H2AC16 | ENSG00000276903 | NCBI 8332

Details for: H2AC16

Gene ID: 8332

Symbol: H2AC16

Ensembl ID: ENSG00000276903

Description: H2A clustered histone 16

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Post-translational protein modification
(R-HSA-597592)
Rmts methylate histone arginines
(R-HSA-3214858)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)
Biological_process
(GO:0008150)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Heterochromatin formation
(GO:0031507)
Nucleosome
(GO:0000786)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 9.3701
Cell Significance Index: -3.8600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.9115
Cell Significance Index: 22.7300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 0.8660
Cell Significance Index: -2.6600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8569
Cell Significance Index: 38.8400
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.7811
Cell Significance Index: 4.4400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7084
Cell Significance Index: 20.4100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.5145
Cell Significance Index: 7.7100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4927
Cell Significance Index: 10.2200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4853
Cell Significance Index: 31.3100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4791
Cell Significance Index: 56.5000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4109
Cell Significance Index: 40.6500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3827
Cell Significance Index: 41.6300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3638
Cell Significance Index: 59.1700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3401
Cell Significance Index: 4.6400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.3381
Cell Significance Index: 3.5000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3042
Cell Significance Index: 18.2700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2938
Cell Significance Index: 55.9100
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.2902
Cell Significance Index: 2.9100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2839
Cell Significance Index: 6.1500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2570
Cell Significance Index: 8.2300
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.2466
Cell Significance Index: 2.4400
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.2060
Cell Significance Index: 2.6100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2009
Cell Significance Index: 7.0600
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.1633
Cell Significance Index: 1.7700
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.1248
Cell Significance Index: 1.7500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1229
Cell Significance Index: 8.5000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1174
Cell Significance Index: 6.1000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1062
Cell Significance Index: 1.6000
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.0888
Cell Significance Index: 0.6900
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.0721
Cell Significance Index: 0.6300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0567
Cell Significance Index: 51.1600
Cell Name: germ cell (CL0000586)
Fold Change: 0.0563
Cell Significance Index: 0.4300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0377
Cell Significance Index: 0.5400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0368
Cell Significance Index: 0.9200
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0288
Cell Significance Index: 0.4000
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.0204
Cell Significance Index: 0.2900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0195
Cell Significance Index: 8.6300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0169
Cell Significance Index: 0.3600
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.0113
Cell Significance Index: 0.1100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0092
Cell Significance Index: 1.6500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0062
Cell Significance Index: 3.3700
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0020
Cell Significance Index: -1.5100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0024
Cell Significance Index: -1.3600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0056
Cell Significance Index: -4.2300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0163
Cell Significance Index: -2.2400
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0166
Cell Significance Index: -0.6800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0179
Cell Significance Index: -1.0100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0195
Cell Significance Index: -3.9200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0199
Cell Significance Index: -1.2200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0203
Cell Significance Index: -3.4700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0211
Cell Significance Index: -0.9900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0228
Cell Significance Index: -2.8000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0332
Cell Significance Index: -2.3500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0334
Cell Significance Index: -0.7000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0338
Cell Significance Index: -3.8700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0344
Cell Significance Index: -4.4500
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0356
Cell Significance Index: -0.5000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0404
Cell Significance Index: -4.1300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0525
Cell Significance Index: -1.3800
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.0559
Cell Significance Index: -0.5800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0561
Cell Significance Index: -0.6100
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0569
Cell Significance Index: -0.6200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0577
Cell Significance Index: -1.5400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0621
Cell Significance Index: -4.6300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0622
Cell Significance Index: -1.5900
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.0633
Cell Significance Index: -0.4600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0649
Cell Significance Index: -3.4100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0672
Cell Significance Index: -0.8600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0705
Cell Significance Index: -1.1800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0710
Cell Significance Index: -3.3100
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: -0.0740
Cell Significance Index: -0.3600
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0827
Cell Significance Index: -1.2000
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0901
Cell Significance Index: -1.0200
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0905
Cell Significance Index: -0.5900
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.0912
Cell Significance Index: -0.9700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0947
Cell Significance Index: -3.1000
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0985
Cell Significance Index: -1.2400
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.1051
Cell Significance Index: -1.0600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1118
Cell Significance Index: -3.5600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1128
Cell Significance Index: -4.1400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1162
Cell Significance Index: -4.0700
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1216
Cell Significance Index: -1.5900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1223
Cell Significance Index: -4.2500
Cell Name: helper T cell (CL0000912)
Fold Change: -0.1232
Cell Significance Index: -1.7500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1248
Cell Significance Index: -2.4400
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1291
Cell Significance Index: -2.7000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1304
Cell Significance Index: -3.5500
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.1320
Cell Significance Index: -1.9300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1336
Cell Significance Index: -3.9400
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1345
Cell Significance Index: -3.3600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1350
Cell Significance Index: -3.4400
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1403
Cell Significance Index: -2.0100
Cell Name: immature alpha-beta T cell (CL0000790)
Fold Change: -0.1409
Cell Significance Index: -1.0500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1474
Cell Significance Index: -4.2300
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.1480
Cell Significance Index: -1.7700
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1492
Cell Significance Index: -1.9300
Cell Name: keratocyte (CL0002363)
Fold Change: -0.1519
Cell Significance Index: -2.4100
Cell Name: peg cell (CL4033014)
Fold Change: -0.1558
Cell Significance Index: -3.6000
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1580
Cell Significance Index: -3.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H2AC16 is a histone H2A variant that is characterized by its ability to bind to DNA and interact with other chromatin-modifying enzymes. It has a unique histone tail that allows it to interact with various proteins and regulate chromatin structure. H2AC16 is also involved in the regulation of gene expression, particularly in the context of cellular differentiation and development. Its expression is restricted to specific cell types, including lymphoid lineage-restricted progenitor cells, goblet cells, and intestinal epithelial cells. **Pathways and Functions** H2AC16 is involved in several key pathways, including: 1. **Chromatin organization**: H2AC16 plays a crucial role in the organization of chromatin structure, particularly in the context of gene expression and cellular differentiation. 2. **Deubiquitination**: H2AC16 is involved in the regulation of deubiquitination, a process that involves the removal of ubiquitin molecules from histones. 3. **Heterochromatin organization**: H2AC16 is involved in the organization of heterochromatin, a region of chromatin that is characterized by the presence of highly compacted DNA. 4. **Gene expression**: H2AC16 regulates gene expression by interacting with chromatin-modifying enzymes and other transcription factors. 5. **Cellular differentiation**: H2AC16 plays a role in the regulation of cellular differentiation, particularly in the context of lymphoid lineage-restricted progenitor cells. **Clinical Significance** The clinical significance of H2AC16 is not well established, but its dysregulation has been implicated in various diseases, including: 1. **Cancer**: Aberrant expression of H2AC16 has been observed in various types of cancer, including lymphoma and leukemia. 2. **Autoimmune diseases**: H2AC16 has been implicated in the regulation of immune responses, and its dysregulation has been observed in autoimmune diseases, such as multiple sclerosis. 3. **Neurological disorders**: H2AC16 has been implicated in the regulation of gene expression in the nervous system, and its dysregulation has been observed in neurological disorders, such as Alzheimer's disease. In conclusion, H2AC16 is a critical component of chromatin structure and function, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of H2AC16 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.