Details for: EIF1

Gene ID: 10209

Symbol: EIF1

Ensembl ID: ENSG00000173812

Description: eukaryotic translation initiation factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1524.8941
    Cell Significance Index: -237.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 937.3002
    Cell Significance Index: -237.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 732.3504
    Cell Significance Index: -301.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 688.5541
    Cell Significance Index: -279.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 625.6531
    Cell Significance Index: -295.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 583.4149
    Cell Significance Index: -300.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 441.9228
    Cell Significance Index: -296.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 293.3093
    Cell Significance Index: -280.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 215.7498
    Cell Significance Index: -266.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 76.8301
    Cell Significance Index: -235.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 75.7416
    Cell Significance Index: -298.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 46.0345
    Cell Significance Index: -123.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 43.9599
    Cell Significance Index: -96.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.3461
    Cell Significance Index: 353.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 12.0158
    Cell Significance Index: 212.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 11.1370
    Cell Significance Index: 303.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 11.0141
    Cell Significance Index: 517.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 10.6133
    Cell Significance Index: 494.8400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 10.1429
    Cell Significance Index: 59.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.5668
    Cell Significance Index: 176.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 9.1409
    Cell Significance Index: 479.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.5338
    Cell Significance Index: 1093.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.2643
    Cell Significance Index: 541.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.0755
    Cell Significance Index: 971.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.0693
    Cell Significance Index: 913.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.5191
    Cell Significance Index: 171.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.3031
    Cell Significance Index: 775.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.2959
    Cell Significance Index: 3438.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.8964
    Cell Significance Index: 1062.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.8042
    Cell Significance Index: 374.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.6020
    Cell Significance Index: 2476.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.5318
    Cell Significance Index: 652.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.8953
    Cell Significance Index: 170.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.3423
    Cell Significance Index: 49.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.2900
    Cell Significance Index: 303.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.9134
    Cell Significance Index: 668.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6525
    Cell Significance Index: 189.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.6375
    Cell Significance Index: 106.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.5038
    Cell Significance Index: 73.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.3445
    Cell Significance Index: 77.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5305
    Cell Significance Index: 250.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.0759
    Cell Significance Index: 55.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.0362
    Cell Significance Index: 585.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.0027
    Cell Significance Index: 1515.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4471
    Cell Significance Index: 287.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0997
    Cell Significance Index: 220.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.9879
    Cell Significance Index: 724.3100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.6600
    Cell Significance Index: 4.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.6272
    Cell Significance Index: 71.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5375
    Cell Significance Index: 192.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3778
    Cell Significance Index: 71.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0136
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0301
    Cell Significance Index: -56.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0588
    Cell Significance Index: -6.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0675
    Cell Significance Index: -1.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0847
    Cell Significance Index: -6.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1084
    Cell Significance Index: -80.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1214
    Cell Significance Index: -223.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1454
    Cell Significance Index: -223.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1848
    Cell Significance Index: -251.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2567
    Cell Significance Index: -160.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3118
    Cell Significance Index: -198.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3702
    Cell Significance Index: -208.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5145
    Cell Significance Index: -233.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5868
    Cell Significance Index: -123.5900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5898
    Cell Significance Index: -3.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5901
    Cell Significance Index: -37.1900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6622
    Cell Significance Index: -8.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7938
    Cell Significance Index: -8.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.2595
    Cell Significance Index: -137.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.5903
    Cell Significance Index: -231.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.6457
    Cell Significance Index: -188.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.7133
    Cell Significance Index: -105.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.7253
    Cell Significance Index: -201.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.7846
    Cell Significance Index: -45.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.8328
    Cell Significance Index: -51.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.1341
    Cell Significance Index: -57.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.4837
    Cell Significance Index: -190.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.5895
    Cell Significance Index: -35.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.6481
    Cell Significance Index: -45.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.6609
    Cell Significance Index: -120.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.7372
    Cell Significance Index: -78.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.7980
    Cell Significance Index: -291.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -3.0354
    Cell Significance Index: -170.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.1967
    Cell Significance Index: -214.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.7857
    Cell Significance Index: -121.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.8101
    Cell Significance Index: -23.0200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -4.3407
    Cell Significance Index: -37.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.5286
    Cell Significance Index: -98.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.5900
    Cell Significance Index: -78.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.6676
    Cell Significance Index: -69.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.8045
    Cell Significance Index: -294.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -5.0647
    Cell Significance Index: -263.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.0786
    Cell Significance Index: -60.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -5.9149
    Cell Significance Index: -144.3200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -5.9926
    Cell Significance Index: -124.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.0365
    Cell Significance Index: -177.8000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -6.2832
    Cell Significance Index: -48.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.3160
    Cell Significance Index: -279.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -6.8555
    Cell Significance Index: -133.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF1 is a highly conserved protein across eukaryotic species, with high sequence identity among different organisms. It is a member of the eIF family, which plays a central role in the translation initiation process. EIF1 is composed of three subunits: EIF1A, EIF1B, and EIF1D, which interact with other translation factors to form the eIF complex. This complex is responsible for recruiting ribosomes to the mRNA and facilitating the initiation of translation. **Pathways and Functions:** EIF1 is involved in multiple pathways, including: 1. **Regulation of translational initiation**: EIF1 plays a crucial role in recruiting ribosomes to the mRNA and facilitating the initiation of translation. It interacts with other translation factors, such as eIF2 and eIF3, to form the eIF complex. 2. **Positive regulation of mRNA cis-splicing via the spliceosome**: EIF1 has been shown to interact with the spliceosome, a complex involved in the splicing of pre-mRNA. This interaction regulates the processing of pre-mRNA and the subsequent translation of the mature mRNA. 3. **Regulation of the 43s and 48s preinitiation complexes**: EIF1 is involved in the formation and regulation of the 43s and 48s preinitiation complexes, which are essential for the translation initiation process. **Clinical Significance:** EIF1 has been implicated in various diseases, including: 1. **Cancer**: EIF1 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. This overexpression is associated with poor prognosis and reduced survival rates. 2. **Neurological disorders**: EIF1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Mutations in the EIF1 gene have been associated with these diseases. 3. **Infectious diseases**: EIF1 has been shown to be involved in the regulation of the translation of viral mRNAs, making it a potential target for antiviral therapies. In conclusion, EIF1 is a critical protein involved in the regulation of eukaryotic translation initiation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 3312417831

Symbol: EIF1_HUMAN

Name: A121

UniProtKB Accession Codes:

P41567 Q9UNQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 EMDB 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7904817

Title: Expressed sequence tags identify a human isolog of the suil translation initiation factor.

PubMed ID: 7904817

DOI: 10.1006/bbrc.1994.1040

PubMed ID: 10347211

Title: Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1 (eIF1(A121/SUI1)).

PubMed ID: 10347211

DOI: 10.1074/jbc.274.23.16487

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9732867

Title: Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

PubMed ID: 9732867

DOI: 10.1038/29703

PubMed ID: 11073994

Title: Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.

PubMed ID: 11073994

DOI: 10.1128/mcb.20.23.8944-8957.2000

PubMed ID: 12435632

Title: The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection.

PubMed ID: 12435632

DOI: 10.1101/gad.1020902

PubMed ID: 14600024

Title: Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing.

PubMed ID: 14600024

DOI: 10.1101/gad.1141803

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22813744

Title: The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2beta.

PubMed ID: 22813744

DOI: 10.1016/j.celrep.2012.04.007

PubMed ID: 24319994

Title: The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

PubMed ID: 24319994

DOI: 10.1021/bi4009775

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29987188

Title: Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and -independent translation.

PubMed ID: 29987188

DOI: 10.1128/mcb.00139-18

PubMed ID: 10228174

Title: Structure and interactions of the translation initiation factor eIF1.

PubMed ID: 10228174

DOI: 10.1093/emboj/18.9.2631

Sequence Information:

  • Length: 113
  • Mass: 12732
  • Checksum: A7BC7F9B53FFEB2C
  • Sequence:
    • MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV 
KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI GLAKDDQLKV HGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.