Details for: TIAL1

Gene ID: 7073

Symbol: TIAL1

Ensembl ID: ENSG00000151923

Description: TIA1 cytotoxic granule associated RNA binding protein like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 366.1315
    Cell Significance Index: -56.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 220.9795
    Cell Significance Index: -56.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 170.5071
    Cell Significance Index: -70.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 136.8712
    Cell Significance Index: -64.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 130.9516
    Cell Significance Index: -53.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 120.1240
    Cell Significance Index: -61.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 96.4536
    Cell Significance Index: -64.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.3188
    Cell Significance Index: -53.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.7990
    Cell Significance Index: -61.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.8592
    Cell Significance Index: -53.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.3556
    Cell Significance Index: -64.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.0873
    Cell Significance Index: -46.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.5051
    Cell Significance Index: -25.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.5080
    Cell Significance Index: 525.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.8640
    Cell Significance Index: 2585.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8565
    Cell Significance Index: 25.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6224
    Cell Significance Index: 97.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6081
    Cell Significance Index: 42.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2542
    Cell Significance Index: 35.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1383
    Cell Significance Index: 228.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0956
    Cell Significance Index: 217.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0319
    Cell Significance Index: 141.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0193
    Cell Significance Index: 120.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9981
    Cell Significance Index: 51.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9946
    Cell Significance Index: 122.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9856
    Cell Significance Index: 353.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9823
    Cell Significance Index: 63.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9615
    Cell Significance Index: 43.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9159
    Cell Significance Index: 56.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9010
    Cell Significance Index: 162.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8631
    Cell Significance Index: 40.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8594
    Cell Significance Index: 469.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8512
    Cell Significance Index: 23.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8231
    Cell Significance Index: 23.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7665
    Cell Significance Index: 35.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7085
    Cell Significance Index: 39.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6869
    Cell Significance Index: 303.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6506
    Cell Significance Index: 83.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5899
    Cell Significance Index: 16.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4229
    Cell Significance Index: 292.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3783
    Cell Significance Index: 26.7600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3634
    Cell Significance Index: 5.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3539
    Cell Significance Index: 27.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3394
    Cell Significance Index: 64.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3118
    Cell Significance Index: 53.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2428
    Cell Significance Index: 31.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2301
    Cell Significance Index: 14.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1854
    Cell Significance Index: 9.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1792
    Cell Significance Index: 29.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1406
    Cell Significance Index: 10.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0818
    Cell Significance Index: 154.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0436
    Cell Significance Index: 67.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0397
    Cell Significance Index: 0.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0297
    Cell Significance Index: 54.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0267
    Cell Significance Index: 16.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0233
    Cell Significance Index: 0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0093
    Cell Significance Index: 4.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0061
    Cell Significance Index: -8.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0262
    Cell Significance Index: -19.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0337
    Cell Significance Index: -24.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0415
    Cell Significance Index: -25.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0420
    Cell Significance Index: -31.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0546
    Cell Significance Index: -5.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0671
    Cell Significance Index: -1.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0691
    Cell Significance Index: -2.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0876
    Cell Significance Index: -49.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0903
    Cell Significance Index: -1.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0914
    Cell Significance Index: -9.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1154
    Cell Significance Index: -6.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1162
    Cell Significance Index: -3.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1664
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1704
    Cell Significance Index: -35.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1823
    Cell Significance Index: -52.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2122
    Cell Significance Index: -30.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2188
    Cell Significance Index: -4.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2513
    Cell Significance Index: -6.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2648
    Cell Significance Index: -17.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3115
    Cell Significance Index: -7.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3438
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3441
    Cell Significance Index: -39.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4385
    Cell Significance Index: -50.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4827
    Cell Significance Index: -21.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5197
    Cell Significance Index: -3.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5267
    Cell Significance Index: -16.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5313
    Cell Significance Index: -11.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5434
    Cell Significance Index: -56.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6256
    Cell Significance Index: -23.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6663
    Cell Significance Index: -52.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7095
    Cell Significance Index: -17.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7452
    Cell Significance Index: -37.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7453
    Cell Significance Index: -19.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7596
    Cell Significance Index: -14.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8894
    Cell Significance Index: -54.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8960
    Cell Significance Index: -20.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1590
    Cell Significance Index: -31.0600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.1672
    Cell Significance Index: -28.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2898
    Cell Significance Index: -37.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3056
    Cell Significance Index: -34.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.3163
    Cell Significance Index: -14.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3661
    Cell Significance Index: -29.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TIAL1 exhibits several key characteristics that distinguish it from other RNA binding proteins: 1. **RNA binding specificity**: TIAL1 binds to specific RNA sequences, including AREs, which are commonly found in mRNAs involved in stress granule formation and apoptosis. 2. **Stress granule formation**: TIAL1 is involved in the formation of stress granules, which are cytosolic structures that regulate mRNA translation and stability. 3. **Apoptosis regulation**: TIAL1 regulates apoptosis by modulating the expression of pro-apoptotic and anti-apoptotic genes. 4. **Cell proliferation regulation**: TIAL1 also regulates cell proliferation by modulating the expression of genes involved in cell cycle progression. **Pathways and Functions** TIAL1 is involved in several cellular pathways, including: 1. **Apoptotic process**: TIAL1 regulates apoptosis by modulating the expression of pro-apoptotic and anti-apoptotic genes. 2. **Cytolytic granule**: TIAL1 is involved in the formation of cytolytic granules, which are cytosolic structures that regulate cell death. 3. **Cytoplasmic stress granule**: TIAL1 regulates cytoplasmic stress granule formation, which is involved in the regulation of mRNA translation and stability. 4. **Defense response**: TIAL1 is involved in the defense response against viral infections and other cellular stresses. 5. **Stem cell proliferation**: TIAL1 regulates stem cell proliferation by modulating the expression of genes involved in cell cycle progression. **Clinical Significance** TIAL1 has significant clinical implications, particularly in the context of: 1. **Cancer**: TIAL1 is overexpressed in certain types of cancer, including breast cancer, and may contribute to tumor progression and metastasis. 2. **Autoimmune diseases**: TIAL1 is involved in the regulation of immune responses and may contribute to the development of autoimmune diseases, such as multiple sclerosis. 3. **Neurological disorders**: TIAL1 may play a role in the regulation of neuronal function and may contribute to the development of neurological disorders, such as Alzheimer's disease. In conclusion, TIAL1 is a critical RNA binding protein that regulates various cellular processes, including apoptosis, cytosolic stress granule formation, and immune response regulation. Its clinical significance is underscored by its overexpression in certain types of cancer and autoimmune diseases, as well as its potential role in the development of neurological disorders. Further research is needed to fully elucidate the functions of TIAL1 and its clinical implications.

Genular Protein ID: 3777636495

Symbol: TIAR_HUMAN

Name: Nucleolysin TIAR

UniProtKB Accession Codes:

Q01085 A8K3T0 A8K4L9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 1 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1326761

Title: Identification and functional characterization of a TIA-1-related nucleolysin.

PubMed ID: 1326761

DOI: 10.1073/pnas.89.18.8681

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 8576255

Title: Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities.

PubMed ID: 8576255

DOI: 10.1074/jbc.271.5.2783

PubMed ID: 10613902

Title: RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules.

PubMed ID: 10613902

DOI: 10.1083/jcb.147.7.1431

PubMed ID: 17135269

Title: Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing.

PubMed ID: 17135269

DOI: 10.1074/jbc.c600198200

PubMed ID: 17488725

Title: Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.

PubMed ID: 17488725

DOI: 10.1074/jbc.m700688200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20932473

Title: DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

PubMed ID: 20932473

DOI: 10.1016/j.molcel.2010.09.018

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 375
  • Mass: 41591
  • Checksum: 2F8D1C7169A7817E
  • Sequence:
    • MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEHTSNDPY CFVEFYEHRD 
AAAALAAMNG RKILGKEVKV NWATTPSSQK KDTSNHFHVF VGDLSPEITT EDIKSAFAPF 
GKISDARVVK DMATGKSKGY GFVSFYNKLD AENAIVHMGG QWLGGRQIRT NWATRKPPAP 
KSTQENNTKQ LRFEDVVNQS SPKNCTVYCG GIASGLTDQL MRQTFSPFGQ IMEIRVFPEK 
GYSFVRFSTH ESAAHAIVSV NGTTIEGHVV KCYWGKESPD MTKNFQQVDY SQWGQWSQVY 
GNPQQYGQYM ANGWQVPPYG VYGQPWNQQG FGVDQSPSAA WMGGFGAQPP QGQAPPPVIP 
PPNQAGYGMA SYQTQ

Genular Protein ID: 3033932434

Symbol: Q49AS9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q49AS9

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 ProteomicsDB 1 RefSeq 6 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 252
  • Mass: 27925
  • Checksum: 02978189CBE4B242
  • Sequence:
    • MDARVVKDMA TGKSKGYGFV SFYNKLDAEN AIVHMGGQWL GGRQIRTNWA TRKPPAPKST 
QENNTKQLRF EDVVNQSSPK NCTVYCGGIA SGLTDQLMRQ TFSPFGQIME IRVFPEKGYS 
FVRFSTHESA AHAIVSVNGT TIEGHVVKCY WGKESPDMTK NFQQVDYSQW GQWSQVYGNP 
QQYGQYMANG WQVPPYGVYG QPWNQQGFGV DQSPSAAWMG GFGAQPPQGQ APPPVIPPPN 
QAGYGMASYQ TQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.