Details for: PABPN1

Gene ID: 8106

Symbol: PABPN1

Ensembl ID: ENSG00000100836

Description: poly(A) binding protein nuclear 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 354.5593
    Cell Significance Index: -55.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 201.6611
    Cell Significance Index: -51.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 138.3186
    Cell Significance Index: -56.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 129.2461
    Cell Significance Index: -61.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 127.6285
    Cell Significance Index: -51.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.8641
    Cell Significance Index: -58.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 90.9508
    Cell Significance Index: -61.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.3183
    Cell Significance Index: -51.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.7828
    Cell Significance Index: -61.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7588
    Cell Significance Index: -55.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.9324
    Cell Significance Index: -62.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.1622
    Cell Significance Index: -46.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.0952
    Cell Significance Index: -28.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.5946
    Cell Significance Index: 72.5100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.5740
    Cell Significance Index: 19.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1811
    Cell Significance Index: 140.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0087
    Cell Significance Index: 402.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9369
    Cell Significance Index: 50.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7148
    Cell Significance Index: 46.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.7064
    Cell Significance Index: 490.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4634
    Cell Significance Index: 263.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4601
    Cell Significance Index: 797.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4565
    Cell Significance Index: 200.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4486
    Cell Significance Index: 178.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3571
    Cell Significance Index: 47.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3063
    Cell Significance Index: 142.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2904
    Cell Significance Index: 209.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2043
    Cell Significance Index: 56.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1128
    Cell Significance Index: 25.7100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.1122
    Cell Significance Index: 15.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1097
    Cell Significance Index: 31.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1063
    Cell Significance Index: 396.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0842
    Cell Significance Index: 23.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9936
    Cell Significance Index: 189.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9098
    Cell Significance Index: 41.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8923
    Cell Significance Index: 394.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8488
    Cell Significance Index: 168.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7709
    Cell Significance Index: 54.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7436
    Cell Significance Index: 38.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6992
    Cell Significance Index: 90.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6652
    Cell Significance Index: 78.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6524
    Cell Significance Index: 40.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5647
    Cell Significance Index: 42.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5047
    Cell Significance Index: 30.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4835
    Cell Significance Index: 27.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4197
    Cell Significance Index: 32.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4182
    Cell Significance Index: 26.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3847
    Cell Significance Index: 11.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3457
    Cell Significance Index: 2.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3017
    Cell Significance Index: 15.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2892
    Cell Significance Index: 37.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2632
    Cell Significance Index: 26.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1987
    Cell Significance Index: 9.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1867
    Cell Significance Index: 6.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1554
    Cell Significance Index: 140.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0957
    Cell Significance Index: 180.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0387
    Cell Significance Index: 52.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0283
    Cell Significance Index: 43.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0256
    Cell Significance Index: 16.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0123
    Cell Significance Index: 9.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0095
    Cell Significance Index: 17.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0050
    Cell Significance Index: 2.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0195
    Cell Significance Index: -14.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0309
    Cell Significance Index: -0.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0654
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0703
    Cell Significance Index: -52.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0715
    Cell Significance Index: -7.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0729
    Cell Significance Index: -12.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0945
    Cell Significance Index: -0.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1037
    Cell Significance Index: -58.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1122
    Cell Significance Index: -70.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1130
    Cell Significance Index: -7.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1234
    Cell Significance Index: -2.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2023
    Cell Significance Index: -29.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2345
    Cell Significance Index: -5.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3287
    Cell Significance Index: -69.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3335
    Cell Significance Index: -38.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3736
    Cell Significance Index: -7.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4011
    Cell Significance Index: -45.9500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4349
    Cell Significance Index: -5.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4695
    Cell Significance Index: -13.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4764
    Cell Significance Index: -6.5000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4810
    Cell Significance Index: -2.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4907
    Cell Significance Index: -10.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4917
    Cell Significance Index: -51.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6118
    Cell Significance Index: -17.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6294
    Cell Significance Index: -20.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6543
    Cell Significance Index: -51.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6644
    Cell Significance Index: -29.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6812
    Cell Significance Index: -8.1200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6897
    Cell Significance Index: -8.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7175
    Cell Significance Index: -7.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7586
    Cell Significance Index: -46.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7953
    Cell Significance Index: -13.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7973
    Cell Significance Index: -19.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8770
    Cell Significance Index: -33.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8843
    Cell Significance Index: -15.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9235
    Cell Significance Index: -27.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9752
    Cell Significance Index: -50.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PABPN1 is a nuclear protein that binds to poly(A) RNA, facilitating its export from the nucleus and translation. It is also involved in RNA processing, including 3'-end processing, polyadenylation, and splicing. PABPN1 has multiple domains, including a poly(A)-binding domain, a RNA recognition motif (RRM), and a C-terminal domain that interacts with RNA polymerase II. The protein is highly phosphorylated, which regulates its activity and interactions with other proteins. PABPN1 has been shown to be involved in various cellular processes, including cell proliferation, differentiation, and survival. **Pathways and Functions** PABPN1 is involved in several signaling pathways, including: 1. **MAPK cascade**: PABPN1 interacts with MAPK kinases, influencing the activation of mitogen-activated protein kinases (MAPKs) and their downstream targets. 2. **RNA processing**: PABPN1 regulates RNA processing, including 3'-end processing, polyadenylation, and splicing. 3. **Gene expression**: PABPN1 influences gene expression by regulating the export of poly(A) RNA from the nucleus and its translation. 4. **Viral infection pathways**: PABPN1 interacts with viral proteins, influencing the replication and transcription of viral genomes. 5. **Cellular stress response**: PABPN1 is involved in the cellular response to stress, including heat shock and oxidative stress. **Clinical Significance** PABPN1 has been implicated in various diseases, including: 1. **Cancer**: PABPN1 is overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative disorders**: PABPN1 is involved in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: PABPN1 interacts with viral proteins, influencing the replication and transcription of viral genomes. 4. **Muscular dystrophy**: PABPN1 is involved in the regulation of muscle gene expression, influencing the development of muscular dystrophy. In conclusion, PABPN1 is a multifunctional RNA-binding protein that plays a crucial role in various cellular processes, including RNA processing, gene expression, and viral infection pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully understand the functions of PABPN1 and its role in human disease.

Genular Protein ID: 998601644

Symbol: PABP2_HUMAN

Name: Nuclear poly(A)-binding protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9462747

Title: Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy.

PubMed ID: 9462747

DOI: 10.1038/ng0298-164

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10205180

Title: Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery.

PubMed ID: 10205180

DOI: 10.1093/emboj/18.8.2273

PubMed ID: 11001936

Title: Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA.

PubMed ID: 11001936

DOI: 10.1093/oxfordjournals.hmg.a018924

PubMed ID: 10688363

Title: Deciphering the cellular pathway for transport of poly(A)-binding protein II.

PubMed ID: 10688363

DOI: 10.1017/s1355838200991908

PubMed ID: 11689481

Title: Oligomerization of polyalanine expanded PABPN1 facilitates nuclear protein aggregation that is associated with cell death.

PubMed ID: 11689481

DOI: 10.1093/hmg/10.21.2341

PubMed ID: 11371506

Title: The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression.

PubMed ID: 11371506

DOI: 10.1093/hmg/10.11.1129

PubMed ID: 14663186

Title: An aggregate-prone conformational epitope in trinucleotide repeat diseases.

PubMed ID: 14663186

DOI: 10.1097/00001756-200312190-00009

PubMed ID: 15169763

Title: Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.

PubMed ID: 15169763

DOI: 10.1074/jbc.m403927200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17103222

Title: FRG1P-mediated aggregation of proteins involved in pre-mRNA processing.

PubMed ID: 17103222

DOI: 10.1007/s00412-006-0083-3

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21700224

Title: Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.

PubMed ID: 21700224

DOI: 10.1016/j.molcel.2011.04.026

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 27871484

Title: Identification of a nuclear exosome decay pathway for processed transcripts.

PubMed ID: 27871484

DOI: 10.1016/j.molcel.2016.09.025

PubMed ID: 27209344

Title: Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.

PubMed ID: 27209344

DOI: 10.1016/j.nmd.2016.05.001

PubMed ID: 12673802

Title: Oculopharyngeal muscular dystrophy (OPMD) due to a small duplication in the PABPN1 gene.

PubMed ID: 12673802

DOI: 10.1002/humu.9138

Sequence Information:

  • Length: 306
  • Mass: 32749
  • Checksum: 2E5B0AEFEA5AFBC3
  • Sequence:
  • MAAAAAAAAA AGAAGGRGSG PGRRRHLVPG AGGEAGEGAP GGAGDYGNGL ESEELEPEEL 
    LLEPEPEPEP EEEPPRPRAP PGAPGPGPGS GAPGSQEEEE EPGLVEGDPG DGAIEDPELE 
    AIKARVREME EEAEKLKELQ NEVEKQMNMS PPPGNAGPVI MSIEEKMEAD ARSIYVGNVD 
    YGATAEELEA HFHGCGSVNR VTILCDKFSG HPKGFAYIEF SDKESVRTSL ALDESLFRGR 
    QIKVIPKRTN RPGISTTDRG FPRARYRART TNYNSSRSRF YSGFNSRPRG RVYRGRARAT 
    SWYSPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.