Details for: PABPN1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 354.5593
Cell Significance Index: -55.1500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 201.6611
Cell Significance Index: -51.1500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 138.3186
Cell Significance Index: -56.9800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 129.2461
Cell Significance Index: -61.0200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 127.6285
Cell Significance Index: -51.8500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 113.8641
Cell Significance Index: -58.5700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 90.9508
Cell Significance Index: -61.0300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 54.3183
Cell Significance Index: -51.8600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 49.7828
Cell Significance Index: -61.3800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.7588
Cell Significance Index: -55.6100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.9324
Cell Significance Index: -62.8700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.1622
Cell Significance Index: -46.5700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.0952
Cell Significance Index: -28.6600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.5946
Cell Significance Index: 72.5100 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 2.5740
Cell Significance Index: 19.8400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.1811
Cell Significance Index: 140.7200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0087
Cell Significance Index: 402.9500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.9369
Cell Significance Index: 50.9300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.7148
Cell Significance Index: 46.6800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.7064
Cell Significance Index: 490.9900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.4634
Cell Significance Index: 263.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.4601
Cell Significance Index: 797.3900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4565
Cell Significance Index: 200.0200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4486
Cell Significance Index: 178.1200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.3571
Cell Significance Index: 47.1600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3063
Cell Significance Index: 142.0900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2904
Cell Significance Index: 209.8700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.2043
Cell Significance Index: 56.6000 - Cell Name: peg cell (CL4033014)
Fold Change: 1.1128
Cell Significance Index: 25.7100 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.1122
Cell Significance Index: 15.6000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.1097
Cell Significance Index: 31.8100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1063
Cell Significance Index: 396.8200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.0842
Cell Significance Index: 23.4900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9936
Cell Significance Index: 189.0800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9098
Cell Significance Index: 41.2400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8923
Cell Significance Index: 394.4900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8488
Cell Significance Index: 168.4500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.7709
Cell Significance Index: 54.5200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7436
Cell Significance Index: 38.6300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.6992
Cell Significance Index: 90.3400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6652
Cell Significance Index: 78.4500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6524
Cell Significance Index: 40.1000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5647
Cell Significance Index: 42.0900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5047
Cell Significance Index: 30.3000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4835
Cell Significance Index: 27.1300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4197
Cell Significance Index: 32.2100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4182
Cell Significance Index: 26.3600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3847
Cell Significance Index: 11.0900 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.3457
Cell Significance Index: 2.7600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3017
Cell Significance Index: 15.8400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2892
Cell Significance Index: 37.0800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2632
Cell Significance Index: 26.0400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1987
Cell Significance Index: 9.2700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1867
Cell Significance Index: 6.5600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1554
Cell Significance Index: 140.3000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0957
Cell Significance Index: 180.2100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0387
Cell Significance Index: 52.6000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0283
Cell Significance Index: 43.5100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0256
Cell Significance Index: 16.2800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0123
Cell Significance Index: 9.0500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0095
Cell Significance Index: 17.5100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0056
Cell Significance Index: 0.1500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0050
Cell Significance Index: 2.2700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0195
Cell Significance Index: -14.7800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0309
Cell Significance Index: -0.7400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0654
Cell Significance Index: -1.1000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0703
Cell Significance Index: -52.0600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0715
Cell Significance Index: -7.3100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0729
Cell Significance Index: -12.4500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0945
Cell Significance Index: -0.8700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1037
Cell Significance Index: -58.5100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1122
Cell Significance Index: -70.0500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1130
Cell Significance Index: -7.6000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1234
Cell Significance Index: -2.2800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2023
Cell Significance Index: -29.4100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2345
Cell Significance Index: -5.9900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3287
Cell Significance Index: -69.2300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3335
Cell Significance Index: -38.8700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3736
Cell Significance Index: -7.8200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4011
Cell Significance Index: -45.9500 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.4349
Cell Significance Index: -5.5700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4695
Cell Significance Index: -13.7900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4764
Cell Significance Index: -6.5000 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.4810
Cell Significance Index: -2.9600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4907
Cell Significance Index: -10.4500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4917
Cell Significance Index: -51.2000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6118
Cell Significance Index: -17.4600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6294
Cell Significance Index: -20.1600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6543
Cell Significance Index: -51.8200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6644
Cell Significance Index: -29.3900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6812
Cell Significance Index: -8.1200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.6897
Cell Significance Index: -8.5600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.7175
Cell Significance Index: -7.8000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7586
Cell Significance Index: -46.5100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.7953
Cell Significance Index: -13.6300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7973
Cell Significance Index: -19.9300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8770
Cell Significance Index: -33.2100 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.8843
Cell Significance Index: -15.2900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9235
Cell Significance Index: -27.2000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.9752
Cell Significance Index: -50.8000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 998601644
Symbol: PABP2_HUMAN
Name: Nuclear poly(A)-binding protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9462747
Title: Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy.
PubMed ID: 9462747
DOI: 10.1038/ng0298-164
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10205180
Title: Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery.
PubMed ID: 10205180
PubMed ID: 11001936
Title: Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA.
PubMed ID: 11001936
PubMed ID: 10688363
Title: Deciphering the cellular pathway for transport of poly(A)-binding protein II.
PubMed ID: 10688363
PubMed ID: 11689481
Title: Oligomerization of polyalanine expanded PABPN1 facilitates nuclear protein aggregation that is associated with cell death.
PubMed ID: 11689481
PubMed ID: 11371506
Title: The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression.
PubMed ID: 11371506
PubMed ID: 14663186
Title: An aggregate-prone conformational epitope in trinucleotide repeat diseases.
PubMed ID: 14663186
PubMed ID: 15169763
Title: Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.
PubMed ID: 15169763
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17103222
Title: FRG1P-mediated aggregation of proteins involved in pre-mRNA processing.
PubMed ID: 17103222
PubMed ID: 17289661
Title: Molecular composition of IMP1 ribonucleoprotein granules.
PubMed ID: 17289661
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21700224
Title: Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
PubMed ID: 21700224
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 27871484
Title: Identification of a nuclear exosome decay pathway for processed transcripts.
PubMed ID: 27871484
PubMed ID: 27209344
Title: Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.
PubMed ID: 27209344
PubMed ID: 12673802
Title: Oculopharyngeal muscular dystrophy (OPMD) due to a small duplication in the PABPN1 gene.
PubMed ID: 12673802
DOI: 10.1002/humu.9138
Sequence Information:
- Length: 306
- Mass: 32749
- Checksum: 2E5B0AEFEA5AFBC3
- Sequence:
MAAAAAAAAA AGAAGGRGSG PGRRRHLVPG AGGEAGEGAP GGAGDYGNGL ESEELEPEEL LLEPEPEPEP EEEPPRPRAP PGAPGPGPGS GAPGSQEEEE EPGLVEGDPG DGAIEDPELE AIKARVREME EEAEKLKELQ NEVEKQMNMS PPPGNAGPVI MSIEEKMEAD ARSIYVGNVD YGATAEELEA HFHGCGSVNR VTILCDKFSG HPKGFAYIEF SDKESVRTSL ALDESLFRGR QIKVIPKRTN RPGISTTDRG FPRARYRART TNYNSSRSRF YSGFNSRPRG RVYRGRARAT SWYSPY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.