Details for: XCL1

Gene ID: 6375

Symbol: XCL1

Ensembl ID: ENSG00000143184

Description: X-C motif chemokine ligand 1

Associated with

  • Chemokine receptors bind chemokines
    (R-HSA-380108)
  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Signaling by gpcr
    (R-HSA-372790)
  • Antimicrobial humoral immune response mediated by antimicrobial peptide
    (GO:0061844)
  • Ccr chemokine receptor binding
    (GO:0048020)
  • Cell-cell signaling
    (GO:0007267)
  • Cellular response to interleukin-4
    (GO:0071353)
  • Cellular response to transforming growth factor beta stimulus
    (GO:0071560)
  • Chemokine-mediated signaling pathway
    (GO:0070098)
  • Chemokine activity
    (GO:0008009)
  • Chemokine receptor binding
    (GO:0042379)
  • Eosinophil chemotaxis
    (GO:0048245)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Inflammatory response
    (GO:0006954)
  • Killing of cells of another organism
    (GO:0031640)
  • Mature natural killer cell chemotaxis
    (GO:0035782)
  • Negative regulation of cd4-positive, alpha-beta t cell proliferation
    (GO:2000562)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of t-helper 1 cell activation
    (GO:2000518)
  • Negative regulation of t-helper 1 type immune response
    (GO:0002826)
  • Negative regulation of t cell cytokine production
    (GO:0002725)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Neutrophil chemotaxis
    (GO:0030593)
  • Positive regulation of b cell chemotaxis
    (GO:2000538)
  • Positive regulation of cd4-positive, alpha-beta t cell proliferation
    (GO:2000563)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of granzyme a production
    (GO:2000513)
  • Positive regulation of granzyme b production
    (GO:0071663)
  • Positive regulation of immunoglobulin production in mucosal tissue
    (GO:2000558)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of leukocyte chemotaxis
    (GO:0002690)
  • Positive regulation of natural killer cell chemotaxis
    (GO:2000503)
  • Positive regulation of neutrophil chemotaxis
    (GO:0090023)
  • Positive regulation of release of sequestered calcium ion into cytosol
    (GO:0051281)
  • Positive regulation of t-helper 1 cell cytokine production
    (GO:2000556)
  • Positive regulation of t-helper 2 cell cytokine production
    (GO:2000553)
  • Positive regulation of t cell chemotaxis
    (GO:0010820)
  • Positive regulation of t cell cytokine production
    (GO:0002726)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of thymocyte migration
    (GO:2000412)
  • Positive regulation of transforming growth factor beta production
    (GO:0071636)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of inflammatory response
    (GO:0050727)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to virus
    (GO:0009615)
  • Signal transduction
    (GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.0302
    Cell Significance Index: -12.2000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 20.1819
    Cell Significance Index: 54.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.8726
    Cell Significance Index: -12.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 12.7668
    Cell Significance Index: 264.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 7.4522
    Cell Significance Index: 261.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.4985
    Cell Significance Index: 129.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.2516
    Cell Significance Index: 81.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.3460
    Cell Significance Index: 50.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2644
    Cell Significance Index: -6.9600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5945
    Cell Significance Index: 24.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0677
    Cell Significance Index: 16.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0509
    Cell Significance Index: 47.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8523
    Cell Significance Index: 162.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7016
    Cell Significance Index: 69.4100
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.6757
    Cell Significance Index: 1.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4886
    Cell Significance Index: 10.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4730
    Cell Significance Index: 427.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3633
    Cell Significance Index: 59.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2891
    Cell Significance Index: 31.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2470
    Cell Significance Index: 4.0700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.1350
    Cell Significance Index: 2.3200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1263
    Cell Significance Index: 1.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1085
    Cell Significance Index: 6.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1081
    Cell Significance Index: 21.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0988
    Cell Significance Index: 6.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0313
    Cell Significance Index: 3.6500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0111
    Cell Significance Index: 0.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0010
    Cell Significance Index: -0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0059
    Cell Significance Index: -0.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0062
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0164
    Cell Significance Index: -12.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0195
    Cell Significance Index: -0.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0204
    Cell Significance Index: -11.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0210
    Cell Significance Index: -11.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0269
    Cell Significance Index: -12.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0293
    Cell Significance Index: -10.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0407
    Cell Significance Index: -11.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0423
    Cell Significance Index: -1.3600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0499
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0513
    Cell Significance Index: -10.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0518
    Cell Significance Index: -10.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0563
    Cell Significance Index: -10.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0573
    Cell Significance Index: -7.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0668
    Cell Significance Index: -9.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0715
    Cell Significance Index: -12.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0850
    Cell Significance Index: -10.4500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0889
    Cell Significance Index: -1.2100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0901
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0913
    Cell Significance Index: -10.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1091
    Cell Significance Index: -11.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1114
    Cell Significance Index: -14.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1154
    Cell Significance Index: -13.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1209
    Cell Significance Index: -5.6800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1399
    Cell Significance Index: -1.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1598
    Cell Significance Index: -12.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1675
    Cell Significance Index: -11.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1765
    Cell Significance Index: -4.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1924
    Cell Significance Index: -14.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1967
    Cell Significance Index: -5.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2095
    Cell Significance Index: -9.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2161
    Cell Significance Index: -13.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2173
    Cell Significance Index: -14.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2191
    Cell Significance Index: -11.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2192
    Cell Significance Index: -5.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2353
    Cell Significance Index: -2.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2368
    Cell Significance Index: -12.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2800
    Cell Significance Index: -10.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2894
    Cell Significance Index: -12.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2897
    Cell Significance Index: -10.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2948
    Cell Significance Index: -3.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2999
    Cell Significance Index: -9.8200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3228
    Cell Significance Index: -3.0600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3355
    Cell Significance Index: -5.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3378
    Cell Significance Index: -7.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3388
    Cell Significance Index: -12.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3429
    Cell Significance Index: -10.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3442
    Cell Significance Index: -9.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3574
    Cell Significance Index: -9.1300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3884
    Cell Significance Index: -9.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3911
    Cell Significance Index: -12.3700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.3940
    Cell Significance Index: -1.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3961
    Cell Significance Index: -4.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3977
    Cell Significance Index: -10.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3981
    Cell Significance Index: -11.3600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3989
    Cell Significance Index: -6.4000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.4003
    Cell Significance Index: -4.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4050
    Cell Significance Index: -10.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4084
    Cell Significance Index: -12.0300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4093
    Cell Significance Index: -3.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4096
    Cell Significance Index: -12.0300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4190
    Cell Significance Index: -5.9600
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.4232
    Cell Significance Index: -5.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4304
    Cell Significance Index: -10.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4450
    Cell Significance Index: -10.2800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.4631
    Cell Significance Index: -3.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4772
    Cell Significance Index: -13.6800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4785
    Cell Significance Index: -12.1900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.4786
    Cell Significance Index: -4.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** XCL1 is a member of the X-C motif chemokine family, characterized by its ability to bind to the CCR1 receptor. It is a small, secreted protein that is produced by various cell types, including immune cells and epithelial cells. XCL1 is known for its ability to induce chemotaxis in immune cells, including natural killer cells, T cells, and eosinophils. Its expression is regulated by various cytokines and growth factors, including IL-1, IL-4, and TGF-β. **Pathways and Functions:** XCL1 is involved in various signaling pathways, including: 1. Chemokine-mediated signaling: XCL1 binds to its receptor, CCR1, triggering a signaling cascade that regulates immune responses. 2. G protein-coupled receptor signaling: XCL1 interacts with G protein-coupled receptors, including Gαq, to regulate cellular responses. 3. Cell-cell signaling: XCL1 interacts with other chemokines and cytokines to regulate immune cell interactions. 4. Inflammatory response: XCL1 is involved in the recruitment of immune cells to sites of inflammation. XCL1's functions include: 1. Immune cell recruitment: XCL1 recruits immune cells to sites of inflammation, including natural killer cells, T cells, and eosinophils. 2. Immune cell activation: XCL1 activates immune cells, including natural killer cells and T cells, to regulate immune responses. 3. Anti-inflammatory effects: XCL1 has anti-inflammatory effects, including the regulation of cytokine production and the inhibition of T cell activation. **Clinical Significance:** XCL1's dysregulation has been implicated in various diseases, including: 1. Autoimmune disorders: XCL1's dysregulation has been linked to autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. 2. Cancer: XCL1's dysregulation has been implicated in cancer, including the promotion of tumor growth and metastasis. 3. Inflammatory bowel disease: XCL1's dysregulation has been linked to inflammatory bowel disease, including Crohn's disease and ulcerative colitis. In summary, XCL1 is a multifaceted chemokine that plays a crucial role in immune regulation and inflammation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation.

Genular Protein ID: 2961578349

Symbol: XCL1_HUMAN

Name: Lymphotactin

UniProtKB Accession Codes:

P47992 Q52MA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 46 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7602097

Title: Molecular cloning and functional characterization of human lymphotactin.

PubMed ID: 7602097

PubMed ID: 7875320

Title: Molecular cloning of a novel C or gamma type chemokine, SCM-1.

PubMed ID: 7875320

DOI: 10.1016/0014-5793(95)00093-o

PubMed ID: 7615002

Title: Cloning of ATAC, an activation-induced, chemokine-related molecule exclusively expressed in CD8+ T lymphocytes.

PubMed ID: 7615002

DOI: 10.1002/eji.1830250638

PubMed ID: 8849694

Title: Structure and expression of two highly related genes encoding SCM-1/human lymphotactin.

PubMed ID: 8849694

DOI: 10.1016/0014-5793(96)01004-6

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11601972

Title: Monomeric solution structure of the prototypical 'C' chemokine lymphotactin.

PubMed ID: 11601972

DOI: 10.1021/bi011106p

Sequence Information:

  • Length: 114
  • Mass: 12517
  • Checksum: FABA16063C3FC165
  • Sequence:
    • MRLLILALLG ICSLTAYIVE GVGSEVSDKR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF 
ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.