Details for: SNRPB2

Gene ID: 6629

Symbol: SNRPB2

Ensembl ID: ENSG00000125870

Description: small nuclear ribonucleoprotein polypeptide B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 339.5958
    Cell Significance Index: -52.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 189.2026
    Cell Significance Index: -47.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 169.0628
    Cell Significance Index: -69.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 145.4707
    Cell Significance Index: -68.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 131.2635
    Cell Significance Index: -67.5200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 103.0368
    Cell Significance Index: -69.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.8162
    Cell Significance Index: -65.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.2466
    Cell Significance Index: -48.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.4276
    Cell Significance Index: -68.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.2408
    Cell Significance Index: -43.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.1011
    Cell Significance Index: -17.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.3643
    Cell Significance Index: 42.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.8020
    Cell Significance Index: 332.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.5431
    Cell Significance Index: 49.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.5669
    Cell Significance Index: 74.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.1197
    Cell Significance Index: 108.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.5446
    Cell Significance Index: 66.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3273
    Cell Significance Index: 319.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8028
    Cell Significance Index: 84.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7410
    Cell Significance Index: 112.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4572
    Cell Significance Index: 179.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4390
    Cell Significance Index: 785.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4200
    Cell Significance Index: 38.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4019
    Cell Significance Index: 228.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3996
    Cell Significance Index: 15.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3759
    Cell Significance Index: 40.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3243
    Cell Significance Index: 169.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2797
    Cell Significance Index: 565.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2786
    Cell Significance Index: 150.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1430
    Cell Significance Index: 206.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1221
    Cell Significance Index: 79.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1138
    Cell Significance Index: 83.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0769
    Cell Significance Index: 139.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0272
    Cell Significance Index: 927.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9900
    Cell Significance Index: 17.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7631
    Cell Significance Index: 35.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6864
    Cell Significance Index: 136.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6535
    Cell Significance Index: 17.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4322
    Cell Significance Index: 12.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4237
    Cell Significance Index: 9.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3705
    Cell Significance Index: 74.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2825
    Cell Significance Index: 27.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2594
    Cell Significance Index: 11.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2172
    Cell Significance Index: 37.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1823
    Cell Significance Index: 3.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1267
    Cell Significance Index: 6.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1165
    Cell Significance Index: 1.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1105
    Cell Significance Index: 5.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0980
    Cell Significance Index: 18.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0955
    Cell Significance Index: 34.2400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0902
    Cell Significance Index: 0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0816
    Cell Significance Index: 61.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0155
    Cell Significance Index: 10.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0085
    Cell Significance Index: 6.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0018
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0160
    Cell Significance Index: -9.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0177
    Cell Significance Index: -33.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0265
    Cell Significance Index: -0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0382
    Cell Significance Index: -70.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0398
    Cell Significance Index: -4.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0467
    Cell Significance Index: -71.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0605
    Cell Significance Index: -82.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0744
    Cell Significance Index: -47.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0751
    Cell Significance Index: -42.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1134
    Cell Significance Index: -51.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1280
    Cell Significance Index: -26.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1309
    Cell Significance Index: -37.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1555
    Cell Significance Index: -17.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1571
    Cell Significance Index: -18.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1801
    Cell Significance Index: -4.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2247
    Cell Significance Index: -5.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2426
    Cell Significance Index: -14.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3057
    Cell Significance Index: -9.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3457
    Cell Significance Index: -21.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3478
    Cell Significance Index: -9.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3605
    Cell Significance Index: -52.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3641
    Cell Significance Index: -2.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4204
    Cell Significance Index: -11.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4391
    Cell Significance Index: -12.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4779
    Cell Significance Index: -26.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5055
    Cell Significance Index: -57.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5598
    Cell Significance Index: -44.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6541
    Cell Significance Index: -68.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7049
    Cell Significance Index: -47.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7639
    Cell Significance Index: -58.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8812
    Cell Significance Index: -8.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9031
    Cell Significance Index: -26.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9191
    Cell Significance Index: -12.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9541
    Cell Significance Index: -58.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0559
    Cell Significance Index: -18.1000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -1.0573
    Cell Significance Index: -6.0100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.1313
    Cell Significance Index: -7.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1619
    Cell Significance Index: -20.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2597
    Cell Significance Index: -55.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.2847
    Cell Significance Index: -19.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3912
    Cell Significance Index: -51.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4297
    Cell Significance Index: -36.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5034
    Cell Significance Index: -56.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.5155
    Cell Significance Index: -12.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNRPB2 is a member of the U2 small nuclear ribonucleoprotein (snRNP) family, which plays a pivotal role in the splicing of pre-mRNA. This process is essential for the generation of mature mRNA, which ultimately affects protein expression and cellular function. SNRPB2 is specifically involved in the catalytic step 2 of the spliceosome, where it interacts with the U2 snRNA to facilitate the removal of introns and the joining of exons. **Pathways and Functions:** The spliceosome complex, in which SNRPB2 is a key component, is a multi-protein machine that undergoes a series of conformational changes during the splicing process. These changes allow the complex to recognize and bind to specific sequences within the pre-mRNA, ultimately leading to the removal of introns and the formation of mature mRNA. SNRPB2's involvement in this process highlights its importance in regulating gene expression and cellular function. Furthermore, SNRPB2 has been implicated in various cellular processes, including: 1. **Immune cell development and function:** SNRPB2 is significantly expressed in immune cells, such as CD8-alpha-alpha-positive, alpha-beta intraepithelial T cells, and hematopoietic stem cells. Its presence in these cells suggests a critical role in the development and regulation of immune responses. 2. **RNA processing:** SNRPB2's involvement in the spliceosome complex highlights its importance in RNA processing, a process essential for the generation of mature mRNA. 3. **Cellular differentiation:** SNRPB2's expression in various cell types, including epithelial cells of the nephron and radial glial cells, suggests its role in cellular differentiation and development. **Clinical Significance:** The clinical significance of SNRPB2 lies in its potential role in various diseases, including: 1. **Immune disorders:** Dysregulation of immune cell development and function can lead to autoimmune diseases or impaired immune responses. SNRPB2's involvement in immune cell development and function makes it a potential target for therapeutic interventions. 2. **Cancer:** Alterations in RNA processing and splicing have been implicated in the development and progression of various cancers. SNRPB2's role in RNA processing and its expression in cancer cells suggest its potential as a biomarker or therapeutic target. 3. **Neurological disorders:** SNRPB2's expression in radial glial cells and its involvement in RNA processing highlight its potential role in neurological disorders, such as neurodegenerative diseases. In conclusion, SNRPB2 is a critical component of the spliceosome complex, playing a pivotal role in RNA processing and cellular function. Its expression in various cell types, including immune cells, highlights its importance in immune development and function. Further research is necessary to fully elucidate the clinical significance of SNRPB2 and its potential role in various diseases.

Genular Protein ID: 1137708271

Symbol: RU2B_HUMAN

Name: U2 small nuclear ribonucleoprotein B''

UniProtKB Accession Codes:

P08579 B2R7J3 D3DW21 Q9UJD4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 7 EMDB 37 Ensembl 2 EvolutionaryTrace 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 41 PDBsum 41 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2951739

Title: Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B' antigen.

PubMed ID: 2951739

DOI: 10.1073/pnas.84.8.2421

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12084575

Title: Crooked neck is a component of the human spliceosome and implicated in the splicing process.

PubMed ID: 12084575

DOI: 10.1016/s0167-4781(02)00368-8

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9716128

Title: Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA.

PubMed ID: 9716128

DOI: 10.1038/29234

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 225
  • Mass: 25486
  • Checksum: 67C949CC7E14A92A
  • Sequence:
    • MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG QAFVIFKELG 
SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD KEKKKEKKKA KTVEQTATTT 
NKKPGQGTPN SANTQGNSTP NPQVPDYPPN YILFLNNLPE ETNEMMLSML FNQFPGFKEV 
RLVPGRHDIA FVEFENDGQA GAARDALQGF KITPSHAMKI TYAKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.