H4C3 | ENSG00000197061 | NCBI 8364

Details for: H4C3

Gene ID: 8364

Symbol: H4C3

Ensembl ID: ENSG00000197061

Description: H4 clustered histone 3

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 208.4817
Cell Significance Index: -52.8800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 194.2480
Cell Significance Index: -80.0200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 170.0406
Cell Significance Index: -80.2800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 163.6905
Cell Significance Index: -84.2000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 119.9960
Cell Significance Index: -80.5200
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 103.7640
Cell Significance Index: -16.1400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 58.5828
Cell Significance Index: -72.2300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.6120
Cell Significance Index: -77.3900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.5757
Cell Significance Index: -47.8400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 12.6520
Cell Significance Index: -27.6900
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 9.8769
Cell Significance Index: 76.1300
Cell Name: germ cell (CL0000586)
Fold Change: 9.1515
Cell Significance Index: 69.1000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 8.8480
Cell Significance Index: 96.1900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 6.7252
Cell Significance Index: 56.4900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 5.5892
Cell Significance Index: 659.1400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.3603
Cell Significance Index: 112.2000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.9055
Cell Significance Index: 257.5600
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.3900
Cell Significance Index: 43.4200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.7698
Cell Significance Index: 178.7000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.5215
Cell Significance Index: 158.9200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.2753
Cell Significance Index: 103.1300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.6366
Cell Significance Index: 295.0300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.5800
Cell Significance Index: 194.2700
Cell Name: odontoblast (CL0000060)
Fold Change: 1.5336
Cell Significance Index: 196.6000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.4989
Cell Significance Index: 43.1900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4936
Cell Significance Index: 296.4100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.4779
Cell Significance Index: 117.0500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.4534
Cell Significance Index: 642.6000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3611
Cell Significance Index: 186.9200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3459
Cell Significance Index: 36.6400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.2992
Cell Significance Index: 14.7600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.1241
Cell Significance Index: 79.5000
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.0505
Cell Significance Index: 573.6800
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.0029
Cell Significance Index: 26.3700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.9482
Cell Significance Index: 53.2100
Cell Name: peg cell (CL4033014)
Fold Change: 0.9345
Cell Significance Index: 21.5900
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.8251
Cell Significance Index: 4.6900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7235
Cell Significance Index: 78.6900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.6839
Cell Significance Index: 501.4300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5098
Cell Significance Index: 87.0500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4942
Cell Significance Index: 48.8900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.4741
Cell Significance Index: 54.3200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.4412
Cell Significance Index: 14.1300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.4405
Cell Significance Index: 126.7400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4165
Cell Significance Index: 19.4200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3219
Cell Significance Index: 11.3100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3125
Cell Significance Index: 282.2000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2931
Cell Significance Index: 47.6700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2658
Cell Significance Index: 13.8100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1841
Cell Significance Index: 35.0400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1668
Cell Significance Index: 4.9000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1227
Cell Significance Index: 15.8500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1098
Cell Significance Index: 39.4000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0913
Cell Significance Index: 18.3100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0820
Cell Significance Index: 2.1900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0128
Cell Significance Index: -0.6500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0195
Cell Significance Index: -14.7900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0272
Cell Significance Index: -51.2200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0362
Cell Significance Index: -3.7000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0482
Cell Significance Index: -88.8600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0514
Cell Significance Index: -0.8600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0575
Cell Significance Index: -88.5700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0632
Cell Significance Index: -2.5900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0692
Cell Significance Index: -94.1100
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0898
Cell Significance Index: -1.0700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0934
Cell Significance Index: -69.1600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1111
Cell Significance Index: -70.5700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1187
Cell Significance Index: -66.9300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1767
Cell Significance Index: -80.1900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1804
Cell Significance Index: -112.6700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1851
Cell Significance Index: -8.7000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1937
Cell Significance Index: -6.7300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2941
Cell Significance Index: -21.9200
Cell Name: kidney cell (CL1000497)
Fold Change: -0.3106
Cell Significance Index: -2.4800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3343
Cell Significance Index: -8.5400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4611
Cell Significance Index: -97.1300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4791
Cell Significance Index: -10.3800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4834
Cell Significance Index: -70.2700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6355
Cell Significance Index: -8.6700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6559
Cell Significance Index: -11.2400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7325
Cell Significance Index: -76.2700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.8015
Cell Significance Index: -22.4000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.8146
Cell Significance Index: -12.2800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.9271
Cell Significance Index: -19.7500
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.9747
Cell Significance Index: -10.0900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9997
Cell Significance Index: -61.2900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.0167
Cell Significance Index: -78.0200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.0988
Cell Significance Index: -17.0000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.2974
Cell Significance Index: -19.4400
Cell Name: Sertoli cell (CL0000216)
Fold Change: -1.4038
Cell Significance Index: -19.6900
Cell Name: preadipocyte (CL0002334)
Fold Change: -1.6785
Cell Significance Index: -32.7600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.7121
Cell Significance Index: -44.0100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.7153
Cell Significance Index: -75.8700
Cell Name: Mueller cell (CL0000636)
Fold Change: -1.7209
Cell Significance Index: -13.2400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.8602
Cell Significance Index: -54.7900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.8870
Cell Significance Index: -69.2700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.9071
Cell Significance Index: -62.4400
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -1.9119
Cell Significance Index: -19.2900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.9406
Cell Significance Index: -17.8700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.9541
Cell Significance Index: -56.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H4C3 is a histone protein that belongs to the H4 family, which is one of the five main histone types. Histones are highly conserved proteins that play a central role in the structure and function of chromatin. H4C3 is specifically characterized by its ability to form dimers with other histone proteins, such as H3.1 and H3.2, to form a chromatin fiber. The gene is also notable for its involvement in various post-translational modifications, including acetylation, methylation, and ubiquitination, which regulate its function and interactions with other proteins. **Pathways and Functions** H4C3 is involved in numerous cellular processes, including: 1. **Development and Differentiation**: H4C3 is highly expressed in embryonic development and differentiation, particularly in the hindbrain and neural crest cells. 2. **DNA Repair**: H4C3 is involved in the assembly of the pre-replicative complex and the repair of DNA double-strand breaks through homologous recombination. 3. **Cell Cycle Regulation**: H4C3 is required for the assembly of the Orc complex at the origin of replication and the regulation of the cell cycle. 4. **Epigenetic Regulation**: H4C3 is involved in the regulation of gene expression through histone modifications, such as acetylation and methylation. 5. **Signaling Pathways**: H4C3 is involved in various signaling pathways, including Notch, Wnt, and Rho GTPase signaling, which regulate cellular responses to stimuli. **Clinical Significance** The dysregulation of H4C3 has been implicated in various diseases, including: 1. **Cancer**: H4C3 is overexpressed in certain types of cancer, such as lymphoma and leukemia, and is associated with poor prognosis. 2. **Neurodegenerative Diseases**: H4C3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it plays a role in the regulation of gene expression and chromatin structure. 3. **Immune System Disorders**: H4C3 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, H4C3 is a multifunctional gene that plays a critical role in various cellular processes, including development, differentiation, DNA repair, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and regulation in normal and pathological conditions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.