Details for: RNF113A

Gene ID: 7737

Symbol: RNF113A

Ensembl ID: ENSG00000125352

Description: ring finger protein 113A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 94.1205
    Cell Significance Index: -14.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.6563
    Cell Significance Index: -12.6000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 42.8453
    Cell Significance Index: -17.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.8916
    Cell Significance Index: -15.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 35.6263
    Cell Significance Index: -16.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.9932
    Cell Significance Index: -18.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.0098
    Cell Significance Index: -16.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.2608
    Cell Significance Index: -16.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.0107
    Cell Significance Index: -15.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2916
    Cell Significance Index: -16.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5948
    Cell Significance Index: -9.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6945
    Cell Significance Index: 197.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3955
    Cell Significance Index: 138.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9033
    Cell Significance Index: 58.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7656
    Cell Significance Index: 124.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6783
    Cell Significance Index: 19.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5644
    Cell Significance Index: 39.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4550
    Cell Significance Index: 28.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3126
    Cell Significance Index: 36.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3085
    Cell Significance Index: 42.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3027
    Cell Significance Index: 8.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2962
    Cell Significance Index: 15.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2876
    Cell Significance Index: 13.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2776
    Cell Significance Index: 7.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2754
    Cell Significance Index: 33.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2740
    Cell Significance Index: 7.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2581
    Cell Significance Index: 114.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2485
    Cell Significance Index: 12.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2395
    Cell Significance Index: 16.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2275
    Cell Significance Index: 10.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2001
    Cell Significance Index: 9.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1965
    Cell Significance Index: 107.3100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1920
    Cell Significance Index: 1.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1888
    Cell Significance Index: 5.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1853
    Cell Significance Index: 23.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1679
    Cell Significance Index: 30.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1393
    Cell Significance Index: 1.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1386
    Cell Significance Index: 26.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1269
    Cell Significance Index: 6.6100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0928
    Cell Significance Index: 0.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0621
    Cell Significance Index: 8.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0579
    Cell Significance Index: 11.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0457
    Cell Significance Index: 0.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0164
    Cell Significance Index: 1.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0156
    Cell Significance Index: 5.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0124
    Cell Significance Index: 0.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0047
    Cell Significance Index: -0.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0049
    Cell Significance Index: -3.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0067
    Cell Significance Index: -12.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0094
    Cell Significance Index: -0.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0105
    Cell Significance Index: -19.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0123
    Cell Significance Index: -19.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0134
    Cell Significance Index: -18.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0154
    Cell Significance Index: -11.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0174
    Cell Significance Index: -0.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0177
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0186
    Cell Significance Index: -13.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0212
    Cell Significance Index: -0.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0230
    Cell Significance Index: -0.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0244
    Cell Significance Index: -15.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0253
    Cell Significance Index: -14.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0332
    Cell Significance Index: -9.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0346
    Cell Significance Index: -21.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0359
    Cell Significance Index: -16.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0397
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0501
    Cell Significance Index: -5.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0547
    Cell Significance Index: -0.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0585
    Cell Significance Index: -2.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0685
    Cell Significance Index: -1.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0734
    Cell Significance Index: -0.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0818
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0880
    Cell Significance Index: -18.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1114
    Cell Significance Index: -16.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1598
    Cell Significance Index: -4.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1613
    Cell Significance Index: -16.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1685
    Cell Significance Index: -3.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1749
    Cell Significance Index: -10.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1990
    Cell Significance Index: -15.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2017
    Cell Significance Index: -11.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2032
    Cell Significance Index: -15.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2034
    Cell Significance Index: -12.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2151
    Cell Significance Index: -3.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2237
    Cell Significance Index: -15.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2320
    Cell Significance Index: -4.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2415
    Cell Significance Index: -6.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2961
    Cell Significance Index: -8.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2980
    Cell Significance Index: -6.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3087
    Cell Significance Index: -5.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3203
    Cell Significance Index: -5.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3327
    Cell Significance Index: -13.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3514
    Cell Significance Index: -3.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3669
    Cell Significance Index: -16.2300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3773
    Cell Significance Index: -3.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3806
    Cell Significance Index: -13.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3933
    Cell Significance Index: -19.8700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3999
    Cell Significance Index: -6.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4000
    Cell Significance Index: -3.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** RNF113A is a member of the RING (Really Interesting New Gene) family of E3 ubiquitin-protein ligases, characterized by the presence of a RING domain, which is essential for its ubiquitination activity. 2. **Expression Pattern:** RNF113A is widely expressed in various cell types, including germ cells, pancreatic A cells, blood cells, and immune cells, suggesting its involvement in fundamental cellular processes. 3. **Subcellular Localization:** RNF113A is predominantly localized to the nucleus, where it interacts with various proteins involved in DNA repair, RNA metabolism, and transcriptional regulation. **Pathways and Functions:** 1. **DNA Repair:** RNF113A plays a critical role in maintaining genome stability by regulating the ubiquitination of proteins involved in DNA repair pathways, such as BRCA1 and BRCA2. 2. **RNA Metabolism:** RNF113A is involved in the regulation of RNA splicing, processing, and degradation, influencing the production of mature mRNAs and the stability of transcripts. 3. **Immune Regulation:** RNF113A modulates the activity of immune cells, including T cells and B cells, by regulating the ubiquitination of proteins involved in immune signaling pathways. 4. **Metabolism:** RNF113A is also involved in the regulation of metabolic processes, including the metabolism of rRNA and the processing of capped intron-containing pre-mRNAs. **Clinical Significance:** 1. **Cancer:** Alterations in RNF113A expression have been linked to various types of cancer, including breast, lung, and colon cancer, suggesting its potential as a biomarker or therapeutic target. 2. **Neurological Disorders:** RNF113A has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it may play a role in the regulation of protein degradation and clearance. 3. **Immunological Disorders:** RNF113A is involved in the regulation of immune responses, and its dysregulation may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Genetic Disorders:** RNF113A has been linked to genetic disorders, such as Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and increased risk of cancer. In conclusion, RNF113A is a multifunctional gene that plays a critical role in maintaining genome stability, regulating RNA metabolism, and modulating immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1038231579

Symbol: R113A_HUMAN

Name: E3 ubiquitin-protein ligase RNF113A

UniProtKB Accession Codes:

O15541 B2RBR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EMDB 6 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9224902

Title: Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25.

PubMed ID: 9224902

DOI: 10.1016/s0378-1119(97)00108-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22365833

Title: Dynamic protein-protein interaction wiring of the human spliceosome.

PubMed ID: 22365833

DOI: 10.1016/j.molcel.2011.12.034

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25612912

Title: A novel X-linked trichothiodystrophy associated with a nonsense mutation in RNF113A.

PubMed ID: 25612912

DOI: 10.1136/jmedgenet-2014-102418

PubMed ID: 28978524

Title: RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.

PubMed ID: 28978524

DOI: 10.1152/ajpcell.00193.2017

PubMed ID: 29144457

Title: A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.

PubMed ID: 29144457

DOI: 10.1038/nature24484

PubMed ID: 29361316

Title: Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

PubMed ID: 29361316

DOI: 10.1016/j.cell.2018.01.010

PubMed ID: 29360106

Title: Structure of the human activated spliceosome in three conformational states.

PubMed ID: 29360106

DOI: 10.1038/cr.2018.14

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

Sequence Information:

  • Length: 343
  • Mass: 38787
  • Checksum: F76E28037A6FF78B
  • Sequence:
    • MAEQLSPGKA VDQVCTFLFK KPGRKGAAGR RKRPACDPEP GESGSSSDEG CTVVRPEKKR 
VTHNPMIQKT RDSGKQKAAY GDLSSEEEEE NEPESLGVVY KSTRSAKPVG PEDMGATAVY 
ELDTEKERDA QAIFERSQKI QEELRGKEDD KIYRGINNYQ KYMKPKDTSM GNASSGMVRK 
GPIRAPEHLR ATVRWDYQPD ICKDYKETGF CGFGDSCKFL HDRSDYKHGW QIERELDEGR 
YGVYEDENYE VGSDDEEIPF KCFICRQSFQ NPVVTKCRHY FCESCALQHF RTTPRCYVCD 
QQTNGVFNPA KELIAKLEKH RATGEGGASD LPEDPDEDAI PIT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.