Gene H4C3 - ENSG00000197061 | NCBI Gene ID: 8364

Details for: H4C3

Gene ID: 8364

Symbol: H4C3

Ensembl ID: ENSG00000197061

Description: H4 clustered histone 3

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 5.89
Marker Score: 3942.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 3.97
Marker Score: 3882
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.43
Marker Score: 4142
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.28
Marker Score: 2571.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.2
Marker Score: 1599
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 3.14
Marker Score: 2299
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.12
Marker Score: 2944
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.96
Marker Score: 2646
Cell Name: oogonial cell (CL0000024)
Fold Change: 2.88
Marker Score: 4140
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.86
Marker Score: 8164
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.79
Marker Score: 1028
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.78
Marker Score: 1630
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.77
Marker Score: 860
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.77
Marker Score: 7763
Cell Name: follicular B cell (CL0000843)
Fold Change: 2.77
Marker Score: 2998
Cell Name: malignant cell (CL0001064)
Fold Change: 2.74
Marker Score: 36842
Cell Name: blood cell (CL0000081)
Fold Change: 2.69
Marker Score: 31262
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.67
Marker Score: 795
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.63
Marker Score: 19581
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.6
Marker Score: 1876
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.58
Marker Score: 34001
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.5
Marker Score: 7431
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.49
Marker Score: 2659.5
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.48
Marker Score: 16162
Cell Name: mature T cell (CL0002419)
Fold Change: 2.44
Marker Score: 24205.5
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.44
Marker Score: 14494
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.42
Marker Score: 2340.5
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.42
Marker Score: 4921
Cell Name: memory B cell (CL0000787)
Fold Change: 2.4
Marker Score: 1815
Cell Name: naive T cell (CL0000898)
Fold Change: 2.4
Marker Score: 1544.5
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.39
Marker Score: 2252
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.35
Marker Score: 2608
Cell Name: enteric neuron (CL0007011)
Fold Change: 2.33
Marker Score: 1241
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.33
Marker Score: 23616
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 2.31
Marker Score: 900
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.31
Marker Score: 3197
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.3
Marker Score: 991
Cell Name: naive B cell (CL0000788)
Fold Change: 2.26
Marker Score: 2016
Cell Name: secretory cell (CL0000151)
Fold Change: 2.26
Marker Score: 4121
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.25
Marker Score: 119119
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.23
Marker Score: 5079.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.22
Marker Score: 3868
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.2
Marker Score: 1381
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.18
Marker Score: 2332
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.17
Marker Score: 21844
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.16
Marker Score: 4519
Cell Name: Unknown (CL0000548)
Fold Change: 2.16
Marker Score: 1572
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 2.16
Marker Score: 5861.5
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.14
Marker Score: 6724
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.13
Marker Score: 7895
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.13
Marker Score: 5791
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.12
Marker Score: 5681
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.12
Marker Score: 2130
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.11
Marker Score: 8635
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.1
Marker Score: 8268
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.09
Marker Score: 4100
Cell Name: thymocyte (CL0000893)
Fold Change: 2.08
Marker Score: 2178.5
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.08
Marker Score: 4892
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 2.06
Marker Score: 1752.5
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.06
Marker Score: 2138
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.05
Marker Score: 2173
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.03
Marker Score: 4958
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.03
Marker Score: 6412
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 2.03
Marker Score: 649
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.03
Marker Score: 615
Cell Name: centroblast (CL0009112)
Fold Change: 2.02
Marker Score: 996.5
Cell Name: B-1b B cell (CL0000821)
Fold Change: 2.02
Marker Score: 464
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.01
Marker Score: 1889
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.01
Marker Score: 3411
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.99
Marker Score: 1097
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.98
Marker Score: 2013
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.98
Marker Score: 1044
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.98
Marker Score: 399.5
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.97
Marker Score: 2118
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.96
Marker Score: 1646
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.95
Marker Score: 1294
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.95
Marker Score: 2866
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.94
Marker Score: 3870
Cell Name: Unknown (CL0002371)
Fold Change: 1.94
Marker Score: 2056
Cell Name: male germ cell (CL0000015)
Fold Change: 1.93
Marker Score: 557
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.93
Marker Score: 12320
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.92
Marker Score: 773
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.92
Marker Score: 3425.5
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.92
Marker Score: 1705
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.92
Marker Score: 671
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.91
Marker Score: 445.5
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.91
Marker Score: 3137
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.91
Marker Score: 4022
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 1.9
Marker Score: 1244
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.89
Marker Score: 820
Cell Name: leukocyte (CL0000738)
Fold Change: 1.88
Marker Score: 1081
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.88
Marker Score: 449.5
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.87
Marker Score: 463
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.87
Marker Score: 2760
Cell Name: basal cell (CL0000646)
Fold Change: 1.87
Marker Score: 2417
Cell Name: kidney cell (CL1000497)
Fold Change: 1.85
Marker Score: 1236
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.85
Marker Score: 2075
Cell Name: supporting cell (CL0000630)
Fold Change: 1.85
Marker Score: 3471
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.85
Marker Score: 2009
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.84
Marker Score: 508

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Other Information

Description

**Key Characteristics** H4C3 is a histone protein that belongs to the H4 family, which is one of the five main histone types. Histones are highly conserved proteins that play a central role in the structure and function of chromatin. H4C3 is specifically characterized by its ability to form dimers with other histone proteins, such as H3.1 and H3.2, to form a chromatin fiber. The gene is also notable for its involvement in various post-translational modifications, including acetylation, methylation, and ubiquitination, which regulate its function and interactions with other proteins. **Pathways and Functions** H4C3 is involved in numerous cellular processes, including: 1. **Development and Differentiation**: H4C3 is highly expressed in embryonic development and differentiation, particularly in the hindbrain and neural crest cells. 2. **DNA Repair**: H4C3 is involved in the assembly of the pre-replicative complex and the repair of DNA double-strand breaks through homologous recombination. 3. **Cell Cycle Regulation**: H4C3 is required for the assembly of the Orc complex at the origin of replication and the regulation of the cell cycle. 4. **Epigenetic Regulation**: H4C3 is involved in the regulation of gene expression through histone modifications, such as acetylation and methylation. 5. **Signaling Pathways**: H4C3 is involved in various signaling pathways, including Notch, Wnt, and Rho GTPase signaling, which regulate cellular responses to stimuli. **Clinical Significance** The dysregulation of H4C3 has been implicated in various diseases, including: 1. **Cancer**: H4C3 is overexpressed in certain types of cancer, such as lymphoma and leukemia, and is associated with poor prognosis. 2. **Neurodegenerative Diseases**: H4C3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it plays a role in the regulation of gene expression and chromatin structure. 3. **Immune System Disorders**: H4C3 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, H4C3 is a multifunctional gene that plays a critical role in various cellular processes, including development, differentiation, DNA repair, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and regulation in normal and pathological conditions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.