807
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.86
Marker Score: 15331
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 4.8
Marker Score: 2910
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 4.78
Marker Score: 3608
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.77
Marker Score: 252115
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.75
Marker Score: 7316.5
Cell Name: naive B cell (CL0000788)
Fold Change: 4.68
Marker Score: 4181
Cell Name: memory T cell (CL0000813)
Fold Change: 4.52
Marker Score: 1943
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.51
Marker Score: 11466
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.5
Marker Score: 23678
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.48
Marker Score: 59153
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.47
Marker Score: 3805
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.45
Marker Score: 1447
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 4.44
Marker Score: 2030
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.41
Marker Score: 4897
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.34
Marker Score: 26372
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.33
Marker Score: 2634
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.32
Marker Score: 241622
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.29
Marker Score: 11849
Cell Name: blood cell (CL0000081)
Fold Change: 4.29
Marker Score: 49856.5
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 4.28
Marker Score: 3631
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.24
Marker Score: 11902
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.2
Marker Score: 10250
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.13
Marker Score: 3994
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.1
Marker Score: 17575
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.06
Marker Score: 3464
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.05
Marker Score: 9876
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.05
Marker Score: 4889
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.05
Marker Score: 967
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.05
Marker Score: 10842
Cell Name: supporting cell (CL0000630)
Fold Change: 4.04
Marker Score: 7595
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.04
Marker Score: 5948
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.04
Marker Score: 4313
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.03
Marker Score: 9174
Cell Name: naive T cell (CL0000898)
Fold Change: 4
Marker Score: 2575
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.99
Marker Score: 14159
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.98
Marker Score: 3924
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.97
Marker Score: 6317
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.97
Marker Score: 3114
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 3.95
Marker Score: 2628
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.95
Marker Score: 3726
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.91
Marker Score: 25457
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.88
Marker Score: 2760
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.83
Marker Score: 28479
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.8
Marker Score: 3571
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.78
Marker Score: 3254
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.75
Marker Score: 2069
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.74
Marker Score: 4137
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.73
Marker Score: 2453
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.72
Marker Score: 24206
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.7
Marker Score: 3855
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.69
Marker Score: 3294
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 3.69
Marker Score: 3832
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.69
Marker Score: 3289
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 3.68
Marker Score: 2051
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.67
Marker Score: 3008
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.67
Marker Score: 3265
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.67
Marker Score: 1208
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.67
Marker Score: 9248
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.65
Marker Score: 4176
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.65
Marker Score: 2452
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.64
Marker Score: 3194
Cell Name: memory B cell (CL0000787)
Fold Change: 3.62
Marker Score: 2737
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.62
Marker Score: 1161
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.61
Marker Score: 2076
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.61
Marker Score: 2995
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.6
Marker Score: 3868
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.59
Marker Score: 5198
Cell Name: reticular cell (CL0000432)
Fold Change: 3.58
Marker Score: 1308
Cell Name: endocrine cell (CL0000163)
Fold Change: 3.58
Marker Score: 1852
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 3.58
Marker Score: 941.5
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.58
Marker Score: 22826
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.57
Marker Score: 8107
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.57
Marker Score: 1606
Cell Name: immature B cell (CL0000816)
Fold Change: 3.55
Marker Score: 2351
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.55
Marker Score: 5815
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.55
Marker Score: 21030
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.54
Marker Score: 2982
Cell Name: megakaryocyte (CL0000556)
Fold Change: 3.54
Marker Score: 2012
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 3.52
Marker Score: 935
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.51
Marker Score: 805
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.5
Marker Score: 4132.5
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.5
Marker Score: 4214

Hover over a box to see details here...

**Key characteristics:** - The gene is located on chromosome 17q21.1. - It is a large gene encoding a protein of 533 amino acids. - It is a key regulator of protein synthesis and is involved in a variety of cellular processes, including translation initiation, elongation, and termination. **Pathways and functions:** - The RPS25 gene is involved in the initiation of protein synthesis by binding to the 5' cap of mRNA and facilitating the binding of the initiator complex. - It is also involved in the elongation of polypeptide chains by interacting with the ribosome and catalyzing the binding of amino acids to the growing polypeptide chain. - It is also involved in the termination of protein synthesis by binding to the stop codon and facilitating the release of the completed polypeptide chain. - In addition to its role in protein synthesis, the RPS25 gene is also involved in a variety of cellular processes, including cell migration, cell cycle regulation, and apoptosis. **Clinical significance:** - Mutations in the RPS25 gene have been linked to a number of human diseases, including cancer and neurodegenerative disorders. - Inhibition of RPS25 has been shown to suppress protein synthesis and inhibit cell growth, suggesting that it may be a potential therapeutic target for cancer and other diseases that are characterized by abnormal protein synthesis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S25

Genular Protein ID: 3507771066

Symbol: RS25_HUMAN

Name: 40S ribosomal protein S25

UniProtKB Accession Codes:

P62851 B2R4M7 P25111

Database IDs:

Citations:

PubMed ID: 1748303

Title: Cloning and sequencing a cDNA encoding human ribosomal protein S25.

PubMed ID: 1748303

DOI: 10.1016/0378-1119(91)90335-9

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

Length: 125
Mass: 13742
Checksum: B8E05F04FCF2F1A9
Sequence:

MPPKDDKKKK DAGKSAKKDK DPVNKSGGKA KKKKWSKGKV RDKLNNLVLF DKATYDKLCK 
EVPNYKLITP AVVSERLKIR GSLARAALQE LLSKGLIKLV SKHRAQVIYT RNTKGGDAPA 
AGEDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPS25

Associated with

Cells (max top 100)

Other Information

Cloning and sequencing a cDNA encoding human ribosomal protein S25. PubMed ID: 1748303

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399