SDCBP | ENSG00000137575 | NCBI 6386

Details for: SDCBP

Associated with

Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Eph-ephrin signaling
(R-HSA-2682334)
Ephrin signaling
(R-HSA-3928664)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
L1cam interactions
(R-HSA-373760)
Nervous system development
(R-HSA-9675108)
Neurofascin interactions
(R-HSA-447043)
Neutrophil degranulation
(R-HSA-6798695)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation of necroptotic cell death
(R-HSA-5675482)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Actin cytoskeleton organization
(GO:0030036)
Adherens junction
(GO:0005912)
Azurophil granule lumen
(GO:0035578)
Blood microparticle
(GO:0072562)
Cell adhesion molecule binding
(GO:0050839)
Chemical synaptic transmission
(GO:0007268)
Cytoplasm
(GO:0005737)
Cytoskeletal anchor activity
(GO:0008093)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endoplasmic reticulum membrane
(GO:0005789)
Ephrin receptor binding
(GO:0046875)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extracellular vesicle
(GO:1903561)
Focal adhesion
(GO:0005925)
Frizzled binding
(GO:0005109)
Growth factor binding
(GO:0019838)
Identical protein binding
(GO:0042802)
Interleukin-5 receptor binding
(GO:0005137)
Interleukin-5 receptor complex
(GO:0005895)
Intracellular signal transduction
(GO:0035556)
Ionotropic glutamate receptor binding
(GO:0035255)
Melanosome
(GO:0042470)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Negative regulation of receptor internalization
(GO:0002091)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neurexin family protein binding
(GO:0042043)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Plasma membrane
(GO:0005886)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of extracellular exosome assembly
(GO:1903553)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Presynapse
(GO:0098793)
Presynapse assembly
(GO:0099054)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein sequestering activity
(GO:0140311)
Protein targeting to membrane
(GO:0006612)
Ras protein signal transduction
(GO:0007265)
Regulation of mitotic cell cycle
(GO:0007346)
Substrate-dependent cell migration, cell extension
(GO:0006930)
Syndecan binding
(GO:0045545)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

melanocyte CL0000148

CSI 127.07

rCSI 94.11%

PRS 13.75
elicited macrophage CL0000861

CSI 102.61

rCSI 94.21%

PRS 18.05
extravillous trophoblast CL0008036

CSI 66.78

rCSI 82.62%

PRS 13.67
myeloid leukocyte CL0000766

CSI 64.27

rCSI 59.3%

PRS 15.97
CD14-low, CD16-positive monocyte CL0002396

CSI 63.5

rCSI 48.93%

PRS 14.29
Hofbauer cell CL3000001

CSI 54.49

rCSI 100%

PRS 19.54
intermediate monocyte CL0002393

CSI 51.52

rCSI 77.73%

PRS 15.56
alveolar macrophage CL0000583

CSI 50.68

rCSI 83.48%

PRS 18.34
alternatively activated macrophage CL0000890

CSI 50.37

rCSI 63.32%

PRS 23.93
skin fibroblast CL0002620

CSI 45.33

rCSI 39.08%

PRS 24.97
placental villous trophoblast CL2000060

CSI 45.25

rCSI 69.92%

PRS 14.59
classical monocyte CL0000860

CSI 43.34

rCSI 64.25%

PRS 77.3
retinal blood vessel endothelial cell CL0002585

CSI 41.76

rCSI 66.69%

PRS 17.12
mucous neck cell CL0000651

CSI 37.33

rCSI 53.8%

PRS 24.91
macrophage CL0000235

CSI 36.81

rCSI 66.97%

PRS 55.73
pulmonary artery endothelial cell CL1001568

CSI 33.15

rCSI 45.11%

PRS 23.75
retinal pigment epithelial cell CL0002586

CSI 32.74

rCSI 65.01%

PRS 16.59
foveolar cell of stomach CL0002179

CSI 30.48

rCSI 64.87%

PRS 25.05
pancreatic acinar cell CL0002064

CSI 29.63

rCSI 39.38%

PRS 17.09
lung macrophage CL1001603

CSI 27.11

rCSI 60.56%

PRS 17.89
endothelial cell of artery CL1000413

CSI 26.96

rCSI 39.5%

PRS 63.36
syncytiotrophoblast cell CL0000525

CSI 26.52

rCSI 76.4%

PRS 29.79
monocyte CL0000576

CSI 26.26

rCSI 47.47%

PRS 41.08
basophil CL0000767

CSI 25.29

rCSI 53.5%

PRS 31.32
forebrain radial glial cell CL0013000

CSI 24.32

rCSI 78.03%

PRS 22.64
granulocyte CL0000094

CSI 24.17

rCSI 36.93%

PRS 19.88
non-classical monocyte CL0000875

CSI 23.46

rCSI 37.6%

PRS 45.51
lung endothelial cell CL1001567

CSI 22.76

rCSI 53.07%

PRS 36.42
blood vessel endothelial cell CL0000071

CSI 22.36

rCSI 46.4%

PRS 15.61
pancreatic ductal cell CL0002079

CSI 22

rCSI 42.78%

PRS 15.99
keratocyte CL0002363

CSI 21.15

rCSI 50.85%

PRS 23.25
lung interstitial macrophage CL4033043

CSI 21.04

rCSI 47.24%

PRS 31.86
CD14-positive, CD16-positive monocyte CL0002397

CSI 20.5

rCSI 26.87%

PRS 22.02
Kupffer cell CL0000091

CSI 20.25

rCSI 46.31%

PRS 15.08
conjunctival epithelial cell CL1000432

CSI 19.8

rCSI 30.25%

PRS 15.67
endothelial cell of lymphatic vessel CL0002138

CSI 19.4

rCSI 38.45%

PRS 44.2
endothelial cell of placenta CL0009092

CSI 19.06

rCSI 93.96%

PRS 21.17
promonocyte CL0000559

CSI 18.18

rCSI 31.15%

PRS 21.13
mononuclear phagocyte CL0000113

CSI 17.12

rCSI 37.69%

PRS 17.42
CD1c-positive myeloid dendritic cell CL0002399

CSI 16.87

rCSI 20.38%

PRS 18.51
vein endothelial cell CL0002543

CSI 16.69

rCSI 45.55%

PRS 55.31
basal cell of prostate epithelium CL0002341

CSI 16.32

rCSI 47.21%

PRS 34.12
vasa recta ascending limb cell CL1001131

CSI 16.28

rCSI 73.65%

PRS 51.61
ciliated epithelial cell CL0000067

CSI 16.21

rCSI 14.25%

PRS 11.33
colon macrophage CL0009038

CSI 15.3

rCSI 70.69%

PRS 32.35
small intestine goblet cell CL1000495

CSI 15.21

rCSI 33.31%

PRS 20.85
cerebral cortex endothelial cell CL1001602

CSI 15.15

rCSI 26.21%

PRS 11.86
epithelial cell of lung CL0000082

CSI 14.97

rCSI 12.41%

PRS 14.72
alveolar adventitial fibroblast CL4028006

CSI 14.66

rCSI 23.16%

PRS 15.63
vein endothelial cell of respiratory system CL4033008

CSI 14.53

rCSI 99.76%

PRS 30.39
keratinocyte CL0000312

CSI 13.92

rCSI 11.67%

PRS 18.67
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 13.84

rCSI 83.71%

PRS 34.66
natural T-regulatory cell CL0000903

CSI 13.82

rCSI 26.17%

PRS 41.8
tissue-resident macrophage CL0000864

CSI 13.73

rCSI 64.24%

PRS 31.7
stem cell CL0000034

CSI 13.68

rCSI 13.19%

PRS 11.07
megakaryocyte-erythroid progenitor cell CL0000050

CSI 12.78

rCSI 11.54%

PRS 13.94
microcirculation associated smooth muscle cell CL0008035

CSI 12.71

rCSI 36.8%

PRS 17.7
CD14-positive monocyte CL0001054

CSI 12.45

rCSI 15.51%

PRS 22.05
myeloid cell CL0000763

CSI 12.41

rCSI 51.11%

PRS 45.3
capillary endothelial cell CL0002144

CSI 11.63

rCSI 21.31%

PRS 54.94
mammary gland epithelial cell CL0002327

CSI 11.42

rCSI 40.06%

PRS 27.88
Langerhans cell CL0000453

CSI 11.4

rCSI 17.41%

PRS 27.38
tracheobronchial serous cell CL0019001

CSI 11.37

rCSI 49.13%

PRS 29.25
endothelial cell of uterus CL0009095

CSI 11.13

rCSI 81.34%

PRS 41.53
mesodermal cell CL0000222

CSI 11.09

rCSI 13.31%

PRS 15.37
pancreatic stellate cell CL0002410

CSI 10.79

rCSI 62.76%

PRS 23.41
pancreatic A cell CL0000171

CSI 10.5

rCSI 11%

PRS 16.68
adventitial cell CL0002503

CSI 10.43

rCSI 24.91%

PRS 24
glioblast CL0000030

CSI 10.3

rCSI 16.43%

PRS 13.41
vasa recta descending limb cell CL1001285

CSI 10.12

rCSI 80.79%

PRS 57.12
activated CD4-positive, alpha-beta T cell CL0000896

CSI 9.82

rCSI 9.07%

PRS 28.27
conventional dendritic cell CL0000990

CSI 9.54

rCSI 7.97%

PRS 43.31
enteric smooth muscle cell CL0002504

CSI 9.18

rCSI 13.1%

PRS 17.6
fallopian tube secretory epithelial cell CL4030006

CSI 8.77

rCSI 8.44%

PRS 16.17
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 8.5

rCSI 14.54%

PRS 31.17
endothelial cell of venule CL1000414

CSI 8.44

rCSI 74.86%

PRS 55.09
enterocyte CL0000584

CSI 8.43

rCSI 13.59%

PRS 24.6
myeloid dendritic cell CL0000782

CSI 8.39

rCSI 12.16%

PRS 23.22
bronchial goblet cell CL1000312

CSI 8.08

rCSI 32.28%

PRS 33.43
neutrophil CL0000775

CSI 7.95

rCSI 44.46%

PRS 30.17
radial glial cell CL0000681

CSI 7.56

rCSI 10.51%

PRS 16.04
metallothionein-positive alveolar macrophage CL4033042

CSI 7.53

rCSI 81.88%

PRS 55.65
Bergmann glial cell CL0000644

CSI 7.06

rCSI 9.66%

PRS 15.57
naive T cell CL0000898

CSI 7.04

rCSI 4.9%

PRS 22.16
respiratory suprabasal cell CL4033048

CSI 6.97

rCSI 8.94%

PRS 18.03
stromal cell CL0000499

CSI 6.96

rCSI 19.59%

PRS 21.65
endothelial cell of arteriole CL1000412

CSI 6.66

rCSI 36.94%

PRS 43.13
T-helper 1 cell CL0000545

CSI 6.65

rCSI 12%

PRS 40
unswitched memory B cell CL0000970

CSI 6.61

rCSI 5.56%

PRS 24.95
stromal cell of ovary CL0002132

CSI 6.54

rCSI 17.97%

PRS 25.75
acinar cell CL0000622

CSI 6.4

rCSI 9.38%

PRS 20.51
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 6.24

rCSI 12.44%

PRS 26.25
myofibroblast cell CL0000186

CSI 6.2

rCSI 8.59%

PRS 22.26
enterocyte of epithelium of large intestine CL0002071

CSI 6.15

rCSI 32.31%

PRS 27.24
lung ciliated cell CL1000271

CSI 6.14

rCSI 7.1%

PRS 11.43
mast cell CL0000097

CSI 6.08

rCSI 13.12%

PRS 60.72
type B pancreatic cell CL0000169

CSI 6.06

rCSI 13.41%

PRS 14.5
common dendritic progenitor CL0001029

CSI 5.99

rCSI 7.52%

PRS 20.08
hepatic stellate cell CL0000632

CSI 5.96

rCSI 22.31%

PRS 13.22
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 5.88

rCSI 3.96%

PRS 18.83

astrocyte of the cerebral cortex CL0002605

CSI -5.1

rCSI -11.4%

PRS 9.6%
alpha-beta T cell CL0000789

CSI -4.4

rCSI -5.2%

PRS 20.9%
renal alpha-intercalated cell CL0005011

CSI -2.7

rCSI -3.6%

PRS 20.6%
neural cell CL0002319

CSI -1.9

rCSI -7.2%

PRS 22.0%
platelet CL0000233

CSI -1.8

rCSI -7.5%

PRS 30.7%
common lymphoid progenitor CL0000051

CSI -1.8

rCSI -2.4%

PRS 29.7%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -1.7

rCSI -5.4%

PRS 10.5%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -1.7

rCSI -3.1%

PRS 12.8%
enteroendocrine cell of small intestine CL0009006

CSI -1.1

rCSI -2.5%

PRS 23.8%
regular ventricular cardiac myocyte CL0002131

CSI -0.8

rCSI -5.3%

PRS 12.2%
fibroblast of cardiac tissue CL0002548

CSI -0.7

rCSI -3.5%

PRS 11.0%
neural progenitor cell CL0011020

CSI -0.7

rCSI -3.0%

PRS 15.0%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -0.7

rCSI -2.4%

PRS 8.6%
exhausted T cell CL0011025

CSI -0.5

rCSI -8.0%

PRS 55.0%
kidney connecting tubule epithelial cell CL1000768

CSI -0.4

rCSI -1.0%

PRS 11.8%
central nervous system neuron CL2000029

CSI -0.3

rCSI -2.1%

PRS 8.4%
amacrine cell CL0000561

CSI -0.2

rCSI -0.5%

PRS 12.0%
sncg GABAergic cortical interneuron CL4023015

CSI -0.1

rCSI -0.2%

PRS 10.0%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.0

rCSI 0.0%

PRS 25.6%
ventricular cardiac muscle cell CL2000046

CSI 0.1

rCSI 0.2%

PRS 55.6%
bronchiolar smooth muscle cell CL4033017

CSI 0.1

rCSI 1.3%

PRS 46.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.1

rCSI 0.4%

PRS 9.4%
L6b glutamatergic cortical neuron CL4023038

CSI 0.1

rCSI 0.3%

PRS 9.8%
group 2 innate lymphoid cell CL0001069

CSI 0.1

rCSI 0.6%

PRS 50.5%
Cajal-Retzius cell CL0000695

CSI 0.1

rCSI 1.0%

PRS 32.5%
B-2 B cell CL0000822

CSI 0.1

rCSI 2.8%

PRS 68.2%
B-1 B cell CL0000819

CSI 0.1

rCSI 3.4%

PRS 64.0%
retina horizontal cell CL0000745

CSI 0.1

rCSI 0.2%

PRS 14.5%
medium spiny neuron CL1001474

CSI 0.2

rCSI 1.3%

PRS 6.1%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.0%

PRS 22.8%
hair follicular keratinocyte CL2000092

CSI 0.2

rCSI 3.0%

PRS 56.9%
small pre-B-II cell CL0000954

CSI 0.2

rCSI 0.2%

PRS 32.0%
odontoblast CL0000060

CSI 0.2

rCSI 5.5%

PRS 60.5%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.3

rCSI 1.4%

PRS 9.7%
paneth cell of colon CL0009009

CSI 0.3

rCSI 3.1%

PRS 42.3%
pancreatic epsilon cell CL0005019

CSI 0.3

rCSI 1.5%

PRS 36.0%
neuroendocrine cell CL0000165

CSI 0.3

rCSI 1.2%

PRS 31.4%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.3

rCSI 0.6%

PRS 9.2%
mesenchymal lymphangioblast CL0005021

CSI 0.4

rCSI 9.2%

PRS 62.0%
mature B cell CL0000785

CSI 0.4

rCSI 0.3%

PRS 19.4%
large pre-B-II cell CL0000957

CSI 0.4

rCSI 1.1%

PRS 26.8%
parietal epithelial cell CL1000452

CSI 0.4

rCSI 1.1%

PRS 12.9%
kidney resident macrophage CL1000698

CSI 0.4

rCSI 7.9%

PRS 83.1%
renal principal cell CL0005009

CSI 0.4

rCSI 1.1%

PRS 20.4%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.4

rCSI 2.3%

PRS 30.4%
periportal region hepatocyte CL0019026

CSI 0.4

rCSI 1.7%

PRS 21.6%
retinal cone cell CL0000573

CSI 0.5

rCSI 0.7%

PRS 12.0%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.5

rCSI 5.2%

PRS 21.1%
transit amplifying cell CL0009010

CSI 0.5

rCSI 0.8%

PRS 25.4%
podocyte CL0000653

CSI 0.5

rCSI 2.4%

PRS 15.3%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.5

rCSI 0.7%

PRS 20.1%
late pro-B cell CL0002048

CSI 0.6

rCSI 1.4%

PRS 43.7%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.6

rCSI 3.3%

PRS 52.4%
intestinal tuft cell CL0019032

CSI 0.6

rCSI 0.9%

PRS 17.9%
tracheal goblet cell CL1000329

CSI 0.6

rCSI 1.3%

PRS 31.0%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.7

rCSI 3.3%

PRS 20.5%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 0.7

rCSI 1.7%

PRS 39.8%
erythroblast CL0000765

CSI 0.7

rCSI 1.8%

PRS 25.4%
thymocyte CL0000893

CSI 0.7

rCSI 2.5%

PRS 47.6%
sst GABAergic cortical interneuron CL4023017

CSI 0.7

rCSI 0.9%

PRS 9.7%
uterine smooth muscle cell CL0002601

CSI 0.7

rCSI 4.6%

PRS 69.3%
renal interstitial pericyte CL1001318

CSI 0.7

rCSI 2.0%

PRS 14.5%
transitional stage B cell CL0000818

CSI 0.8

rCSI 2.6%

PRS 41.9%
intraepithelial lymphocyte CL0002496

CSI 0.8

rCSI 2.2%

PRS 56.8%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 0.8

rCSI 1.1%

PRS 31.8%
regular atrial cardiac myocyte CL0002129

CSI 0.8

rCSI 2.6%

PRS 16.5%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.8

rCSI 2.0%

PRS 9.0%
glandular epithelial cell CL0000150

CSI 0.8

rCSI 2.2%

PRS 30.4%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.8

rCSI 3.7%

PRS 51.8%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 0.9

rCSI 0.5%

PRS 21.6%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 0.9

rCSI 1.0%

PRS 13.7%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.9

rCSI 2.1%

PRS 24.8%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 0.9

rCSI 0.9%

PRS 24.5%
fraction A pre-pro B cell CL0002045

CSI 0.9

rCSI 1.0%

PRS 31.8%
intrahepatic cholangiocyte CL0002538

CSI 0.9

rCSI 2.2%

PRS 28.0%
centrilobular region hepatocyte CL0019029

CSI 0.9

rCSI 2.4%

PRS 24.3%
transit amplifying cell of small intestine CL0009012

CSI 0.9

rCSI 4.1%

PRS 29.0%
progenitor cell CL0011026

CSI 1.0

rCSI 2.0%

PRS 25.8%
mature alpha-beta T cell CL0000791

CSI 1.0

rCSI 3.5%

PRS 26.7%
hepatocyte CL0000182

CSI 1.0

rCSI 1.7%

PRS 14.5%
paneth cell of epithelium of small intestine CL1000343

CSI 1.0

rCSI 2.7%

PRS 24.2%
primordial germ cell CL0000670

CSI 1.1

rCSI 5.2%

PRS 68.9%
granulocyte monocyte progenitor cell CL0000557

CSI 1.1

rCSI 0.9%

PRS 17.5%
blood vessel smooth muscle cell CL0019018

CSI 1.1

rCSI 8.8%

PRS 16.0%
T follicular helper cell CL0002038

CSI 1.1

rCSI 0.8%

PRS 25.2%
innate lymphoid cell CL0001065

CSI 1.1

rCSI 2.3%

PRS 23.5%
retinal ganglion cell CL0000740

CSI 1.1

rCSI 2.5%

PRS 11.2%
memory T cell CL0000813

CSI 1.2

rCSI 2.3%

PRS 34.9%
megakaryocyte progenitor cell CL0000553

CSI 1.2

rCSI 21.4%

PRS 44.8%
cerebellar granule cell CL0001031

CSI 1.3

rCSI 1.8%

PRS 14.2%
BEST4+ enteroycte CL4030026

CSI 1.3

rCSI 1.6%

PRS 16.5%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.3

rCSI 2.3%

PRS 9.2%
direct pathway medium spiny neuron CL4023026

CSI 1.3

rCSI 31.1%

PRS 7.4%
IgA plasma cell CL0000987

CSI 1.4

rCSI 1.4%

PRS 28.9%
glial cell CL0000125

CSI 1.4

rCSI 5.3%

PRS 15.4%
pluripotent stem cell CL0002248

CSI 1.4

rCSI 41.8%

PRS 35.0%
megakaryocyte CL0000556

CSI 1.4

rCSI 6.1%

PRS 27.6%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 1.5

rCSI 2.3%

PRS 37.1%
follicular B cell CL0000843

CSI 1.5

rCSI 5.4%

PRS 53.1%
intestinal epithelial cell CL0002563

CSI 1.5

rCSI 1.6%

PRS 16.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SDCBP](/details-gene/6386) (Syndecan Binding Protein) encodes Syntenin-1, a versatile PDZ domain-containing scaffolding protein that plays a crucial role in intracellular signaling, protein trafficking, and cytoskeletal organization. It functions as an adaptor, linking transmembrane proteins, such as syndecans and ephrin receptors, to various downstream signaling cascades and the actin cytoskeleton [Link](https://doi.org/10.1073/pnas.94.25.13683). **Overall**, [SDCBP](/details-gene/6386) shows highly significant expression in [melanocytes](/details-cell/CL0000148), various populations of macrophages and monocytes, and placental trophoblasts, suggesting key roles in pigmentation, innate immunity, and embryonic development. Its function is implicated in diverse biological processes including cell migration, exosome secretion, and the regulation of cell growth. Clinically, it is associated with OMIM entry [602217](https://omim.org/entry/602217). ## Cellular Roles and Expression Landscape The expression profile of [SDCBP](/details-gene/6386) highlights its importance in specific, functionally distinct cell lineages. **Overall**, its most significant expression is observed in [melanocytes](/details-cell/CL0000148) (CSI: 127.07), suggesting a primary role in pigmentation and melanosome biology, a finding supported by proteomic analyses identifying it as a melanosomal protein [Link](https://doi.org/10.1021/pr025562r). A second major functional niche for [SDCBP](/details-gene/6386) is within the myeloid compartment of the innate immune system. It is highly significant in various macrophage populations, including [elicited macrophages](/details-cell/CL0000861), [alveolar macrophages](/details-cell/CL0000583), and placental [Hofbauer cells](/details-cell/CL3000001), as well as in their circulating precursors, such as [CD14-low, CD16-positive monocytes](/details-cell/CL0002396) and [classical monocytes](/details-cell/CL0000860). This pattern points towards a central function in monocyte-macrophage effector activities, such as phagocytosis, migration, and inflammatory signaling. Furthermore, [SDCBP](/details-gene/6386) is prominently expressed in specialized placental cells like [extravillous trophoblasts](/details-cell/CL0008036) and [placental villous trophoblasts](/details-cell/CL2000060), implicating it in the processes of placental development, invasion, and maternal-fetal interface maintenance. Conversely, the gene's significance is consistently low in cells of the nervous system, including [astrocytes of the cerebral cortex](/details-cell/CL0002605) and various cortical neurons, as well as in the lymphoid lineage, such as [alpha-beta T cells](/details-cell/CL0000789). This restricted expression pattern underscores its specialized roles, primarily outside of neuronal signaling and adaptive immunity. ## Pathways and Molecular Function [SDCBP](/details-gene/6386) functions as a key molecular hub, integrating signals from the cell surface to the intracellular machinery. Its molecular function is defined by its ability to bind a wide array of proteins via its two PDZ domains. Key binding partners include syndecans ([GO:0045545](https://www.ebi.ac.uk/QuickGO/term/GO:0045545)), ephrin receptors ([GO:0046875](https://www.ebi.ac.uk/QuickGO/term/GO:0046875)), and frizzled receptors ([GO:0005109](https://www.ebi.ac.uk/QuickGO/term/GO:0005109)), positioning it at the crossroads of multiple signaling pathways [Link](https://doi.org/10.1016/s0896-6273(00)80663-7). This scaffolding activity translates into the regulation of numerous biological processes. Its involvement in [Actin cytoskeleton organization](/details-go/GO:0030036) and its localization to [focal adhesions](/details-go/GO:0005925) and [adherens junctions](/details-go/GO:0005912) are consistent with its role in modulating [positive regulation of cell migration](/details-go/GO:0030335) [Link](https://doi.org/10.1091/mbc.12.2.339). The gene is a critical component of [Intracellular signal transduction](/details-go/GO:0035556), participating in the [Ras protein signal transduction](/details-go/GO:0007265) pathway and the [positive regulation of JNK cascade](/details-go/GO:0046330). Significantly, [SDCBP](/details-gene/6386) is strongly associated with vesicle trafficking, particularly the [positive regulation of exosomal secretion](/details-go/GO:1903543) and [extracellular exosome assembly](/details-go/GO:1903553). This aligns with its localization to [extracellular exosomes](/details-go/GO:0070062) and suggests a mechanism by which it influences cell-cell communication. In the immune context, its participation in the [Neutrophil degranulation](/details-pathway/R-HSA-6798695) pathway is consistent with its high expression in myeloid cells. Moreover, its role in [Eph-ephrin signaling](/details-pathway/R-HSA-2682334) and [Axon guidance](/details-pathway/R-HSA-422475) highlights its developmental functions, despite its low expression in many mature neural cell types. ## Research Directions The unique expression pattern and multifaceted functions of [SDCBP](/details-gene/6386) suggest several avenues for future investigation. Its roles in disparate biological systems, from skin pigmentation to innate immunity, warrant further mechanistic exploration. Based on the available data, several testable hypotheses can be proposed: 1. Given its status as the top expressed gene in [melanocytes](/details-cell/CL0000148) and its localization to [melanosomes](/details-go/GO:0042470), [SDCBP](/details-gene/6386) may function as a critical trafficking protein that regulates the maturation and transport of melanosomes along the actin cytoskeleton for subsequent transfer to keratinocytes. 2. In the context of macrophages, where [SDCBP](/details-gene/6386) is highly expressed, its role in exosome secretion ([GO:1903543](https://www.ebi.ac.uk/QuickGO/term/GO:1903543)) suggests it orchestrates the packaging and release of inflammatory cytokines and other signaling molecules, thereby modulating the local immune microenvironment. 3. The high significance of [SDCBP](/details-gene/6386) in [extravillous trophoblasts](/details-cell/CL0008036), coupled with its known function in promoting cell migration and epithelial-to-mesenchymal transition ([GO:0010718](https://www.ebi.ac.uk/QuickGO/term/GO:0010718)), indicates it is likely a key driver of trophoblast invasion into the uterine wall, a process essential for successful placentation. To test the first hypothesis regarding its role in melanosome biology, a compelling experimental approach would be to utilize a CRISPR-Cas9 system to knock out [SDCBP](/details-gene/6386) in a human melanocyte cell line. The consequences could be assessed by quantifying melanin content, analyzing melanosome morphology and staging via transmission electron microscopy, and tracking melanosome movement using live-cell imaging. A co-culture system with keratinocytes would further allow for the direct measurement of melanosome transfer efficiency in the absence of [SDCBP](/details-gene/6386). Therapeutically, [SDCBP](/details-gene/6386) presents a complex profile. As an intracellular scaffolding protein, it is not an ideal target for monoclonal antibodies. However, its role in promoting cell migration, proliferation, and exosome-mediated communication is frequently co-opted in cancer metastasis. Therefore, [SDCBP](/details-gene/6386) could be a promising target for small molecule inhibitors designed to disrupt its protein-protein interactions via the PDZ domains. Given its links to oncogenic pathways, inhibition would be the therapeutic strategy, particularly in malignancies derived from cells where it is highly expressed, such as melanoma.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 4139229000

Symbol: SDCB1_HUMAN

Name: Syntenin-1

UniProtKB Accession Codes:

O00560 B2R5Q7 B4DUH3 B7ZLN2 O00173 O43391 Q14CP2

Database IDs:

Citations:

PubMed ID: 9391086

Title: Syntenin, a PDZ protein that binds syndecan cytoplasmic domains.

PubMed ID: 9391086

DOI: 10.1073/pnas.94.25.13683

PubMed ID: 9511750

Title: Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene.

PubMed ID: 9511750

DOI: 10.1016/s0378-1119(97)00562-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9883737

Title: PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.

PubMed ID: 9883737

DOI: 10.1016/s0896-6273(00)80663-7

PubMed ID: 10230395

Title: A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.

PubMed ID: 10230395

DOI: 10.1016/s1097-2765(00)80470-0

PubMed ID: 10770943

Title: Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin.

PubMed ID: 10770943

DOI: 10.1074/jbc.m002459200

PubMed ID: 11152476

Title: The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity.

PubMed ID: 11152476

DOI: 10.1074/jbc.m010647200

PubMed ID: 11432873

Title: Schwannomin isoform-1 interacts with syntenin via PDZ domains.

PubMed ID: 11432873

DOI: 10.1074/jbc.m105792200

PubMed ID: 11179419

Title: Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments.

PubMed ID: 11179419

DOI: 10.1091/mbc.12.2.339

PubMed ID: 11498591

Title: Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein.

PubMed ID: 11498591

DOI: 10.1126/science.1059157

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26032692

Title: Syntenin and syndecan in the biogenesis of exosomes.

PubMed ID: 26032692

DOI: 10.1111/boc.201500010

PubMed ID: 25219541

Title: Targeting tumor invasion: the roles of MDA-9/Syntenin.

PubMed ID: 25219541

DOI: 10.1517/14728222.2014.959495

PubMed ID: 26539120

Title: Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells.

PubMed ID: 26539120

DOI: 10.3389/fphar.2015.00241

PubMed ID: 25893292

Title: Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization.

PubMed ID: 25893292

DOI: 10.1038/onc.2015.100

PubMed ID: 26291527

Title: MDA-9/syntenin control.

PubMed ID: 26291527

DOI: 10.1002/jcp.25136

PubMed ID: 12679023

Title: PDZ tandem of human syntenin: crystal structure and functional properties.

PubMed ID: 12679023

DOI: 10.1016/s0969-2126(03)00052-2

PubMed ID: 12842047

Title: Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.

PubMed ID: 12842047

DOI: 10.1016/s0969-2126(03)00125-4

PubMed ID: 15081807

Title: The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography.

PubMed ID: 15081807

DOI: 10.1016/j.jmb.2004.02.057

PubMed ID: 16533050

Title: The binding of the PDZ tandem of syntenin to target proteins.

PubMed ID: 16533050

DOI: 10.1021/bi052225y

PubMed ID: 27386966

Title: Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.

PubMed ID: 27386966

DOI: 10.1038/ncomms12101

Sequence Information:

Length: 298
Mass: 32444
Checksum: 574E1349F86F949F
Sequence:

MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY PELSQYMGLS 
LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND VGIRRAEIKQ GIREVILCKD 
QDGKIGLRLK SIDNGIFVQL VQANSPASLV GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ 
AFGEKITMTI RDRPFERTIT MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE 
INGQNVIGLK DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV

Genular Protein ID: 1783094541

Symbol: B4DHN5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DHN5

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 239
Mass: 25968
Checksum: C8ECBFCEDF02B3A7
Sequence:

MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY PELSQYMGLS 
LNEEEIRANV AVVSGAPLQG LVQANSPASL VGLRFGDQVL QINGENCAGW SSDKAHKVLK 
QAFGEKITMT IRDRPFERTI TMHKDSTGHV GFIFKNGKIT SIVKDSSAAR NGLLTEHNIC 
EINGQNVIGL KDSQIADILS TSGTVVTITI MPAFIFEHII KRMAPSIMKS LMDHTIPEV

Genular Protein ID: 3473848320

Symbol: G5EA09_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5EA09

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 318
Mass: 34819
Checksum: DEA5027C28090AFB
Sequence:

MIKLWTNRDL HIIVMVKNPA KMSLYPSLED LKVDKVIQAQ TAFSANPANP AILSEASAPI 
PHDGNLYPRL YPELSQYMGL SLNEEEIRAN VAVVSGAPLQ GLVARPSSIN YMVAPVTGND 
VGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV GLRFGDQVLQ 
INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTIT MHKDSTGHVG FIFKNGKITS 
IVKDSSAARN GLLTEHNICE INGQNVIGLK DSQIADILST SGTVVTITIM PAFIFEHIIK 
RMAPSIMKSL MDHTIPEV

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	\|— Ascending colon Healthy UBERON0001156_PATO0000461
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	\|— Caecum Healthy UBERON0001153_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	\|— Colonic epithelium Healthy UBERON0000397_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fallopian tube UBERON0003889
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Middle lobe of right lung UBERON0002174
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Prostate gland UBERON0002367
	Rectum UBERON0001052
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Small intestine UBERON0002108
	\|— Small intestine Healthy UBERON0002108_PATO0000461
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	Transverse colon UBERON0001157
	Type 1 diabetes mellitus MONDO0005147
	Type 2 diabetes mellitus MONDO0005148
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: SDCBP

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. PubMed ID: 9391086

Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene. PubMed ID: 9511750

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. PubMed ID: 9883737

A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. PubMed ID: 10230395

Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin. PubMed ID: 10770943

The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. PubMed ID: 11152476

Schwannomin isoform-1 interacts with syntenin via PDZ domains. PubMed ID: 11432873

Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments. PubMed ID: 11179419

Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. PubMed ID: 11498591

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. PubMed ID: 12643545

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. PubMed ID: 22660413

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Syntenin and syndecan in the biogenesis of exosomes. PubMed ID: 26032692

Targeting tumor invasion: the roles of MDA-9/Syntenin. PubMed ID: 25219541

Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells. PubMed ID: 26539120

Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization. PubMed ID: 25893292

MDA-9/syntenin control. PubMed ID: 26291527

PDZ tandem of human syntenin: crystal structure and functional properties. PubMed ID: 12679023

Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm. PubMed ID: 12842047

The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography. PubMed ID: 15081807

The binding of the PDZ tandem of syntenin to target proteins. PubMed ID: 16533050

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. PubMed ID: 27386966

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The sequence of the human genome. PubMed ID: 11181995

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

PubMed ID: 9391086

PubMed ID: 9511750

PubMed ID: 14702039

PubMed ID: 16421571

PubMed ID: 15489334

PubMed ID: 9883737

PubMed ID: 10230395

PubMed ID: 10770943

PubMed ID: 11152476

PubMed ID: 11432873

PubMed ID: 11179419

PubMed ID: 11498591

PubMed ID: 12643545

PubMed ID: 17081065

PubMed ID: 19413330

PubMed ID: 21269460

PubMed ID: 22660413

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 26032692

PubMed ID: 25219541

PubMed ID: 26539120

PubMed ID: 25893292

PubMed ID: 26291527

PubMed ID: 12679023

PubMed ID: 12842047

PubMed ID: 15081807

PubMed ID: 16533050

PubMed ID: 27386966

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16421571

PubMed ID: 19413330

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 11237011

PubMed ID: 11181995

PubMed ID: 15496913

PubMed ID: 16421571

PubMed ID: 19413330

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 24275569