Details for: TRGJP2

Gene ID: 6972

Symbol: TRGJP2

Ensembl ID: ENSG00000211688

Description: T cell receptor gamma joining P2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 7.9839
    Cell Significance Index: 156.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5527
    Cell Significance Index: 37.6100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3315
    Cell Significance Index: 4.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2606
    Cell Significance Index: 3.0800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1176
    Cell Significance Index: 1.9100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1141
    Cell Significance Index: 1.6700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0227
    Cell Significance Index: 0.2800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0128
    Cell Significance Index: 0.1700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0054
    Cell Significance Index: -0.1100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0057
    Cell Significance Index: -0.0800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0089
    Cell Significance Index: -0.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0093
    Cell Significance Index: -0.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0106
    Cell Significance Index: -0.4000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0153
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0157
    Cell Significance Index: -0.2000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0165
    Cell Significance Index: -0.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0169
    Cell Significance Index: -0.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0176
    Cell Significance Index: -0.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0197
    Cell Significance Index: -0.2600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0208
    Cell Significance Index: -0.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0220
    Cell Significance Index: -0.2700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0226
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0244
    Cell Significance Index: -0.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0274
    Cell Significance Index: -0.4600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0278
    Cell Significance Index: -0.2600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0282
    Cell Significance Index: -0.3200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0284
    Cell Significance Index: -0.3900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0304
    Cell Significance Index: -0.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0308
    Cell Significance Index: -0.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0310
    Cell Significance Index: -0.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0312
    Cell Significance Index: -0.3400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0312
    Cell Significance Index: -0.3800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0324
    Cell Significance Index: -0.5500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0331
    Cell Significance Index: -0.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0348
    Cell Significance Index: -0.4000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0358
    Cell Significance Index: -0.3200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0361
    Cell Significance Index: -0.4000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0369
    Cell Significance Index: -0.3500
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.0388
    Cell Significance Index: -0.4100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0390
    Cell Significance Index: -0.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0392
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0398
    Cell Significance Index: -0.4200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0419
    Cell Significance Index: -0.3900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0436
    Cell Significance Index: -0.4300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0436
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0437
    Cell Significance Index: -0.4100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0459
    Cell Significance Index: -0.3800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0461
    Cell Significance Index: -0.4100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0483
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0495
    Cell Significance Index: -0.3800
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0502
    Cell Significance Index: -0.4900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0524
    Cell Significance Index: -0.3500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0528
    Cell Significance Index: -0.5500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0531
    Cell Significance Index: -0.4300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0578
    Cell Significance Index: -0.4300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0610
    Cell Significance Index: -0.3900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0641
    Cell Significance Index: -0.6400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0646
    Cell Significance Index: -0.3900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0658
    Cell Significance Index: -0.5400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0738
    Cell Significance Index: -0.4000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0768
    Cell Significance Index: -0.7900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0769
    Cell Significance Index: -0.7800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0817
    Cell Significance Index: -0.9400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0907
    Cell Significance Index: -0.7700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0933
    Cell Significance Index: -0.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0936
    Cell Significance Index: -0.9000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0964
    Cell Significance Index: -0.7500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1020
    Cell Significance Index: -0.9100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1119
    Cell Significance Index: -0.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGJP2 is a gene that belongs to the gamma joining (GJ) family of genes, which are involved in the development and maturation of gamma-delta T cells. The TRGJP2 gene encodes a protein that is specifically expressed in mature gamma-delta T cells, natural killer cells, and other immune cells. Notably, TRGJP2 is also expressed in non-immune cells, such as cerebral cortex endothelial cells and club cells, highlighting its broader roles in development and tissue homeostasis. **Pathways and Functions:** TRGJP2 plays a crucial role in the development and function of gamma-delta T cells, which are essential for innate immunity. Gamma-delta T cells are involved in the recognition and elimination of pathogens, and TRGJP2 is necessary for the proper maturation and function of these cells. TRGJP2 also interacts with other signaling molecules, such as the T cell receptor (TCR), to regulate the activation and proliferation of gamma-delta T cells. Furthermore, TRGJP2 has been implicated in the regulation of natural killer cell function and the development of innate lymphoid cells. In addition to its role in the immune system, TRGJP2 has also been shown to be involved in the development and function of non-immune cells. For example, TRGJP2 is expressed in cerebral cortex endothelial cells, where it may play a role in the regulation of blood-brain barrier function. TRGJP2 has also been found in club cells, where it may contribute to the regulation of airway homeostasis. **Clinical Significance:** Dysregulation of TRGJP2 has been implicated in various diseases, including autoimmune disorders, cancer, and neurological conditions. For example, mutations in TRGJP2 have been associated with autoimmune diseases such as multiple sclerosis and type 1 diabetes. Additionally, TRGJP2 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it may contribute to tumorigenesis. Furthermore, TRGJP2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of immune responses and inflammation. The expression of TRGJP2 in cerebral cortex endothelial cells may also be relevant to the pathogenesis of neurodegenerative diseases, where it may contribute to the disruption of blood-brain barrier function. In conclusion, TRGJP2 is a gene that plays a critical role in the development and function of gamma-delta T cells and other immune cells, as well as non-immune cells. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of TRGJP2.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.