Details for: TAL2

Gene ID: 6887

Symbol: TAL2

Ensembl ID: ENSG00000186051

Description: TAL bHLH transcription factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 9.0876
    Cell Significance Index: -2.3100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.9251
    Cell Significance Index: 24.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1638
    Cell Significance Index: 28.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1516
    Cell Significance Index: 52.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8870
    Cell Significance Index: 168.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6185
    Cell Significance Index: 61.1900
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.6098
    Cell Significance Index: 5.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5988
    Cell Significance Index: 19.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5039
    Cell Significance Index: 454.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3108
    Cell Significance Index: 7.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3105
    Cell Significance Index: 50.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2799
    Cell Significance Index: 30.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1906
    Cell Significance Index: 3.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1527
    Cell Significance Index: 10.5600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.1393
    Cell Significance Index: 1.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1272
    Cell Significance Index: 2.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1151
    Cell Significance Index: 6.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0913
    Cell Significance Index: 2.0000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0545
    Cell Significance Index: 0.4200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0506
    Cell Significance Index: 0.7100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0451
    Cell Significance Index: 0.5900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0313
    Cell Significance Index: 0.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0220
    Cell Significance Index: 6.3300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0183
    Cell Significance Index: 0.2400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0175
    Cell Significance Index: 0.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0117
    Cell Significance Index: 1.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0086
    Cell Significance Index: 5.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0080
    Cell Significance Index: 0.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0052
    Cell Significance Index: 0.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0052
    Cell Significance Index: 0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0023
    Cell Significance Index: 1.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0030
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0032
    Cell Significance Index: -1.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0034
    Cell Significance Index: -2.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0035
    Cell Significance Index: -0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0038
    Cell Significance Index: -0.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0050
    Cell Significance Index: -0.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0061
    Cell Significance Index: -1.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0073
    Cell Significance Index: -0.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0079
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0103
    Cell Significance Index: -1.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0105
    Cell Significance Index: -1.9000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0107
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0115
    Cell Significance Index: -2.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0118
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0129
    Cell Significance Index: -1.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0129
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0145
    Cell Significance Index: -1.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0175
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0176
    Cell Significance Index: -2.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0177
    Cell Significance Index: -2.2900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0185
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0194
    Cell Significance Index: -1.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0199
    Cell Significance Index: -0.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0217
    Cell Significance Index: -1.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0217
    Cell Significance Index: -0.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0228
    Cell Significance Index: -1.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0230
    Cell Significance Index: -1.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0238
    Cell Significance Index: -0.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0239
    Cell Significance Index: -1.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0262
    Cell Significance Index: -0.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0276
    Cell Significance Index: -2.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0333
    Cell Significance Index: -2.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0349
    Cell Significance Index: -2.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0379
    Cell Significance Index: -1.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0390
    Cell Significance Index: -1.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0394
    Cell Significance Index: -2.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0396
    Cell Significance Index: -0.4300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0411
    Cell Significance Index: -0.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0452
    Cell Significance Index: -1.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0465
    Cell Significance Index: -2.1900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0473
    Cell Significance Index: -0.5600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0505
    Cell Significance Index: -0.5000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0506
    Cell Significance Index: -0.4300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0542
    Cell Significance Index: -0.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0549
    Cell Significance Index: -2.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0568
    Cell Significance Index: -1.9900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0574
    Cell Significance Index: -0.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0577
    Cell Significance Index: -1.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0605
    Cell Significance Index: -1.6200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0623
    Cell Significance Index: -0.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0626
    Cell Significance Index: -3.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0637
    Cell Significance Index: -2.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0642
    Cell Significance Index: -2.4300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0647
    Cell Significance Index: -0.8200
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0647
    Cell Significance Index: -0.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0663
    Cell Significance Index: -2.1100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0666
    Cell Significance Index: -0.8400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0670
    Cell Significance Index: -0.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0684
    Cell Significance Index: -1.6700
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0733
    Cell Significance Index: -0.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0743
    Cell Significance Index: -0.8100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0756
    Cell Significance Index: -2.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** TAL2 acts as a transcriptional regulator by binding to specific DNA sequences and interacting with RNA polymerase II to facilitate the transcription of target genes. 2. **Cell Fate Determination:** TAL2 plays a critical role in determining the fate of cells in the immune system, including the development of neuroendocrine cells, conventional dendritic cells, and granulocyte-monocyte progenitor cells. 3. **Multifunctional:** TAL2 is involved in regulating the expression of genes involved in various cellular processes, including cell proliferation, differentiation, survival, and migration. 4. **Tissue-Specific Expression:** TAL2 is expressed in a variety of tissues, including the immune system, nervous system, and epithelial tissues, suggesting its role in regulating cell fate and development in multiple tissues. **Pathways and Functions:** 1. **Chromatin Remodeling:** TAL2 interacts with chromatin-modifying proteins to regulate chromatin structure and facilitate the transcription of target genes. 2. **DNA Binding:** TAL2 binds to specific DNA sequences, including those involved in the regulation of gene expression, to modulate the transcription of target genes. 3. **RNA Polymerase II Specificity:** TAL2 interacts with RNA polymerase II to facilitate the transcription of target genes, ensuring the precise regulation of gene expression. 4. **Protein Binding and Dimerization:** TAL2 interacts with other transcription factors and co-factors to form protein complexes that regulate gene expression. 5. **Signaling Pathways:** TAL2 is involved in regulating signaling pathways, including those involved in cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of the TAL2 gene has been implicated in various diseases, including cancer, autoimmune disorders, and neurological disorders. For example, TAL2 has been identified as a tumor suppressor gene in certain types of cancer, including T-cell acute lymphoblastic leukemia (TALL). Additionally, TAL2 has been implicated in the pathogenesis of autoimmune disorders, such as multiple sclerosis, and neurological disorders, such as Parkinson's disease. Further research is needed to fully understand the role of TAL2 in human disease and to develop targeted therapies for its dysregulation. In conclusion, the TAL2 gene is a critical regulator of cell fate and development in the immune system and beyond. Its dysregulation has been implicated in various diseases, highlighting the need for further research to fully understand its role in human disease and to develop targeted therapies.

Genular Protein ID: 3183666809

Symbol: TAL2_HUMAN

Name: T-cell acute lymphocytic leukemia protein 2

UniProtKB Accession Codes:

Q16559 A0AVI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1763056

Title: TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.

PubMed ID: 1763056

DOI: 10.1073/pnas.88.24.11416

PubMed ID: 8152805

Title: Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity.

PubMed ID: 8152805

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 108
  • Mass: 12291
  • Checksum: DE9D67D940EF4749
  • Sequence:
    • MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY INFLVKVLGE 
QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS PGPSHHIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.