Details for: SQLE
Gene ID: 6713
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SQLE
Ensembl ID: ENSG00000104549
Description: squalene epoxidase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 21.79rCSI 25.19%PRS 43.43
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CSI 20.56rCSI 31.78%PRS 51.49
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CSI 18.92rCSI 41.8%PRS 40.56
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CSI 17.28rCSI 55.45%PRS 59.79
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CSI 16.26rCSI 17.03%PRS 50.23
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CSI 15.78rCSI 19.06%PRS 61.93
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CSI 14.87rCSI 18.66%PRS 63.91
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CSI 13.63rCSI 18.93%PRS 52.74
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CSI 13.08rCSI 25.44%PRS 56.04
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CSI 12.92rCSI 20.62%PRS 46.75
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CSI 12.68rCSI 12.21%PRS 53.81
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CSI 12.59rCSI 12.57%PRS 47.18
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CSI 11.93rCSI 14.76%PRS 49.43
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CSI 11.36rCSI 13.63%PRS 51.66
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CSI 10.62rCSI 10.24%PRS 44.07
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CSI 10.53rCSI 35.58%PRS 60.22
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CSI 10rCSI 8.38%PRS 58.34
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CSI 9.89rCSI 13.48%PRS 46.14
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CSI 9.18rCSI 39.85%PRS 68.13
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CSI 8.88rCSI 11.4%PRS 51.26
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CSI 8.61rCSI 42.43%PRS 64.96
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CSI 8.57rCSI 9.11%PRS 66.04
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CSI 8.47rCSI 24.09%PRS 51.96
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CSI 7.76rCSI 5.42%PRS 56.14
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CSI 7.31rCSI 11.84%PRS 50.96
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CSI 7.31rCSI 16.38%PRS 37.07
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CSI 7.02rCSI 10.36%PRS 70.27
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CSI 6.87rCSI 10.48%PRS 49.98
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CSI 6.77rCSI 15.43%PRS 50.8
-
CSI 6.68rCSI 16.54%PRS 51.47
-
CSI 6.63rCSI 6.91%PRS 53.88
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CSI 6.26rCSI 4.95%PRS 40.64
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CSI 6.12rCSI 7.18%PRS 56.59
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CSI 5.99rCSI 34.88%PRS 63.49
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CSI 5.99rCSI 5.26%PRS 41.93
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CSI 5.95rCSI 3.96%PRS 57.13
-
CSI 5.84rCSI 45.74%PRS 67.41
-
CSI 5.69rCSI 5.05%PRS 51.88
-
CSI 5.39rCSI 19.12%PRS 64.22
-
CSI 5.26rCSI 7.71%PRS 51.06
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CSI 5.24rCSI 3.88%PRS 46.21
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CSI 5.2rCSI 8.73%PRS 36.29
-
CSI 5.18rCSI 7.9%PRS 70.38
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CSI 5.14rCSI 28.08%PRS 53.55
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CSI 4.87rCSI 14.44%PRS 63.88
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CSI 4.68rCSI 6.22%PRS 59.07
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CSI 4.61rCSI 3.57%PRS 54.54
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CSI 4.59rCSI 7.06%PRS 52.01
-
CSI 4.59rCSI 4.8%PRS 56.81
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CSI 4.57rCSI 9.08%PRS 51.54
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CSI 4.5rCSI 19.79%PRS 45.24
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CSI 4.44rCSI 6.07%PRS 59.03
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CSI 4.42rCSI 12.65%PRS 68.44
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CSI 4.31rCSI 6.21%PRS 63.33
-
CSI 4.3rCSI 9.61%PRS 60.88
-
CSI 3.87rCSI 7.94%PRS 45.31
-
CSI 3.86rCSI 3.64%PRS 53.57
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CSI 3.81rCSI 7.66%PRS 42.84
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CSI 3.78rCSI 21.78%PRS 53.67
-
CSI 3.75rCSI 3.11%PRS 52.35
-
CSI 3.71rCSI 3.25%PRS 63.81
-
CSI 3.7rCSI 3.34%PRS 50.36
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CSI 3.68rCSI 10.85%PRS 57.3
-
CSI 3.67rCSI 52.07%PRS 45.02
-
CSI 3.66rCSI 5.81%PRS 64.55
-
CSI 3.65rCSI 7.77%PRS 66.51
-
CSI 3.65rCSI 5.66%PRS 61.97
-
CSI 3.64rCSI 6.86%PRS 64.05
-
CSI 3.59rCSI 2.82%PRS 60.34
-
CSI 3.33rCSI 11.41%PRS 43.3
-
CSI 3.3rCSI 4.41%PRS 54.58
-
CSI 3.29rCSI 10.66%PRS 55.23
-
CSI 3.25rCSI 3.34%PRS 71.45
-
CSI 3.22rCSI 8.36%PRS 57.67
-
CSI 3.14rCSI 4.29%PRS 55.83
-
CSI 3.08rCSI 3.3%PRS 52.02
-
CSI 3.08rCSI 5.04%PRS 43.23
-
CSI 3.07rCSI 5.5%PRS 52.11
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CSI 3.03rCSI 4.48%PRS 58.97
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CSI 2.99rCSI 60.91%PRS 46.22
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CSI 2.94rCSI 59.78%PRS 44.88
-
CSI 2.91rCSI 5.14%PRS 35.28
-
CSI 2.88rCSI 7.3%PRS 48.59
-
CSI 2.85rCSI 5.91%PRS 50.75
-
CSI 2.83rCSI 7.56%PRS 45.12
-
CSI 2.83rCSI 4.84%PRS 63.04
-
CSI 2.8rCSI 3.83%PRS 62.09
-
CSI 2.74rCSI 6.52%PRS 63.96
-
CSI 2.7rCSI 4.9%PRS 46.12
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CSI 2.64rCSI 9.48%PRS 34.94
-
CSI 2.59rCSI 6.81%PRS 73.8
-
CSI 2.58rCSI 3.77%PRS 57.2
-
CSI 2.56rCSI 2.97%PRS 62.55
-
CSI 2.52rCSI 2.22%PRS 58.89
-
CSI 2.51rCSI 2.9%PRS 47.35
-
CSI 2.42rCSI 9.13%PRS 42.2
-
CSI 2.4rCSI 2.51%PRS 52.25
-
CSI 2.26rCSI 1.7%PRS 58.15
-
CSI 2.22rCSI 2.19%PRS 56.07
-
CSI 2.19rCSI 8.54%PRS 74.17
-
CSI 0.1rCSI 1.0%PRS 40.5%
-
CSI 0.2rCSI 3.1%PRS 85.1%
-
CSI 0.2rCSI 5.8%PRS 75.1%
-
CSI 0.3rCSI 0.8%PRS 37.7%
-
CSI 0.3rCSI 1.6%PRS 64.0%
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CSI 0.4rCSI 4.5%PRS 68.0%
-
CSI 0.5rCSI 1.1%PRS 51.3%
-
CSI 0.5rCSI 1.6%PRS 40.2%
-
CSI 0.5rCSI 3.8%PRS 71.4%
-
CSI 0.5rCSI 5.1%PRS 74.9%
-
CSI 0.5rCSI 5.0%PRS 88.2%
-
CSI 0.6rCSI 3.1%PRS 67.6%
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CSI 0.6rCSI 5.8%PRS 76.0%
-
CSI 0.6rCSI 3.4%PRS 67.5%
-
CSI 0.7rCSI 2.6%PRS 53.8%
-
CSI 0.7rCSI 3.4%PRS 76.6%
-
CSI 0.7rCSI 2.9%PRS 68.1%
-
CSI 0.7rCSI 2.7%PRS 45.3%
-
CSI 0.7rCSI 5.3%PRS 40.6%
-
CSI 0.7rCSI 3.2%PRS 70.2%
-
CSI 0.8rCSI 3.8%PRS 52.0%
-
CSI 0.8rCSI 0.8%PRS 59.2%
-
CSI 0.8rCSI 1.4%PRS 43.6%
-
CSI 0.9rCSI 2.1%PRS 35.0%
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CSI 0.9rCSI 5.3%PRS 84.6%
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CSI 0.9rCSI 12.9%PRS 72.0%
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CSI 0.9rCSI 3.1%PRS 67.7%
-
CSI 0.9rCSI 9.8%PRS 92.7%
-
CSI 1.0rCSI 9.3%PRS 66.7%
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CSI 1.0rCSI 11.0%PRS 71.0%
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CSI 1.0rCSI 2.8%PRS 66.4%
-
CSI 1.1rCSI 2.3%PRS 70.3%
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CSI 1.1rCSI 3.1%PRS 69.0%
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CSI 1.1rCSI 1.7%PRS 45.9%
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CSI 1.1rCSI 3.8%PRS 39.9%
-
CSI 1.1rCSI 1.7%PRS 65.1%
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CSI 1.1rCSI 2.1%PRS 42.4%
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CSI 1.2rCSI 2.6%PRS 67.0%
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CSI 1.3rCSI 1.8%PRS 65.6%
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CSI 1.3rCSI 3.3%PRS 48.8%
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CSI 1.3rCSI 6.7%PRS 65.2%
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CSI 1.3rCSI 3.0%PRS 68.0%
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CSI 1.3rCSI 2.1%PRS 38.4%
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CSI 1.3rCSI 3.8%PRS 68.4%
-
CSI 1.3rCSI 2.0%PRS 54.1%
-
CSI 1.3rCSI 6.0%PRS 52.6%
-
CSI 1.4rCSI 3.3%PRS 72.1%
-
CSI 1.4rCSI 2.3%PRS 59.0%
-
CSI 1.4rCSI 2.0%PRS 56.1%
-
CSI 1.4rCSI 2.0%PRS 58.9%
-
CSI 1.4rCSI 2.2%PRS 68.6%
-
CSI 1.4rCSI 4.1%PRS 51.4%
-
CSI 1.5rCSI 3.5%PRS 58.2%
-
CSI 1.5rCSI 3.7%PRS 43.2%
-
CSI 1.5rCSI 1.9%PRS 37.4%
-
CSI 1.5rCSI 2.3%PRS 61.7%
-
CSI 1.5rCSI 1.2%PRS 54.7%
-
CSI 1.5rCSI 2.0%PRS 76.1%
-
CSI 1.5rCSI 4.2%PRS 66.6%
-
CSI 1.5rCSI 1.9%PRS 58.4%
-
CSI 1.5rCSI 6.1%PRS 72.3%
-
CSI 1.6rCSI 3.3%PRS 55.0%
-
CSI 1.6rCSI 4.6%PRS 43.8%
-
CSI 1.6rCSI 2.0%PRS 55.6%
-
CSI 1.6rCSI 2.5%PRS 58.2%
-
CSI 1.6rCSI 3.9%PRS 66.6%
-
CSI 1.7rCSI 2.0%PRS 36.1%
-
CSI 1.7rCSI 2.2%PRS 59.8%
-
CSI 1.7rCSI 2.3%PRS 48.1%
-
CSI 1.7rCSI 1.3%PRS 71.3%
-
CSI 1.8rCSI 2.2%PRS 34.5%
-
CSI 1.8rCSI 3.2%PRS 69.7%
-
CSI 1.8rCSI 1.6%PRS 64.1%
-
CSI 1.8rCSI 3.2%PRS 68.2%
-
CSI 1.8rCSI 4.0%PRS 62.3%
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CSI 1.8rCSI 2.8%PRS 62.9%
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CSI 1.9rCSI 11.4%PRS 71.0%
-
CSI 1.9rCSI 1.6%PRS 55.2%
-
CSI 1.9rCSI 4.5%PRS 62.4%
-
CSI 1.9rCSI 3.1%PRS 59.4%
-
CSI 1.9rCSI 7.3%PRS 37.1%
-
CSI 1.9rCSI 57.8%PRS 75.3%
-
CSI 2.0rCSI 1.8%PRS 54.7%
-
CSI 2.0rCSI 2.4%PRS 61.4%
-
CSI 2.0rCSI 5.5%PRS 61.6%
-
CSI 2.1rCSI 12.2%PRS 37.7%
-
CSI 2.1rCSI 1.8%PRS 58.2%
-
CSI 2.1rCSI 2.2%PRS 67.1%
-
CSI 2.2rCSI 3.7%PRS 73.0%
-
CSI 2.2rCSI 8.5%PRS 74.2%
-
CSI 2.2rCSI 2.2%PRS 56.1%
-
CSI 2.3rCSI 1.7%PRS 58.2%
-
CSI 2.4rCSI 2.5%PRS 52.3%
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CSI 2.4rCSI 9.1%PRS 42.2%
-
CSI 2.5rCSI 2.9%PRS 47.4%
-
CSI 2.5rCSI 2.2%PRS 58.9%
-
CSI 2.6rCSI 3.0%PRS 62.6%
-
CSI 2.6rCSI 3.8%PRS 57.2%
-
CSI 2.6rCSI 6.8%PRS 73.8%
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CSI 2.6rCSI 9.5%PRS 34.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1601676275
Symbol: ERG1_HUMAN
Name: Squalene monooxygenase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9286711
Title: Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1.
PubMed ID: 9286711
PubMed ID: 10666321
Title: Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase.
PubMed ID: 10666321
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8626488
Title: Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells.
PubMed ID: 8626488
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24449766
Title: The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.
PubMed ID: 24449766
DOI: 10.1128/mcb.01140-13
PubMed ID: 26434806
Title: The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.
PubMed ID: 26434806
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28972164
Title: A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.
PubMed ID: 28972164
PubMed ID: 29765154
Title: The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation.
PubMed ID: 29765154
PubMed ID: 30626872
Title: Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
PubMed ID: 30626872
Sequence Information:
- Length: 574
- Mass: 63923
- Checksum: 6957F5CF1F1624C8
- Sequence:
MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN GGLLGRQQSG SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK GTNISETSLI GTAACTSTSS QNDPEVIIVG AGVLGSALAA VLSRDGRKVT VIERDLKEPD RIVGEFLQPG GYHVLKDLGL GDTVEGLDAQ VVNGYMIHDQ ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE PNAKFIEGVV LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV SVSSHFVGFL MKNAPQFKAN HAELILANPS PVLIYQISSS ETRVLVDIRG EMPRNLREYM VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK RGVLLLGDAY NMRHPLTGGG MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLRKA CFLYFKLGGE CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW ITKPRALLSS GAVLYKACSV IFPLIYSEMK YMVH
Genular Protein ID: 3551262024
Symbol: Q5HYI4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 574
- Mass: 63794
- Checksum: C4C6B0DB5CBB8909
- Sequence:
MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN GGLLGRQQSG SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK GTNISETSLI GTAACTSTSS QNDPEVIIVG AGVLGSALAA VLSRDGRKVT VIERDLKEPD RIVGEFLQPG GYHVLKDLGL GDTVEGLDAQ VVNGYMIHDQ ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE PNAKFIEGVV LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV SVSSHFVGFL MKNAPQFKAN HAELILANPG PVLIYQISSS ETRVLVDIRG EMPRNLREYM VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK RGVLLLGDAY NMRHPLTGGG MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLGKA CFLYFKLGGE CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW ITKPRALLSS GAVLYKACSV IFPLIYSEMK YMVH