Details for: EIF1

Gene ID: 10209

Symbol: EIF1

Ensembl ID: ENSG00000173812

Description: eukaryotic translation initiation factor 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.69
    Marker Score: 11,932
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.5
    Marker Score: 13,975
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.44
    Marker Score: 73,132
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.37
    Marker Score: 8,265
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.32
    Marker Score: 15,538
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.28
    Marker Score: 52,324
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.24
    Marker Score: 3,800
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.23
    Marker Score: 6,809
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.14
    Marker Score: 174,920
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 5.11
    Marker Score: 9,326
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.97
    Marker Score: 2,556
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.94
    Marker Score: 3,745
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.92
    Marker Score: 3,168
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.9
    Marker Score: 1,807
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.89
    Marker Score: 4,370
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.89
    Marker Score: 4,166
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.83
    Marker Score: 15,244
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.82
    Marker Score: 3,456
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.75
    Marker Score: 251,307
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.74
    Marker Score: 8,131
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.62
    Marker Score: 1,104
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.55
    Marker Score: 254,329
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.54
    Marker Score: 1,952
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.46
    Marker Score: 5,384
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.4
    Marker Score: 4,886
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.37
    Marker Score: 6,319
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.36
    Marker Score: 11,689
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.32
    Marker Score: 4,078
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.31
    Marker Score: 11,908
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.31
    Marker Score: 10,517
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.3
    Marker Score: 56,727
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.29
    Marker Score: 49,862
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.25
    Marker Score: 11,912
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 4.23
    Marker Score: 2,580
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.23
    Marker Score: 2,572
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.21
    Marker Score: 22,127
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.18
    Marker Score: 2,448
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.17
    Marker Score: 1,357
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.15
    Marker Score: 10,112
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.12
    Marker Score: 3,985
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.12
    Marker Score: 3,223
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.09
    Marker Score: 14,535
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.09
    Marker Score: 3,489
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.08
    Marker Score: 17,490
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.08
    Marker Score: 6,005
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.07
    Marker Score: 933
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.07
    Marker Score: 5,020
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.07
    Marker Score: 4,342
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.06
    Marker Score: 3,186
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.06
    Marker Score: 7,623
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.05
    Marker Score: 1,824
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.04
    Marker Score: 3,430
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.04
    Marker Score: 4,863
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 4.01
    Marker Score: 3,286
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4
    Marker Score: 26,074
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4
    Marker Score: 3,939
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.99
    Marker Score: 3,436
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.99
    Marker Score: 3,577
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.99
    Marker Score: 1,056
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.97
    Marker Score: 2,048
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.97
    Marker Score: 1,044
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.97
    Marker Score: 25,303
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.96
    Marker Score: 4,258
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.95
    Marker Score: 2,809
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.95
    Marker Score: 4,291
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.94
    Marker Score: 8,972
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.94
    Marker Score: 9,927
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.94
    Marker Score: 916
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.91
    Marker Score: 1,100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.9
    Marker Score: 2,400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.9
    Marker Score: 3,422
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.83
    Marker Score: 3,407
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.83
    Marker Score: 1,397
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.83
    Marker Score: 3,598
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.82
    Marker Score: 3,212
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.8
    Marker Score: 3,354
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.8
    Marker Score: 1,729
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.8
    Marker Score: 6,789
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.79
    Marker Score: 18,631
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.77
    Marker Score: 1,076
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 3.77
    Marker Score: 999
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.76
    Marker Score: 936
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.76
    Marker Score: 1,568
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.76
    Marker Score: 27,955
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.75
    Marker Score: 994
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 3.74
    Marker Score: 814
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.74
    Marker Score: 2,831
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.74
    Marker Score: 1,106
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.74
    Marker Score: 1,935
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.73
    Marker Score: 3,098
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.72
    Marker Score: 3,591
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.72
    Marker Score: 3,771
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.72
    Marker Score: 1,055
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.72
    Marker Score: 4,251
  • Cell Name: club cell (CL0000158)
    Fold Change: 3.71
    Marker Score: 4,329
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 3.68
    Marker Score: 1,039
  • Cell Name: platelet (CL0000233)
    Fold Change: 3.68
    Marker Score: 1,666
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.68
    Marker Score: 2,438
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.68
    Marker Score: 6,028
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.67
    Marker Score: 2,417

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF1 is a highly conserved protein across eukaryotic species, with high sequence identity among different organisms. It is a member of the eIF family, which plays a central role in the translation initiation process. EIF1 is composed of three subunits: EIF1A, EIF1B, and EIF1D, which interact with other translation factors to form the eIF complex. This complex is responsible for recruiting ribosomes to the mRNA and facilitating the initiation of translation. **Pathways and Functions:** EIF1 is involved in multiple pathways, including: 1. **Regulation of translational initiation**: EIF1 plays a crucial role in recruiting ribosomes to the mRNA and facilitating the initiation of translation. It interacts with other translation factors, such as eIF2 and eIF3, to form the eIF complex. 2. **Positive regulation of mRNA cis-splicing via the spliceosome**: EIF1 has been shown to interact with the spliceosome, a complex involved in the splicing of pre-mRNA. This interaction regulates the processing of pre-mRNA and the subsequent translation of the mature mRNA. 3. **Regulation of the 43s and 48s preinitiation complexes**: EIF1 is involved in the formation and regulation of the 43s and 48s preinitiation complexes, which are essential for the translation initiation process. **Clinical Significance:** EIF1 has been implicated in various diseases, including: 1. **Cancer**: EIF1 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. This overexpression is associated with poor prognosis and reduced survival rates. 2. **Neurological disorders**: EIF1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Mutations in the EIF1 gene have been associated with these diseases. 3. **Infectious diseases**: EIF1 has been shown to be involved in the regulation of the translation of viral mRNAs, making it a potential target for antiviral therapies. In conclusion, EIF1 is a critical protein involved in the regulation of eukaryotic translation initiation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 3312417831

Symbol: EIF1_HUMAN

Name: A121

UniProtKB Accession Codes:

P41567 Q9UNQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 9 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7904817

Title: Expressed sequence tags identify a human isolog of the suil translation initiation factor.

PubMed ID: 7904817

DOI: 10.1006/bbrc.1994.1040

PubMed ID: 10347211

Title: Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1 (eIF1(A121/SUI1)).

PubMed ID: 10347211

DOI: 10.1074/jbc.274.23.16487

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9732867

Title: Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

PubMed ID: 9732867

DOI: 10.1038/29703

PubMed ID: 11073994

Title: Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.

PubMed ID: 11073994

DOI: 10.1128/mcb.20.23.8944-8957.2000

PubMed ID: 12435632

Title: The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection.

PubMed ID: 12435632

DOI: 10.1101/gad.1020902

PubMed ID: 14600024

Title: Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing.

PubMed ID: 14600024

DOI: 10.1101/gad.1141803

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22813744

Title: The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2beta.

PubMed ID: 22813744

DOI: 10.1016/j.celrep.2012.04.007

PubMed ID: 24319994

Title: The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

PubMed ID: 24319994

DOI: 10.1021/bi4009775

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29987188

Title: Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and -independent translation.

PubMed ID: 29987188

DOI: 10.1128/mcb.00139-18

PubMed ID: 10228174

Title: Structure and interactions of the translation initiation factor eIF1.

PubMed ID: 10228174

DOI: 10.1093/emboj/18.9.2631

Sequence Information:

  • Length: 113
  • Mass: 12732
  • Checksum: A7BC7F9B53FFEB2C
  • Sequence:
    • MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV 
KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI GLAKDDQLKV HGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.